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| 1 | Advances in the Pathogenesis of Alzheimer’s Disease:Focusing on Tau-Mediated Neurodegeneration显示文摘In addition to senile plaques and cerebral amyloid angiopathy,the hyperphosphorylation of tau protein and formation of intraneuronal neurofibrillary tangles(NFTs)represents another neuropathological hallmark in AD brain.Tau is a microtubule-associated protein and localizes predominantly in the axons of neurons with the primary function in maintaining microtubules stability.When the balance between tau phosphorylation and dephosphorylation is changed in favor of the former,tau is hyperphosphorylated and the level of the free tau fractions elevated.The hyperphosphorylation of tau protein and formation of NFTs represent a characteristic neuropathological feature in AD brain.We have discussed the role of Aβin AD in our previous review,this review focused on the recent advances in tau-mediated AD pathology,mainly including tau hyperphosphorylation,propagation of tau pathology and the relationship between tau and Aβ. | Yale Duan Suzhen Dong Feng Gu Yinghe Hu Zheng Zhao | 2012 | Translational Neurodegeneration2012，1，1： | 15 |
| 2 | Advances in the pathogenesis of Alzheimer’s disease:a re-evaluation of amyloid cascade hypothesis显示文摘Alzheimer’s disease(AD)is a common neurodegenerative disease characterized clinically by progressive deterioration of memory,and pathologically by histopathological changes including extracellular deposits of amyloid-beta(A-beta)peptides forming senile plaques(SP)and the intracellular neurofibrillary tangles(NFT)of hyperphosphorylated tau in the brain.This review focused on the new developments of amyloid cascade hypothesis with details on the production,metabolism and clearance of A-beta,and the key roles of some important A-beta-related genes in the pathological processes of AD.The most recent research advances in genetics,neuropathology and pathogenesis of the disease were also discussed. | Suzhen Dong Yale Duan Yinghe Hu Zheng Zhao | 2012 | Translational Neurodegeneration2012，1，1： | 13 |
| 3 | LS-SVM and Monte Carlo methods based reliability analysis for settlement of soft clayey foundation显示文摘A method which adopts the combination of least squares support vector machine(LS-SVM) and Monte Carlo(MC) simulation is used to calculate the foundation settlement reliability.When using LS-SVM,choosing the training dataset and the values for LS-SVM parameters is the key.In a representative sense,the orthogonal experimental design with four factors and five levels is used to choose the inputs of the training dataset,and the outputs are calculated by using fast Lagrangian analysis continua(FLAC).The decimal ant colony algorithm(DACA) is also used to determine the parameters.Calculation results show that the values of the two parameters,and δ2 have great effect on the performance of LS-SVM.After the training of LS-SVM,the inputs are sampled according to the probabilistic distribution,and the outputs are predicted with the trained LS-SVM,thus the reliability analysis can be performed by the MC method.A program compiled by Matlab is employed to calculate its reliability.Results show that the method of combining LS-SVM and MC simulation is applicable to the reliability analysis of soft foundation settlement. | Yinghe Wang Xinyi Zhao Baotian Wang | 2013 | Journal of Rock Mechanics and Geotechnical Engineering2013，5，4： | 5 |
| 4 | Single MoTe_(2) sheet electrocatalytic microdevice for in situ revealing the activated basal plane sites by vacancies engineering显示文摘Activating basal plane inert sites will endow MoTe_(2) with prominent hydrogen evolution reaction(HER)catalytic capability and arouse a new family of HER catalysts.Herein,we fabricated single MoTe_(2) sheet electrocatalytic microdevice for in situ revealing the activated basal plane sites by vacancies introducing.Through the extraction of electrical parameters of single MoTe_(2) sheet,the in-plane and interlayer conductivities were optimized effectively by Te vacancies due to the defect levels.More deeply,Te vacancies can induce the delocalization of electrons around Mo atoms and shift the d-band center,as a consequence,facilitate the adsorption of H from the catalyst surface for HER catalysis.Benefiting by the coordinated regulation of band structure and local charge density,the overpotential at−10 mA·cm^(−2)was reduced to 0.32 V after Te vacancies compared to 0.41 V for the basal plane sites of same MoTe_(2) nanosheet.Meanwhile,the insights gained from single nanosheet electrocatalytic microdevice can be applied to the improved HER of the commercial MoTe_(2) power.That the in situ testing of the atomic structure-electrical behavior-electrochemical properties of a single nanosheet before/after vacancies introducing provides reliable insight to structure-activity relationships. | Huan Yang Yinghe Zhao Qunlei Wen Yan Mi Youwen Liu Huiqiao Li Tianyou Zhai | 2021 | Nano Research2021，14，12： | 3 |
