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| 1 | Heavy metal concentrations of agricultural soils and vegetables from Dongguan, Guangdong显示文摘118 农业土壤和 43 件蔬菜样品的一个总数从 Dongguan 城市被收集,广东,中国。空间分发,来源,累积特征和在农业土壤和蔬菜的重金属的潜在的风险被三条不同途径在细节描绘,包括在土壤和蔬菜的八个金属元素的全部的内容,在在学习的土壤的重金属的 GIS 地图和 multivariate 分析。结果证明在农业土壤有象 Cu , Zn , Ni , Pb , Cd 和 Hg 那样的重金属的更高的累积,并且 Pb 的内容( 65.38 mg kg ? 2 )并且 Hg ( 0.24 mg kg ? 2 )分别地是在广东省的土壤的相应重金属的背景内容的 1.82 和 2.82 次。有在附近的 3.4% Cu, 5.9% Ni, 1.7% Cd 和 28% Hg 在所有从有的所有调查地点收集了土壤样品溢出为为土壤标准的中国环境质量的重金属的内容(GB15618-1995,等级 II ) 。在土壤的多金属的污染特征被 Hg 主要反映。到在土壤的八个金属元素有不同来源, Cu, Zn, Ni, Cr 并且这是主要源于父母材料,并且 Pb, Hg 和 Cd 被人为的活动影响。空间分发表演 Cu, Zn, Ni, Cr, Pb 并且农业土壤的 Hg 内容在西方高并且在东方,和 Cd 内容低在西北高,东南并且在在 Dongguan 的西南低。Ni 的蔬菜样品的比率, Pb 并且作为比最大值高的集中,在食物(GB2762-2005 ) 的沾染物的层次分别地是 4.7% , 16.3% 和 48.8% 。在蔬菜的重金属的简历集中因素(BCF ) 的顺序是 Cd > Zn > Cu > 作为 > Ni > Hg > Cr > Pb。在 Dongguan 城市里从农业土壤和蔬菜为食物安全和人健康集中于重金属的潜在的风险是必要的,广东省。 | CAI Limei HUANG Lanchun ZHOU Yongzhang XU Zhencheng PENG Xiaochun YAO Ling'ai ZHOU Yang PENG Ping'an | 2010 | Journal of Geographical Sciences2010，20，1： | 23 |
| 2 | Effect of compound rhodiola sachalinensis A Bor on CCI4-induced liver fibrosis in rats and its probable molecular mechanisms显示文摘AIM: To explore the anti-fibrotic effect of a traditional Chinese medicine, compound rhodiola sachalinensis A Bor on CCl4-induced liver fibrosis in rats and its probable molecular mechanisms. METHODS: Ninety healthy male SD rats were randomly divided into three groups: normal group (n=-10), treatment group of compound rhodiola sachalinensis A Bor (n=-40) and CCl4-induced model group (n=40). The liver fibrosis was induced by CCl4 subcutaneous injection. Treatment group was administered with compound rhodiola sachalinensis A Bor (0.5 g/kg) once a day at the same time. Then the activities of several serum fibrosis-associated enzymes: alanine aminotransferase (ALT), aspartate aminotransferase (AST), N-acetyl-beta-D-glucosaminidase (β-NAG) and the levels ofserum procollagen Ⅲ (PCⅢ), collagen Ⅳ (CⅣ), hyaluronic acid (HA) were assayed. The histooathol(mical chanaes were observed with HE, VG and Masson stain. The expression of TGF-β1 mRNA,αl (I) mRNA and Na+/Ca2+ exchanger (NCX ) mRNA was detected by reverse transcription polymerase chain reaction (RT-PCR) in situ.RESULTS: Compound rhodiola sachalinensis A Bor significantly reduced serum activities of ALT, AST, β-NAG and decreased the levels of PCⅢ, CⅣ, HA, improved the liver histopathological changes, inhibited the expression of TGF-β1 mRNA, α(1) mRNA and Na+/Ca2+ exchanger mRNA in rats. CONCLUSION: Compound rhodiola sachalinensis A Bor can intervene in CCI4-induced liver fibrosis in rats, in which potential mechanisms may be decreasing the production of TGF-β1, reducing the production of collagen, preventing the activation of hepatic stellate cell (HSC) and inhibiting theexpression of TGF-β1 mRNA, αl(I) mRNA and Na+/Ca2+ exchanger mRNA. | Chun-TaoLei Ming-DeJiang Xiao-BinChen YongZhang HuiXu ZhaoWang Xiao-LingWU Wei-ZhengZeng Pi-LongWang | 2003 | World Journal of Gastroenterology2003，9，7： | 21 |
