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| 1 | Clinical features and outcomes of diffuse large B-cell lymphoma based on nodal or extranodal primary sites of origin:Analysis of 1,085 WHO classified cases in a single institution in China显示文摘Objective: To explore the clinicobiologic features and outcomes of diffuse large B-cell lymphoma(DLBCL)patients in China according to the primary site.Methods: A total of 1,085 patients diagnosed with DLBCL in National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College during a 6-year period were enrolled. Their clinical characteristics and outcomes were analyzed according to the primary site.Results: In the 1,085 patients, 679(62.6%) cases were nodal DLBCL(N-DLBCL) and 406 cases(37.4%) were extranodal DLBCL(EN-DLBCL). The most common sites of N-DLBCL were lymphonodus(64.8%), Waldeyer's ring(19.7%), mediastinum(12.8%) and spleen(2.7%), while in EN-DLBCL, stomach(22.4%), intestine(16.0%),nose and sinuses(8.9%), testis(8.4%), skin(7.9%), thyroid(6.9%), central nervous system(CNS)(6.4%), breast(5.7%), bone(3.4%), and salivary gland(2.7%) were most common. N-DLBCL patients tend to present B symptoms, bulky disease, and elevated LDH more often, while age >60 years, extranodal sites >1, Ann Arbor stage I or II, bone marrow involvement, and Ki-67 index >90% were usually seen in EN-DLBCL. The 5-year overall survival(OS) rate and progression-free survival(PFS) rate for all patients were 62.5% and 54.2%. The 5-year OS rate for patients with N-DLBCL and EN-DLBCL were 65.5% and 56.9%(P=0.008), and the 5-year PFS were57.0% and 49.0%(P=0.020). Waldeyer's ring originated DLBCL possessed the highest 5-year OS rate(83.6%) and PFS rate(76.9%) in N-DLBCL. The top five EN-DLBCL subtypes with favorable prognosis were stomach,breast, nose and sinuses, lung, salivary gland, with 5-year OS rate: 70.3%, 69.6%, 69.4%, 66.7% and 63.6%,respectively. While CNS, testis, oral cavity and kidney originated EN-DLBCL faced miserable prognosis, with 5-year OS rate of 26.9%, 38.2%, and 42.9%.Conclusions: In our study, primary sites were associated with clinical characteristics and outcomes. Compared with EN-DLBCL, N-DLBCL had better prognosis. | Yuankai Shi Ying Han Jianliang Yang Peng Liu Xiaohui He Changgong Zhang Shengyu Zhou Liqiang Zhou Yan Qin Yongwen Song Yueping Liu Shulian Wang Jing Jin Lin Gui Yan Sun | 2019 | Chinese Journal of Cancer Research2019，31，1： | 19 |
| 2 | Geographical genetic diversity and divergence of common wild rice (O. rufipogon Griff.) in China显示文摘Using 36 SSR markers and 889 accessions of common wild rice in China, the genetic diversity and the divergence among different geographical populations are investigated. Guangdong Province has the largest number of alleles, which account for 84% of the total alleles detected in the study, followed by Guangxi Province. The Nei's gene diversity indices, from high to low, are in the sequence of Hainan, Guangdong, Guangxi, Fujian, Hunan, Jiangxi, and Yunnan provinces. Two genetic diversity centers of Chinese common wild rice are detected on the basis of geographic analysis, i.e., the region covering Boluo, Zijin, Lufeng, Haifeng, Huidong and Huiyang counties of Guangdong Province and the region covering Yongning, Longan, Laibin and Guigang counties of Guangxi Province. The common wild rice in Yunnan, Hunan, Jiangxi, and Fujian provinces are diverged into respectively independent populations with relatively large genetic distances, whereas, those in Hainan, Guangdong and Guangxi provinces have relatively low genetic divergence. Under the condition of geographic separation, natural selection is considered as one of the primary forces contributing to the divergence of common wild rice in China. | WANG MeiXing ZHANG HongLiang ZHANG DongLing PAN DaJian LI DaoYuan FAN ZhiLan QI YongWen SUN JunLi YANG QingWen LI Chen LI ZiChao | 2008 | Chinese Science Bulletin2008，53，22： | 8 |
