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2篇 您的检索式:作者名="Yongting Lan"
    题名 作者 年代 出处 被引量
1Constitutive Modeling of Slip, Twinning and Detwinning for Mg Alloy and Inhomogeneous Evolution of Microstructure显示文摘Yuan Chen Guijuan Hu Yongting Lan Keshi Zhang Ganwei Cai 2018Acta Mechanica Solida Sinica2018,31,4:3
2Plastin 1 promotes osteoblast differentiation by regulating intracellular Ca2+显示文摘Osteoblast differentiation is a key process in bone homeostasis.Mutations in plastin 3 have been reported to be responsible for X-linked osteoporosis.Plastin 3 and plastin 2 act synergistically to regulate osteoblast differentiation.However,the bone-related function of plastin 1,another family member of plastins,has not been assessed.In this study,we addressed the functional importance of plastin 1 in osteoblasts.We characterized the expression patterns of plastin 1 during osteoblast differentiation and revealed its important role in this process.In both HEK 293T and hFOB1.19 cells,plastin 1 was demonstrated to regulate intracellular Ca2+.Accordingly,we revealed that higher Ca2+concentration promotes osteoblast differentiation.Finally,we found that plastin 1 may play a compensatory role in osteoporosis patients with plastin 3 deficiency.Together,our results indicate that plastin 1 promotes osteoblast differentiation by regulating intracellular Ca2+.Our work sheds new light on the role played by plastins in bone homeostasis.Lianqing Wang Yongting Lan Yanqin Du Xinxin Xiang Wenxiu Tian Baoye Yang Tao Li Qiaoli Zhai 2020Acta Biochimica et Biophysica Sinica2020,52,5:0
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