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| 1 | Abnormal expression of bHLH3 disrupts a flavonoid homeostasis network,causing differences in pigment composition among mulberry fruits显示文摘Mulberry fruits with high concentrations of anthocyanins are favored by consumers because of their good taste,bright color,and high nutritional value.However,neither the regulatory mechanism controlling flavonoid biosynthesis in mulberry nor the molecular basis of different mulberry fruit colors is fully understood.Here,we report that a flavonoid homeostasis network comprising activation and feedback regulation mechanisms determines mulberry fruit color.In vitro and in vivo assays showed that MYBA-bHLH3-TTG1 regulates the biosynthesis of anthocyanins,while TT2L1 and TT2L2 work with bHLH3 or GL3 and form a MYB-bHLH-WD40(MBW)complex with TTG1 to regulate proanthocyanidin(PA)synthesis.Functional and expression analyses showed that bHLH3 is a key regulator of the regulatory network controlling mulberry fruit coloration and that MYB4 is activated by MBW complexes and participates in negative feedback control of the regulatory network to balance the accumulation of anthocyanins and proanthocyanidins.Our research demonstrates that the interaction between bHLH3 and MYB4 in the homeostasis regulatory network ensures that the fruits accumulate desirable flavonoids and that this network is stable in pigmentrich mulberry fruits.However,the abnormal expression of bHLH3 disrupts the balance of the network and redirects flavonoid metabolic flux in pale-colored fruits,resulting in differences in the levels and proportions of anthocyanins,flavones,and flavonols among differently colored mulberry fruits(red,yellow,and white).The results of our study reveal the molecular basis of the diversity of mulberry fruit colors. | Han Li Zhen Yang Qiwei Zeng Shibo Wang Yiwei Luo Yan Huang Youchao Xin Ningjia He | 2020 | Horticulture Research2020，7，1： | 8 |
| 2 | Co-infections of SARS-CoV-2 with multiple common respiratory pathogens in infected patients显示文摘Dear Editor,In late December 2019,an outbreak of severe pneumonia caused by an unknown etiological agent was initially reported in Wuhan,China,and then quickly spread throughout China and even abroad(Zhu et al.,2020).Swift control measures and etiological investigations were conducted by the Chinese government,physicians and researchers,and by using high throughput sequencing and virological testing,the mysterious pneumonia pathogen was shown to be a novel coronavirus(SARS-CoV-2)capable of person-to-person transmission(Zhu et al.,2020).Coronaviruses are a group of non-segmented,enveloped and positive-sense RNA viruses that belong to the subfamily of Coronavirinae in the family of Coronavirdiae and order of Nidovirales. | Dachuan Lin Lei Liu Mingxia Zhang Yunlong Hu Qianting Yang Jiubiao Guo Yongchao Guo Youchao Dai Yuzhong Xu Yi Cai Xinchun Chen Zheng Zhang Kaisong Huang | 2020 | Science China(Life Sciences)2020，63，4： | 6 |
| 3 | Microsurgical resection of craniopharyngioma of the third ventricle via an improved transventricular approach显示文摘Background Craniopharyngioma of the third ventricle is difficult to treat and its therapeutic regimens and operative approaches have been controversial. This study was undertaken to probe indications for microsurgical resection of craniopharyngioma of the third ventricle via an improved transventricular approach, its surgical procedures and therapeutic effects, and prevention of postoperative complications.Methods Fifty-one patients with craniopharyngioma of the third ventricle were treated from January 2000 to October 2004 by an improved transventricular approach for removing the tumor via the interventricular foramen,the intermedius of the septum pellucidum or choroid fissure. Symptoms and signs of the patients, and results of imaging, operation, and follow-up were analyzed. Results Of the 51 patients who had received the improved transventricular resection, 4 underwent a combined approach with an entrance of the pterion. Forty patients (78.43%) underwent total resection and others subtotal resection, without an operative death. Epileptic seizures were found in 3 patients (5.88%) and subdural effusion in the operative field in 4 (7.84%). All patients showed good general conditions after operation, and follow-up for an average of 27.52 months showed relapse of the tumour in 8 patients (15.69%).Conclusions Microsurgical resection of craniopharyngioma of the third ventricle by an improved transventricular approach has advantages of operative safety and efficacy, lower mortality and disability, and less complications. | XUJian-guo YOUChao CAIBo-wen JIANGShu SUNHong GUOFu-you YANGYong-bo WUBo | 2005 | Chinese Medical Journal2005，，10： | 6 |
