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| 1 | Two gap-free reference genomes and a global view of the centromere architecture in rice显示文摘Rice(Oryza sativa),a major staple throughout the world and a model system for plant genomics and breeding,was the first crop genome sequenced almost two decades ago.However,reference genomes for all higher organisms to date contain gaps and missing sequences.Here,we report the assembly and analysis of gap-free reference genome sequences for two elite O.sativa xian/indica rice varieties,Zhenshan 97 and Minghui 63,which are being used as a model system for studying heterosis and yield.Gap-free reference genomes provide the opportunity for a global view of the structure and function of centromeres.We show that all rice centromeric regions share conserved centromere-specific satellite motifs with different copy numbers and structures.In addition,the similarity of CentO repeats in the same chromosome is higher than across chromosomes,supporting a model of local expansion and homogenization.Both genomes have over 395 non-TE genes located in centromere regions,of which∼41%are actively transcribed.Two large structural variants at the end of chromosome 11 affect the copy number of resistance genes between the two genomes.The availability of the two gap-free genomes lays a solid foundation for further understanding genome structure and function in plants and breeding climate-resilient varieties. | Jia-Ming Song Wen-Zhao Xie Shuo Wang Yi-Xiong Guo Dal-Hoe Koo Dave Kudrna Chenbo Gong Yicheng Huang Jia-Wu Feng Wenhui Zhang Yong Zhou Andrea Zuccolo Evan Long Seunghee Lee Jayson Talag Run Zhou Xi-Tong Zhu Daojun Yuan Joshua Udall Weibo Xie Rod AWing Qifa Zhang Jesse Poland Jianwei Zhang Ling-Ling Chen | 2021 | Molecular Plant2021，14，10： | 9 |
| 2 | Mechanobiology:A new frontier for human pluripotent stem cells显示文摘Our understanding of the molecular and cellular mechanisms that control self-renewal,pluripotency and differentiation of human pluripotent stem cells(hPSCs)and our progress toward harnessing the regenerative potential of these cells to treat human diseases are advancing at a rapid rate.Human pluripotent stem cells(hPSCs)include human embryonic stem cells(hESCs)and human induced pluripotent stem cells(hiPSCs).Their unique capacity for indefinite self-renewal(unlimited proliferation)in vitro coupled with their ability to differentiate into almost any cell type present in the adult body(pluripotency)provide a potentially | Jianping Fu Yubing Sun Koh Meng Aw Yong | 2013 | 医用生物力学2013，28，S1： | 1 |
| 3 | Allele frequencies of 15 STR loci of three main ethnic population in Singapore using an in-house marker panel显示文摘 | Yong RY Aw LT Yap EPH | 2004 | Forensic Sci Int2004，141，9： | 1 |
| 4 | Internal and corticalborder-zone infarction:clinical and diffusion weighted imagingfeatures显示文摘 | Yong AW Bang OY Lee PH | 2006 | Stroke2006，37，3： | 1 |
| 5 | Relationship between interleukin-5 and eotaxin in regulating blood and tissue eosinophilia in mice 显示文摘 | Mould AW Matthaei KI Yong IG | 1997 | J Clin Invest1997，99，5： | 1 |
| 6 | Morphological effects on expression of growth differentiation factor 15 (GDF15),a marker of metastasis显示文摘 | Aw Yong KM Zeng Y Vindivich D | 2014 | J Cell Physiol2014，229，： | 1 |
| 7 | Efficient skeletonization of volumetric objects 显示文摘 | Zhou Yong Toga AW | 1999 | IEEE Transactions on Visualization and Computer Graphics1999，5，3： | 1 |
| 8 | Evidence of Assurance Enhancing the Quality of Voluntary Environmental Disclosures : An Empirical Analysis 显示文摘 | Momney Robyn Windsor Carolyn Aw Yong Ting | 2012 | Accounting & Finance2012，52，3： | 1 |
| 9 | Clinical implications of the transversus abdominis plane block in adults显示文摘 | Yong MJ Gorlin AW Modest VE | 2012 | Anesthesidogy Rose- arch and Practice2012，20，73： | 1 |
| 10 | Finite element analysis of plane soil cutting显示文摘 | Yong R N Hanna AW | 1977 | Journal of Terramechanics1977，14，3： | 1 |
| 11 | Internal and cortical border-zone infarction: clinical and diffusion-weighted imaging features 显示文摘 | Yong AW Bang OY Lee PH | 2006 | Stroke2006，37，3： | 1 |
| 12 | Morphological effects on ex- pression of growth differentiation factor 15 ( GDF15 ) ,a marker of metas- tasis显示文摘 | Aw Yong YK Zeng Y Vindivich D | 2014 | J Cell Physiol2014，229，3： | 1 |