| 3 | Recent research advances of self-discharge in supercapacitors:Mechanisms and suppressing strategies显示文摘Supercapacitors are one of the most promising energy storage devices in the fields of vehicle transportation,flexible electronic devices,aerospace,etc.However,the existed self-discharge that is the spontaneous voltage decay after supercapacitors are fully charged,brings about the wide gap between experimental studies and practical utilization of supercapacitors.Although eliminating the selfdischarge completely is not reachable,suppressing the self-discharge rate to the lowest point is possible and feasible.So far,the significant endeavors have been devoted to achieve this goal.Herein,we summary and discuss the possible mechanisms for the self-discharge and the underlying influence factors.Moreover,the strategies to suppress the self-discharge are systemically summed up by three independent but unified aspects:modifying the electrode,modulating the electrolyte and tuning the separator.Finally,the major challenges to suppress the self-discharge of supercapacitors are concluded and the promising strategies are also pointed out and discussed.This review is presented with the view of serving as a guideline to suppress the self-discharge of supercapacitors and to across-the-board facilitate their widespread application. | Kunlun Liu Chang Yu Wei Guo Lin Ni Jinhe Yu Yuanyang Xie Zhao Wang Yongwen Ren Jieshan Qiu | 2021 | Journal of Energy Chemistry2021，30，7： | 6 |
| 4 | Deciphering impacts of climate extremes on Tibetan grasslands in the last fifteen years显示文摘Climate extremes have emerged as a crucial driver of changes in terrestrial ecosystems. The Tibetan Plateau, facing a rapid climate change, tends to favor climate extremes. But we lack a clear understanding of the impacts of such extremes on alpine grasslands. Here we show that extreme events(drought,extreme wet, extreme cold and extreme hot) occurred at a frequency of 0.67–4 months decade^(-1) during2001–2015, with extreme precipitation predominantly occurring in June-to-August and extreme temperatures in May. Drought and extreme wet cause opposite and asymmetric effects on grassland growth,with drought-induced reductions greater than increases due to extreme wet. Grassland responses to extreme temperatures, which predominantly occur in May, show a dipole-like spatial pattern, with extreme hot(cold) events enhanced(reduced) growth in the eastern plateau but slightly reduced(enhanced) growth in the western plateau. These opposite responses to extreme temperatures over the eastern plateau are explained by the possibility that the occurrence of extreme cold slows the preseason temperature accumulation, delaying the triggering of spring phenology, while extreme hot hastens the accumulation. In the western plateau, in contrast, positive responses to extreme cold are induced by accompanying high precipitation. Furthermore, high extremeness of climate events generally led to a much lower extremeness in growth response, implying that the Tibetan grasslands have a relatively high resistance to climate extremes. The ecosystem models tested could not accurately simulate grassland responses to drought and extreme temperatures, and require re-parameterization before trust can be placed in their output for this region. | Dan Liu Tao Wang Tao Yang Zhengjie Yan Yongwen Liu Yutong Zhao Shilong Piao | 2019 | Science Bulletin2019，64，7： | 5 |
| 5 | Safety and immunogenicity of a SARS-CoV-2 inactivated vaccine in patients with chronic hepatitis B virus infection显示文摘Coronavirus disease 2019(COVID-19),caused by SARS-CoV-2 infection,has become a major global public health threat.Although significant advances have been made in developing and applying different vaccines in clinical trials[1,2],data are limited on the safety and efficacy of the inactivated vaccine in patients with chronic liver disease[3].Recent studies have preliminarily described the safety and immunogenicity of SARS-CoV-2 vaccines in patients with nonalcoholic fatty liver disease and in liver transplant recipients[4,5]. | Tiandan Xiang Boyun Liang Hua Wang Xufeng Quan Shengsong He Helong Zhou Yongwen He Dongliang Yang Baoju Wang Xin Zheng | 2021 | Cellular & Molecular Immunology2021，18，12： | 5 |
| 6 | Assessing indica-japonica differentiation of improved rice varieties using microsatellite markers显示文摘To assess the indica-japonica differentiation of improved rice varieties, a total of 512 modern varieties including 301 indica and 211 japonica accessions were analyzed using 36 microsatellites. The Fst coefficients ranged from 0.002 to 0.730 among the loci with an average of 0.315. Significant differentiation was detected at 94.4% of the loci studied (P<0.05, pairwise Fst tests), indicating that there was a high level of indica-japonica differentiation within the improved varieties. At 18 loci, about 74%-98% of the alleles of indica and japonica accessions were distributed in two ranges of amplicon length. Linkage disequilibrium analysis showed that the distribution trends were significantly nonrandomly associated. Using the differentiation trends at the 18 loci, microsatellite index (MI) was proposed for discrimination of the two subspecies. When rice accessions with MI value greater than zero were classified as indica, and those with MI value smaller than zero were classified as japonica, about 96.1% of the accessions could be classified. This result agrees with the classification based on morphological-physiological characters, indicating that this method is feasible and effective. | Yongwen Qi Hongliang Zhang Dongling Zhang Meixing Wang Junli Sun Li Ding Fenghua Wang Zichao Li | 2009 | Journal of Genetics and Genomics2009，36，5： | 5 |
