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| 1 | Tinea faciei in a newborn due toTrichophyton tonsurans显示文摘We report here the first case of neonatal tinea faciei caused by Trichophyton tonsurans in China's Mainland.The mother of the infant had tinea corpris and tinea capitis while the father had tinea incongnito.The infections in the parents were mycologically confirmed to be due to Trichophyton tonsurans.Ttinea faciei in the infant was cured after two-week topical use of amorolfine cream.The mother ceased breastfeeding and took oral terbinafine for 4 weeks.No recurrence was observed in the infant during 12 months of follow-up. | Meihua Fu Yiping Ge Wei Chen Suying Feng Xiaodong She Xiaofang Li Weida Liu | 2013 | The Journal of Biomedical Research2013，27，1： | 3 |
| 2 | k-NN Based Bypass Entropy and Mutual Information Estimation for Incremental Remote-Sensing Image Compressibility Evaluation显示文摘Incremental image compression techniques using priori information are of significance to deal with the explosively increasing remote-sensing image data. However, the potential benefi ts of priori information are still to be evaluated quantitatively for effi cient compression scheme designing. In this paper, we present a k-nearest neighbor(k-NN) based bypass image entropy estimation scheme, together with the corresponding mutual information estimation method. Firstly, we apply the k-NN entropy estimation theory to split image blocks, describing block-wise intra-frame spatial correlation while avoiding the curse of dimensionality. Secondly, we propose the corresponding mutual information estimator based on feature-based image calibration and straight-forward correlation enhancement. The estimator is designed to evaluate the compression performance gain of using priori information. Numerical results on natural and remote-sensing images show that the proposed scheme obtains an estimation accuracy gain by 10% compared with conventional image entropy estimators. Furthermore, experimental results demonstrate both the effectiveness of the proposed mutual information evaluation scheme, and the quantitative incremental compressibility by using the priori remote-sensing frames. | Xijia Liu Xiaoming Tao Yiping Duan Ning Ge | 2017 | China Communications2017，14，8： | 2 |
| 3 | Purification of human prothrombin from Nitschmann fraction Ⅲ using DEAE membrane radial flow chromatography显示文摘 | Tao Sun Ge Chen Yiping Liu | 2000 | Journal of Chromatography B: Biomedical Sciences and Applications2000，742，1： | 1 |
| 4 | Temperature and precipitation control of the spatial variation of terrestrial ecosystem carbon exchange in the Asian region显示文摘 | Zhi Chen Guirui Yu Jianping Ge Xiaomin Sun Takashi Hirano Nobuko Saigusa Qiufeng Wang Xianjin Zhu Yiping Zhang Junhui Zhang Junhua Yan Huimin Wang Liang zhao Yanfen Wang Peili Shi Fenghua Zhao | 2013 | Agricultural and Forest Meteorology2013，，： | 1 |
| 5 | Capacity limitation of nuclear units in grid based on analysis of frequency regulation显示文摘在对系统稳定性和安全的力量格子姿势威胁的原子单位的增加的能力。负担骚乱可以引起单位的超速并且触发超速保护控制器(OPC ) 。阀门的重复行动在设备的安全上有强壮的影响并且可以导致力量系统的倒塌。基于频率规定的分析,为在格子的原子单位的数学模型在这份报纸被建立当负担骚乱发生时,模仿动态过程。OPC 的批评行动为单位作为安全操作的限制被建议。在频率规定的不同式样和在格子的原子单位的许可的能力之间的关系被讨论。这研究能帮助在格子估计原子单位的能力限制。 | Yiping DAI Pan JIANG Lin GAO Weimin KAN Xiaoqing XIAO Ge JIN | 2012 | Frontiers in Energy2012，6，2： | 1 |
| 6 | Guidelines for the diagnosis and treatment of acute pancreatitis in China (2021)显示文摘Acute pancreatitis(AP)is a common acute abdominal condition of the digestive system.In recent years,treatment concepts,methods,and strategies for the diagnosis of AP have advanced,and this has played an important role in promoting the standardization of AP diagnosis and treatment and improving the treatment quality of AP patients.On the basis of previous guidelines and expert consensus,this guideline adopts an evidence-based,problem-based expression;synthesizes important clinical research data at home and abroad in the most recent 5 years;and forms 29 recommendations through multidisciplinary expert discussion,including diagnosis,treatment,and follow-up.It is expected to provide evidence support for the treatment of AP in the clinical setting in China. | Fei Li Shouwang Cai Feng Cao Rufu Chen Deliang Fu Chunlin Ge Chunyi Hao Jihui Hao Heguang Huang Zhixiang Jian Gang Jin Ang Li Haimin Li Shengping Li Weiqin Li Yixiong Li Tingbo Liang Xubao Liu Wenhui Lou Yi Miao Yiping Mou Chenghong Peng Renyi Qin Chenghao Shao Bei Sun Guang Tan Xiaodong Tian Huaizhi Wang Lei Wang Wei Wang Weilin Wang Junmin Wei Heshui Wu Wenming Wu Zheng Wu Changqing Yan Yinmo Yang Xiaoyu Yin Xianjun Yu Chunhui Yuan Taiping Zhang Yupei Zhao on behalf of the Chinese Pancreatic Surgery Association | 2021 | Journal of Pancreatology2021，4，2： | 1 |
