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| 1 | A miRNA-HERC4 pathway promotes breast tumorigenesis by inactivating tumor suppressor LATS1显示文摘The E3 ligase HERC4 is overexpressed in human breast cancer and its expression levels correlated with the prognosis of breast cancer patients. However, the roles of HERC4 in mammary tumorigenesis remain unclear. Here we demonstrate that the knockdown of HERC4 in human breast cancer cells dramatically suppressed their proliferation, survival, migration, and tumor growth in vivo, while the overexpression of HERC4 promoted their aggressive tumorigenic activities. HERC4 is a new E3 ligase for the tumor suppressor LATS1 and destabilizes LATS1 by promoting the ubiquitination of LATS1 miRNA-136-5p and miRNA-1285-5p, expression of which is decreased in human breast cancers and is inversely correlated with the prognosis of breast cancer patients, are directly involved in suppressing the expression of HERC4. In summary, we discover a miRNA-HERC4- LATS1 pathway that plays important roles in the pathogenesis of breast cancer and represents new therapeutic targets for human breast cancer. | Youqin Xu Kaiyuan Ji Meng Wu Bingtao Hao Kai-tai Yao Yang Xu | 2019 | Protein & Cell2019，10，8： | 8 |
| 2 | Preliminary analysis of distribution and variation of perennialmonthly mean water masses in the Bohai Sea,the Huanghai Sea and the East China Sea显示文摘On the basis of perennial monthly mean temperature and salinity data, the classification of monthly water masses at the surface and the bottom in the Bohai Sea, the Huanghai Sea and the East China Sea, has been made by using the method of fuzzy cluster from the modified characteristic of water masses in the shallow water area. In this paper, the basic features, growth and decline patterns of water masses in relation to fishing grounds in the whole shelves of the Bohai Sea, the Huanghai Sea and the East China Sea are discussed with emphasis. | Liu Shuxun, Shen Xinqiang, Wang Youqin and Han Shixin 1. East China Sea Fisheries Research Institute, No. 300, Jungong Road, Shanghai 200090, China | 1992 | Acta Oceanologica Sinica1992，11，4： | 6 |
| 3 | Shake table study on precast segmental concrete double-column piers显示文摘Seismic capacity,including the ultimate load-carrying capacity and ultimate deformation capacity of precast segmental concrete double-column(PSCDC)piers with steel sleeve(SS)connection or grouted corrugated-metal duct(GCMD)connection,has been verified to be similar to those of cast-in-place(CIP)piers by quasi-static tests.However,the lack of knowledge of seismic response characteristics and damage process of PSCDC piers has limited their application in high-intensity seismic areas.Therefore,shake table tests,using variable types and intensities of seismic ground motions,were performed to investigate the seismic behavior of connection joints and to evaluate the seismic performance of PSCDC piers with SS and GCMD connections.Also,a finite element analysis(FEA)model was developed to study the influence of design parameters on the seismic behavior of the piers.The results showed that the main damage in PSCDC piers was caused by the cyclic opening and closing of connection joints.Under high-intensity ground motions,the PSCDC piers had a lower seismic performance than the CIP piers due to a significant decrease of their integrity and stiffness.The seismic performance of PSCDC piers is comparable to CIP piers when using an appropriate initial stress of the prestressing tendons. | Xia Zhanghua Ge Jiping Lin Youqin Qiu Faqiang | 2020 | Earthquake Engineering and Engineering Vibration2020，19，3： | 5 |