| 4 | Protective effect of estrogen against intervertebral disc degeneration is attenuated by miR-221 through targeting estrogen receptor α显示文摘因为终板有,软骨的终板(CEP ) 的机能障碍是 intervertebral 圆盘退化(国际直拨长途电话) 的一个重要 etiologic 方面营养并且在维持合适的圆盘健康的 biomechanical 功能。在这研究,我们在这些效果在堕落人的 CEP 房间和 miR-221 的参与上调查了雌激素的规章的效果。正常、堕落的人的 CEP 纸巾分别地与自发的脊柱侧凸和国际直拨长途电话从病人被收集。CEP 房间从这些纸巾被孤立。聚合酶链反应(PCR ) 和西方的污点分析被执行分别地检测特定的基因和蛋白质的表示。Apoptosis 和房间周期被流动 cytometry 分析。结果证明 aggrecan,骨胶原 II, TGF- 和雌激素受体的层次(嗯) 当 MMP-3, adamts-5, IL-1, TNF- , IL-6,和 miR-221 的层次被增加时,在堕落 CEP 纸巾被减少。有 17beta-estradiol (E2 ) 的堕落 CEP 房间的治疗增加了 aggrecan 和骨胶原的表情 TGF- 的 II,以及分泌物,而是减少的 IL-6 分泌物。而且, E2 禁止了 apoptosis,在 G0/G1 阶段的恢复房间周期前进,并且改进了房间生存能力。这些数据显示雌激素对 CEP 房间的退化有保护的效果。而且,嗯被证实是由酶试金的 miR-221 的一个目标。合成 miR-221 模仿或击倒嗯稀释了 E2 的保护的效果,但是 miR-221 禁止者支持了 E2 的保护的效果。这些结果建议 miR-221 可以通过指向在堕落 CEP 房间损害雌激素的保护的效果嗯。这研究揭示位于 CEP 房间的退化下面的重要机制。 | Bin Sheng Youchao Yuan Xiangyang Liu Yi Zhang Hongzhe Liu Xiongjie Shen Bin Liu Lei Chang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，4： | 5 |
| 5 | Improved adaptive genetic algorithm based RFID positioning显示文摘The existing active tag-based radio frequency identi-fication(RFID)localization techniques show low accuracy in practical applications.To address such problems,we propose a chaotic adaptive genetic algorithm to align the passive tag ar-rays.We use chaotic sequences to generate the intersection points,the weakest single point intersection is used to ensure the convergence accuracy of the algorithm while avoiding the optimization jitter problem.Meanwhile,to avoid the problem of slow convergence and immature convergence of the algorithm caused by the weakening of individual competition at a later stage,we use adaptive rate of change to improve the optimiza-tion efficiency.In addition,to remove signal noise and outliers,we preprocess the data using Gaussian filtering.Experimental results demonstrate that the proposed algorithm achieves high-er localization accuracy and improves the convergence speed. | LI Yu WU Honglan SUN Youchao | 2022 | Journal of Systems Engineering and Electronics2022，33，2： | 4 |
| 6 | Effects of imazethapyr spraying on plant growth and leaf surface microbial communities in Arabidopsis thaliana显示文摘Imazethapyr (IM) is an acetolactate synthase (ALS)-inhibiting herbicide that has been widely used in recent years.However,IM spraying can lead to the accumulation of herbicide residues in leaves.Here,we determined the effects of IM spraying on the plant growth and leaf surface microbial communities of Arabidopsis thaliana after 7 and 14 days of exposure.The results suggested that IM spraying inhibited plant growth.Fresh weight decreased to 48% and 26% of the control value after 7 and 14 days,respectively,of 0.035 kg/ha IM exposure.In addition,anthocyanin content increased 9.2-fold and 37.2-fold relative to the control content after 7 and 14 days of treatment,respectively.Furthermore,IM spraying destroyed the cell structures of the leaves,as evidenced by increases in the number of starch granules and the stomatal closure rate.Reductions in photosynthetic efficiency and antioxidant enzyme activity were observed after IM spraying,especially after 14 days of exposure.The diversity and evenness of the leaf microbiota were not affected by IM treatment,but the composition of community structure at the genus level was altered by IM spraying.Imazethapyr application increased the abundance of Pseudomonas,a genus that includes species pathogenic to plants and humans,indicating that IM potentially increased the abundance of pathogenic bacteria on leaves.Our findings increase our understanding of the relationships between herbicide application and the microbial community structures on plant leaves,and they provide a new perspective for studying the ecological safety of herbicide usage. | Wanyue Liu Mingjing Ke Zhenyan Zhang Tao Lu Youchao Zhu Yan Li Xiangliang Pan Haifeng Qian | 2019 | Journal of Environmental Sciences2019，31，11： | 2 |