| 7 | Robustness Evaluation of Remote-Sensing Image Feature Detectors with TH Priori-Information Data Set显示文摘In this paper,we build a remote-sensing satellite imagery priori-information data set,and propose an approach to evaluate the robustness of remote-sensing image feature detectors.The building TH Priori-Information(TPI)data set with 2297 remote sensing images serves as a standardized high-resolution data set for studies related to remote-sensing image features.The TPI contains 1)raw and calibrated remote-sensing images with high spatial and temporal resolutions(up to 2 m and 7 days,respectively),and 2)a built-in 3-D target area model that supports view position,view angle,lighting,shadowing,and other transformations.Based on TPI,we further present a quantized approach,including the feature recurrence rate,the feature match score,and the weighted feature robustness score,to evaluate the robustness of remote-sensing image feature detectors.The quantized approach gives general and objective assessments of the robustness of feature detectors under complex remote-sensing circumstances.Three remote-sensing image feature detectors,including scale-invariant feature transform(SIFT),speeded up robust features(SURF),and priori information based robust features(PIRF),are evaluated using the proposed approach on the TPI data set.Experimental results show that the robustness of PIRF outperforms others by over 6.2%. | Yiping Duan Xiaoming Tao Xijia Liu Ning Ge | 2020 | China Communications2020，17，10： | 0 |
| 8 | Consensus of clinical diagnosis and treatment for non-functional pancreatic neuroendocrine neoplasms with diameter<2 cm显示文摘In clinical practice,pancreatic neuroendocrine neoplasms(pNENs)with a diameter smaller than 2 cm are commonly referred to as small pNENs.Due to their generally favorable biological characteristics,the diagnosis and treatment of small pNENs differ from other pNENs and are somewhat controversial.In response to this,the Chinese Pancreatic Surgery Association,Chinese Society of Surgery,Chinese Medical Association have developed a consensus on the diagnosis and treatment of small pNENs,which is based on evidence-based medicine and expert opinions.This consensus covers various topics,including concepts,disease assessment,treatment selection,follow-up,and other relevant aspects. | Wu Wenming Cai Shouwang Chen Rufu Fu Deliang Ge Chunlin Hao Chunyi Hao Jihui Huang Heguang Jian Zhixiang Jin Gang Li Fei Li Haimin Li Shengping Li Weiqin LiYixiong Liang Tingbo Liu Xubao Lou Wenhui Miao Yi Mou Yiping Peng Chenghong Qin Renyi Shao Chenghao Sun Bei Tan Guang Wang Huaizhi Wang Lei Wang Wei Wang Weilin Wei Junmin Wu Heshui Wu Zheng Yan Changqing Yang Yinmo Yin Xiaoyu Yu Xianjun Yuan Chunhui Zhao Yupei | 2023 | Journal of Pancreatology2023，6，3： | 0 |
| 9 | Safety and activity of WX-0593(Iruplinalkib)in patients with ALK-or ROS1-rearranged advanced non-small cell lung cancer:a phase 1 dose-escalation and dose-expansion trial显示文摘WX-0593(Iruplinalkib)is a novel,highly selective oral ALK and ROS1 tyrosine kinase inhibitor(TKI).In this study,the safety,antitumor activity,and pharmacokinetics of WX-0593 were evaluated in advanced non-small cell lung cancer(NSCLC)patients with ALK or ROS1 rearrangement.In the dose-escalation phase and dose-expansion phase,patients were treated with WX-0593 until disease progression,unacceptable toxicity,or subject withdrawal.In the dose-escalation phase,the primary endpoints were maximum tolerated dose(MTD),dose-limiting toxicity(DLT),and safety assessed by investigators.In the dose-expansion phase,the primary endpoint was objective response rate(ORR)assessed by investigators.Between September 25,2017 and October 15,2018,a total of 153 patients received WX-0593 treatment.Two dose-limiting toxicities(DLTs)including one grade 3 QT interval prolonged and one grade 2 chronic heart failure were reported at the dose of 300 mg in one patient.MTD was not reached.Overall,140 of the 152(92%)patients experienced treatment-related adverse events(TRAEs)and 35 of the 152(23%)patients had TRAEs≥grade 3.The overall ORR was 59.3%(32 of 54)for the dose-escalation phase and 56.6%(56 of 99)for the dose-expansion phase.For patients who were ALK-rearranged and ALK TKI naive,the ORR were 81.0%(17 of 21)in the dose-escalation phase and 76.3%(29 of 38)in the dose-expansion phase,and for patients who previously received crizotinib as the only ALK TKI,the ORR were 38.1%(8 of 21)and 45.7%(21 of 46)for the two phases,respectively.For patients who were ROS1-rearranged,the ORR were 30.0%(3 of 10)in the dose-escalation phase and 44.4%(4 of 9)in the dose-expansion phase.WX-0593 showed favorable safety and promising antitumor activity in advanced NSCLC patients with ALK or ROS1 rearrangement. | Yuankai Shi Jian Fang Xuezhi Hao Shucai Zhang Yunpeng Liu Lin Wang Jianhua Chen Yi Hu Xiaosheng Hang Juan Li Chunling Liu Yiping Zhang Zhehai Wang Yanping Hu Kangsheng Gu Jian’an Huang Liangming Zhang Jinlu Shan Weiwei Ouyang Yanqiu Zhao Wu Zhuang Yan Yu Jun Zhao Helong Zhang Pei Lu Weidong Li Meimei Si Mingjing Ge Huaize Geng | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 0 |