| 7 | Genetic structure and diversity of Oryza sativa L. in Guizhou,China显示文摘Preserving many kinds of rice resources and rich variations, Guizhou Province is one of the districts with the highest genetic diversity of cultivated rice (Oryza sativa L.) in China. In the current research, genetic diversity and structure of 537 accessions of cultivated rice from Guizhou were studied using 36 microsatellite markers and 39 phenotypic characters. The results showed that the model-based genetic structure was the same as genetic-distance-based one using SSRs but somewhat different from the documented classification (mainly based on phenotype) of two subspecies. The accessions being classified into indica by phenotype but japonica by genetic structure were much more than that being classified into japonica by phenotype but indica by genetic structure. Like Ding Ying’s taxonomic sys- tem of cultivated rice, the subspecific differentiation was the most distinct differentiation within culti- vated rice. But the differentiation within indica or japonica population was different: japonica presented clearer differentiation between soil-watery ecotypes than indica, and indica presented clearer differen- tiation between seasonal ecotypes than japonica. Cultivated rices in Guizhou revealed high genetic diversity at both DNA and phenotypic levels. Possessing the highest genetic diversity and all the nec- essary conditions as a center of genetic diversity, region Southwestern of Guizhou was suggested as the center of genetic diversity of O. sativa L. from Guizhou. | ZHANG DongLing ZHANG HongLiang WEI XingHua QI YongWen WANG Meixing SUN JunLi DING Li TANG ShengXiang QIU Zong'En CAO YongSheng WANG XiangKun LI ZiChao | 2007 | Chinese Science Bulletin2007，52，3： | 5 |
| 8 | Eigen microstates and their evolutions in complex systems显示文摘Emergence refers to the existence or formation of collective behaviors in complex systems.Here,we develop a theoretical framework based on the eigen microstate theory to analyze the emerging phenomena and dynamic evolution of complex system.In this framework,the statistical ensemble composed of M microstates of a complex system with N agents is defined by the normalized N×M matrix A,whose columns represent microstates and order of row is consist with the time.The ensemble matrix A can be decomposed as■,where r=min(N,M),eigenvalueσIbehaves as the probability amplitude of the eigen microstate U_I so that■and U_I evolves following V_I.In a disorder complex system,there is no dominant eigenvalue and eigen microstate.When a probability amplitudeσIbecomes finite in the thermodynamic limit,there is a condensation of the eigen microstate UIin analogy to the Bose–Einstein condensation of Bose gases.This indicates the emergence of U_I and a phase transition in complex system.Our framework has been applied successfully to equilibrium threedimensional Ising model,climate system and stock markets.We anticipate that our eigen microstate method can be used to study non-equilibrium complex systems with unknown orderparameters,such as phase transitions of collective motion and tipping points in climate systems and ecosystems. | Yu Sun Gaoke Hu Yongwen Zhang Bo Lu Zhenghui Lu Jingfang Fan Xiaoteng Li Qimin Deng Xiaosong Chen | 2021 | Communications in Theoretical Physics2021，73，6： | 5 |
