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| 1 | Epirubicin,Cisplatin,5-FU combination chemotherapy in sorafenib-refractory metastatic hepatocellular carcinoma显示文摘AIM:To evaluate the clinical efficacy and safety of epirubicin,cisplatin,and 5-FU combination chemotherapy for the sorafenib-refractory metastatic hepatocellular carcinoma(HCC).METHODS:From April 2009 to June 2012,31 patients who were diagnosed with metastatic and progressive HCC after sorafenib treatment were retrospectively reviewed.Patients were treated with the combination of epirubicin(50 mg/m2Ⅳ;day 1),cisplatin(60 mg/m2Ⅳ;day 1),and 5-FU(1000 mg/m2Ⅳ;day 1-3)[Epirubicin,cisplatin,5-FU combination(ECF)],repeated every 4 wk.RESULTS:The overall response rate was 12.9%.Patients who responded to ECF chemotherapy showed a longer overall survival(OS)and time to progression(TTP)relative to those in the non-responder group(OS:20.4 mo vs 4.9 mo,P<0.001,TTP:9.4 mo vs 2.2 mo,P<0.001).Patients with a stable primary liver mass also exhibited a longer OS and TTP relative to those with progressive disease(OS:13.4 mo vs 5.3 mo,P=0.003;TTP:9.4 mo vs 2.3 mo,P=0.003).The most common hematologic toxicity was thrombocytopenia(87.2%),and the incidence of grade 3-4 neutropenia was 53.9%.Age older than 60,a stable primary mass,and a good response to chemotherapy were prognostic factors for OS and TTP.CONCLUSION:This combination cytotoxic chemotherapy can serve as another treatment option after sorafenib failure for the subset of patients with advanced metastatic HCC. | Ji Eun Lee Si Hyun Bae Jong Young Choi Seung Kew Yoon Young Kyoung You Myung Ah Lee | 2014 | World Journal of Gastroenterology2014，20，1： | 7 |
| 2 | Expert Opinions on the Concept of Blood Stasis in China: An Interview Study显示文摘Objective: To study various experts' opinions on the definition and diagnosis of blood stasis in China. Methods: We e-mailed the selected experts to explain the purpose of the study and to invite them to participate and asked them to name a time for the investigator to call them. Eight experts and five organizations were interviewed in the research community investigating blood stasis in China. Results: Six main categories emerged from the interviews:(1) blood stasis concepts;(2) blood stasis-related biomarkers;(3) methods of diagnosing blood stasis;(4) drugs for promoting blood circulation and dissipating stasis;(5) blood stasis-related diseases; and(6) blood stasis-related societies. The consensus among the interviewed experts was that the definition of blood stasis is rather complicated and that there is no gold standard marker for detecting blood stasis. Conclusion: This paper acquired experts' opinions on the definition and diagnosis of blood stasis in order to establish a modern concept of blood stasis. This paper also developed a diagnostic tool and diagnostic indices for blood stasis and identified biological indices and pathologic mechanisms related to blood stasis, which might be of great reference value in future blood stasis standardization research. | Tae-Young Choi Ji Hee Jun Ju Ah Lee Bongki Park Sooseong You Jeeyoun Jung Myeong Soo Lee | 2016 | Chinese Journal of Integrative Medicine2016，22，11： | 3 |
| 3 | Standardization and Future Directions in Pattern Identification Research: International Brainstorming Session显示文摘An international brainstorming session on standardizing pattern identification(PI) was held at the Korea Institute of Oriental Medicine on October 1, 2013 in Daejeon, South Korea. This brainstorming session was convened to gather insights from international traditional East Asian medicine specialists regarding PI standardization. With eight presentations and discussion sessions, the meeting allowed participants to discuss research methods and diagnostic systems used in traditional medicine for PI. One speaker presented a talk titled 'The diagnostic criteria for blood stasis syndrome: implications for standardization of PI'. Four speakers presented on future strategies and objective measurement tools that could be used in PI research. Later, participants shared information and methodology for accurate diagnosis and PI. They also discussed the necessity for standardizing PI and methods for international collaborations in pattern research. | Jeeyoun Jung Bongki Park Ju Ah Lee Sooseong You Terje Alraek 卞兆祥 Stephen Birch Tae-Hun Kim 徐浩 Chris Zaslawski Byoung-Kab Kang Myeong Soo Lee | 2016 | Chinese Journal of Integrative Medicine2016，22，9： | 3 |