| 10 | Machine learning with active pharmaceutical ingredient/polymer interaction mechanism:Prediction for complex phase behaviors of pharmaceuticals and formulations显示文摘The high throughput prediction of the thermodynamic phase behavior of active pharmaceutical ingredients(APIs)with pharmaceutically relevant excipients remains a major scientific challenge in the screening of pharmaceutical formulations.In this work,a developed machine-learning model efficiently predicts the solubility of APIs in polymers by learning the phase equilibrium principle and using a few molecular descriptors.Under the few-shot learning framework,thermodynamic theory(perturbed-chain statistical associating fluid theory)was used for data augmentation,and computational chemistry was applied for molecular descriptors'screening.The results showed that the developed machine-learning model can predict the API-polymer phase diagram accurately,broaden the solubility data of APIs in polymers,and reproduce the relationship between API solubility and the interaction mechanisms between API and polymer successfully,which provided efficient guidance for the development of pharmaceutical formulations. | Kai Ge Yiping Huang Yuanhui Ji | 2024 | Chinese Journal of Chemical Engineering2024，66，2： | 0 |
| 11 | Guidelines for the diagnosis and treatment of pancreatic cancer in China (2021)显示文摘The incidence of pancreatic cancer has been rising worldwide,and its clinical diagnosis and treatment remain a great challenge.To present the update and improvements in the clinical diagnosis and treatment of pancreatic cancer in recent years,Chinese Pancreatic Association,the Chinese Society of Surgery,Chinese Medical Association revised the Guidelines for the Diagnosis and Treatment of Pancreatic Cancer in China(2014)after reviewing evidence-based and problem-oriented literature published during 2015-2021,mainly focusing on highlight issues regarding diagnosis and surgical treatment of pancreatic cancer,conversion strategies for locally advanced pancreatic cancer,treatment of pancreatic cancer with oligo metastasis,adjuvant and neoadjuvant therapy,standardized processing of surgical specimens and evaluation of surgical margin status,systemic treatment for unresectable pancreatic cancer,genetic testing,as well as postoperative follow up of patients with pancreatic cancer.Forty recommendation items were finally proposed based on the above issues,and the quality of evidence and strength of recommendations were graded using the Grades of Recommendation,Assessment,Development,and Evaluation system.This guideline aims to standardize the clinical diagnosis and therapy,especially surgical treatment of pancreatic cancer in China,and further improve the prognosis of patients with pancreatic cancer. | Yinmo Yang Xueli Bai Dapeng Bian Shouwang Cai Rufu Chen Feng Cao Menghua Dai Chihua Fang Deliang Fu Chunlin Ge Xiaochao Guo Chunyi Hao Jihui Hao Heguang Huang Zhixiang Jian Gang Jin Fei Li Haimin Li Shengping Li Weiqin Li Yixiong Li Hongzhen Li Tingbo Liang Xubao Liu Wenhui Lou Yi Miao Yiping Mou Chenghong Peng Renyi Qin Chenghao Shao Bei Sun Guang Tan Xiaodong Tian Huaizhi Wang Lei Wang Wei Wang Weilin Wang Junmin Wei Heshui Wu Wenming Wu Zheng Wu Jingyong Xu Changqing Yan Xiaoyu Yin Xianjun Yu Chunhui Yuan Taiping Zhang Jixin Zhang Jun Zhou Yupei Zhao on behalf of the Chinese Pancreatic Surgery Association | 2021 | Journal of Pancreatology2021，4，2： | 0 |
| 12 | Establishment,Characterization and Expression Pattern of a Spleen Cell Line,SMSP,Derived from Turbot(Scophthalmus maximus)显示文摘A turbot(Scophthalmus maximus)cell line named SMSP was obtained from the spleen.The origin of the cells was identified by morphology,chromosome number and COI gene.The optimal basic medium,serum concentration and growth temperature of the cells were detected.SMSP cell line is mainly composed of fibroblast-like cells.Most of the SMSP cells contained 44 chromosomes,and the sequence of COI gene confirmed that the cells were originated from turbot.The optimal culture conditions were 24℃,DMEM+10%FBS.The cell line had high transfection efficiency for siRNA and plasmid.After stimulation with lipopolysaccharide(LPS)or poly(I:C),the expressions of immune-related genes such as TNF-β,IL-12s,IL-10 and IL-1βwere up-regulated significantly in the early stage(P<0.05).This study will provide a model for exploring immune mechanism of turbot against pathogen in vitro. | XUE Ting LIU Yiping GE Xuefeng LI Chao | 2023 | Journal of Ocean University of China2023，22，5： | 0 |
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