| 9 | Down-staging depth score to predict outcomes in locally advanced rectal cancer achieving ypl stage after neoadjuvant chemo-radiotherapy versus de novo stage pl cohort:A propensity score-matched analysis显示文摘Objective:Prognosis of patients with locally advanced rectal cancer(LARC)but achieving yp T1–2N0 stage after neoadjuvant concurrent chemo-radiotherapy(CRT)has been shown to be favorable.This study aims to determine whether the long-term outcome of yp T1–2N0 cases can be comparable to that of p T1–2N0 cohort that received definitive surgery for early disease.Method:From January 2008 to December 2013,449 consecutive patients with rectal cancer were treated and their outcome maintained in a database.Patients with LARC underwent total mesorectal excision(TME)surgery at4–8 weeks after completion of CRT,and those achieving stage yp I were identified as a group.As a comparison,stage p I group pertains to patients whose initially limited disease was not upstaged after TME surgery alone.After propensity score matching(PSM),comparisons of local regional control(LC),distant metastasis-free survival(DMFS),disease-free survival(DFS)and overall survival(OS)were performed using Kaplan-Meier analysis and log-rank test between yp I and p I groups.Down-staging depth score(DDS),a novel method of evaluating CRT response,was used for subset analysis.Results:Of the 449 patients,168 matched cases were generated for analysis.Five-year LC,DMFS,DFS and OS for stage p I vs.yp I groups were 96.7%vs.96.4%(P=0.796),92.7%vs.73.6%(P=0.025),91.2%vs.73.6%(P=0.080)and 93.1%vs.72.3%(P=0.040),respectively.In the DDS-favorable subset of the yp I group,LC,DMFS,DFS and OS resulted in no significant differences in comparison with the p I group(P=0.384,0.368,0.277 and0.458,respectively).Conclusions:LC was comparable in both groups;however,distant metastasis developed more frequently in down-staged LARC than de novo early stage cases,reflecting the need to improve the efficacy of systemic treatment despite excellent pathologic response.DDS can be an indicator to identify a subset of the yp I group whose longterm oncologic outcomes are as good as those of stage p I cohort. | Ning Li Jing Jin Jing Yu Shuai Li Yuan Tang Hua Ren Wenyang Liu Shulian Wang Yueping Liu Yongwen Song Hui Fang Zihao Yu Yexiong Li | 2018 | Chinese Journal of Cancer Research2018，30，3： | 4 |
| 10 | Solving algorithm for TA optimization model based on ACO-SA显示文摘An ant colony optimization (ACO)-simulated annealing (SA)-based algorithm is developed for the target assignment problem (TAP) in the air defense (AD) command and control (C2) system of surface to air missile (SAM) tactical unit.The accomplishment process of target assignment (TA) task is analyzed.A firing advantage degree (FAD) concept of fire unit (FU) intercepting targets is put forward and its evaluation model is established by using a linear weighted synthetic method.A TA optimization model is presented and its solving algorithms are designed respectively based on ACO and SA.A hybrid optimization strategy is presented and developed synthesizing the merits of ACO and SA.The simulation examples show that the model and algorithms can meet the solving requirement of TAP in AD combat. | Jun Wang Xiaoguang Gao Yongwen Zhu | 2011 | Journal of Systems Engineering and Electronics2011，22，4： | 4 |
| 11 | Genetic structure and eco-geographical differentiation of cultivated Hsien rice(Oryza sativa L.subsp.indica) in China revealed by microsatellites显示文摘Indica is not only an important rice subspecies widely planted in Asia and the rest of the world,but it is also the genetic background of the majority of hybrid varieties in China.Studies on genetic structure and genetic diversity in indica germplasm resources are important for the classification and utilization of cultivated rice in China.Using a genetically representative core collection comprising 1482 Chinese indica landraces,we analysed the genetic structure,geographic differentiation and diversity.Model-based structure analysis of varieties within three ecotypes revealed nine eco-geographical types partially accordant with certain ecological zones in China.Differentiation of eco-geographical types was attributed to local ecological adaption and physical isolation.These groups may be useful for developing heterotic groups of indica.To facilitate the identification of different ecotypes and eco-geographical types,we identified characteristic SSR alleles of each ecotype and eco-geographical type and a rapid index of discrimination based on characteristic alleles.The characteristic alleles and rapid discrimination index may guide development of heterotic groups,and selection of hybrid parents. | ZHANG DongLing ZHANG HongLiang QI YongWen WANG MeiXing SUN JunLi DING Li LI ZiChao | 2013 | Chinese Science Bulletin2013，58，3： | 3 |
| 12 | NEW SCALING METHOD FOR COMPRESSOR MAPS USING AVERAGE INFINITESIMAL STAGE显示文摘存在的精确表演的评价煤气的汽轮机引擎的多级式的轴流动的压缩机快正在成为一颗大担心,,煤气的汽轮机引擎的使用尽最大努力产生并且在军人,工业增加。以便减少传统的可伸缩方法的分析表演错误,为估计多级式的轴的流动压缩机的特征的一个新可伸缩方法被建议。这个新奇方法基于引擎制造商提供的试验性、部分的数据。拿密度变化的效果进说明,我们介绍平均无穷小的阶段概念,并且从而把压缩进程划分成相应于无穷小的阶段的无穷小的进程的一个无限的数字。随后,我们采用改正的雷纳兹类比方法让可压缩的流动计算以便与类似标准保证好一些的依从。确认检查证明建议方法有足够的精确预言多级式的轴的流动压缩机的离开设计表演特征。 | MA Wentong LIU Yongwen SU Ming | 2007 | Chinese Journal of Mechanical Engineering2007，20，6： | 3 |
