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| 1 | Axial strain enhances osteotomy repair with a concomitant increase in connexin43 expression显示文摘The mechanical environment is known to influence fracture healing. We speculated that connexin43(Cx43) gap junctions, which impact skeletal homeostasis, fracture healing and the osteogenic response to mechanical load,may play a role in mediating the response of the healing bone to mechanical strain. Here, we used an established rat fracture model, which uses a 2 mm osteotomy gap stabilized by an external fixator, to examine the impact of various cyclical axial loading protocols(2%, 10%, and 30% strain) on osteotomy healing. We examined the presence of Cx43 in the osteotomy-healing environment and assessed how mechanical strain modulates Cx43 expression patterns in the callus. We demonstrated that increased cyclical axial strain results in increased radiographic and histologic bone formation. In addition, we show by immunohistochemistry that Cx43 is abundantly expressed in the healing callus, with the expression most robust in samples exposed to increased cyclical axial strain. These data are consistent with the concept that an increase in Cx43 expression by mechanical load may be part of the mechanisms by which mechanical forces enhances fracture healing. | Rishi R Gupta Hyunchul Kim Yu-Kwan Chan Carla Hebert Leah Gitajn David J Yoo Robert V O’Toole Adam H Hsieh Joseph P Stains | 2015 | Bone Research2015，3，2： | 2 |
| 2 | On-line adaptive and nonlinear process monitoring of a pilot-scale sequencing batch reactor显示文摘 | YOO C K VANROLLEGHEM P A | 2006 | Environmental Monitoring and Assessment2006，119，： | 1 |
| 3 | Propagation,expansion,and multilineage differentiation of human somatic stem cells from dermal progenitors显示文摘 | Bartsch G Yoo JJ De Coppi P | 2005 | Stem Cells Dev2005，14，3： | 1 |
| 4 | Prospective trial of synchronous bevacizumab, erlotinib,and concurrent chemoradiation in locally ad- vanced head and neck cancer显示文摘 | YOO D S KIRKPATRICK J P CRACIUNESCU O | 2012 | Clin Cancer Res2012，18，： | 1 |
| 5 | Trends and Fluctuations in the Dates of Ice Break-up of Lakes and Rivers in Northern Europe: the Effect of the North Atlantic Oscillation显示文摘 | Yoo J C Dorico P | 2002 | Journal of Hy- drology2002，268，1： | 1 |
| 6 | Early os- teogenic differentiation of mouse preosteoblasts induced by collagen-derived DGEA-peptide on nanofibrous phage tissue matrices 显示文摘 | Yoo S Y Kobayashi M Lee P P Lee S W | 2011 | Biomacromolecules2011，12，4： | 1 |
| 7 | The iliotibial band in acute knee trauma: patterns of injury on MR imaging显示文摘 | Mansour P Yoo P McKean D et al | 2014 | Skeletal Radiol2014，43，10： | 1 |
| 8 | 查看详情显示文摘 | Fan W Snyder M A Kumar S Lee P S Yoo W C McCormick A V Penn R L Stein A Tsapatsis M | | 0，，： | 1 |
| 9 | Development of transactive memory systems and collective mind in virtual teams显示文摘 | Yoo Y Kanawattanachai P | 2001 | International Journal of Organizational Analy- sis2001，9，2： | 1 |
| 10 | Doxorubicin-conjugated biodegradable polymeric micelles having acid-cleavable linkages显示文摘 | Lee E A Tae G P | 2002 | J Controlled Release2002，82，： | 1 |
| 11 | A complex,four-way variant t(15; 17) in acute promyelocytic leukemia显示文摘 | YOO S J SEO E J LEE J H SEO Y H PARK P W AHN J Y | 2006 | Cancer Genet Cytogenet2006，167，2： | 1 |
| 12 | Microencapsulatiun of α- tocopherol using sodium alginate and its controlled release properties显示文摘 | YOO S H SONG Y B CHANG P S | 2006 | International Journal of Biological Macromolecules2006，38，1： | 1 |
| 13 | Cyclic hydrostatic pressure enhances the chondrogenic phenotype of human mesenchymal progenitor cells differentiated in vitro 显示文摘 | Angele P Yoo JU Smith C | 2003 | J Orthop Res2003，21，： | 1 |
| 14 | Biodegradable polymeric micelles composed of doxorubicin conjugated PLGA-PEG block copolymer显示文摘 | Tae G P | 2001 | J Controlled Release2001，70，： | 1 |
| 15 | Genetic relationships of Bacillus anthracis and closely related species based on variable- number tandem repeat analysis and BOX-PCR genomic finger- printing 显示文摘 | KIM W HONG Y P YOO J H | 2002 | FEMS Microbiol Lett2002，207，： | 1 |
| 16 | Fabrication of MOF-5 membranes using microwave-induced rapid seeding and solvothermal secondary growth显示文摘 | Yoo Y Lai Z P Jeong H K | 2009 | Microporous and Mesoporous Materials2009，123，123： | 1 |
| 17 | Congenital extrahepatic portosystemic shunts显示文摘 | Murray C P Yoo S J Babyn P S | 2003 | Pediatr Radiol2003，33，9： | 1 |
| 18 | Removal of paraffin wax bind from matal injection molded part by supercritical fluids显示文摘 | Kim Y H Yoo K P Lim J S | 2004 | Separation Science and Technology2004，39，8： | 1 |
| 19 | Assessing the effects of animation in online banner advertising: hierarchy of effects model 显示文摘 | Yoo C Y Kim K Stout P A | 2004 | Journal of Interactive Advertising2004，4，2： | 1 |
| 20 | 查看详情显示文摘 | Kalita M P Yoo S Sahu J | | 0，，： | 1 |
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