| 3 | Nasal-type extranodal NK/T cell lymphoma in association with hemophagocytic syndrome:a case report and literature review显示文摘We present a rare case of nasal-type CD56-negative NK/T-cell lymphoma.The patient developed hemophagocytic syndrome during diagnosis and treatment.The patient presented to our hospital(Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China)with“nasal congestion for 3 months and scattered erythema,nodules,and ulcers all over the body for 1 month.”We analyzed clinical manifestations,skin histopathology,immunohistochemistry,and in situ hybridization results.Histopathology of the skin revealed a moderate amount of atypical lymphocyte infiltration between the entire dermis and collagen bundles.Immunohistochemistry showed the following:CD30(+),TIA-1(+),CD3(2GV6)(+),CD5 part(+),CD8 part(+),CD43(+),CD56(-),CD4(-),CD20(-),PAX5(-),PCK(-),P63(-),P40(-),EGFR(-),Ki-67(the hot spot LI is approximately 80%),and in situ hybridization EBER-ROCH(+).The diagnosis made was“NK/T cell lymphoma nasal type”.This type of lymphoma is aggressive,progresses quickly,and has a poor prognosis.Early clinical manifestations are extremely atypical,especially in the absence of rash.Analysis of the skin manifestations of the disease has a positive effect on its early diagnosis,early treatment,and prognosis. | Shuang Chen Yongchu Huang Yuchun Cao Yong Zhang | 2022 | Oncology and Translational Medicine2022，8，2： | 0 |
| 4 | Molecular events in the jaw vascular unit:A traditional review of the mechanisms involved in inflammatory jaw bone diseases显示文摘Inflammatory jaw bone diseases are common in stomatology,including periodontitis,peri-implantitis,medication-related osteonecrosis of the jaw,radiation osteomyelitis of the jaw,age-related osteoporosis,and other specific infections.These diseases may lead to tooth loss and maxillofacial deformities,severely affecting patients'quality of life.Over the years,the reconstruction of jaw bone deficiency caused by inflammatory diseases has emerged as a medical and socioeconomic challenge.Therefore,exploring the pathogenesis of inflammatory diseases associated with jaw bones is crucial for improving prognosis and developing new targeted therapies.Accumulating evidence indicates that the integrated bone formation and dysfunction arise from complex interactions among a network of multiple cell types,including osteoblast-associated cells,immune cells,blood vessels,and lymphatic vessels.However,the role of these different cells in the inflammatory process and the'rules'with which they interact are still not fully understood.Although many investigations have focused on specific pathological processes and molecular events in inflammatory jaw diseases,few articles offer a perspective of integration.Here,we review the changes and mechanisms of various cell types in inflammatory jaw diseases,with the hope of providing insights to drive future research in this field. | Ruyu Wang Haoran Wang Junyu Mu Hua Yuan Yongchu Pang Yuli Wang Yifei Du Feng Han | 2023 | The Journal of Biomedical Research2023，37，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员