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| 1 | Gene expression profiles of hepatic cell-type specific marker genes in progression of liver fibrosis显示文摘AIM: To determine the gene expression profile data for the whole liver during development of dimethylni-trosamine (DMN)-induced hepatic fibrosis.METHODS: Marker genes were identified for different types of hepatic cells, including hepatic stellate cells (HSCs), Kupffer cells (including other inflammatory cells), and hepatocytes, using independent temporal DNA microarray data obtained from isolated hepatic cells. RESULTS: The cell-type analysis of gene expression gave several key results and led to formation of three hypotheses: (1) changes in the expression of HSC-specific marker genes during fibrosis were similar to gene expression data in in vitro cultured HSCs, suggesting a major role of the self-activating characteristics of HSCs in formation of fibrosis; (2) expression of mast cell-specific marker genes reached a peak during liver fibrosis, suggesting a possible role of mast cells in formation of fibrosis; and (3) abnormal expression of hepatocyte-specific marker genes was found across several metabolic pathways during fibrosis, including sulfur-containing amino acid metabolism, fatty acid metabolism, and drug metabolism, suggesting a mechanistic relationship between these abnormalities and symptoms of liver fibrosis. CONCLUSION: Analysis of marker genes for specific hepatic cell types can identify the key aspects of fibro-genesis. Sequential activation of inflammatory cells and the self-supporting properties of HSCs play an important role in development of fibrosis. | Yoshiyuki Takahara Mitsuo Takahashi Hiroki Wagatsuma Fumihiko Yokoya Qing-Wei Zhang Mutsuyo Yamaguchi Hiroyuki Aburatani Norifumi Kawada | 2006 | World Journal of Gastroenterology2006，12，40： | 5 |
| 2 | Protective effects of silybin and analogues against X-ray radiation-induced damage显示文摘Silybin (SLB ) 和类似的类似物,也就是 hesperetin (HESP ) , naringenin (NAN ) 和 naringin (NAR ) ,被相信是为某些癌症作为 chemopreventive 代理人被报导了的自然 flavonoids 的活跃成分。而且, SLB 和类似物被决定了快由脉搏 radiolysis 技术从氧化损坏修理 DNA 底。现在的学习被设计评估 SLB 的保护的效果,软 X-ray-induced 上的类似物在 vitro 损坏 DNA 到 plasmid。DNA 损坏被 agarose 胶化电气泳动决定。SLB 和类似物被发现在 micromolar 集中保护 DNA 免受放射损坏的伤害。在测试的混合物之中, HESP 和 SLB 在阻止 DNA 单个海滨的裂缝(SSB ) 的 X-ray-induced 形成是最有效的。有另外的实验的这些结果的比较证明 SLB 和类似物的能力与混合物的能力相关在 vitro 禁止 DNA 损坏清除自由激进分子。我们的工作表明自然 flavonoids, SLB 和类似物可以对放射损坏被用作有势力辐射防护药物。 | Haiying Fu Mingzhang Lin Yosuke Katsumura Akinari Yokoya Kuniki Hata Yusa Muroya Kentaro Fujii Naoya Shikazono | 2010 | Acta Biochimica et Biophysica Sinica2010，42，7： | 4 |
| 3 | Effects of kinetin and nitrogen on growth rates, pigment and protein contents in wild and phycoerythrin-deficient strains of Hypnea musciformis (Rhodophyta)显示文摘 | Aline P. Martins Nair S. Yokoya Maria Angela M. Carvalho Estela M. Plastino | 2008 | Journal of Applied Phycology2008，，5： | 1 |
| 4 | Range image segmentation based on differential geometry:a hybrid approach显示文摘 | Yokoya N Martin D L | 1989 | IEEE Transactions on Pattern Analysis and Machine Intelligence1989，11，6： | 1 |
