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| 1 | Can control of gut microbiota be a future therapeutic option for inflammatory bowel disease?显示文摘Inflammatory bowel disease(IBD)is a chronic inflammatory condition of the gastrointestinal tract encompassing two main clinical entities,Crohn’s disease and ulcerative colitis.Accumulated evidence indicates that an aberrant immune activation caused by the interplay of genetic susceptibility and environmental impact on the gut microbiota may be involved in the pathogenesis of IBD.Rapid advances in next-generation sequencing technology have enabled a number of studies to identify the alteration of the gut microbiota,termed dysbiosis,in IBD.Moreover,the alteration in the metabolites derived from the gut microbiota in IBD has also been described in many studies.Therefore,microbiota-based interventions such as fecal microbiota transplantation(FMT)have attracted attention as a novel therapeutic option in IBD.However,in clinical trials,the efficacy of FMT for IBD remains controversial.Additional basic and clinical studies are required to validate whether FMT can assume a complementary role in the treatment of IBD.The present review provides a synopsis on dysbiosis in IBD and on the association between the gut microbiota and the pathogenesis of IBD.In addition,we summarize the use of probiotics in IBD and the results of current clinical trials of FMT for IBD. | Atsushi Nishida Kyohei Nishino Keitaro Sakai Yuji Owaki Yoshika Noda Hirotsugu Imaeda | 2021 | World Journal of Gastroenterology2021，27，23： | 6 |
| 2 | Solubilization and distribution of neutral sugar residues derived from polyuronides during the softening in apple fruit显示文摘 | Yoshika Kashimura Y Kaneko K | 1994 | J Japan Soc Hort Sc1994，63，1： | 1 |
| 3 | Detection of the second mesiobuccal canal in misiobuccal roots of maxillary molar teeth ex vivo显示文摘 | Yoshika T Kikuchi I Fukumoto Y | 2005 | J Int Endod2005，38，2： | 1 |
| 4 | The thoracic disc heniation surgical treatment in 23 patients 显示文摘 | Otani K Yoshika M Fujie E | 1988 | Spine1988，13，11： | 1 |
| 5 | The thoracic disc herniation surgical treatment in 23 patients显示文摘 | Otani K Yoshika M Fujie E | 1988 | Spine1988，13，11： | 1 |
| 6 | AFP - producing hepatoid adenocarcinoma in association with Barrett's esophagus with multi- ple liver metastasis responding to paclitaxet/CDDP: a case report 显示文摘 | Chiba N Yoshika T Sakayori M | 2005 | Anticancer Res2005，25，： | 1 |
| 7 | Clinicopathological features of small T1 colorectal cancers显示文摘BACKGROUND Although small colorectal neoplasms(<10 mm)are often easily resected endoscopically and are considered to have less malignant potential compared with large neoplasms(≥10 mm),some are invasive to the submucosa.AIM To clarify the clinicopathological features of small T1 colorectal cancers.METHODS Of 32025 colorectal lesions between April 2001 and March 2018,a total of 1152 T1 colorectal cancers resected endoscopically or surgically were included in this study and were divided into two groups by tumor size:a small group(<10 mm)and a large group(≥10 mm).We compared clinicopathological factors including lymph node metastasis(LNM)between the two groups.RESULTS The incidence of small T1 cancers was 10.1%(116/1152).The percentage of initial endoscopic treatment in small group was significantly higher than in large group(<10 mm 74.1%vs≥10 mm 60.2%,P<0.01).In the surgical resection cohort(n=798),the rate of LNM did not significantly differ between the two groups(small 12.3%vs large 