| 4 | Research on the resource utilization of Baosteel steel slag as concrete material显示文摘The utilization of steel slag has been a worldwide issue for a long time.Attention is increasingly being paid to the technological innovation and development of steel slag.Aiming at the development of environmentally friendly steel slag concrete materials and their use in a recyclable economy,Baosteel has recently been conducting research on and using many new building materials,including steel slag powder concrete,steel slag pervious concrete,steel slag counter weight concrete and so on.In this way,steel slag has been turned from a kind of solid waste into a value-added material.The technology of steel slag utilization has been enriched and developed,while a new model of using Baosteel steel slag in a recyclable economy has also been explored and practised. | JIN Qiang HE Hongzhu YANG Gang ZHANG Chao WANG Youqin | 2009 | Baosteel Technical Research2009，3，4： | 4 |
| 5 | Test and analysis of influencing factors on the permeability coefficient of steel slag permeable concrete显示文摘The steel slag(SS) permeable concrete was prepared by SS.The influences of the aggregate-cement rate,the aggregate particle size,the water-cement rate,the admixture dosage and other factors on the permeability coefficient of SS permeable concrete were analyzed.The law of influence was also investigated.The study serves as a technological reference for the construction and design of SS permeable concrete. | YANG Gang WANG Youqin WANG Hailong JIN Qiang | 2011 | Baosteel Technical Research2011，5，2： | 3 |
| 6 | Hydrogen sulfide system in the pathogenesis of renovascular hypertension in rats显示文摘Objective To investigate the role of hydrogen sulfide (H2S) synthases / H2S pathway in the pathogenesis of renovascular hypertension. Methods Wistar rats were subdivided into 4 groups: (1) 2-kidney, 1-clip (2K-1C group, n=7), (2) control (n=7), (3) sham (n=7), and (4) 2K-1C plus sodium hydrosulfide (NaHS) (NaHS-treated group, n=7). The systolic blood pressure (SBP) was measured by a tail-cuff method using a pulse transducer once a week. Four weeks later, all rats were killed and the concentration of plasma hydrogen sulfide (H2S), the activity of the H2S synthases in the kidneys on both sides, the plasma angiotensin Ⅱconcentration, and the left-to-whole heart weight ratio were measured. Results The SBP was significantly increased in the 2K-1C group (185.4±14.0mmHg) comparing with those in the sham group ( 112.9±6.5mmHg, , or the NaHS-treated group(134.8±9.5mmHg) (both P<0.01). At 4 weeks, the angiotensin Ⅱ concentration in the plasma was increased in the 2K-1C and NaHS-treated group, comparing with the control and the sham group (306.92±7.03 pg/ml and 240.73±13.22 pg/ml vs 122.6±25.49 pg/ml and 125.95±10.55 pg/ml, respectively, both P<0.05). The plasma H2S concentration and the activity of H2S synthases in the left kidney were decreased in the 2K-1C group comparing with those in the sham and the control groups. There was no difference of the activity of the H2S synthases in the right kidneys among the 4 groups. The left-to-whole heart weight ratio was increased in the 2K-1C and the NaHS-treated group camparing with that in the sham and natural control groups. Conclusions Dysfunction of the H2S synthases/H2S pathway was involved in the 2K-1C-induced renovascular hypertension in rat. Exogenous administration of H2S donor can attenuate the development of hypertension. These findings suggest that the H2S synthases/H2S pathway participates in the pathogenesis of renovascular hypertension. | Youqin Cheng Daiqin Wu Guang Yang Xiaoying Li Dayan Huang Bin Geng Chaoshu Tang | 2008 | Journal of Geriatric Cardiology2008，5，2： | 2 |
| 7 | 'Housing Markets,Government Behaviors,and Housing Choice:A Case Study of Three Cities in China显示文摘 | Youqin Huang | | 0，，01： | 1 |
| 8 | Housing Inequality in Transitional Beijing显示文摘 | Huang Youqin and Jiang Leiwen | 2009 | International Journal of Urban and Regional Research2009，33，4： | 1 |