| 3 | A Possible Configuration with Motor-generator Pair for Renewable Energy Integration显示文摘High penetration rates of renewable energy will bring stability problems for the future power grid.One of the critical issues is lack of inertia.In this paper,a synchronous motor-generator pair(MGP)system is proposed as a possible solution for renewable energy integration to enhance inertia and improve grid stability.First,feasibility studies of MGP on inertia,damping,efficiency,and cost are presented.Second,an analytical model is established based on its rotor angle relation.An active power control scheme based on voltage phase difference between renewable energy source and grid is then proposed,and state equations of MGP are derived for small signal stability.Next,two experiments are designed and implemented to verify stable operation and active power regulation of the MGP system.A single-machine infinite bus system is tested to investigate small signal stability and frequency response of MGP.The results show that the MGP system has a solid base in physics and is a feasible solution for providing enough inertia and improving small signal performance in the power grid with high penetration of renewable energy.The paper concludes with a discussion on future research directions to gain a better understanding of MGP. | Siming Wei Yingkun Zhou Song Li Yongzhang Huang | 2017 | CSEE Journal of Power and Energy Systems2017，3，1： | 20 |
| 4 | Comparative proteogenomic analysis of the Leptospira interrogans virulence-attenuated strain IPAV against the pathogenic strain 56601显示文摘稀释毒力的螺旋体 interrogans serovar Lai 紧张 IPAV 被延长实验室经过从在中国孤立的高度剧毒的祖先的紧张导出。我们学习了 IPAV 的基因变化对病原的 L 经由比较分析使它变为无毒害。interrogans serovar Lai 紧张 56601。IPAV 紧张的完全的染色体顺序决心、使用与作比较,然后修正并且重新注解紧张 56601 的染色体顺序。除了他们的高度类似的 genomic,结构和基因顺序, 33 插入的一个总数, 53 删除和 301 个单个核苷酸的变化(SNV ) 在整个直接影响 101 基因的 IPAV 的染色体被检测,在他们的 5 ′ 的任何一个;在上游的区域或在他们的编码区域以内。在他们之中, 44 功能的基因的多数涉及信号 transduction,压力反应, transmembrane 运输和氮新陈代谢。基于量的液体,层析(LC )-MS/MS 数据揭示了的比较 proteomic 分析在 orthologs 的 1 627 选择的对之中,在 IPAV 的 174 基因拉紧,这是 upregulated,与主要在精力的班上的丰富生产和类脂化合物新陈代谢。相反,在紧张 56601 的 228 基因是 upregulated,与在蛋白质翻译和 DNA 复制 / 修理的范畴充实的多数。 genomic 和 proteomic 途径的联合在批评基因说明了那改变的表情或变化,例如编码 Ser/Thr kinase ,碳饥饿蛋白质 CstA ,夫酸安合成酶,GTP有约束力的蛋白质 BipA , ribonucleotide-diphosphate reductase 和磷酸盐 transporter 的那些,并且在脂蛋白或外部膜蛋白质的翻译侧面的改变是可能的在紧张 IPAV 说明毒力变细。 | Yi Zhong Xiao Chang Xing-Jun Cao Yan Zhang Huajun Zheng Yongzhang Zhu Chengsong Cai Zelin Cui Yunyi Zhang Yuan-Yuan Li Xiu-Gao Jiang Guo-Ping Zhao Shengyue Wang Yixue Li Rong Zeng Xuan Li Xiao-Kui Guo | 2011 | Cell Research2011，21，8： | 10 |
| 5 | A new three-layer-funnel-shaped esophagogastric anastomosis for surgical treatment of esophageal carcinoma显示文摘AIM: To reduce the incidence of postoperative anastomoticleak, stenosis, gastroesophageal reflux (GER) for patientswith esophageal carcinoma, and to evaluate the conventionalmethod of esophagectomy and esophagogastroplastymodified by a new three-layer-funnel-shaped (TLF)esophagogastric anastomotic suturing technique.METHODS: From January 1997 to October 1999, patientswith clinical stage Ⅰ and Ⅱ (Ⅱa and Ⅱb) esophagealcarcinoma, which met the enrollment criteria, were surgicallytreated by the new method (Group A) and by conventionaloperation (Group B). All the patients were followed at leastfor 6 months. Postoperative outcomes and complicationswere recorded and compared with the conventional methodin the same hospitals and with that reported previously byMcLarty etalin 1997 (Group C).RESULTS: 58 cases with stage Ⅰ and Ⅱ (Ⅱa and Ⅱb)esophageal