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| 1 | Recent Progress on Two-dimensional Electrocatalysis显示文摘Due to their unique electronic and structural properties triggered by high atomic utilization and easy surface modification,two-dimensional(2D)materials have prodigious potential in electrocatalysis for energy conversion technology in recent years.In this review,we discuss the recent progress on two-dimensional nanomaterials for electrocatalysis.Five categories including metals,transition metal compounds,non-metal,metal-organic framework and other emerging 2D nanomaterials are successively introduced.Finally,the challenges and future development directions of 2D materials for electrocatalysis are also prospected.We hope this review may be helpful for guiding the design and application of 2D nanomaterials in energy conversion technologies. | FANG Wensheng HUANG Lei ZAMAN Shahid WANG Zhitong HAN Youjia XIA Bao Yu | 2020 | Chemical Research in Chinese Universities2020，36，4： | 7 |
| 2 | Sirt3-MnSOD axis represses nicotine-induced mitochondrial oxidative stress and mtDNA damage in osteoblasts显示文摘 | Yong Li Chen Yu Guangsi Shen Guangfei Li Junkang Shen Youjia Xu Jianping Gong | 2015 | Acta Biochimica et Biophysica Sinica2015，47，4： | 6 |
| 3 | Study on genetic engineering of Acremonium chrysogenum, the cephalosporin C producer显示文摘Acremonium chrysogenum is an important filamentous fungus which produces cephalosporin C in industry.This review summarized the study on genetic engineering of Acremonium chrysogenum,including biosynthesis and regulation for fermentation of cephalosporin C,molecular techniques,molecular breeding and transcriptomics of Acremonium chrysogenum.We believe with all the techniques available and full genomic sequence,the industrial strain of Acremonium chrysogenum can be genetically modified to better serve the pharmaceutical industry. | Youjia Hu Baoquan Zhu | 2016 | Synthetic and Systems Biotechnology2016，1，3： | 5 |
| 4 | Toll-like receptor 7 deficiency suppresses type 1 diabetes development by modulating B-cell differentiation and function显示文摘Innate immunity mediated by Toll-like receptors(TLRs),which can recognize pathogen molecular patterns,plays a critical role in type 1 diabetes development.TLR7 is a pattern recognition receptor that senses single-stranded RNAs from viruses and host tissue cells;however,its role in type 1 diabetes development remains unclear.In our study,we discovered that Tlr7-deficient(Tlr7^(−/−))nonobese diabetic(NOD)mice,a model of human type 1 diabetes,exhibited a significantly delayed onset and reduced incidence of type 1 diabetes compared with Tlr7-sufficient(Tlr7^(+/+))NOD mice.Mechanistic investigations showed that Tlr7 deficiency significantly altered B-cell differentiation and immunoglobulin production.Moreover,Tlr7^(−/−)NOD B cells were found to suppress diabetogenic CD4^(+)T-cell responses and protect immunodeficient NOD mice from developing diabetes induced by diabetogenic T cells.In addition,we found that Tlr7 deficiency suppressed the antigen-presenting functions of B cells and inhibited cytotoxic CD8^(+)T-cell activation by downregulating the expression of both nonclassical and classical MHC class I(MHC-I)molecules on B cells.Our data suggest that TLR7 contributes to type 1 diabetes development by regulating B-cell functions and subsequent interactions with T cells.Therefore,therapeutically targeting TLR7 may prove beneficial for disease protection. | Juan Huang Jian Peng James Alexander Pearson Georgios Efthimiou Youjia Hu Ningwen Tai Yanpeng Xing Luyao Zhang Jianlei Gu Jianping Jiang Hongyu Zhao Zhiguang Zhou F.Susan Wong Li Wen | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 5 | The mechanosensitive lncRNA Neat1 promotes osteoblast function through paraspeckle-dependent Smurf1 mRNA retention显示文摘Mechanical stimulation plays an important role in bone remodeling. Exercise-induced mechanical loading enhances bone strength,whereas mechanical unloading leads to bone loss. Increasing evidence has demonstrated that long noncoding RNAs(lnc RNAs) play key roles in diverse biological, physiological and pathological contexts. However, the roles of lnc RNAs in mechanotransduction and their relationships with bone formation remain unknown. In this study, we screened mechanosensing lnc RNAs in osteoblasts and identified Neat1, the most clearly decreased lnc RNA under simulated microgravity. Of note, not only Neat1 expression but also the specific paraspeckle structure formed by Neat1 was sensitive to different mechanical stimulations, which were closely associated with osteoblast function. Paraspeckles exhibited small punctate aggregates under simulated microgravity and elongated prolate or larger irregular structures under mechanical loading. Neat1 knockout mice displayed disrupted bone formation, impaired bone structure and strength, and reduced bone mass. Neat1 deficiency in osteoblasts reduced the response of osteoblasts