| 7 | MXene based mechanically and electrically enhanced film for triboelectric nanogenerator显示文摘The development of triboelectric nanogenerator(TENG)technology which can directly convert ambient mechanical energy into electric energy may affect areas from green energy harvesting to emerging wearing electronics.And,the material of triboelectric layer is critical to the mechanical robustness and electrical output characteristics of the TENGs.Herein,a MXene enhanced electret polytetrafluoroethylene(PTFE)film with a high mechanical property and surface charge density is developed.The MXene/PTFE composite film was synthesized by spraying and annealing treatment.With the doping of MXene,the crystallinity of composite film could be tuned,leading to an enhancement in the tensile property of 450%and reducing the wear volume about 80%in the friction test.Furthermore,the as-fabricated TENG with this composite film outputs 397 V of open-circuit voltage,21µA of short-circuit current,and 232 nC of transfer charge quantity,which are 4,6,and 6 times higher than that of the TENG made by pure PTFE film,respectively.Therefore,this work provides a creative strategy to simultaneously improve the mechanical property and electrical performance of the TENGs,which have great potential in improving device stability under a complex mechanical environment. | Yuyu Gao Guoxu Liu Tianzhao Bu Yaoyao Liu Youchao Qi Yanting Xie Shaohang Xu Weili Deng Weiqing Yang Chi Zhang | 2021 | Nano Research2021，14，12： | 2 |
| 8 | Raindrop energy-powered autonomous wireless hyetometer based on liquid-solid contact electrification显示文摘Triboelectric nanogenerators(TENGs)can directly harvest energy via solid-liquid interface contact electrification,making them very suitable for harvesting raindrop energy and as active rainfall sensors.This technology is promising for realizing a fully self-powered system for autonomous rainfall monitoring combined with energy harvesting/sensing.Here,we report a raindrop energy-powered autonomous rainfall monitoring and wireless transmission system(R-RMS),in which a raindrop-TENG(R-TENG)array simultaneously serves as a raindrop energy harvester and rainfall sensor.At a rainfall intensity of 71 mm/min,the R-TENG array can generate an average short-circuit current,open-circuit voltage,and maximum output power of 15 pA,1800 V,and 325 pW,respectively.The collected energy can be adjusted to act as a stable 2.5 V direct-current source for the whole system by a power management circuit.Meanwhile,the R-TENG array acts as a rainfall sensor,in which the output signal can be monitored and the measured data are wirelessly transmitted.Linder a rainfall intensity of 71 mm/min,the R-RMS can be continuously powered and autonomously transmit rainfall data once every 4 min.This work has paved the way for raindrop energy-powered wireless hyetometers,which have exhibited broad prospects in unattended weather monitoring,field surveys,and the Internet of Things. | Chaoqun Xu Xianpeng Fu Chengyu Li Guoxu Liu Yuyu Gao Youchao Qi Tianzhao Bu Yuanfen Chen Zhong Lin Wang Chi Zhang | 2022 | Microsystems & Nanoengineering2022，8，2： | 2 |
| 9 | MicroRNA-146a rs2910164 polymorphism is associated with susceptibility to non-small cell lung cancer in the Chinese population显示文摘 | Youchao Jia Aimin Zang Yanhong Shang Hua Yang Zizheng Song Zhiyu Wang Lili Ren Yaning Wei Ling Hu Hongyun Shi Hefei Li | 2014 | Medical Oncology2014，，： | 1 |
| 10 | Quantitative determination of 16 polycyclic aromatic hydrocarbons in soil samples using solid-phase microextraction显示文摘 | Wang Yonghua Zhang Juan Ding Youchao | 2009 | Journal of Separation Science2009，，32： | 1 |
| 11 | Microwave-en-hanced H2O2-based process for treating aqueous malachite green solutions:Intermediates and degradation mechanism显示文摘 | Ju Yongming Yang Shaogui Ding Youchao | 2009 | Journal of Hazardous Materials2009，171，123： | 1 |
| 12 | Photocatalytic degradation of rhodamine B by Bi2 WO6 with electron accepting agent under microwave irradiation:Mechanism and pathway显示文摘 | HE Zhong SUN Cheng YANG Shaogui DING Youchao HE Huan WANG Zhiliang | | 0，，： | 1 |