| 4 | Extraction and identification of three major aldose reductase inhibitors from Artemisia montana显示文摘 | Hyun Ah Jung M.D. Nurul Islam Yong Soo Kwon Seong Eun Jin You Kyung Son Jin Ju Park Hee Sook Sohn Jae Sue Choi | 2010 | Food and Chemical Toxicology2010，，2： | 2 |
| 5 | Methylation and microsatellite status and recurrence following adjuvant FOLFOX in colorectal cancer显示文摘 | Sae‐Won Han Hyun‐Jung Lee Jeong Mo Bae Nam‐Yun Cho Kyung‐Hun Lee Tae‐Yong Kim Do‐Youn Oh Seock‐Ah Im Yung‐Jue Bang Seung‐Yong Jeong Kyu Joo Park Jae‐Gahb Park Gyeong Hoon Kang Tae‐You Kim | 2012 | Int J Cancer2012，，9： | 2 |
| 6 | Methylation and microsatellite status and recurrence following adjuvant FOLFOX in colorectal cancer显示文摘 | Sae‐Won Han Hyun‐Jung Lee Jeong Mo Bae Nam‐Yun Cho Kyung‐Hun Lee Tae‐Yong Kim Do‐Youn Oh Seock‐Ah Im Yung‐Jue Bang Seung‐Yong Jeong Kyu Joo Park Jae‐Gahb Park Gyeong Hoon Kang Tae‐You Kim | 2012 | Int. J. Cancer2012，，9： | 1 |
| 7 | Evaluation of chemical constituents from Glehnia littoralis for antiproliferative activity against HT-29 human colon cancer cells显示文摘 | Young Ran Um Chang-Suk Kong Jung Im Lee You Ah Kim Taek Jeong Nam Youngwan Seo | 2009 | Process Biochemistry2009，，1： | 1 |
| 8 | Flavonoid glycosides isolated from Salicornia herbacea inhibit matrix metalloproteinase in HT1080 cells显示文摘 | Chang-Suk Kong You Ah Kim Moon-Moo Kim Jin-Sook Park Jung-Ae Kim Se-Kwon Kim Burm-Jong Lee Taek Jeong Nam Youngwan Seo | 2008 | Toxicology in Vitro2008，，7： | 1 |
| 9 | Hyperoside prevents oxidative damage induced by hydrogen peroxide in lung fibroblast cells via an antioxidant effect显示文摘 | Mei Jing Piao Kyoung Ah Kang Rui Zhang Dong Ok Ko Zhi Hong Wang Ho Jin You Hee Sun Kim Ju Sun Kim Sam Sik Kang Jin Won Hyun | 2008 | BBA - General Subjects2008，，： | 1 |
| 10 | Protective effect of butin against hydrogen peroxide-induced apoptosis by scavenging reactive oxygen species and activating antioxidant enzymes显示文摘 | Rui Zhang Sungwook Chae Kyoung Ah Kang Mei Jing Piao Dong Ok Ko Zhi Hong Wang Doek Bae Park Jae Woo Park Ho Jin You Jin Won Hyun | 2008 | Molecular and Cellular Biochemistry (-)2008，，1： | 1 |
| 11 | Troublesome occipital neuralgia developed by C1,2 harms construct 显示文摘 | Rhee WT You AH Kim SK | 2008 | J Korean Neurosurg Soc2008，43，： | 1 |
| 12 | Bone morphogenctic protein (BMP)-6 signaling and BMP antagonist noggin in prostate cancer 显示文摘 | Haudenschild DR Pahner SM Moseley TA You Z Reddi AH | 2004 | Cancer Res2004，64，22： | 1 |
| 13 | AMI Simulated Sunlight Photoreduction and Elimination of Hg (Ⅱ) and CH3 Hg (Ⅱ) Chloride Salts from Aqueous Suspensions of Titanium Dioxide 显示文摘 | Serpone N Ah - You Tran T P Harris R | 1999 | Sol Energy1999，39，： | 1 |
| 14 | Serum C‐reactive protein is a useful biomarker for predicting outcomes after liver transplantation in patients with hepatocellular carcinoma显示文摘 | Ho Jung An Jeong Won Jang Si Hyun Bae Jong Young Choi Seung Kew Yoon Myung Ah Lee Young Kyoung You Dong Goo Kim Eun Sun Jung | 2012 | Liver Transpl2012，，12： | 1 |
| 15 | Current Research and Future Directions in Pattern Identification: Results of an International Symposium显示文摘A symposium on pattern identification(PI) was held at the Korea Institute of Oriental Medicine(KIOM) on October 2, 2013, in Daejeon, South Korea. This symposium was convened to provide information on the current research in PI as well as suggest future research directions. The participants discussed the nature of PI, possible research questions, strategies and future international collaborations in pattern research. With eight presentations and an extensive panel discussion, the symposium allowed participants to discuss research methods in traditional medicine for PI. One speaker presented the topic, 'Clinical pattern differentiation and contemporary research in PI.' Two speakers presented current trends in research on blood stasis while the remaining five other delegates discussed the research methods and future directions of PI research. The participants engaged in in-depth discussions regarding the nature of PI, potential research questions, strategies and future international collaborations in pattern research. | Myeong Soo Lee Ju Ah Lee Terje Alraek 卞兆祥 Stephen Birch Hirozo Goto Jeeyoun Jung 高尚德 Sang-Kwan Moon Bongki Park Kyung-Mo Park Sooseong You Kyung-Jin Yun Chris Zaslawski | 2016 | Chinese Journal of Integrative Medicine2016，22，12： | 0 |
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