5篇
您的检索式：作者名="Yoji Nishimura"
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| 1 | Prognostic value of KRAS and BRAF mutations in curatively resected colorectal cancer显示文摘AIM: To investigate the prognostic role of KRAS and BRAF mutations after adjustment for microsatellite instability(MSI) status in Japanese colorectal cancer(CRC) population.METHODS: We assessed KRAS and BRAF mutations and MSI status in 813 Japanese patients with curatively resected, stage Ⅰ-Ⅲ CRC and examined associations of these mutations with disease-free survival(DFS) and overall survival(OS) using uni- and multivariate Cox proportional hazards models.RESULTS: KRAS and BRAF mutations were detected in 312(38%) of 812 and 40(5%) of 811 tumors, respectively. KRAS mutations occurred more frequently in females than in males(P = 0.02), while the presence of BRAF mutations was significantly associated with the female gender(P = 0.006), proximal tumor location(P < 0.001), mucinous or poorly differentiated histology(P < 0.001), and MSI-high tumors(P < 0.001). After adjusting for relevant variables, including MSI status, KRAS mutations were associated with poorer DFS(HR = 1.35; 95%CI: 1.03-1.75) and OS(HR = 1.46; 95%CI: 1.09-1.97). BRAF mutations were poor prognostic factors for DFS(HR = 2.20; 95%CI: 1.19-4.06) and OS(HR = 2.30; 95%CI: 1.15-4.71). Neither the BRAF by MSI interaction test nor the KRAS by MSI interaction test yielded statistically significant results for DFS and OS.CONCLUSION: KRAS and BRAF mutations are associated with inferior survival, independent of MSI status, inJapanese patients with curatively resected CRC. | Shigenori Kadowaki Miho Kakuta Shuhei Takahashi Akemi Takahashi Yoshiko Arai Yoji Nishimura Toshimasa Yatsuoka Akira Ooki Kensei Yamaguchi Keitaro Matsuo Kei Muro Kiwamu Akagi | 2015 | World Journal of Gastroenterology2015，21，4： | 14 |
| 2 | Metaraminol and dobutamine for the treatment of hypotension associated with epidural block显示文摘 | YOJI Kajimoto NOBUO Nishimura | 1984 | Resuscitation1984，12，1： | 1 |
| 3 | Clinicopathological characteristics and prognostic impact of colorectalcancers with NRAS mutations显示文摘 | Toshiro Ogura Miho Kakuta Toshimasa Yatsuoka Yoji Nishimura Hirohiko Sakamoto Kensei Yamaguchi Minoru Tanabe Yoichi Tanaka Kiwamu Akagi | 2014 | Oncology Reports2014，，1： | 1 |
| 4 | The clinical features of rectal cancers with high-frequency microsatellite instability (MSI-H) in Japanese males显示文摘 | Tsutomu Ishikubo Yoji Nishimura Kensei Yamaguchi Udompun Khansuwan Yoshiko Arai Terutada Kobayashi Yasuo Ohkura Yojiro Hashiguchi Yoichi Tanaka Kiwamu Akagi | 2004 | Cancer Letters2004，，1： | 1 |
| 5 | The clinical features of rectal cancers with high-frequency microsatellite instability (MSI-H) in Japanese males显示文摘 | Tsutomu Ishikubo Yoji Nishimura Kensei Yamaguchi | 2004 | Cancer Letters2004，216，1： | 1 |
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