| 13 | Disas- for maintenance based on metaheuristic method显示文摘 | Lu Zhong Sun Youchao sembly sequence planning Okafor E G | 2011 | Aircraft Engineering and Aerospace Technology2011，83，3： | 1 |
| 14 | Main- tainability parameter estimation model using particle swarm optimization based nonlinear least-squares method显示文摘 | Lu Zhong Sun Youchao Wu Haiqiao | 2010 | Journal of Computational Information Systems2010，6，14： | 1 |
| 15 | Nonpolar Na_(10)Cd(NO_(3))_(4)(SO_(3)S)_(4) Exhibits a Large Second-Harmonic Generation显示文摘Conventional wisdom says that nonpolar structures do not favorably produce strong second-harmonic generation(SHG)responses since the polarization in their microscopic functional groups are counteracted.Herein,we report the first nonlinear optical thiosulfate,Na_(10)Cd(NO_(3))_(4)(SO_(3)S)_(4),which crystallizes in a nonpolar space group of P−4.However,this thiosulfate exhibits a strong SHG response of about 4.2 times that of the benchmark KH2PO4,which is larger than those of polar sulfates.According to first-principles calculations and a flexible dipole model,the SHG enhancement is mainly ascribed to the larger flexibility of the S=S bond in the SO_(3)S tetrahedra in comparison with the S–O bond in the SO4 tetrahedra.These findings indicate that constructing flexible bonds is an effective strategy to design highperformance nonlinear optical materials regardless of polarity. | Youchao Liu Youquan Liu Zheshuai Lin Yanqiang Li Qingran Ding Xin Chen Lina Li Sangen Zhao Maochun Hong Junhua Luo | 2022 | CCS Chemistry2022，4，2： | 1 |
| 16 | Mi-crowave-enhanced H2O2-based process for treating a-queous malachite green solutions:Intermediates and degra-dation mechanism显示文摘 | Yongming Jua Shaogui Yanga Youchao Dinga | 2009 | Journal of Hazardous Materials2009，171，： | 1 |
| 17 | One-step electrodeposition process to fabricate cathodic superhydrophobic surface显示文摘 | Zhi Chen Feng Li Limei Hao Anqi Chen Youchao Kong | 2011 | Applied Surface Science2011，，： | 1 |
| 18 | Discovery of a mammalian FASN inhibitor against xenografts of non-small cell lung cancer and melanoma显示文摘Dear Editor,Cancer cells need to reprogram fatty acid(FA)metabolism to promote cell growth and survival through exogenous lipid uptake and FA biosynthesis catalyzed by the multidomain containing mammalian FA synthase(FASN).1,2 The bidirectional relationships of oncogenic signaling and de novo lipogenesis(DNL)suggest that FASN is a druggable target in many cancers. | Danfeng Cao Jie Yang Youchao Deng Meng Su Yeji Wang Xueqiong Feng Yi Xiong Enhe Bai Yanwen Duan Yong Huang | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 1 |
| 19 | Reliability assessment of the information theory for the systems consisting of different success - failure model units 显示文摘 | Sun Youchao | 1999 | Transactions of Nanjing University of Aeronautics & Astronautics1999，16，2： | 1 |
| 20 | Boosting self-trapped exciton emission from Cs_(3)Cu_(2)I_(5)nanocrystals by doping-enhanced exciton-phonon coupling显示文摘Self-trapped excitons(STEs)emission from halide perovskites with strong exciton-phonon coupling has attracted considerable attention due to the widespread application in optoelectronic devices.Nevertheless,the in-depth understanding of the relationship between exciton-phonon coupling and luminescence intensity remains incomplete.Herein,a doping-enhanced exciton-phonon coupling effect is observed in Cs_(3)Cu_(2)I_(5)nanocrystals(NCs),which leads to a remarkable increasement of their STEs emission efficiency.Mechanism study shows that the hetero-valent substitution of Cu+with alkaline-earth metal ions(AE^(2+))causes a greater degree of Jahn-Teller distortion between the ground state and excited state structures of[Cu_(2)I_(5)]_(3)-clusters as evidenced by our spectral analysis and first-principles calculations.As a consequence,an X-ray detector based on these Cs_(3)Cu_(2)I_(5):AE NCs delivers an X-ray imaging resolution of up to 10 lp·mm^(-1) and a low detection limit of 0.37μGyair·s^(-1),disclosing the potential of doping-enhanced exciton-phonon coupling effect in improving STEs-emission and practical application for X-ray imaging. | Xiaohan Li Aijun Liu Zhaoyu Wang Youchao Wei Qun Lin Yameng Chen Yongsheng Liu Maochun Hong | 2023 | Nano Research2023，16，7： | 0 |
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