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| 1 | Features of extrahepatic metastasis after radiofrequency ablation for hepatocellular carcinoma显示文摘BACKGROUND Extrahepatic metastasis(EHM)of hepatocellular carcinoma(HCC)is associated with poor outcomes.However,the clinical features and risk factors of EHM of HCC after radiofrequency ablation(RFA)remain unclear.AIM To elucidate the characteristics and risk factors of EHM after RFA for HCC.METHODS From January 2008 to December 2017,we retrospectively enrolled 661 patients who underwent RFA as first-line treatment for HCC at 2 tertiary hospitals.The inclusion criteria were age≥18 years,a diagnosis of HCC,and treatment-naivety.Abdominal computed tomography(CT)or magnetic resonance imaging(MRI)and alpha-fetoprotein measurements were routinely performed at 1 mo after RFA and followed-up at intervals of 3-6 mo.Univariate analyses were performed using the chi-squared test or Student’s t-test,and univariate and multivariate analyses were performed via logistic regression,as appropriate.RESULTS EHM was diagnosed in 44 patients(6.7%)during a median follow-up period of 1204 days.The 10-year cumulative rate of HCC recurrence and EHM was 92.7%and 33.7%,respectively.Initial recurrence was most often intrahepatic,and the rate of extrahepatic recurrence at initial recurrence was only 1.2%.The median time to the diagnosis of EHM was 2.68 years,and 68.2%of patients developed EHM within 2 years of the first recurrence,regardless of recurrence-free survival and 75.0%of patients developed EHM within 5 years after first recurrence.EHM was mostly diagnosed via abdominal CT/MRI in 33(75.0%)and 38 of 44 patients(86.4%)with EHM had either positive abdominal CT scan results or serum AFP level elevation.In multivariate analysis,recurrence-free survival<2 years,ablation zone/tumor size<2,and alpha-fetoprotein level>400 IU/mL were associated with a high EHM risk.CONCLUSION EHM occurs following multiple intrahepatic recurrences after RFA and combined contrast-enhanced abdominal CT and serum AFP were useful for surveillance.Patients especially with high-risk factors require close follow-up for EHM. | Jae H Yoon Young J Goo Chae-Jun Lim Sung K Choi Sung B Cho Sang S Shin Chung H Jun | 2020 | World Journal of Gastroenterology2020，26，32： | 3 |
| 2 | Microstructual,electrical properties and temperature stability of resonant frequency in Pb(Ni1/2W1/2)O3-Pb(Mn1/3Nb2/3)O3-Pb(Zr,Ti)O3 ceramics for high-power piezoelectric tranformer显示文摘 | Yoo J H Lee Y W Yoon K H | 2001 | Jpn J Appl Phy Part12001，40，5： | 2 |
| 3 | Microwave dielectric properties of CaO3-δ (M = Sn,Ti)ceramics显示文摘 | Kim H J Jung H J Yoon K H | 1999 | Journal Mater Res1999，14，： | 2 |
| 4 | Continuous HMM applied to quantization of on - line Korean character spaces显示文摘 | JUNG K C YOON S M KIM H J | 2000 | Pattern Recognition Letters2000，21，： | 2 |
| 5 | A UML-based Test Model for Component Integration Test显示文摘 | Choi B J Yoon H J Jeon J O | 1999 | Workshop on Software Atchitecture and Component1999，，12： | 1 |
| 6 | Nitric oxide inhibits the shedding of the glycosylphosphatidylinositol-anchored dipeptidase from porcine renal proximal tubules 显示文摘 | Park S W Yoon H J Lee H B | 2002 | Biochem J2002，364，1： | 1 |
| 7 | Sequence-based screening for putative polyketide synthase gene-harboring clones from a soil metagenome library 显示文摘 | JI S C KIM D YOON J H | 2006 | J Microbiol Biotechnol2006，16，： | 1 |
| 8 | Anaerobic and aerobic degradation of pyridine by a newly isolated denitrifying bacterium 显示文摘 | Rhee S K Lee G M Yoon J H | 1997 | Appl Environ Microb1997，63，7： | 1 |
| 9 | Measurement of Particle Velocity and Characterization of Deposition in Aluminum Alloy Kinetic Spraying Process 显示文摘 | Wu J Fang H Yoon S | 2005 | Applied Surface Scince2005，252，： | 1 |
| 10 | A theoretical model for respirator cartridge service Life显示文摘 | YOON Y H NELSON J H | 1984 | Am Ind Hyg As- soc J1984，45，8： | 1 |
| 11 | Effect of water content on transient nonequilibrium NAPL-gas mass transfer during soil vapor extraction显示文摘 | Yoon H K Kim J H Liljestrand H M | 2002 | Journal of ContaminantHydrology2002，54，12： | 1 |
| 12 | Finite element analysis of steady-state three-dimensional helical extrusion of twisted sections using recurrent boundary condition显示文摘 | Park Y B Yoon J H Yang D Y | 1994 | Int J Mech Sci1994，36，2： | 1 |
| 13 | Prevention of anterior glottic stenosis after transoral microresection of glottic lesions involving the anterior commissure with mitomycin C显示文摘 | ROH J L YOON Y H | 2005 | Laryngoscope2005，115，6： | 1 |
| 14 | Adsorption of BSA on highly carboxylated microspheres-quantitative effects of surface functional groups and interaction forces显示文摘 | Yoon J Y Park H Y Kim J H | 1996 | J Colloid Interf Sci1996，177，2： | 1 |
| 15 | DNA-ElNA relatedness among Thermoactinomyces species:Thermoactinomyces candidus as a synonym of Thermoactinomyces vulgaris and Thermoactinomyces thalpophilus as a synonym of Thermoactinomyces sacchari显示文摘 | Yoon J H Shin Y K Park Y H | 2000 | Int J Syst Evol Microbiol2000，50，： | 1 |
| 16 | Evaluation of traumatic brain injured patients in correlation with functional status by localized 1 H-MR spectroscopy 显示文摘 | Yoon S J Lee J H Kim S T | 2005 | Clin Rehabi2005，19，2： | 1 |
| 17 | Proteomic analysis of porcine pancreas development 显示文摘 | CHOI J S CHO Y K YOON S H | 2009 | BMB Rep2009，42，10： | 1 |
| 18 | Investigation on vari- able shear modulus of magnetorheologieal elastomer based on natural rubber due to change of fabrication design显示文摘 | Yoon J H Yang I H Jeong U C | 2013 | Poly- mer Engineering and Science2013，53，5： | 1 |
| 19 | Scanning Laser Radar Based Target Position Designation for Parking Aid System显示文摘 | JUNG H G CHOYH YOON P J | 2008 | Intelligent Transportation Systems2008，9，3： | 1 |
| 20 | 查看详情显示文摘 | Maeng Y J Yoon B S Suh M H Im W B Lee S H | | 0，，： | 1 |
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