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| 1 | Glycosylation engineering of therapeutic IgG antibodies: challenges for the safety, functionality and efficacy显示文摘IgG 的 Fc 区域的 Glycosylation 在安全和治疗学的抗体的临床的功效上有深刻影响。当复杂类型的 oligosaccharide 纳入了 Fc 的 Asn297 的 biantennary 为抗体受动器功能是必要的时,海藻糖和外部手臂的糖属于核心 heptasaccharide 产生结构的异质(glycoforms ) 展出唯一的生物活动。因此,有效、量的 glycan 分析技术为治疗学的抗体的发展和质量控制是日益重要的,并且 Fc 的 glycan 侧面作为批评优秀属性被认出。在过去的十年,我们 IgG-Fc 的结构 / 功能上的 glycosylation 的影响的理解通过 X 光检查结晶、原子的磁性的回声研究很快成长了,它为新奇抗体治疗学的设计提供可能性。而且,用基于 endoglycosidase 的 glycosynthases 的 chemoenzymatic glycoengineering 途径可以作为下一代的治疗学的抗体与理想的功能便于同类的 IgG glycoforms 的发展。因此, Fc glycans 是在精确药的时代的治疗学的 IgG 抗体的安全,功能,和功效的改进的肥沃的地面。 | Yusuke Mimura Toshihiko Katoh Radka Saldova Roisin O'Flaherty Tomonori Izumi Yuka Mimura-Kimura Toshiaki Utsunomiya Yoichi Mizukami Kenji Yamamoto Tsuneo Matsumoto Pauline M. Rudd | 2018 | Protein & Cell2018，9，1： | 2 |
| 2 | Promi nent Laterality of the Posterior Cerebral Artery at Three Dimen sional Time-of-Flight MR Angiography in M1-Segment Middle Cerebral Artery Ocelusion显示文摘 | Akihiro Uemura Toshihiro O'uchi Yoichi Kikuchi | 2004 | AJNR2004，25，1： | 1 |
| 3 | A micromachmed vibrating rate gyroscope with independent beams for the drive and detection modes显示文摘 | Yoichi M Masaya T Kuniki O | 2000 | Sensors and Actuators2000，80，： | 1 |
| 4 | Three-dimensional Non- contact Manipulation by Opposite Ultrasonic Phased Arrays显示文摘 | Takayuki H Yoichi O Jun R | 2014 | Japanese Journal of Applied Physics2014，53，07： | 1 |
| 5 | Exp ression of surviving correlated with vessel invasion is a marker of poor prognosis in small adenocarcinoma of the lung显示文摘 | Mzuki I Fumihiro O Yoichi K | 2002 | Oncol Rep2002，9，4： | 1 |
| 6 | Potassiumcarbonate-promoted stereospecific 5-endo-tfigcyclizationof 显示文摘 | Hiroaki O Yoichi K Nobutaka F | 2006 | org Lett2006，8，5： | 1 |
| 7 | Prominent Laterality of the Posterior Cerebral Artery at Three-Dimensional Time- of-Flight MR Angiography in Ml- Segment Middle Cerebral Artery Occlusion显示文摘 | Akihiro Uemura Toshihiro O' uchi Yoichi Kikuchi | 2004 | AJNR2004，25，： | 1 |
| 8 | Associative memory retrieval induced by fluctuations in a pulsed networks 显示文摘 | Takashi K Yoichi O | 2000 | Physical Review E2000，62，2： | 1 |
| 9 | Toluene diisocyanate (TDI) induces production of inflammatory cytokines and chemokines by bronchial epithelial cells via the epidermal growth factor receptor and p38 mitogen-activated protein kinase pathways 显示文摘 | Hirohisa O Yoichi N Shizuka I | 2006 | Exp Lung Res2006，32，6： | 1 |
| 10 | Effect of Preparation Temperature on Cyclic CO2Captureand Multiple Carbonation-Calcination Cycles for a New Ca-Based CO2Sorbent显示文摘 | Masahiko A Toshiyuki N Junro M Yoichi N Haruhiko O | 2001 | Industial and Engineering ChemistryResearch2001，69，： | 1 |
| 11 | The Effects of Rockfall Volume on Runout Distance 显示文摘 | YOICHI O HIKARU K TOSHIAKI S | 2000 | Engineering Geology2000，58，2： | 1 |
| 12 | Erect leaves caused by brassinosteroid deficiency increase biomass production and grain yield in rice显示文摘 | Tomoaki S Yoichi M Oshiyuki O et a/ | 2005 | Nature Biotechnology2005，24，1： | 1 |
| 13 | Isolation and characterization of monoclonal antibodies that inhibit hepatitis C virus NS3protease显示文摘 | Takamasa U Satoru M Yoichi O | 2000 | Joural of Virology2000，74，14： | 1 |
| 14 | Selective minimum-norm solution of the biomagnetic inverse problem 显示文摘 | KANTA M YOICHI O | 1995 | IEEE Trans on Biomed Eng1995，42，6： | 1 |
| 15 | Friction and wear of titanium boride ceramics at elevated temperatures显示文摘 | TETSUYA S YOICHI Y YASUO O | | J Jpn Ceram Soc0，101，3： | 1 |
| 16 | An Efficient Heteroge- neous Pd Catalyst for the Suzuki Coupling: Pd/AI203 显示文摘 | DAISUKE K YOICHI M MAKOTO O | 2007 | Chem Lett2007，36，7： | 1 |
| 17 | Molecular clo- ning and gene expression of FOXL2 in the frog Rana rugosa显示文摘 | Yuki O Yoshinobu U Yoichi M | 2008 | General and Comparative Endocrinology2008，153，： | 1 |
| 18 | Effect of metal ions on decomposition of chlorinated organic substances by ozonation in acetic acid显示文摘 | Kiyokazu O Tsung-Yueh T Yoichi N | 2005 | Chemosphere2005，58，4： | 1 |
| 19 | Three- dimensional Noncontaet Manipulation by Opposite Ultrasonic Phased Arrays 显示文摘 | Takayuki H Yoichi O Jun R | 2014 | Japanese Journal of Applied Physics2014，53，： | 1 |
| 20 | Expression of survivin correlated with vessel invasion is a marker of poor prognosis in small adenocarcinoma of the lung 显示文摘 | Mzuki I Fumihiro O Yoichi K | 2002 | Oncol Rep2002，9，4： | 1 |
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