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| 1 | Regulation of MYC gene expression by aberrant Wnt/β-catenin signaling in colorectal cancer显示文摘The Wnt/β-catenin signaling pathway controls intestinal homeostasis and mutations in components of this pathway are prevalent in human colorectal cancers(CRCs).These mutations lead to inappropriate expression of genes controlled by Wnt responsive DNA elements(WREs). T-cell factor/Lymphoid enhancer factor transcription factors bind WREs and recruit the β-catenin transcriptional co-activator to activate target gene expression. Deregulated expression of the c-MYC proto-oncogene(MYC) by aberrant Wnt/β-catenin signaling drives colorectal carcinogenesis. In this review,we discuss the current literature pertaining to the identification and characterization of WREs that control oncogenic MYC expression in CRCs. A common theme has emerged whereby these WREs often map distally to the MYC genomic locus and control MYC gene expression through long-range chromatin loops with the MYC proximal promoter. We propose that by determining which of these WREs is critical for CRC pathogenesis,novel strategies can be developed to treat individuals suffering from this disease. | Sherri Rennoll Gregory Yochum | 2015 | World Journal of Biological Chemistry2015，6，4： | 9 |
| 2 | Intersection of Hippo/YAP and Wnt/β-catenin signaling pathways显示文摘传统地,表明小径被察觉了以一种自治方式行动调整织物形态学,尺寸,区别,和开发。最近的证据建议这些小径经常交叉并且互相调整得到适当回答到刺激的一个复杂集合。知道为开发,生长,和动态平衡重要的二条小径是 Wnt/-catenin 和河马 / 笨蛋小径。成长数据显示这二条小径以适当地调整织物生长并且修理的很多个方法影响对方。这些小径的解除管制经常贡献 tumorigenesis。在这评论,我们将讨论在 Wnt/-catenin 和河马 / 笨蛋小径之间的交叉的点并且这些相互作用怎么贡献动态平衡,机关修理,和 tumorigenesis。 | Wesley M. Konsavage Jr Gregory S. Yochum | 2013 | Acta Biochimica et Biophysica Sinica2013，45，2： | 6 |
| 3 | 基于位置和开放链接数据的旅游推荐系统综述显示文摘利用开放链接数据解决基于位置的推荐系统中存在的信息过载问题是目前的研究热点,并在旅游领域展现出了巨大的潜力。首先给出推荐系统的基本概况;然后对旅游开放链接数据进行了概况;从文献分类、应用分类和研究成果对基于位置和开放链接数据的旅游推荐系统从2014—2018年的相关文献进行了详细考察,并从基于位置的单点推荐、旅游路线推荐、GPS轨迹推荐、基于媒介的地理标签推荐、基于本体的位置推荐和基于位置的朋友推荐等6类典型的应用进行分类考察,最后对全文并为该领域指明了研究方向。 | YOCHUM Phatpicha 常亮 古天龙 祝曼丽 | 2020 | 智能系统学报2020，15，1： | 4 |
| 4 | CD4+T cell tolerance to parechymale self antigens requirs presentation by bone marrow derived antigen presenting cells显示文摘 | ADLER A J MARSH D W YOCHUM G S | 1998 | Exp Med1998，187，10： | 1 |
| 5 | Nuclear AXIN2represses MYC gene expression显示文摘 | Rennoll SA Konsavage WM Jr Yochum GS | 2014 | Biochem Biophys Res Commun2014，443，1： | 1 |
| 6 | Management of discogenic low-back pain with a non-surgical decompression system ( DRX9000TM)- Case Report 显示文摘 | Pergolizzi J Yochum T Florio F | 2008 | US Museuloskeletal Review2008，3，1： | 1 |
| 7 | A beta-catenin/TCF-coordinated chromatin loop at MYC integrates 5' and 3' Wnt responsive enhancers显示文摘 | Yochum GS Sherrick CM Macpartlin M | 2010 | Proc Natl Acad Sci USA2010，107，1： | 1 |
| 8 | Serial analysis of chromatin occupancy identifiesβ-catenin target genes in colorectal carcinoma cells显示文摘 | Yochum GS McW eeney S Rajaraman V | 2007 | Proc Natl Acad Sci USA2007，104，9： | 1 |
| 9 | Management of discogenic low back pain with a non-surgical decompression system (DRXg000) 显示文摘 | Pergolizzi J Yochum T Florio F | 2008 | US Musculoskeletal Review2008，3，1： | 1 |
| 10 | Modification of single-walled carbon nanotube electrodes by layer-by-layer assembly for electrochromic devices显示文摘 | Jain V Yochum H M Montazami R | | 0，，07： | 1 |
| 11 | A genome-wide screen for beta-catenin binding sites identifies a downstream enhancer element that controls c-Myc gene expression显示文摘 | Yochum G S Cleland R Goodman R H | 2008 | Mol Cell Biol2008，28，24： | 1 |
| 12 | Static and changing port economic impacts显示文摘 | Yochum G R | 1998 | Maritime Policy Management1998，2，15： | 1 |
| 13 | Travel Attractions Recommendation with Travel Spatial-Temporal Knowledge Graphs显示文摘 | Weitao Zhang Tianlong Gu Wenping Sun Yochum Phatpicha Liang Chang Chenzhong Bin | 2018 | 国际计算机前沿大会会议论文集2018，，2： | 1 |
| 14 | A beta- catenirdTCF-coordinated chromatin loop at MYC integrates 5' and 3' Wnt responsive enhancers显示文摘 | Yochum GS Sherrick CM Macpartlin M | 2010 | Proc Natl Acad Sci USA2010，107，1： | 1 |
| 15 | Static and Changing Port Ec- onomic Impacts显示文摘 | Yochum G R Agarwal V B | 1988 | Maritime Policy Management1988，15，2： | 1 |
| 16 | Static and changing port economic impacts 显示文摘 | YOCHUM G R AGARWAL V B | 1988 | Maritime Policy Management1988，15，2： | 1 |
| 17 | CD4+ T cell tolerance to parenchymal self-antigens requires presentation by bone marrow-derived antigen-presenting cells 显示文摘 | Marsh DW Yochum GS | 1998 | J Exp Med1998，，： | 1 |
| 18 | Management of discognic low back pain with a non-surgical decompression system( DRX9000 )- Case Report显示文摘 | Pergolizzi J Yochum T Florio F | 2008 | US Musculoskeletal Review2008，3，1： | 1 |
| 19 | Intersection of Hippo/YAP and W nt/beta-catenin signaling pathways 显示文摘 | Konsavage WM Yochum GS | 2013 | Acta Bio- chim Biophys Sin(Shanghai)2013，45，： | 1 |
| 20 | Nuclear AXIN2 re- presses MYC gene expression 显示文摘 | Rennoll SA Konsavage WM Jr Yochum GS | 2014 | Biochem Biophys Res Com- mun2014，443，1： | 1 |
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