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| 1 | Application of human umbilical cord blood-derived mesenchymal stem cells in disease models显示文摘Human umbilical cord blood-derived mesenchymal stem cells(hUCB-MSCs) are regarded as an alternative source of bone marrow-derived mesenchymal stem cells because collection of cord blood is less invasive than that of bone marrow.hUCB-MSCs have recently been studied for evaluation of their potential as a source of cell therapy.In this review,the general characteristics of hUCBMSCs and their therapeutic effects on various diseases in vitro and in vivo will be discussed. | Ju-Yeon Kim Hong Bae Jeon Yoon Sun Yang Wonil Oh Jong Wook Chang | 2010 | World Journal of Stem Cells2010，2，2： | 14 |
| 2 | Diffuse large B-cell lymphoma with histone H3 trimethylation at lysine 27: another poor prognostic phenotype independent of c-Myc/Bcl2 coexpression显示文摘 | Eun Ji Oh Woo Ick Yang June-Won Cheong Sung-eun Choi Sun Och Yoon | 2014 | Human Pathology2014，，10： | 2 |
| 3 | Rational Design and Application of an Indolium-Derived Heptamethine Cyanine with Record-Long Second Near-Infrared Emission显示文摘Heptamethine cyanine dyes,typified by indocyanine green,have been extensively employed as bioimaging indicators and theranostic agents.Significant efforts have been made to develop functional heptamethine cyanine dyes with outstanding bioimaging and theranostic utilities.In this work,we rationally designed and successfully developed a novel indolium-like heptamethine cyanine dye by installing indolium-derived polycyclic aromatic hydrocarbons on the terminal ends of a conjugated polyene backbone.This dye showed excellent photostability and showed bright fluorescent emission in the second near-infrared(NIR-Ⅱ)window with a peak at approximately 1120 nm.Such long wavelength emission prompted a superior bioimaging resolution in vivo.In particular,this NIR-Ⅱ dye had the remarkable capability of marking the blood vessels of the hindlimbs,abdomens,and brains of mice.More significantly,this dye involved a typical indolium-like heptamethine skeleton and exhibited two strong absorption bands in the 700–1300 nm NIR range,which endowed it with an intrinsic tumor-targeting capability and a high photothermal conversion efficiency(up to 68.2%),serving for the photothermal therapy of tumors under the guidance of NIR-Ⅱ fluorescence imaging.This work provides an efficient design strategy for achieving indolium-like heptamethine cyanine dyes with further NIR-Ⅱ emission. | Xiaoxie Ma Yurou Huang Syed Ali Abbas Abedi Heejeong Kim Tan Teck Boon Davin Xiaogang Liu Wen-Chao Yang Yao Sun Sheng Hua Liu Jun Yin Juyoung Yoon Guang-Fu Yang | 2022 | CCS Chemistry2022，4，6： | 2 |
| 4 | Relationship between intravascular ultrasound parameters and fractional flow reserve in intermediate coronary artery stenosis of left anterior descending artery: Intravascular ultrasound volumetric analysis显示文摘 | Hyoung‐Mo Yang Seung‐Jea Tahk Hong‐Seok Lim Myeong‐Ho Yoon So‐Yeon Choi Byoung‐Joo Choi Xiong Jie Jin Gyo‐Seung Hwang Jin‐Sun Park Joon‐Han Shin | 2014 | Intervent2014，，3： | 1 |
| 5 | Prevalence of Gastroesophageal Reflux Disease Symptoms and Uninvestigated Dyspepsia in Korea: A Population-Based Study显示文摘 | Sun Young Yang Oh Young Lee Young Tae Bak Dae Won Jun Sang Pyo Lee Sung Hee Lee Geun Tae Park Byung Chul Yoon Ho Soon Choi Jun Soo Hahm Min Ho Lee Dong Hoo Lee | 2008 | Digestive Diseases and Sciences2008，，1： | 1 |