| 13 | Artesunate and Dihydroartemisinin Inhibit Rabies Virus Replication显示文摘Rabies is caused by infection of rabies virus(RABV)and remains a serious threat to the global public health.Except for the requirement for cold chain and high cost of human rabies immune globulin,no small molecule drugs are currently available for clinical treatment of rabies.So,it is of great importance to identify novel compounds that can effectively inhibit RABV infection.Artesunate(ART)and dihydroartemisinin(DHA),two derivatives of artemisinin,are widely used for treatment of malaria in adults and children,showing high safety.In this study,we found that both ART and DHA were able to inhibit RABV replication in host cells at a low concentration(0.1μmol/L).The antiviral effects of ART and DHA were independent of viral strains and cell lines.Pre-treatment with ART or DHA for 2 h in vitro did not affect the viral replication in host cells,implying that ART and DHA neither reduced the viability of RABV directly nor inhibited the binding and entrance of the virus to host cells.Further studies revealed that ART and DHA inhibited RABV genomic RNA synthesis and viral gene transcription.Treatment with ART or DHA(5 mg/kg)by intramuscular injection improved,to some extent,the survival rate of RABV-challenged mice.Combination treatment with derivatives of artemisinin and mannitol significantly improved the survival rate of RABV-challenged mice.The results suggest that ART and DHA have a great potential to be explored as new anti-rabies agents for treatment of rabies. | Jun Luo Yue Zhang Yang Wang Qing Liu Jiesen Li Hongling He Yongwen Luo Shile Huang Xiaofeng Guo | 2021 | Virologica Sinica2021，36，4： | 2 |
| 14 | Improved Region Merging Algorithm for Remote Sensing Images显示文摘To segment high-resolution remote sensing images(RSIs)accurately on an object level and meet the precise boundary dividing requirement,an improved superpixel segmentation and region merging algorithm is proposed.Simple linear iterative clustering(SLIC)is widely used because of its advantages in performance and effect;however,it causes over-segmentation,which is very disadvantageous to information extraction.In this proposed method,SLIC is firstly adopted for initial superpixel partition.The second stage follows the iterative merging procedure,which uses a hierarchical clustering algorithm and introduces a local binary pattern(LBP)texture feature operator during the process of merging.The experimental results indicate that the proposed method achieved a good segmentation and region merging performance,and worked effectively on cloud detection preprocessing in high-resolution RSIs with cloud and snow overlap situations. | Zhuo Wu Xiaohua Wang Yongwen Shen Yueting Shi | 2020 | Journal of Beijing Institute of Technology2020，29，1： | 2 |
| 15 | Analysis of Protein Moiety of Polysaccharide Conjugates Water-extracted from Low Grade Green Tea显示文摘 | CHEN Xiaoqiang SHAO Shengrong XIE Jianchun YUAN Hao LI Qian WU Long WU Zhengqi YUAN Haibo JIANG Yongwen | 2018 | Chemical Research in Chinese Universities2018，34，4： | 2 |
| 16 | A New Class of Amide Ligands Enable Cu-Catalyzed Coupling of Sodium Methanesulfinate with (Hetero)aryl Chlorides显示文摘 | Dawei Ma Songtao Niu Jinlong Zhao Xi Jiang Yongwen Jiang Xiaojing Zhang Tiemin Sun | 2017 | Chinese Journal of Chemistry2017，35，11： | 2 |
| 17 | Analysis of Flight Dynamics Characteristics of Tilt Quad Rotor with Partial Tilt-Wing显示文摘The aerodynamic model of propeller,wing,fuselage and vertical tail are established for the tilt quad rotor(TQR)with partial tilt-wing,and then the flight dynamic model is established.Based on the six-degree-of-freedom equation and the small disturbance linearization assumption,the trimming and stability of the tilt quad rotor with partial tilt-wing and the tilt quad rotor without tilt-wing are analyzed.The results show that in the hovering state,due to the existence of tilt-wing,the propeller wake reduces the downwash on the wing,thereby reducing the vertical weight gain of the aircraft.It is beneficial to increase the endurance time and improve the endurance performance.The transition corridor of the TQR with tilt-wing is narrower than that of the TQR without tilt-wing,but the transition corridor of TQR with tilt-wing still has a large space for design.Furthermore,the stability analysis shows that the Dutch roll damping ratio is larger,and in other modes the aircraft has a certain stability.The manipulation response analysis shows that in the transition mode the lateral-directional coupling is strong. | WANG Zhi gang DUAN Dengyan YANG Yongwen YU Hongrui LI Jianbo | 2019 | Transactions of Nanjing University of Aeronautics and Astronautics2019，36，6： | 2 |
