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| 1 | Genome Warehouse: A Public Repository Housing Genome-scale Data显示文摘The Genome Warehouse(GWH)is a public repository housing genome assembly data for a wide range of species and delivering a series of web services for genome data submission,storage,release,and sharing.As one of the core resources in the National Genomics Data Center(NGDC),part of the China National Center for Bioinformation(CNCB;https://ngdc.cncb.ac.cn),GWH accepts both full and partial(chloroplast,mitochondrion,and plasmid)genome sequences with different assembly levels,as well as an update of existing genome assemblies.For each assembly,GWH collects detailed genome-related metadata of biological project,biological sample,and genome assembly,in addition to genome sequence and annotation.To archive high-quality genome sequences and annotations,GWH is equipped with a uniform and standardized procedure for quality control.Besides basic browse and search functionalities,all released genome sequences and annotations can be visualized with JBrowse.By May 21,2021,GWH has received 19,124 direct submissions covering a diversity of 1108 species and has released 8772 of them.Collectively,GWH serves as an important resource for genomescale data management and provides free and publicly accessible data to support research activities throughout the world.GWH is publicly accessible at https://ngdc.cncb.ac.cn/gwh. | Meili Chen Yingke Ma Song Wu Xinchang Zheng Hongen Kang Jian Sang Xingjian Xu Lili Hao Zhaohua Li Zheng Gong Jingfa Xiao Zhang Zhang Wenming Zhao Yiming Bao | 2021 | Genomics, Proteomics & Bioinformatics2021，19，4： | 12 |
| 2 | The Global Landscape of SARS-CoV-2 Genomes, Variants, and Haplotypes in 2019nCoVR显示文摘On January 22,2020,China National Center for Bioinformation(CNCB)released the 2019 Novel Coronavirus Resource(2019nCoVR),an open-access information resource for the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).2019nCoVR features a comprehensive integration of sequence and clinical information for all publicly available SARS-CoV-2 isolates,which are manually curated with value-added annotations and quality evaluated by an automated in-house pipeline.Of particular note,2019nCoVR offers systematic analyses to generate a dynamic landscape of SARS-CoV-2 genomic variations at a global scale.It provides all identified variants and their detailed statistics for each virus isolate,and congregates the quality score,functional annotation,and population frequency for each variant.Spatiotemporal change for each variant can be visualized and historical viral haplotype network maps for the course of the outbreak are also generated based on all complete and high-quality genomes available.Moreover,2019nCoVR provides a full collection of SARS-CoV-2 relevant literature on the coronavirus disease 2019(COVID-19),including published papers from PubMed as well as preprints from services such as bioRxiv and medRxiv through Europe PMC.Furthermore,by linking with relevant databases in CNCB,2019nCoVR offers data submission services for raw sequence reads and assembled genomes,and data sharing with NCBI.Collectively,SARS-CoV-2 is updated daily to collect the latest information on genome sequences,variants,haplotypes,and literature for a timely reflection,making 2019nCoVR a valuable resource for the global research community.2019nCoVR is accessible at https://bigd.big.ac.cn/ncov/. | Shuhui Song Lina Ma Dong Zou Dongmei Tian Cuiping Li Junwei Zhu Meili Chen Anke Wang Yingke Ma Mengwei Li Xufei Teng Ying Cui Guangya Duan Mochen Zhang Tong Jin Chengmin Shi Zhenglin Du Yadong Zhang Chuandong Liu Rujiao Li Jingyao Zeng Lili Hao Shuai Jiang Hua Chen Dali Han Jingfa Xiao Zhang Zhang Wenming Zhao Yongbiao Xue Yiming Bao | 2020 | Genomics, Proteomics & Bioinformatics2020，18，6： | 4 |
| 3 | Integrated Wide Area Protection and Control for Power Grid Security显示文摘The traditional“three defense lines”for power systems are based on local information and static protection&control strategy,which are not suitable to modern large-scale power systems.In order to improve the security of UHV hybrid power grids,the Integrated Wide Area Protection&Control(IWAPC)is proposed in this paper by applying the new technologies of synchronized high-speed communication,which integrates“three defense lines”and promotes existing wide area protection only for security control.The IWAPC is the hierarchical protection and control system which provides the protection and control for wide area power networks to improve their reliability and security.It is divided into three levels,the local bay level,the substation integrated protection level and the wide area protection level.The wide area real-time protection and control information platform is the most important part of the IWAPC,which is based on a synchronized wide area communication network.The key technologies and new development trends include network topology analysis,wide area backup protection,wide area intelligent reclosing,wide area load shedding,wide area auto-switching,overload cutoff and transfer,transmission section protection,intelligent system splitting and dynamic stability control.It cannot only integrate three lines of defense for power system protection and control,but also improve security of the power grid. | Qingping Wang Zhiqian Bo Yingke Zhao Xiaowei Ma Ming Zhang Hao Zheng Lin Wang | 2019 | CSEE Journal of Power and Energy Systems2019，5，2： | 2 |
