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| 1 | Effect of human umbilical cord-derived mesenchymal stem cells on lung damage in severe COVID-19 patients:a randomized,double-blind,placebo-controlled phase 2 trial显示文摘Treatment of severe Coronavirus Disease 2019(COVID-19)is challenging.We performed a phase 2 trial to assess the efficacy andsafety of human umbilical cord-mesenchymal stem cells(UC-MScs)to treat severe coViD-19 patients with lung damage,based onour phase 1 data.In this randomized,double-blind,and placebo-controlled trial,we recruited 101 severe coVID-19 patients withlung damage.They were randomly assigned at a 2:1 ratio to receive either UC-MSCs(4×10^(7)cells per infusion)or placebo on day 0,3,and 6.The primary endpoint was an altered proportion of whole lung lesion volumes from baseline to day 28.Other imagingoutcomes,6-minute walk test(6-MWT),maximum vital capacity,diffusing capacity,and adverse events were recorded and analyzed.In all,100 COVID-19 patients were finally received either UC-MSCs in=65)or placebo(n=35).UC-MSCs administrationexerted numerical improvement in whole lung lesion volume from baseline to day 28 compared with the placebo(the mediandifference was-13.31%,95%Cl-29.14%,2.13%,P=0.08).UC-MSCs significanty reduced the proportions of solid componentlesion volume compared with the placebo(median difference:-15.45%;95%CI-30.82%,-0.39%;P=0.043).The 6-MWT showedan increased distance in patients treated with UC-MSCs(difference:27.00 m;95%CI 0.00,57.00;P=0.057).The incidence of adverseevents was similar in the two groups.These results suggest that UC-MSCs treatment is a safe and potentially effective therapeuticapproach for COVID-19 patients with lung damage.A phase 3 trial is required to evaluate effects on reducing mortality andpreventing long-term pulmonary disability. | Lei Shi Hai Huang Xuechun Lu Xiaoyan Yan Xiaojing Jiang Ruonan Xu Siyu Wang Chao Zhang Xin Yuan Zhe Xu Lei Huang Jun-Liang Fu Yuanyuan Li Yu Zhang Wei-Qi Yao Tianyi Liu Jinwen Song Liangliang Sun Fan Yang Xin Zhang Bo Zhang Ming Shi Fanping Meng Yanning Song Yongpei Yu Jiqiu Wen Qi Li Qing Mao Markus Maeurer Alimuddin Zumla Chen Yao Wei-Fen Xie Fu-Sheng Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 13 |
| 2 | Unified stochastic and robust unit commitment显示文摘 | ZHAO Chaoyue GUAN Yongpei | 2013 | IEEE Trans on Power Systems2013，28，33： | 1 |
| 3 | Robust unit commitment with wind power and pumped storage hydro显示文摘 | JIANG Ruiwei WANG Jianhui GUAN Yongpei | 2012 | IEEE Trans on Power Systems2012，27，2： | 1 |
| 4 | Robust unit com- mitment with wind power and pumped storage hydro显示文摘 | JIANG Ruiwei WANG Jianhui GUAN Yongpei | 2012 | IEEE Transactions on Power Systems2012，27，2： | 1 |
| 5 | A chance-constrained two-stage stochastic program for unit commitment with uncertain wind power output显示文摘 | Wang Qianfan Guan Yongpei Wang Jianhui | 2012 | IEEE Transactions on Power Systems2012，27，1： | 1 |
| 6 | Robust unit commitment with wind power and pumped storage hydro显示文摘 | Jiang Ruiwei Wang Jianhui Guan Yongpei | 2012 | IEEE Trans on Power Systems2012，27，2： | 1 |
| 7 | Optimal deployment of public charging stations for plug-in hybrid electric vehicles显示文摘 | Fang He Di Wu Yafeng Yin Yongpei Guan | 2013 | Transportation Research Part B2013，，： | 1 |
| 8 | The crane scheduling problem: models and solution approaches 显示文摘 | Cuan Yongpei Yang K H Zhou Zhili | 2013 | Annals of Operations Research2013，203，1： | 1 |
| 9 | A pricing approach for bandwidth allocation in differentiated service networks显示文摘 | GUANA Yongpei YANG Wei-lai OWENB Henry | 2008 | Computer & Operations Resarch2008，35，12： | 1 |
| 10 | Robust unit commitment with wind power and pumped storage hydro显示文摘 | Jiang Ruiwei Wang Jianhui Guan Yongpei | 2012 | IEEE Transactions on Power Systems2012，27，2： | 1 |
| 11 | Robust unit co- mmitment with wind power and pumped storage hydro显示文摘 | JIANG Ruiwei WANG Jianhui GUAN Yongpei | 2012 | IEEE Transactions on Power Systems2012，27，2： | 1 |
| 12 | Stochastic unit commitment with uncertain demand response显示文摘 | WANG Qianfan WANG Jianhui GUAN Yongpei | 2013 | IEEE Transac- tions on Power Systems2013，28，1： | 1 |
| 13 | Robust unit commitment with wind power and pumped storage hydro显示文摘 | Jiang Ruiwei Wang Jianhui Guan Yongpei | 2012 | IEEE Transactions on Power Systems2012，27，2： | 1 |
| 14 | The inverse optimal value problem显示文摘 | Ahmed S Yongpei Guan | 2005 | Mathematical Programming2005，102，1： | 1 |
| 15 | Robust unit commitment with wind power and pumped storage hydro显示文摘 | Jiang Ruiwei Wang Jianhui Guan Yongpei | 2012 | IEEE Transactions on Power Systems2012，27，2： | 1 |
| 16 | A chance- constrained two-stage stochastic program for unit commitment with uncertain wind power output显示文摘 | WANG Qianfan GUAN Yongpei WANG Jianhui | 2012 | IEEE Trans on Power Systems2012，27，1： | 1 |
| 17 | Optimal deploymentof public charging stations for plug-in hybrid electric vehi-cles 显示文摘 | He Fang Wu Di Yin Yongpei | 2013 | Transportation Research Part B : Methodological2013，47，： | 1 |
| 18 | A pricing approach for bandwidth allocation in differentiated service networks显示文摘 | GUAN Yongpei WElL G OWEN Henry | 2008 | Computers & Operations Research2008，35，： | 1 |
| 19 | A pricing ap- proach for bandwidth allocation in differentiated service networks显示文摘 | Guan Yongpei Wei L G Owen H | 2008 | Computers & Operations Research2008，35，： | 1 |
| 20 | The inverse optimal value problem显示文摘 | Ahmed S Yongpei Guan | 2005 | Mathematical Programming2005，102，1： | 1 |
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