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| 1 | Swelling acidic poly(ionic liquid)s as efficient catalysts for the esterification of cyclohexene and formic acid显示文摘Acidic poly(ionic liquid)s(PILs)with swelling ability were synthesized by free radical copolymerization of N-vinylimidazolium ionic liquids,divinylbenzene(DVB)and sodium acrylate(NaAA),and further acidification by sulfuric acid.The swelling ability of acidic PILs was greatly affected by cross-linker content and chain length of 3-alkyl-substituents on imidazolium.Cross-linked network structures could be observed from the cryogenic scanning electron microscopy(cryo-SEM)images of the swollen acidic PILs in formic acid.Acidic PILs with network structures in swollen state exhibited excellent activities in the esterification of cyclohexene and formic acid,and the catalytic activities were in positive correlation with their swelling abilities.Acidic PIL with 3-octyl-substituent and 2.5 mol%DVB(PIL-C8-2.5DVB-HSO4)had the highest swelling ability in formic acid and exhibited comparable catalytic activities with homogeneous catalysts such as sulfuric acid and p-toluenesulfonic acid. | Xin Wang Sanguan Ma Bihua Chen Jingshun Zhang Yongya Zhang Guohua Gao | 2020 | Green Energy & Environment2020，5，2： | 3 |
| 2 | The efficacy of NP11-4-derived immunotoxin scFv-artesunate in reducing hepatic fibrosis inducedby Schistosoma japonicum in mice显示文摘Schistosomiasis is one of the most prevalent parasitic diseases in China,and hepatic fibrosis caused by schistosome infection is the principal cause of death.The aim of this study was to evaluate the efficacy of NP11-4derived immunotoxin scFv-artesunate on Schistosoma japonicum-induced hepatic fibrosis.A single-chain variable fragment (scFv) was generated from the murine anti-Schistosoma japonicum (S.japanicum) monoclonal antibody NP11-4.The scFv was expressed as a soluble protein and purified by Ni-affinity chromatography.After conjugation with artesunate,the binding ability with soluble egg antigens (SEA) was determined by an enzyme-linked immunosorbent assay (ELISA).The biological activity of purified scFv,scFv-artesunate (immunotoxin),and artesunate was detected in vivo.Image-Pro Plus software was used to analyze the size of egg granuloma and the extent of liver fibrosis.The recombinant scFv expession vector was constructed and expressed successfully.After purification by a His-trap Ni-affinity column,the scFv yield was approximately 0.8 mg/L of culture medium.ELISA results showed that chemical conjugation did not affect the binding activity of the immunotoxin.Our animal experiments indicated that the immunotoxin could significantly reduce the size of egg granuloma in the liver and inhibit hepatic fibrosis.The immunotoxin could be used as a promising candidate in the targeted therapy of S.japonicum-induced hepatic fibrosis. | Hong Li Chunyan Gu Yongya Ren Yang Dai Xiaojuan Zhu Jing Xu Yuhua Li Zhenning Qiu Jin Zhu Yinchang Zhu Xiaohong Guan Zhenqing Feng | 2011 | The Journal of Biomedical Research2011，25，2： | 3 |
| 3 | Effect of varying NaCl doses on flavonoid production in suspension cells of Ginkgo biloba : relationship to chlorophyll fluorescence, ion homeostasis, antioxidant system and ultrastructure显示文摘 | Ying Chen Fangzhi Lin Hua Yang Li Yue Fei Hu Junlin Wang Yongya Luo Fuliang Cao | 2014 | Acta Physiologiae Plantarum2014，，12： | 1 |
| 4 | Tibetan Mastiffs in Yushu显示文摘A Tibetan Mastiff-Tanggya When I was a teenager,my family had a baby mastiff.Because a lock natural of white hair decorated the mastiff's chest,he was given the name'Tanggya'.I remember Tanggya was a big dog when I was still a little girl. Whenever he stood on his hind legs,he seemed as tall as my father.When guests came to visit,he always jumped on them and barked constantly. Only my father could briefly calm him down,and nobody amongst our siblings dared to get close to him.Tanggya was never released u... | Yongya Zhaxi | 2008 | China's Tibet2008，19，4： | 0 |
| 5 | Rational design and crystallographic analysis of novel isoform-selective TRKA inhibitors for cancer therapy显示文摘To the Editor:Tropomyosin receptor kinase A/B/C(TRKA/B/C)are encoded by neurotrophic tyrosine receptor kinase 1/2/3(NTRK1/2/3),respectively.NTRK gene fusions are the most common drivers of malignancies.Additionally,TRKA is the most common oncogene in TRK family,which is detected in 7.4%of human tumors. | Guan Wang Yongya Wu Chengyong Wu Wen Shuai Tingting Jiang Aoxue Wang Faqian Bu Qiu Sun Liang Ouyang | 2023 | Acta Pharmaceutica Sinica B2023，13，1： | 0 |
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