| 5 | Strain-sensitive ferromagnetic two-dimensional Cr_(2)Te_(3)显示文摘Searching for room temperature magnetic two-dimensional(2D)materials is a charming goal,but the number of satisfied materials is tiny.Strain can introduce considerable deformation into the lattice structure of 2D materials,and thus significantly modulate their intrinsic properties.In this work,we demonstrated a remarkable strain-modulated magnetic properties in the chemical vapor deposited Cr_(2)Te_(3) nanoflakes grown on mica substrate.We found the Curie temperature of Cr_(2)Te_(3) nanoflakes can be positively and negatively modulated under tensile and compressive strain respectively,with a maximum varied value of -40 and-90 K,dependent on the thickness of samples.Besides,the coercive field of Cr_(2)Te_(3) nanoflakes also showed a significant decrease under the applied strain,suggesting the decrease of exchange interaction or the change of the magnetization direction.This work suggests a promise to employ interfacial strain to accelerate the practical application of room temperature 2D magnetics. | Junchuan Zhong Mingshan Wang Teng Liu Yinghe Zhao Xiang Xu Shasha Zhou Junbo Han Lin Gan Tianyou Zhai | 2022 | Nano Research2022，15，2： | 1 |
| 6 | A Universal Atomic Substitution Conversion Strategy Towards Synthesis of Large‑Size Ultrathin Nonlayered Two‑Dimensional Materials显示文摘Nonlayered two-dimensional(2D)materials have attracted increasing attention,due to novel physical properties,unique surface structure,and high compatibility with microfabrication technique.However,owing to the inherent strong covalent bonds,the direct synthesis of 2D planar structure from nonlayered materials,especially for the realization of large-size ultrathin 2D nonlayered materials,is still a huge challenge.Here,a general atomic substitution conversion strategy is proposed to synthesize large-size,ultrathin nonlayered 2D materials.Taking nonlayered CdS as a typical example,large-size ultrathin nonlayered CdS single-crystalline flakes are successfully achieved via a facile low-temperature chemical sulfurization method,where pre-grown layered CdI2 flakes are employed as the precursor via a simple hot plate assisted vertical vapor deposition method.The size and thickness of CdS flakes can be controlled by the CdI2 precursor.The growth mechanism is ascribed to the chemical substitution reaction from I to S atoms between CdI2 and CdS,which has been evidenced by experiments and theoretical calculations.The atomic substitution conversion strategy demonstrates that the existing 2D layered materials can serve as the precursor for difficult-to-synthesize nonlayered 2D materials,providing a bridge between layered and nonlayered materials,meanwhile realizing the fabrication of large-size ultrathin nonlayered 2D materials. | Mei Zhao Sijie Yang Kenan Zhang Lijie Zhang Ping Chen Sanjun Yang Yang Zhao Xiang Ding Xiaotao Zu Yuan Li Yinghe Zhao Liang Qiao Tianyou Zhai | 2021 | Nano-Micro Letters2021，13，11： | 1 |
| 7 | 5-HMF attenuates inflammation and demyelination in experimental autoimmune encephalomyelitis mice by inhibiting the MIF-CD74 interaction显示文摘The neuroprotective role of 5-hydroxymethyl-2-furfural(5-HMF)has been demonstrated in a variety of neurological diseases.The aim of this study is to investigate the effect of 5-HMF on multiple sclerosis(MS).IFN-γ-stimulated murine microglia(BV2 cells)are considered a cell model of MS.With 5-HMF treatment,microglial M1/2 polarization and cytokine levels are detected.The interaction of 5-HMF with migration inhibitory factor(MIF)is predicted using online databases.The experimental autoimmune encephalomyelitis(EAE)mouse model is established,followed by a 5-HMF injection.The results show that 5-HMF facilitates IFN-γ-stimulated microglial M2 polarization and attenuates the inflammatory response.According to the network pharmacology and molecular docking results,5-HMF has a binding site for MIF.Further results show that blocking MIF activity or silencing CD74 enhances microglial M2 polarization,reduces inflammatory activity,and prevents ERK1/2 phosphorylation.5-HMF inhibits the MIF-CD74 interaction by binding to MIF,thereby inhibiting microglial M1 polarization and enhancing the anti-inflammatory response.5-HMF ameliorates EAE,inflammation,and demyelination in vivo.In conclusion,our research indicates that 5-HMF promotes microglial M2 polarization by inhibiting the MIF-CD74 interaction,thereby attenuating inflammation and demyelination in EAE mice. | Dongsheng Guan Yingxia Li Yinglin Cui Huanghong Zhao Ning Dong Kun Wang Deqi Ren Tiantian Song Xiaojing Wang Shijie Jin Yinghe Gao Mengmeng Wang | 2023 | Acta Biochimica et Biophysica Sinica2023，55，8： | 0 |