carcinoma, including 38 males and 20 femalesaged from 34 to 78 (mean age: 57), were surgically treatedby the TLF anastomosis and 64 by conventional method inour hospitals from January 1997 to October 1999. The qualityof swallowing was improved significantly (Wilcoxon W=2 142,P=0.0 001) 2 to 3 months after the new operation in GroupA. Only one patient had a blind anastomatic fistula diagnosedby barium swallow test 2 months but healed up 3 weekslater. Postoperative complications occurred in 25 (43 %)patients, anastomotic stenosis in 8 (14 %), and GER in 13(22 %). The incidences of postoperative anastomotic leak,stenosis and GER were significantly decreased by the TLFanastomosis method compared with that of conventionalmethods (x2=6.566, P =0.038; x2=10.214, P= 0.006;x2=21.265, P=0.000).CONCLUSION: The new three-layer-funnel-shapedesophagogastric anastomosis (TLFEGA) hasmore advantagesto reduce postoperative complications of anastomotic leak,stricture and GER. | Han-LeiDan YangBai HuiMeng JieZhang YongZhang Ya-LiZhang Zhen-ShuZhang Dian-YuanZhou | 2003 | World Journal of Gastroenterology2003，9，1： | 10 |
| 6 | Realization Methodology of a 5-axis Spline Interpolator in an Open CNC System显示文摘由使用不一致的合理B花键( NURBS )曲线的优点代表空间曲线,有对5轴合适的两倍 NURBS 曲线的一种说明格式协调了即时插值被介绍代替当前的5轴协调线性插值方法有缺陷者在低速度,在 sculptured 的低精确性、庞大的数字控制( NC )文件出现用机器制造。有介绍格式的 NC 文件的一个产生过程被介绍并且在一台开的计算机认识到插值的方法数字控制(计算机数值控制) 系统自己被开发。这些说明了建议方法和它避免 5 轴的所有缺乏的能力的可行性线性插值方法。 | Wang Yongzhang Ma Xiongbo Chen Liangji Han Zhenyu | 2007 | Chinese Journal of Aeronautics2007，20，4： | 10 |
| 7 | Realization of a 5-axis NURBS Interpolation with Controlled Angular Velocity显示文摘5 轴机床在与建筑群细工品用机器制造的数字控制(计算机数值控制) 塑造的高速度、高精确的计算机起一个重要作用。为用机器制造的 5 轴的一种不一致的合理 B 花键(NURBS ) 插值格式被建议适应用机器制造的高速度(高速存储器) 。与这种插值格式,在取向向量之间的角度被选择为一个开的控制器构造在即时插值过程完成合理取向向量的取向 B 花键的参数。在线性轴和旋转的轴之间的协调运动由造联系位置花键的插值弧长度到取向花键的角度的多项式花键被完成。在支持的控制器的这种插值格式和它的实现方法的算法常规详细被讨论。最后,建议 NURBS 插值格式的性能被一个实际例子表明。 | LIU Yuan LI Hui WANG Yongzhang | 2012 | Chinese Journal of Aeronautics2012，25，1： | 8 |
| 8 | Soil pollution by polycyclic aromatic hydrocarbons: A comparison of two Chinese cities显示文摘Soil samples from Huizhou and Zhanjiang,China were analyzed for 16 priority polycyclic aromatic hydrocarbons (PAHs) with harmonized sampling,sample extraction and analysis quantification methods.The concentrations and sources of PAHs in soil samples of the two cities were compared.Almost all of the PAH components were detectable in 103 soil samples.The concentrations of ∑ PAHs ranged from 35.40 to 534.5 μg/kg in soil samples from Huizhou,and ranged from 9.50 to 6618.00 μg/kg in samples from Zhanjiang.Evident differences of concentrations,compositions and sources of PAHs in soils were observed between the two cities.The average concentrations of individual component and the sum of a group of PAHs in soil samples from Zhanjiang were significantly higher than those in Huizhou (P < 0.05).Phe,Flu,Pyr,Bbf and Baa were the dominant PAH components both in soil samples from Huizhou and Zhanjiang.Except for these five components,Bap,I1p,Daa and Bgp were also the dominant PAH components in soil samples from Zhanjiang.Coal combustion and liquid fossil fuel combustion were the same sources of PAHs in the two cities with different contributions,and petroleum played a key role in PAHs release in Zhanjiang. | Jin Ma Yongzhang Zhou | 2011 | Journal of Environmental Sciences2011，23，9： | 7 |
