5篇
您的检索式：作者名="Yoon Minjong"
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| 1 | Metabolic interplay between glycolysis and mitochondrial oxidation: The reverse Warburg effect and its therapeutic implication显示文摘Aerobic glycolysis, i.e., the Warburg effect, may contribute to the aggressive phenotype of hepatocellular carcinoma. However, increasing evidence highlights the limitations of the Warburg effect, such as high mitochondrial respiration and low glycolysis rates in cancer cells. To explain such contradictory phenomena with regard to the Warburg effect, a metabolic interplay between glycolytic and oxidative cells was proposed, i.e., the 'reverse Warburg effect'. Aerobic glycolysis may also occur in the stromal compartment that surrounds the tumor; thus, the stromal cells feed the cancer cells with lactate and this interaction prevents the creation of an acidic condition in the tumor microenvironment. This concept provides great heterogeneity in tumors, which makes the disease difficult to cure using a single agent. Understanding metabolic flexibility by lactate shuttles offers new perspectives to develop treatments that target the hypoxic tumor microenvironment and overcome the limitations of glycolytic inhibitors. | Minjong Lee Jung-Hwan Yoon | 2015 | World Journal of Biological Chemistry2015，6，3： | 9 |
| 2 | Fucoidan protects hepatocytes from apoptosis and inhibits invasion of hepatocellular carcinoma by up-regulating p42/44 MAPK-dependent NDRG-1/CAP43显示文摘Fucoidan is a traditional Chinese medicine suggested to possess anti-tumor effects.In this study the anti-metastatic effects of fucoidan were investigated in vitro in human hepatocellular carcinoma(HCC) cells(Huh-7 and SNU-761) under normoxic and hypoxic conditions and in vivo using a distant liver metastasis model involving injection of MH134 cells into spleen via the portal vein.Its ability to protect hepatocytes against bile acid(BA)-induced apoptosis was investigated in primary hepatocytes.Fucoidan was found to suppress the invasion of HCC cells through up-regulation of p42/44 MAPKdependent NDRG-1/CAP43 and partly,under normoxic conditions,through up-regulation of p42/44MAPK-dependent VMP-1 expression.It also significantly decreased liver metastasis in vivo.As regards its hepatoprotective effect,fucoidan decreased BA-induced hepatocyte apoptosis as shown by the attenuation of caspase-8,and-7 cleavages and suppression of the mobilization of caspase-8 and Fas associated death domain(FADD) into the death-inducing signaling complex.In summary,fucoidandisplays inhibitory effects on proliferation of HCC cells and protective effects on hepatocytes.The results suggest fucoidan is a potent suppressor of tumor invasion with hepatoprotective effects. | Yuri Cho Jung-Hwan Yoon Jeong-ju Yoo Minjong Lee Dong Hyeon Lee Eun Ju Cho Jeong-Hoon Lee Su Jong Yu Yoon Jun Kim Chung Yong Kim | 2015 | Acta Pharmaceutica Sinica B2015，5，6： | 3 |
| 3 | Efficacy of Adefovir-Based Combination Therapy for Patients with Lamivudine- and Entecavir-Resistant Chronic Hepatitis B Virus Infection显示文摘 | Yun Bin Lee Jeong-Hoon Lee Won-mook Choi Young Youn Cho Jeong-ju Yoo Minjong Lee Dong Hyeon Lee Yuri Cho Su Jong Yu Yoon Jun Kim Jung-Hwan Yoon Chung Yong Kim Hyo-Suk Lee | 2013 | Antimicrobial Agents and Chemotherapy2013，，12： | 1 |
| 4 | Formation of Polypyrrole in Cu2+ Ion-exchanged MCM-41显示文摘 | Choi Jun Rye Kim Yanghee Yoon Minjong | 2002 | Bull Korean Chem Soc2002，22，9： | 1 |
| 5 | Efficacy of antiviral prophylaxis in HB sAg‐negative, anti‐ HB c positive patients undergoing hematopoietic stem cell transplantation显示文摘 | Jeong‐Ju Yoo Eun Ju Cho Young Youn Cho Minjong Lee Dong Hyeon Lee Yuri Cho Jeong‐Hoon Lee Su Jong Yu Sung‐Soo Yoon Jung‐Hwan Yoon Yoon Jun Kim | 2015 | Liver Int2015，，12： | 1 |
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