| 8 | The Unusual AGN Host NGC 1266:Evidence for Shocks in a Molecular Gas Rich S0 Galaxy with a Low Luminosity Nucleus显示文摘NGC 1266 is a lenticular galaxy(S0)hosting an active galactic nucleus(AGN),and known to contain a large amount of shocked gas.We compare the luminosity ratio of mid-J CO lines to IR continuum with star-forming galaxies(SFGs),and then model the CO spectral line energy distribution(SLED).We confirm that in the mid-and high-J regions(J_(up)=4-13),the C-type shock(v_(s)=25 km s^(-1),n_(H)=5×10^(4)cm^(-3))can reproduce the CO observations well.The galaxy spectral energy distribution(SED)is constructed and modeled by the code X-CIGALE and obtains a set of physical parameters including the star formation rate(SFR,1.17±0.47 M_(⊙)yr^(-1)).Also,our work provides SFR derivation of[C II]from the neutral hydrogen regions only(1.38±0.14 M_(⊙)yr^(-1)).Previous studies have illusive conclusions on the AGN or starburst nature of the NGC 1266 nucleus.Our SED model shows that the hidden AGN in the system is intrinsically low-luminosity,consequently the infrared luminosity of the AGN does not reach the expected level.Archival data from Nu STAR hard X-ray observations in the 3-79 keV band shows a marginal detection,disfavoring presence of an obscured luminous AGN and implying that a compact starburst is more likely dominant for the NGC 1266 nucleus. | Peibin Chen Yinghe Zhao Junfeng Wang | 2023 | Research in Astronomy and Astrophysics2023，23，1： | 0 |
| 9 | Spatially Resolved Properties of the GW170817 Host Galaxy显示文摘GW170817 is the unique gravitational-wave(GW)event associated with the electromagnetic(EM)counterpart GRB 170817A.NGC 4993 is identified as the host galaxy of GW170817/GRB 170817A.In this paper,we focus on the spatially resolved properties of NGC 4993.We present the photometric results from the comprehensive data analysis of the high spatial-resolution images in the different optical bands.The morphological analysis reveals that NGC 4993 is a typical early-type galaxy without significant remnants of a major galaxy merger.The spatially resolved stellar population properties of NGC 4993 suggest that the galaxy center has passive evolution with the outskirt formed by gas accretion.We derive the merging rate of the compact object per galaxy by a co-evolution scenario of a supermassive black hole and its host galaxy.If the galaxy formation is at redshift 1.0,the merging rate per galaxy is from 3.2×10^(-4)to 7.7×10^(-5)within the merging decay time from 1.0 to 5.0 Gyr.The results provide vital information for ongoing GW EM counterpart detections.The Hubble space telescope data analysis presented in this paper can be also applied to Chinese Space Station Telescope research in the future. | Yubin Li Jirong Mao Jianbo Qin Xianzhong Zheng Fengshan Liu Yinghe Zhao Xiaohong Zhao | 2023 | Research in Astronomy and Astrophysics2023，23，7： | 0 |
| 10 | Single-atom catalysts with anionic metal centers: Promising electrocatalysts for the oxygen reduction reaction and beyond显示文摘Ongoing efforts to develop single-atom catalysts(SACs) for the oxygen reduction reaction(ORR) typically focus on SACs with cationic metal centers,while SACs with anionic metal centers(anionic SACs) have been generally neglected.However,anionic SACs may offer excellent active sites for ORR,since anionic metal centers could facilitate the activation of O_(2) by back donating electrons to the antibonding orbitals of O_(2).In this work,we propose a simple guideline for designing anionic SACs:the metal centers should have larger electronegativity than the surrounding atoms in the substrate on which the metal atoms are supported.By means of density functional theory(DFT) simulations,we identified 13 anionic metal centers(Co,Ni,Cu,Ru,Rh,Pd,Ag,Re,Os,Ir,Pt,Au,and Hg) dispersed on pristine or defective antimonene substrates as new anionic SACs,among which anionic Au and Co metal centers exhibit limiting potentials comparable to,or even better than,conventional Pt-based catalysts towards ORR.We also found that anionic Os and Re metal centers on the defective antimonene can electrochemically catalyze the nitrogen reduction reaction(NRR) with a limiting potential close to that of stepped Ru(0001).Overall,our work shows promise towards the rational design of anionic SACs and their utility for applications as electrocatalysts for ORR and other important electrochemical reactions. | Jinxing Gu Yinghe Zhao Shiru Lin Jingsong Huang Carlos R.Cabrera Bobby G.Sumpter Zhongfang Chen | 2021 | Journal of Energy Chemistry2021，30，12： | 0 |
| 11 | Capturing 2D van der Waals magnets with high probability for experimental demonstration from materials science literature显示文摘2D van der Waals(vdW)magnets have opened intriguing prospects for next-generation spintronic nanodevices.Machine learning techniques and density functional theory calculations enable the discovery of 2D vdW magnets to be accelerated;however,current computational frameworks based on these state-ofthe-art approaches cannot offer probability analysis on whether a 2D vdW magnet can be experimentally demonstrated.Herein,a new framework can be established to overcome this challenge.Via the framework,2D vdW magnets with high probability for experimental demonstration are captured from materials science literature.The key to the successful establishment is the introduction of the theory of mutual information.Historical validation of predictions substantiates the high reliability of the framework.For example,half of the 302D vdW magnets discovered in the literature published prior to 2017 have been experimentally demonstrated in the subsequent years.This framework has the potential to become a revolutionary force for progressing experimental discovery of 2D vdW magnets. | Haiyang Song Yinghe Zhao Eleanor Turner YuWu Yuan Li Menghao Wu Guang Feng Huiqiao Li Tianyou Zhai | 2023 | InfoMat2023，5，4： | 0 |
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