| 9 | Cross-Reaction of SARS-CoV Antigen with Autoantibodies in Autoimmune Diseases显示文摘To investigate the significance of the SARS-associated coronavirus (SARS-CoV) antibody, detected by ELISA and indirect immunofluorescence assays (IFA) for the SARS-CoV Vero E6 cell lysates, in non-SARS subjects,114 serum samples from healthy controls and 104 serum specimens from autoimmune disease patients were collected. The results of ELISA showed that among 114 sera from healthy controls, 4 (3.5 %) were positive of SARS-CoV-IgG antibody and 114 (100%) were all negative of SARS-CoV-IgM antibody; the specificity of SARS-CoV-IgG antibody for SARS patients was 96.5%, but the specificity of both SARS-CoV-IgG and -IgM antibodies for SARS patients was 100%. In 58 cases with SLE, positive rates of SARS-CoV-IgG and -IgM antibodies were 32.8% (19/58) and 8.6% (5/58), respectively, in which 11 cases (19%) were positive of both SARS-CoV-IgG and -IgM antibodies; in 10 cases with SS, positive rate of both SARS-CoV-IgG and -IgM antibodies was 10% (1/10); in 16 cases with MCTD, positive rate of SARS-CoV-IgG was 37.5% (6/16), positive rate of both SARS-CoV-IgG and -IgM antibodies was 6.3% (1/16); in 20 cases with RA, one case was positive (5%) of SARS-CoV-IgG. However, of all samples with positive SARS-CoV-IgG and -IgM antibodies for autoimmune diseases and healthy controls, SARS-CoV RNA and antibodies were all negative by RT-PCR and IFA. All sera for negative or positive ELISA results were also negative or positive results using ELISA with Vero E6 cells lysates. These studies showed that SARS-CoV Vero E6 cell lysates for the ELISA to detect SARS-CoV antibodies could lead to the false-positive reactions or cross-reactions of SARS-CoV antibodies in non-SARS diseases and healthy controls, and the false-positive reactions or cross-reactions were related to Vero E6 cell lysates and autoantibodies in non-SARS population. | YunshanWang ShanhuiSun HongShen LihuaJiang MaoxiuZhang DongjieXiao YangLiu XiaoliMa YongZhang NongjianGuo TanghongJia | 2004 | Cellular & Molecular Immunology2004，1，4： | 6 |
| 10 | Approximation Algorithm for Weighted Weak Vertex Cover显示文摘The problem of efficiently monitoring the network flow is regarded as the problem to find out the minimum weighted weak vertex cover set for a given graph G = (V, E). In this paper, we give an approximation algorithm to solve it, which has the approximation ratio ln d+1 1, where d is the maximum degree of the vertex in graph G, and improve the previous work. | YongZhang HongZhu | 2004 | Journal of Computer Science & Technology2004，19，6： | 5 |
| 11 | OPEN ARCHITECTURE CNC SYSTEM HITCNC AND KEY TECHNOLOGY显示文摘Aiming at the characteristics of modularity and reconfigurable in open architecture com-puter numerical control (CNC) system,the open architecture CNC system,Harbin Institute of Tech-nology computer numerical control (HITCNC),is researched and manufactured based on the interface standards. The system’s external interfaces are coincident with the corresponding international stan-dards,and the internal interfaces follow the open modular architecture controller (OMAC) agreement. In the research and manufacturing process,object-oriented technology is used to ensure the openness of the HITCNC,and