10.9%,P=0.70).In addition,there were also no significant differences between the two groups in pathological factors such as histological grade,vascular invasion,or lymphatic invasion.CONCLUSION Because there was no significant difference in the rate of LNM between small and large T1 colorectal cancers,the requirement for additional surgical resection should be determined according to pathological findings,regardless of tumor size. | Yuki Takashina Shin-Ei Kudo Katsuro Ichimasa Yuta Kouyama Kenichi Mochizuki Yoshika Akimoto Yasuharu Maeda Yuichi Mori Masashi Misawa Noriyuki Ogata Toyoki Kudo Tomokazu Hisayuki Takemasa Hayashi Kunihiko Wakamura Naruhiko Sawada Toshiyuki Baba Fumio Ishida Kazunori Yokoyama Mitsuru Daita Tetsuo Nemoto Hideyuki Miyachi | 2021 | World Journal of Clinical Cases2021，9，33： | 1 |
| 8 | Comparison of exercise capacity evalua ted by cardiopulmonary exercise test and hemodynamic parameters in patients with a trial septal defect显示文摘 | Nakanishi N Yoshika T Fujii T | 1992 | Kokyu To Junkan1992，40，8： | 1 |
| 9 | The thoracic dise heniation surgical treatment in 23 patients显示文摘 | OTANI K YOSHIKA M FUJIE E | 1988 | Spine1988，13，11： | 1 |
| 10 | Osteogenic potential of cultured bone/ceramic construct:comparison with marrow mesenchymal cell/ceramic composite显示文摘 | Iida J Yoshika T Akahane M | 2004 | Cell Transplant2004，13，4： | 1 |
| 11 | Preparation of sulfuric acid-catalyzed phenolated wood resin显示文摘 | YOSHIKA M YAO Y G | 1998 | Wood Science and Technology1998，32，4： | 1 |
| 12 | Expression and role of SNAT3 in the placenta显示文摘 | YOSHIKA C YASUDA S KIMURA F | 2009 | Placenta2009，30，12： | 1 |
| 13 | The central mechanism underlying hypertension:a review of the roles of sodium ions,epithelial sodium channels,the renin-angiotensin-aldosterone system,oxidative stress and endogenous digitalis in the brain显示文摘 | Takahashi H Yoshika M Komiyama Y | | 0，，： | 1 |
| 14 | Removal of formaldehyde from indoor air by passive type air-cleaning materials显示文摘 | YOSHIKA SEKINE ATSUSHI NISHIMUR | 2001 | Atmospheric Environment2001，35，： | 1 |
| 15 | Determination of acetaldehyde and acetone emanating from human skin using a passive flux sampler--HPLC system显示文摘 | Yoshika Sekine Satomi Toyooka Simon F Watts | 2007 | Journal of Chromatography B2007，，859： | 1 |
| 16 | Rigid polyurethane foams from combined liquefaction mixtures of wood and starch 显示文摘 | Yao Y Yoshika M Shiraishi N | 1995 | Mokuzai Gakkaishi1995，41，7： | 1 |
| 17 | Effect of Cr, Mo and Cu on the atmospheric corrosion resistance of ferritic stainless steels in a coastal environment 显示文摘 | Yoshihiro Yazawa Keiichi Yoshika and Fusao Togashi | 1994 | Kawasaki Steel Technical Report1994，31，： | 1 |
| 18 | Glycyrthetic acid inhibits tumor-promotingactivity of teleocidin and 12-o-tetradecanoylphorbol-13-acetate in two stage mouse skin carcinogenesis显示文摘 | Nishino H Yoshika K lwashima A | 1986 | Jpn J Cancer Res Gann1986，77，1： | 1 |
| 19 | The central mecha- nism underlying hypertension : a review of the roles of sodium ions, epithelial sodium channels, the renin-angiotensin-aldosterone sys- tem, oxidative stress and endogenous digitalis in the brain 显示文摘 | Takahashi H Yoshika M Komiyama Y | 2011 | Hypertens Res2011，34，11： | 1 |
| 20 | Effect of Cr, Mo and Cu on the atmospheric corrosion resistance of ferritic stainless steels in a coastal environment显示文摘 | Yoshihiro Yazawa Keiichi Yoshika and Fusao Togashi | 1994 | Kawasaki Steel Technical Report1994，31，： | 1 |
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