| 4 | MPoxVR: A comprehensive genomic resource for monkeypox virus variant surveillance显示文摘Monkeypox is a viral zoonotic disease endemic in Central and West Africa.Since January 1,2022,3413 laboratory-confirmed monkeypox cases and one death have been reported from 50 countries/territories in five WHO regions(as of June 22,2022;https://www.who.int/emergencies/disease-outbreak-news/item/2022-DON396),and 1310 new cases and eight new countries have been reported in the past week.Genomic epidemiology is vital to determine the similarity between viruses and suggest possible links between cases,origins of infection,and transmission dynamics when combined with epidemiological information.However,one of the priority evidence gaps relating to the monkeypox outbreak is genome sequencing and in-host variation analysis.1 So,timely sharing both raw sequence data and consensus genomic data are useful to public health investigators and academic partners undertaking related studies. | Yingke Ma Meili Chen Yiming Bao Shuhui Song MPoxVR Team | 2022 | The Innovation2022，3，5： | 2 |
| 5 | Integrated protection based on multifrequency domain information for UHV half-wavelength AC transmission line显示文摘Half-wavelength AC Transmission(HWACT)can improve capability of AC transmission significantly.According to the basic principle of HWACT,the electromagnetic transient model of HWACT is built to analyze the fault transient process of transmission line.Based on fault characteristics of HWACT,the adaptability of traditional protections for transmission lines is analyzed briefly,such as current differential protection,distance protection and over current protection.In order to solve the problems of conventional protection caused by HWACT,a novel integrated protection based on multi-frequency domain information is proposed in this paper,which uses both the power frequency information and transient information.The integrated protection based on multi-frequency domain information takes advantages of power frequency and transient protections,which can not only improve the performance of traditional protection of AC transmission line but also realize fast fault judgment by transient travelling wave protection. | Qingping Wang Zhiqian Bo Xiaowei Ma Ming Zhang Yingke Zhao Yi Zhu Lin Wang | 2016 | Protection and Control of Modern Power Systems2016，1，1： | 1 |
| 6 | Three-dimensionally interconnected Co9S8/MWCNTs composite cathode host for lithium–sulfur batteries显示文摘Several challenging issues,such as the poor conductivity of sulfur,shuttle effects,large volume change of cathode,and the dendritic lithium in anode,have led to the low utilization of sulfur and hampered the commercialization of lithium–sulfur batteries.In this study,a novel three-dimensionally interconnected network structure comprising Co9 S8 and multiwalled carbon nanotubes(MWCNTs)was synthesized by a solvothermal route and used as the sulfur host.The assembled batteries delivered a specific capacity of1154 m Ah g-1 at 0.1 C,and the retention was 64%after 400 cycles at 0.5 C.The polar and catalytic Co9 S8 nanoparticles have a strong adsorbent effect for polysulfide,which can effectively reduce the shuttling effect.Meanwhile,the three-dimensionally interconnected CNT networks improve the overall conductivity and increase the contact with the electrolyte,thus enhancing the transport of electrons and Li ions.Polysulfide adsorption is greatly increased with the synergistic effect of polar Co9 S8 and MWCNTs in the three-dimensionally interconnected composites,which contributes to their promising performance for the lithium–sulfur batteries. | Shengyu Zhao Xiaohui Tian Yingke Zhou Ben Ma Angulakshmi Natarajan | 2020 | Journal of Energy Chemistry2020，29，7： | 1 |
| 7 | U-Net-based deep learning for tracking and quantitative analysis of intracellular vesicles in time-lapse microscopy images显示文摘Fluorescence microscopy has become an essential tool for biologists,to visualize the dynamics of intracellular structures with specific labeling.Quantitatively measuring the dynamics of moving objects inside the cell is pivotal for understanding of the underlying regulatory mechanism.Protein-containing vesicles are involved in various biological processes such as material transportation,organelle interaction,and hormonal regulation,whose dynamic characteristics are signi¯cant to disease diagnosis and drug screening.Although some algorithms have been developed for vesicle tracking,most of them have limited performance when dealing with images with low resolution,poor signal-to-noise ratio(SNR)and complicated motion.Here,we proposed a novel deep learning-based method for intracellular vesicle tracking.We trained the U-Net for vesicle localization and motion classification,with demonstrates great performance in both simulated datasets and real biological samples.By combination with fan-shaped tracker(FsT)we have previously developed,this hybrid new algorithm significantly improved the performance of particle tracking with the function of subsequently automated vesicle motion classification.Furthermore,its performance was further demonstrated in analyzing with vesicle dynamics in different temperature,which achieved reasonable outcomes.Thus,we anticipate that this novel method would have vast applications in analyzing the vesicle dynamics in living cells. | Zhichao Liu Heng Zhang Luhong Jin Jincheng Chen Alexander Nedzved Sergey Ablameyko Qing Ma Jiahui Yu Yingke Xu | 2022 | Journal of Innovative Optical Health Sciences2022，15，5： | 0 |
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