| 18 | RDFAdaptor:Efficient ETL Plugins for RDF Data Process显示文摘Purpose:The interdisciplinary nature and rapid development of the Semantic Web led to the mass publication of RDF data in a large number of widely accepted serialization formats,thus developing out the necessity for RDF data processing with specific purposes.The paper reports on an assessment of chief RDF data endpoint challenges and introduces the RDF Adaptor,a set of plugins for RDF data processing which covers the whole life-cycle with high efficiency.Design/methodology/approach:The RDFAdaptor is designed based on the prominent ETL tool—Pentaho Data Integration—which provides a user-friendly and intuitive interface and allows connect to various data sources and formats,and reuses the Java framework RDF4J as middleware that realizes access to data repositories,SPARQL endpoints and all leading RDF database solutions with SPARQL 1.1 support.It can support effortless services with various configuration templates in multi-scenario applications,and help extend data process tasks in other services or tools to complement missing functions.Findings:The proposed comprehensive RDF ETL solution—RDFAdaptor—provides an easy-to-use and intuitive interface,supports data integration and federation over multi-source heterogeneous repositories or endpoints,as well as manage linked data in hybrid storage mode.Research limitations:The plugin set can support several application scenarios of RDF data process,but error detection/check and interaction with other graph repositories remain to be improved.Practical implications:The plugin set can provide user interface and configuration templates which enable its usability in various applications of RDF data generation,multi-format data conversion,remote RDF data migration,and RDF graph update in semantic query process.Originality/value:This is the first attempt to develop components instead of systems that can include extract,consolidate,and store RDF data on the basis of an ecologically mature data warehousing environment. | Jiao Li Guojian Xian Ruixue Zhao Yongwen Huang Yuantao Kou Tingting Luo Tan Sun | 2021 | Journal of Data and Information Science2021，6，3： | 2 |
| 19 | Puerarin mediates hepatoprotection against CCl 4 -induced hepatic fibrosis rats through attenuation of inflammation response and amelioration of metabolic function显示文摘 | Rong Li Lingyuan Xu Tao Liang Yongwen Li Shijun Zhang Xiaoqun Duan | 2013 | Food and Chemical Toxicology2013，，： | 1 |
| 20 | Deformation Analysis and Fixture Design of Thin-walled Cylinder in Drilling Process Based on TRIZ Theory显示文摘Thin-walled cylindrical workpiece is easy to deform during machining and clamping processes due to the insufficient rigidi.Moreover,it’s also difficult to ensure the perpendicularity of flange holes during drilling process.In this paper,the element birth and death technique is used to obtain the axial deformation of the hole through finite element simulation.The measured value of the perpendicularity of the hole was compared with the simulated value to verify then the rationality of the simulation model.To reduce the perpendicularity error of the hole in the drilling process,the theory of inventive principle solution(TRIZ)was used to analyze the drilling process of thin-walled cylinder,and the corresponding fixture was developed to adjust the supporting surface height adaptively.Three different fixture supporting layout schemes were used for numerical simulation of drilling process,and the maximum,average and standard deviation of the axial deformation of the flange holes and their maximum hole perpendicularity errors were comparatively analyzed,and the optimal arrangement was optimized.The results show that the proposed deformation control strategy can effectively improve the drilling deformation of thin-walled cylindrical workpiece,thereby significantly improving the machining quality of the parts. | Fulin WANG Bo SHENG Yongwen WU Jiawang LI Zhou XU Zhaoxia ZHU | 2021 | Mechanical Engineering Science2021，3，1： | 1 |
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