static programming is applied in the CNC system according to the idea of modu-larization disassembly. The HITCNC also actualizes real-time and unreal-time modules adopting real-time dynamical linked library (RTDLL) and component object model (COM). Finite state ma-chine (FSM) is adopted to do dynamically modeling of HITCNC. The complete separation between the software and the hardware is achieved in the HITCNC by applying the SoftSERCANS technique. The application of the above key techniques decreases the programming workload greatly,and uses software programs replacing hardware functions,which offers plenty technique ensures for the open-ness of HITCNC. Finally,based on the HITCNC,a three-dimensional milling system is established. On the system,series experiments are done to validate the expandability and interchangeability of HITCNC. The results of the experiments show that the established open architecture CNC system HITCNC is correct and feasible,and has good openness. | WANG Yongzhang LIU Tao FU Hongya HAN Zhenyu | 2007 | Chinese Journal of Mechanical Engineering2007，20，2： | 4 |
| 12 | The Impact on Environmental Kuznets Curve by Trade and Foreign Direct Investment in China显示文摘Based on data of trade, foreign directinvestment (FDI), economic development andenvironmental conditions in China’s 30 provincesbetween 1990-2002, this paper deals with the impacton Environmental Kuznets Curve (EKC) of tradeand FDI in China. The results show no direct impacton EKC of trade, on the one hand. However, tradecontributes significantly to economic growth, andhas played a positive role in introducing advancedpollution prevention technology and environmentalmanagement methodology to China. Therefore, aproactive trade policy will help solve the environmentalpollution problem brought by economic growth. Onthe other hand, there is a positive correlation betweenFDI and pollutant emission, which proves that FDIdoes have some negative influence on environmentin China due to hasty introduction of foreign capitaland inadequate environmental management systemin China. | Yang Haisheng 1, Jia Jia 2, Zhou Yongzhang 1& Wang Shugong 1,31 Center for Earth Environment & Resources, Zhongshan University, Guangzhou, 5102752 Lingnan College, Zhongshan University, Guangzhou, 5102753 Institute of Environmental Science, Zhongshan University, Guangzhou, 510275 | 2005 | Chinese Journal of Population,Resources and Environment2005，3，2： | 4 |
| 13 | Declines in the tuber‐feeding waterbird guild at Shengjin Lake National Nature Reserve, China – a barometer of submerged macrophyte collapse显示文摘 | Anthony D.Fox LeiCao YongZhang MarkBarter Mei JuanZhao Fan JuanMeng Si LongWang | 2011 | Aquatic Conserv: Mar. Freshw. Ecosyst2011，，： | 3 |
| 14 | An apple (Malus domestica) AP2/ERF transcription factor modulates carotenoid accumulation显示文摘Color is an important trait for horticultural crops.Carotenoids are one of the main pigments for coloration and have important implications for photosynthesis in plants and benefits for human health.Here,we identified an APETALA2(AP2)/ETHYLENE RESPONSE FACTOR(ERF)transcription factor named MdAP2-34 in apple(Malus domestica Borkh.).MdAP2-34 expression exhibited a close correlation with carotenoid content in‘Benin Shogun’and‘Yanfu 3’fruit flesh.MdAP2-34 promotes carotenoid accumulation in