| 9 | Heat Shock Protein 72 Protects Retinal Ganglion Cells in Rat Model of Acute Glaucoma显示文摘Purpose: To investigate whether the induction of heat shock protein (HSP)72 by heat stress (HS) or zinc (Zn2+ ) administration can increase survival of retinal ganglion cells (RGC) in rat model of acute experimental glaucoma.Methods: Acute glaucoma model was made by intracameral irrigation with BSS at 102 mmHg for two hours in right eyes of male Wistar rats. Glaucoma model rats were treated with HS once a week (six rats) or intraperitoneal injection of zinc sulfate (24.6 mg/kg) every two weeks (six rats), and were referred to as HS group and zinc group, respectively. Untreated model rats served as damage group (six rats). In control groups, quercetin (400 mg/kg) was intraperitoneally injected to inhibit the induction of heat shock proteins 6 hours before HS or zinc administration, and were referred to as HS+que group (six rats) and zinc+que group (six rats), respectively. Subsequent to 16 days of IOP elevation, the rats were sacrificed. Eyes were quickly enucleated, and the retinas were dissected. RGC were labeled with Nissl staining and counted under microscope.Results: The average RGC density in normal Wistar rats was (2504±181) cells/mm2. In damage group, it decreased to (2015±111 ) cells/mm2. The RGC densities at 1,2, and 3 mm from the center of the optic nerve head were (2716±215), (2496±168), and (2317±171) cells/mm2, respectively, for normal rats and (2211±133), (1969±154),and (1872±68) cells/mm2, respectively, for damage group. The latter was significantly lower at all locations compared with the former (P=0.027 for each, Mann-Whitney test).The average RGC densities were (2207±200) cells/mm2 for HS group, (2272±155) cells/mm2 for zinc group, (1964±188) cells/mm2 for HS+que group, (2051 ±214) cells/mm2 for zinc+que group and (2015±111 ) cells/mm2 for damage group. There were significant differences in density of labeled RGCs among the five groups (P=0.040,Kruskal-Wallis test). Both HS and zinc group had higher RGC densities than damage group (P =0.036 between HS and damage group,P=0.019 between zinc and damage group, Mann-Whitney test). There was no significant difference in RGC densitiy between control groups and damage group(P=0.260 between HS+que and damage group,P=0.748 between zinc+que and damage group, Mann-Whitney test).Conclusions: The results demonstrated that the induction of HSP72 in RGCs by HS or zinc administration plays an important role in the survival of RGCs in rat model of acute glaucoma. A novel therapeutic approach to glaucoma through an enhanced induction of endogenous HSP72 could be possible. | Guoping Qing Xuanchu Duan Youqin Jiang | 2005 | Eye Science2005，21，3： | 1 |
| 10 | Urban Housing in China:Market Transition, Housing Mobility and Neighbourhood Change 显示文摘 | Li Si-ming and Huang Youqin | 2006 | Housing Studies2006，21，5： | 1 |
| 11 | Experimental and analytical studies on dynamic characteristics of a large span cable-stayed bridge 显示文摘 | Ren Weixin Peng Xuelin Lin Youqin | 2005 | Engineering Structures2005，27，： | 1 |
| 12 | Urban Hous Change显示文摘 | Li Siming Huang Youqin | 2006 | Housing Studies2006，，5： | 1 |
| 13 | Housing Markets, Government Behaviors, and Housing Choice: A Case Study of Three Cities in China显示文摘 | Huang Youqin | 2004 | Environment and Planning2004，，2： | 1 |
| 14 | Response of nanosized cobahoxide electrodes as pH sensors显示文摘 | LI Qingwen LUO Guoan SHU Youqin | 2000 | Anal Chim Acta2000，409，： | 1 |
| 15 | Second Home Ownership in Transitional Urban China显示文摘 | Huang Youqin Yi Chengdong | 2011 | Housing Studies2011，，3： | 1 |
| 16 | Differentiation between intestial tubereu losis and Crohn's disease in endoscopic biopsy specimens by polymerage chain reaction显示文摘 | Huatian G Youqin C | 2002 | Am J Gastroenterel2002，97，6： | 1 |
| 17 | Experimental and analytical studies on dynamic characteristics of a large span cable-stayed bridge 显示文摘 | Ren Weixin Peng Xuelin Lin Youqin | 2005 | Engineering Structures2005，27，： | 1 |
| 18 | Differentiation between Intestinal Tubereulosis and Crohn's Disease in Endoscopic Biopsy Specimens by Polymerage Chain Reaction显示文摘 | Huatian G Youqin C | 2002 | Am J Gastroenterel2002，97，6： | 1 |
| 19 | Residential Mobility in Chinese Cities:A Longitudinal Analysis显示文摘 | Youqin H F F D | 2006 | 2006，，05： | 1 |
| 20 | Renters’ Housing Behaviour in Transitional Urban China显示文摘 | Youqin Huang | 2003 | Housing Studies2003，，1： | 1 |
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