| 6 | Diagnostic utility of anti- Saccharomyces cerevisiae antibody (ASCA) and Interferon-γ assay in the differential diagnosis of Crohn’s disease and intestinal tuberculosis显示文摘 | You Sun Kim Young-Ho Kim Won Ho Kim Joo Sung Kim Young Sook Park Suk-Kyun Yang Byong Duk Ye Byung Ik Jang Sung-Ae Jung Yoon Tae Jeen Jae Hee Cheon Yong Sung Choi Jai Hyun Choi Beom Jin Kim Chang Hwan Choi Dong Soo Han | 2011 | Clinica Chimica Acta2011，，17： | 1 |
| 7 | Immunological properties of umbilical cord blood-derived mesenchymal stromal cells显示文摘 | Wonil Oh Dal-Soo Kim Yoon Sun Yang Jae Kwon Lee | 2008 | Cellular Immunology2008，，2： | 1 |
| 8 | Anti-gastritis and wound healing effects of Momordicae Semen extract and its active component显示文摘 | Kiwon Jung Young-Won Chin Yoon Hee Chung Yang Hae Park Hunseung Yoo Dong Sun Min Bongyong Lee Jinwoong Kim | 2013 | Immunopharmacology and Immunotoxicology2013，，1： | 1 |
| 9 | Comparative study between doxorubicin-eluting beads and conventional transarterial chemoembolization for treatment of hepatocellular carcinoma显示文摘 | Myeong Jun Song Ho Jong Chun Do Seon Song Hee Yeon Kim Sun Hong Yoo Chung-Hwa Park Si Hyun Bae Jong Young Choi U Im Chang Jin Mo Yang Hae Giu Lee Seung Kew Yoon | 2012 | Journal of Hepatology2012，，6： | 1 |
| 10 | Kale Juice Improves Coronary Artery Disease Risk Factors in Hypercholesterolemic Men显示文摘Objective To evaluate the effect of 3-month kale (Brassica oleracea acephala) juice supplementation on coronary artery disease risk factors among hypercholesterolemic men. Methods Thirty-two men with hypercholesterolemia (> 200 mg/dL) were recruited after annual health examinations among the faculty and staff at university. The subjects consumed 150 mL of kale juice per day for a 12-week intervention period. Dietary and anthropometric assessments were performed and blood samples were collected to evaluate biochemical profiles before and after supplementation. Results Serum concentrations of HDL-cholesterol, and HDL- to LDL-cholesterol ratio were significantly increased by 27% (P<0.0001) and 52% (P<0.0001), respectively. The LDL-cholesterol concentration and the atherogenic index were significantly reduced by 10% (P=0.0007) and 24.2% (P<0.0001), respectively without affecting body mass index, waist and hip circumferences, or nutrient intakes after three months of supplementation. While there was no difference in the concentration of malondialdehyde, significant increase in glutathione peroxidase activity (P=0.0005) were accompanied by a significant increase in the serum selenium level (P=0.0132). It was also found that the responses of these risk factors to kale juice administration were dependent on smoking status. Conclusion Regular meals supplementation with kale juice can favorably influence serum lipid profiles and antioxidant systems, and hence contribute to reduce the risks of coronary artery disease in male subjects with hyperlipidemia. | SOO YEON KIM SUN YOON SOO MI KWON KYE SOOK PARK YANG CHA LEE-KIM | 2008 | Biomedical and Environmental Sciences2008，21，2： | 1 |
| 11 | Immunological properties of umbilical cord blood-derived mesenchymal stromal cells显示文摘 | Wonil Oh Dal-Soo Kim Yoon Sun Yang Jae Kwon Lee | 2008 | Cellular Immunology2008，，2： | 1 |