MdAP2-34-OVX transgenic apple calli and fruits by participating in the carotenoid biosynthesis pathway.The major carotenoid contents of phytoene andβ-carotene were much higher in overexpressing MdAP2-34 transgenic calli and fruit skin,yet the predominant compound of lutein showed no obvious difference,indicating that MdAP2-34 regulates phytoene andβ-carotene accumulation but not lutein.MdPSY2-1(phytoene synthase 2)is a major gene in the carotenoid biosynthesis pathway in apple fruit,and the MdPSY2-1 gene is directly bound and transcriptionally activated by MdAP2-34.In addition,overexpressing MdPSY2-1 in apple calli mainly increases phytoene and total carotenoid contents.Our findings will advance and extend our understanding of the complex molecular mechanisms of carotenoid biosynthesis in apple,and this research is valuable for accelerating the apple breeding process. | Qingyuan Dang Haiyun Sha Jiyun Nie Yongzhang Wang Yongbing Yuan Dongjie Jia | 2021 | Horticulture Research2021，8，1： | 3 |
| 15 | Growth and Optical Spectra of Tb^(3+)/Eu^(3+) Co-doped Cubic NaYF_4 Single Crystal for White Light Emitting Diode显示文摘High quality Tb^(3+)/Eu^(3+) co-doped cubic NaYF_4 single crystal in the size of Φ1.0 cm×6.6 cm was grown by a modified Bridgman method using KF as assistant flux for NaF-YF_3 system under the condition of completely closed Pt crucible.A white light emission from the combination of the violet-blue,blue,green,orange,and red lights with chromaticity coordinates of x = 0.3107,y = 0.3274,correlated color temperature of T_c = 6637 K,color rendering index of R_a = 83,and color quality scale of Q_a = 82 could be obtained from 1.51 mol%Tb^(3+) and 1.42 mol%Eu^(3+) co-doped cubic NaYF_4 single crystal when being excited by a 369 nm light.This indicates that Tb^(3+)/Eu^(3+) co-doped cubic NaYF_4 single crystal has a potential application in white light emitting diode excited by ultraviolet light. | Yongzhang Jiang Haiping Xia Jiazhong Zhang Shuo Yang Haochuan Jiang Baojiu Chen | 2015 | Journal of Materials Science & Technology2015，31，12： | 2 |
| 16 | Comparative Study of Apoptosis-related Gene Loci in Human,Mouse and Rat Genomes显示文摘Many genes are involved in mammalian cell apoptosis pathway. These apoptosis genes often contain characteristic functional domains, and can be classified into at least 15 functional groups, according to previous reports. Using an integrated bioinformatics platform for motif or domain search from three public mammalian proteomes (International Protein Index database for human, mouse, and rat), we systematically cataloged all of the proteins involved in mammalian apoptosis pathway. By localizing those proteins onto the genomes, we obtained a gene locus centric apoptosis gene catalog for human, mouse and rat.Further phylogenetic analysis showed that most of the apoptosis related gene loci are conserved among these three mammals. Interestingly, about one-third of apoptosis gene loci form gene clusters on mammal chromosomes, and exist in the three species, which indicated that mammalian apoptosis gene orders are also conserved. In addition, some tandem duplicated gene loci were revealed by comparing gene loci clusters in the three species. All data produced in this work were stored in a relational database and may be viewed at http://pcas.cbi.pku.edu.cn/database/apd.php. | Yan-BinYIN YongZHANG PengYU Jing-ChuLUO YingJIANG Song-GangLI | 2005 | Acta Biochimica et Biophysica Sinica2005，37，5： | 2 |
