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| 1 | FibroSURE^(TM) and FibroScan~ in relation to treatment response in chronic hepatitis C virus显示文摘AIM:To compare histological endpoint assessment using noninvasive alternatives to biopsy during treatment in a chronic hepatitis C virus(HCV)cohort.METHODS:Patients with chronic HCV were randomized to receive interferon-based therapy for 24(genotypes 2/3)or 48(genotype 1)wk.FibroSURE~TM(FS)was assessed at baseline and at week-12 post-treatment follow-up.Baseline biopsy for METAVIR was assessed by a single pathologist.FibroScan~ transient elastogra-phy(TE)was performed during treatment in a patient subset.RESULTS:Two thousand and sixty patients(n = 253 in Asia)were classif ied as METAVIR F0-1(n = 1682)or F2-4(n = 378).For F2-4,FS(n = 2055)had sensitiv-ity and specif icity of 0.87 and 0.61,respectively,with area under the receiver-operating curve of 0.82;corre-sponding values for TE(n = 214)and combined FS/TE(n = 209)were 0.77,0.88 and 0.88,and 0.93,0.68 and 0.88.Overall FS/TE agreement for F2-4 was 71%(κ = 0.41)and higher in Asians vs non-Asians(κ = 0.86 vs 0.35;P < 0.001).Combined FS/TE had 97% accuracy in Asians(n = 33).Baseline FS(0.38 vs 0.51,P < 0.001)and TE(8.0 kPa vs 11.9 kPa,P = 0.006)scores were lower in patients with sustained virological response than in nonresponders,and were maintained through follow-up.CONCLUSION:FS and TE may reliably differentiate mild from moderate-advanced disease,with a potential for high diagnostic accuracy in Asians with chronic HCV. | Keyur Patel Mireen Friedrich-Rust Yoav Lurie Mircea Grigorescu Carol Stanciu Chuan-Mo Lee Eugene R Schiff Dieter Hussinger Michael P Manns Guido Gerken Isabelle Colle Michael Torbenson Erik Pulkstenis G Mani Subramanian John G McHutchison Stefan Zeuzem | 2011 | World Journal of Gastroenterology2011，17，41： | 4 |
| 2 | Controlling the false discovery rate in behavior genetics research显示文摘 | Yoav Bi Dan D Greg E Neri K Ilan G | 2001 | Behavioural Brain Research2001，125，1： | 1 |
| 3 | Probabilistic Prediction of Temporal Locality 显示文摘 | Yoav E Dror G | 2007 | IEEE Computer Architecture Letters2007，6，1： | 1 |
| 4 | Polarization-based Vision Through Haze显示文摘 | Yoav Y S Srinivasa G N Shree K N | 2003 | Applied Opitics2003，42，3： | 1 |
| 5 | A lipid emulsion reduces mortality from clomipramine overdose in rats显示文摘 | Yoav G ()delia G Shahiel C | 2002 | Vet Hum Toxicol2002，44，1： | 1 |
| 6 | Controlling the false discovery rate in behavior genetics research 显示文摘 | Yoav B I Dan D Greg E Ilan G | 2001 | Behav Brain Res2001，125，1： | 1 |
| 7 | Associations of anti-hypertensive treatments with Alzheimer's disease,vascular dementia,and other dementias显示文摘 | Neil M Davies Patrick G Kehoe Yoav Ben-Shlomo | | 0，，04： | 1 |
| 8 | The pmsthodontic concept of crown-to-root ratio : A review of the literature显示文摘 | Yoav G Avishai S | 2005 | Prosthetic Dent2005，93，： | 1 |
| 9 | Sciatic nerve palsy due to hematoma after thrombolysis therapy for acute pulmonary embolism after total hip arthroplasty显示文摘 | Yoram W Yoav M Vladimir G | 2006 | The Journal of Arthroplasty April2006，3，： | 1 |
| 10 | A lipid emulsion reduces mortality from clomipramine overdose in rats 显示文摘 | Yoav G Odelia G Shaltiel C | 2002 | Vet Hum Toxi- col2002，44，1： | 1 |
| 11 | Human specific loss of olfactory receptor genes显示文摘 | Yoav G Orna M Svante P | 2003 | Proc Natl Acad Sci U S A2003，100，： | 1 |
| 12 | Arrestment of Telenomus remus (Hymenoptera:Scelionidae) by a kairomone associated with eggs of its host,Spodoptera frugiperda (Lepidoptera:Noctuidae)显示文摘 | Yoav G Lewis W J Tumlinaon J H | 1996 | Biological Control1996，35，6： | 1 |
| 13 | Instant dehazing of images using polarization显示文摘 | Yoav Y S Srinivasa G N Shree K N | 2001 | Computer Vision & Pattern Recognition2001，1，： | 1 |
| 14 | Polarization-based vision through haze显示文摘 | Yoav Y S Srinivasa G N Shree K N | 2003 | Optical Society of American2003，42，3： | 1 |
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