| 12 | 脐的绳索血间充质的干细胞经由 paracrine 保护 amyloid-42 neurotoxicity显示文摘 AIM:To understand the neuroprotective mechanism of human umbilical cord blood-derived mesenchymal stem cells(hUCB-MSCs) against amyloid-β42(Aβ42) exposed rat primary neurons.METHODS:To evaluate the neuroprotective effect of hUCB-MSCs,the cells were co-cultured with Aβ42-exposed rat primary neuronal cells in a Transwell apparatus.To assess the involvement of soluble fac-tors released from hUCB-MSCs in neuroprotection,an antibody-based array using co-cultured media was conducted.The neuroprotective roles of the identified hUCB-MSC proteins was assessed by treating recombi-nant proteins or specific small interfering RNAs(siRNAs) for each candidate protein in a co-culture system.RESULTS:The hUCB-MSCs secreted elevated levels ofdecorin and progranulin when co-cultured with rat pri-mary neuronal cells exposed to Aβ42.Treatment with recombinant decorin and progranulin protected from Aβ42-neurotoxicity in vitro.In addition,siRNA-mediat-ed knock-down of decorin and progranulin production in hUCB-MSCs reduced the anti-apoptotic effects of hUCB-MSC in the co-culture system.CONCLUSION:Decorin and progranulin may be involved in anti-apoptotic activity of hUCB-MSCs exposed to Aβ42. | Ju-Yeon Kim Dong Hyun Kim Ji Hyun Kim Yoon Sun Yang Wonil Oh Eun Hui Lee Jong Wook Chang | 2012 | World Journal of Stem Cells2012，4，11： | 1 |
| 13 | Physical activity and other lifestyle factors in relation to the prevalence of colorectal adenoma: a colonoscopy-based study in asymptomatic Koreans显示文摘 | Ji Hyun Song Young Sun Kim Sun Young Yang Su Jin Chung Min Jung Park Seon Hee Lim Jeong Yoon Yim Joo Sung Kim Hyun Chae Jung | 2013 | Cancer Causes & Control2013，，9： | 1 |
| 14 | Systemic Cytotoxic Chemotherapy of Patients With Advanced Hepatocellular Carcinoma in the Era of Sorafenib Nonavailability显示文摘 | Eileen L. Yoon Jong Eun Yeon Hyun Jung Lee Sang Jun Suh Sun Jae Lee Seong Hee Kang Keunhee Kang Yang Jae Yoo Ji Hoon Kim Hyung Joon Yim Kwan Soo Byun | 2014 | Journal of Clinical Gastroenterology2014，，3： | 1 |
| 15 | CXC chemokine receptor 1 enhances the ability of human umbilical cord blood-derived mesenchymal stem cells to migrate toward gliomas显示文摘 | Seong Muk Kim Dal-Soo Kim Chang Hyun Jeong Dong Hyun Kim Ji Hyun Kim Hong Bae Jeon Soon-Jae Kwon Sin-Soo Jeun Yoon Sun Yang Wonil Oh Jong Wook Chang | 2011 | Biochemical and Biophysical Research Communications2011，，4： | 1 |
| 16 | Exosome-guided direct reprogramming of tumor-associated macrophages from protumorigenic to antitumorigenic to fight cancer显示文摘Highly immunosuppressive tumor microenvironment containing various protumoral immune cells accelerates malignant transformation and treatment resistance.In particular,tumor-associated macrophages(TAMs),as the predominant infiltrated immune cells in a tumor,play a pivotal role in regulating the immunosuppressive tumor microenvironment.As a potential therapeutic strategy to counteract TAMs,here we explore an exosome-guided in situ direct reprogramming of tumor-supportive M2-polarized TAMs into tumor-attacking M1-type macrophages.Exosomes derived from M1-type macrophages(M1-Exo)promote a phenotypic switch from anti-inflammatory M2-like TAMs toward pro-inflammatory M1-type macrophages with high conversion efficiency.Reprogrammed M1 macrophages possessing protein-expression profiles similar to those of classically activated M1 macrophages display significantly increased phagocytic function and robust cross-presentation ability,potentiating antitumor immunity surrounding the tumor.Strikingly,these M1-Exo also lead to the conversion of human patient-derived TAMs into M1-like macrophages that highly express MHC class II,offering the clinical potential of autologous and allogeneic exosome-guided direct TAM reprogramming for arming macrophages to join the fight against cancer. | Hyosuk Kim Hyun-Ju Park Hyo Won Chang Ji Hyun Back Su Jin Lee Yae Eun Park Eun Hye Kim Yeonsun Hong Gijung Kwak Ick Chan Kwon Ji Eun Lee Yoon Se Lee Sang Yoon Kim Yoosoo Yang Sun Hwa Kim | 2023 | Bioactive Materials2023，，7： | 0 |
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