| 17 | Effects of rare-earth elements on the glass-forming ability and mechanical properties of Cu_(46)Zr_(47-x)Al_7M_x(M = Ce,Pr,Tb,and Gd) bulk metallic glasses显示文摘Cu46Zr47-xAl7Mx(M = Ce,Pr,Tb,and Gd) bulk metallic glassy(BMG) alloys were prepared by copper-mold vacuum suction casting.The effects of rare-earth elements on the glass-forming ability(GFA),thermal stability,and mechanical properties of Cu46Zr47-xAl7Mx were investigated.The GFA of Cu46Zr47-xAl7Mx(M = Ce,Pr) alloys is dependent on the content of Ce and Pr,and the optimal content is 4.at %.Cu46Zr47-xAl7Tbx(x = 2,4,and 5) amorphous alloys with a diameter of 5 mm can be prepared.The GFA of Cu46Zr47-xAl7Gdx(x = 2,4,and 5) increases with increasing Gd.Tx and Tp of all decrease.Tg is dependent on the rare-earth element and its content.△Tx for most of these alloys decreases except the Cu46Zr42Al7Gd5 alloy.The activation energies △Eg,△Ex,and △Ep for the Cu46Zr42Al7Gd5 BMG alloy with Kissinger equations are 340.7,211.3,and 211.3 kJ/mol,respectively.These values with Ozawa equations are 334.8,210.3,and 210.3 kJ/mol,respectively.The Cu46Zr45Al7Tb2 alloy presents the highest microhardness,Hv 590,while the Cu46Zr43Al7Pr4 alloy presents the least,Hv 479.The compressive strength(σc.f.) of the Cu46Zr43Al7Gd4 BMG alloy is higher than that of the Cu46Zr43Al7Tb4 BMG alloy. | XIE Zhiwei ZHANG Yongzhang YANG Yuanzheng CHEN Xianzhao TAO Pingjun | 2010 | Rare Metals2010，29，5： | 2 |
| 18 | Global antimicrobial resistance:a system-wide comprehensive investigation using the Global One Health Index显示文摘Background:Antimicrobial resistance(AMR)is one of the top ten global public health challenges.However,given the lack of a comprehensive assessment of worldwide AMR status,our objective is to develop a One Health-based system-wide evaluation tool on global AMR.Methods:We have further developed the three-hierarchical Global One Health Index(GOHI)-AMR indicator scheme,which consists of five key indicators,17 indicators,and 49 sub-indicators,by incorporating 146 countries'data from diverse authoritative databases,including WHO's Global Antimicrobial Resistance and Use Surveillance System(GLASS)and the European CDC.We investigated the overall-or sub-rankings of GOHI-AMR at the international/regional/national levels for data preprocessing and score calculation utilizing the existing GOHI methodology.Additionally,a correlation analysis was conducted between the GOHI-AMR and other socioeconomic factors.Results:The average GOHI-AMR score for 146 countries is 38.45.As expected,high-income countries(HICs)outperform the other three income groups on overall rankings and all five key indicators of GOHI-AMR,whereas lowincome countries unexpectedly outperform upper-middle-income countries and lower-middle-income countries on the antibiotics-resistant key indicator(ARR)and ARR-subordinate indicators,including carbapenem-,β-lactam-,and quinolone resistance,and even HICs on aminoglycoside resistance.There were no significant differences among the four groups on the environmental-monitoring indicator(P>0.05).GOHI-AMR was positively correlated with gross domestic product,life expectancy,and AMR-related publications,but negatively