| 13 | Internal and cortical border--zone infarc- tion: clinical and diffusion--weighted imaging features显示文摘 | Yong AW Bang OY LeePH | 2006 | Stroke2006，37，3： | 1 |
| 14 | Relationship between interleukin-5 and eotaxin in regulating blood and tissue eosinophilia in mice 显示文摘 | Mould AW Matthaei KI Yong IG | 1997 | J Clin Invest1997，99，5： | 1 |
| 15 | Internal and cortical border - zone infarction : clinical and diffusion weighted imaging features 显示文摘 | Yong AW Bang OY Lee PH | 2006 | Stroke2006，37，3： | 1 |
| 16 | Livedoid vasculopathy and its association with factor V Leiden mutation 显示文摘 | Yong AA Tan AW Giam YC | 2012 | Singapore Med J2012，53，12： | 1 |
| 17 | Internal and cortical border-zone infarction:clinical and diffusion-weighted imaging features显示文摘 | Yong AW Bang OY Lee PH | 2006 | Stroke2006，37，3： | 1 |
| 18 | Morphological Effects on Expression of Growth Differentiation Factor 15 (GDF15), a Marker of Metastasis显示文摘 | Koh Meng Aw Yong Yu Zeng Donald Vindivich Jude M. Phillip Pei‐Hsun Wu Denis Wirtz Robert H. Getzenberg | 2014 | Physiol2014，，3： | 1 |
| 19 | Internal and cortical border-zone infarction: clinical and diffusion-weighted imaging features显示文摘 | YONG AW BANG OY LEE PH | 2006 | Stroke2006，37，3： | 1 |
| 20 | Acute hospital-community hospital care bundle for elderly orthopedic surgery patients:A propensity score-matched economic analysis显示文摘BACKGROUND While Singapore attains good health outcomes,Singapore’s healthcare system is confronted with bed shortages and prolonged stays for elderly people recovering from surgery in acute hospitals.An Acute Hospital-Community Hospital(AHCH)care bundle has been developed to assist patients in postoperative rehabilitation.The core concept is to transfer patients out of AHs when clinically recommended and into CHs,where they can receive more beneficial dedicated care to aid in their recovery,while freeing up bed capacities in AHs.AIM To analyze the AH length of stay(LOS),costs,and savings associated with the AH-CH care bundle intervention initiated and implemented in elderly patients aged 75 years and above undergoing elective orthopedic surgery.METHODS A total of 8621:1 propensity score-matched patients aged 75 years and above who underwent elective orthopedic surgery in Singapore General Hospital(SGH)before(2017-2018)and after(2019-2021)the care bundle intervention period was analyzed.Outcome measures were AH LOS,CH LOS,hospitalization metrics,postoperative 30-d mortality,and modified Barthel Index(MBI)scores.The costs of AH inpatient hospital stay in the matched cohorts were compared using cost data in Singapore dollars.RESULTS Of the 862 matched elderly patients undergoing elective orthopedic surgery before and after the care bundle intervention,the age distribution,sex,American Society of Anesthesiologists classification,Charlson Comorbidity Index,and surgical approach were comparable between both groups.Patients transferred to CHs after the surgery had a shorter median AH LOS(7 d vs 9 d,P<0.001).The mean total AH inpatient cost per patient was 14.9%less for the elderly group transferred to CHs(S$24497.3 vs S$28772.8,P<0.001).The overall AH U-turn rates for elderly patients within the care bundle were low,with a 0%mortality rate following orthopedic surgery.When elderly patients were discharged from CHs,their MBI scores increased significantly(50.9 vs 71.9,P<0.001).CONCLUSION The AH-CH care bundle initiated and implemented in the Department of Orthopedic Surgery appears to be effective and cost-saving for SGH.Our results indicate that transitioning care between acute and community hospitals using this care bundle effectively reduces AH LOS in elderly patients receiving orthopedic surgery.Collaboration between acute and community care providers can assist in closing the care delivery gap and enhancing service quality. | Ivan En-Howe Tan Aik Yong Chok Yun Zhao Yonghui Chen Chee Hoe Koo Junjie Aw Mave Hean Teng Soh Chek Hun Foo Kwok Ann Ang Emile John Kwong Wei Tan Andrew Hwee Chye Tan Marianne Kit Har Au | 2023 | World Journal of Orthopedics2023，14，4： | 0 |
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