| 5 | A Novel Missense Mutation of Mineralocorticoid Receptor Gene in One Japanese Family with a Renal Form of Psendohypoaldosteronism Type 1 显示文摘 | Tajima T Kitagawa H Yokoya S | 2000 | J Clin Endo Metab2000，85，12： | 1 |
| 6 | Range image segmentation based on differential geometry: a hybrid approach显示文摘 | Yokoya N Levine M D | 1989 | IEEE Transactions on Pattern Analysis and Machine Intelligence1989，11，6： | 1 |
| 7 | Callus induction and micropropagation improved by colchicine and phytoregulators in Kappaphycus alvarezii( Rhodophyta, Solieriaceae ) 显示文摘 | Hayashi L Yokoya N S Kikuchi D M | 2008 | J Appl Phycol2008，20，： | 1 |
| 8 | Fractal based analysis and interpolation of 3D natural surface shapes and their application to terrain Modeling显示文摘 | YOKOYA N YAMAMOTO K | 1980 | Computer Vision Graphics and Image Processing1980，46，3： | 1 |
| 9 | Numerical analysis of immersion nozzles outlet flow pattern through using swirling flow in continuous casting 显示文摘 | Yokoya S Westhoff R Asako Y | 1994 | Tetsu-to-Hagane1994，80，10： | 1 |
| 10 | Fractal-based analysis and interpolation of 3D natural surface shapes and their application to terrain modeling 显示文摘 | Yokoya N Yamamoto K | 1989 | Computer Vision Graphics and Image Processing1989，46，3： | 1 |
| 11 | Nutrients removed by Kappaphycus alvarezii(Rhodophyta,Solieriaceae)in integrated cultivation with fishes in re-circulating water显示文摘 | HAYASHI L YOKOYA N S OSTINI S | 2008 | Aquaculture2008，277，34： | 1 |
| 12 | Effect of escin on adrenocorticotropin and corticosterone levels in rat plasma 显示文摘 | Hiai S Yokoya ma H Oura H | 1981 | Chen Pharm Bull(Tokyo)1981，29，2： | 1 |
| 13 | Elevated Levels of Human Chorionic Gonadotropin-β, a Marker of Active Neurohypophyseal Germinoma, Detected by Immune Complex Transfer Enzyme Immunoassay显示文摘 | Atsuko Yoshizawa Susumu Yokoya Kenichi Oyama Syozo Yamada | 2004 | Pituitary2004，，3： | 1 |
| 14 | Swirling Flow Effect in Bottomless Immersion Nozzle on Bulk Flow in High Throughput Slab Continuous Casting Mold 显示文摘 | Shinichiro Yokoya Shigeo Takagi Kenji Tada | 2001 | ISIJ International2001，41，10： | 1 |
| 15 | A robust method for registration and segmentation of multiple range images 显示文摘 | Masuda T Yokoya N | 1995 | Computer Vision and Image Understanding1995，61，3： | 1 |
| 16 | Augmentation of tendon attachment to porous ceramics by bone marrow stromal cells in a rabbit model显示文摘 | Omae H Mochizuki Y Yokoya S | | 0，，： | 1 |
| 17 | Image database systems: A survey显示文摘 | Tamura H Yokoya N | 1984 | Pattern recognition1984，17，1： | 1 |
| 18 | Anabolic steroid and gonadotropin releasing hormone analog combined treatment increased pubertal height gain and adult height in two children who entered puberty with short stature 显示文摘 | Satoh M Yokoya S | 2006 | J Pediatr Endocrinol Metab2006，19，9： | 1 |
| 19 | Bimodal polarons and hole transport in poly (3-hexylthiophene): fullerene blend films显示文摘 | GUO J OHKITA H YOKOYA S etal | 2010 | Journal of the American Chemical Society2010，132，28： | 1 |
| 20 | Callus induction and micropropagation improved by colchieine and phytoregulators in Kappaphycus alvarezii (Rhodophyta, Solieriaceae) 显示文摘 | Hayashi L Yokoya N S Kikuchi D M | 2008 | Journal of Applied Phycology2008，20，5： | 1 |
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