with natural growth rate and chronic respiratory disease.In contrast to Cyprus,the remarkably lower prevalence of'ESKAPE pathogens'in high-scoring Sweden and Denmark highlights Europe's huge gaps.China and Russia outperformed the other three BRICS countries on all key indicators,particularly India's ARR and Brazil's AMR laboratory network and coordination capacity.Furthermore,significant internal disparities in carbapenem-resistant Klebsiella pneumoniae(CRKP)and methicillin-resistant Staphylococcus aureus(MRSA)prevalence were observed between China and the USA,with MRSA prevalence both gradually declining,whereas CRKP prevalence has been declining in the USA but increasing in China,consistent with higher carbapenems-related indicator'performance in USA.Conclusions:GOHI-AMR is the most comprehensive tool currently available for the assessment of AMR status worldwide.We discovered unique features impacting AMR in each country and offered precise recommendations to improve the capacity to tackle AMR in low-ranking countries. | Nan Zhou Zile Cheng Xiaoxi Zhang Chao Lv Chaoyi Guo Haodong Liu Ke Dong Yan Zhang Chang Liu Yunfu Chang Sheng Chen Xiaokui Guo Xiao-Nong Zhou Min Li Yongzhang Zhu | 2022 | Infectious Diseases of Poverty2022，11，4： | 2 |
| 19 | A truncated mutation of MucA in Pseudomonas aeruginosa from a bronchiectasis patient affects T3SS expression and inflammasome activation显示文摘Pseudomonas aeruginosa is an opportunistic pathogen that causes chronic airway infection in bronchiectasis patients and is closely associated with poor prognosis.Strains isolated from chronically infected patients typically have a mucoid phenotype due to the overproduction of alginate.In this study,we isolate a P.aeruginosa strain from the sputum of a patient with bronchiectasis and find that a truncated mutation occurred in mucA,which is named mucA117.mucA117 causes the strain to transform into a mucoid phenotype,downregulates the expression of T3SS and inflammasome ligands such as fliC and allows it to avoid inflammasome activation.The truncated mutation of the MucA protein may help P.aeruginosa escape clearance by the immune system,enabling long-term colonization. | Yanan Liu Lin Du Yongzhang Zhu Xuefei Liu Ning Zhou Congcong Li Qingtian Li Ping He | 2022 | Acta Biochimica et Biophysica Sinica2022，54，11： | 1 |
| 20 | Re-characterization of an extrachromosomal circular plasmid in the pathogenic Leptospira interrogans serovar Lai strain 56601显示文摘在中国,(str.56601 ) 螺旋体 interrogans serovar Lai 紧张 56601 是在人和动物引起严重细螺旋体病的主要病原的紧张之一。完全在 2003 定序的这 organismwas 的染色体。在 2011,然而,我们由于广泛地在螺旋体染色体散布的重复序列在 str.56601 染色体识别了并且改正一些集会错误。在这研究,我们重新分析以前报导在染色体 andrectified 的活动、噬菌体相关的 genomic 岛用各种各样的试验性的方法在 plasmid 和染色体详细说明了顺序信息。分开的圆形的 extrachromosomal plasmid 也是的 presenceof 证实岛在 L 报导了,并且它在 genomic 区域的地点是到 genomic 的 determinedrelative。由基于的脉搏地胶化电气泳动和 plasmid 的联合的 interrogans serovar Lai 基于抽取的南部的污点 analysis.This 报告证实分开的 extrachromosomal 通报 plasmid 不集成于 L 的染色体。interrogans str.56601 并且显著地改进了我们 L 的 genomic 组织,进化,和致病的理解。interrogans。特别地,这 extrachromosomal 通报 plasmid 的描述将在病原的螺旋体种类贡献 geneticmanipulation 系统的开发。 | Lili Huang Weinan Zhui Ping He Yan Zhang Xuran Zhuang Guoping Zhao Xiaokui Guo Jinhong Qin Yongzhang Zhu | 2014 | Acta Biochimica et Biophysica Sinica2014，46，7： | 1 |
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