to mechanical stimulation. In vivo, Neat1 knockout in mice weakened the bone phenotypes in response to mechanical loading and hindlimb unloading stimulation. Mechanistically, paraspeckles promoted nuclear retention of E3 ubiquitin ligase Smurf1 m RNA and downregulation of their translation, thus inhibiting ubiquitination-mediated degradation of the osteoblast master transcription factor Runx2, a Smurf1 target. Our study revealed that Neat1 plays an essential role in osteoblast function under mechanical stimulation, which provides a paradigm for the function of the lnc RNA-assembled structure in response to mechanical stimulation and offers a therapeutic strategy for long-term spaceflight-or bedrest-induced bone loss and age-related osteoporosis. | Caizhi Liu Xingcheng Gao Yuheng Li Weijia Sun Youjia Xu Yingjun Tan Ruikai Du Guohui Zhong Dingsheng Zhao Zizhong Liu Xiaoyan Jin Yinlong Zhao Yinbo Wang Xinxin Yuan Junjie Pan Guodong Yuan Youyou Li Wenjuan Xing Guanghan Kan Yanqing Wang Qi Li Xuan Han Jianwei Li Shukuan Ling Yingxian Li | 2022 | Bone Research2022，10，2： | 3 |
| 6 | Scenario simulation of water retention services under land use/cover and climate changes: a case study of the Loess Plateau, China显示文摘Comprehensive assessments of ecosystem services in environments under the influences of human activities and climate change are critical for sustainable regional ecosystem management. Therefore,integrated interdisciplinary modelling has become a major focus of ecosystem service assessment. In this study, we established a model that integrates land use/cover change(LUCC), climate change, and water retention services to evaluate the spatial and temporal variations of water retention services in the Loess Plateau of China in the historical period(2000–2015) and in the future(2020–2050). An improved Markov-Cellular Automata(Markov-CA) model was used to simulate land use/land cover patterns, and ArcGIS 10.2 software was used to simulate and assess water retention services from 2000 to 2050 under six combined scenarios, including three land use/land cover scenarios(historical scenario(HS), ecological protection scenario(EPS), and urban expansion scenario(UES)) and two climate change scenarios(RCP4.5 and RCP8.5, where RCP is the representative concentration pathway). LUCCs in the historical period(2000–2015) and in the future(2020–2050) are dominated by transformations among agricultural land, urban land and grassland. Urban land under UES increased significantly by 0.63×10^(3) km^(2)/a, which was higher than the increase of urban land under HS and EPS. In the Loess Plateau, water yield decreased by 17.20×10^(6) mm and water retention increased by 0.09×10^(6) mm in the historical period(2000–2015),especially in the Interior drainage zone and its surrounding areas. In the future(2020–2050), the pixel means of water yield is higher under RCP4.5 scenario(96.63 mm) than under RCP8.5 scenario(95.46mm), and the pixel means of water retention is higher under RCP4.5 scenario(1.95 mm) than under RCP8.5 scenario(1.38 mm). RCP4.5-EPS shows the highest total water retention capacity on the plateau scale among the six combined scenarios, with the value of 1.27×10^(6) mm. Ecological restoration projects in the Loess Plateau have enhanced soil and water retention. However, more attention needs to be paid not only to the simultaneous increase in water retention services and evapotranspiration but also to the type and layout of restored vegetation. Furthermore, urbanization needs to be controlled to prevent uncontrollable LUCCs and climate change. Our findings provide reference data for the regional water and land resources management and the sustainable development of socio-ecological systems in the Loess Plateau under LUCC and climate change scenarios. | SUN Dingzhao LIANG Youjia PENG Shouzhang | 2022 | Journal of Arid Land2022，14，4： | 2 |
| 7 | Simulating land-use change and its effect on biodiversity conservation in a watershed in northwest China显示文摘Introduction:Land-use management strategies play a major role in biodiversity change.In many parts of the world,local governments are under increasing pressure to regulate human activity to mitigate negative impacts on ecosystems.Outcomes/other:This study aimed to analyze the effects of different land-use patterns on biodiversity change across a typical artificial desert watershed.We first analyzed land-cover change based on past and future management scenarios in a watershed spanning Gaotai,Linze,and Ganzhou counties in northwest China.We then analyzed the effect of different land-use patterns on biodiversity change in the watershed.We found that the crucial landcover changes are likely to occur in the wetland reserves and areas established for the Grain for Green Project around the oases,and such changes could affect biodiversity throughout the entire watershed landscape.Discussion:The use of spatial analysis to illustrate explicit changes in ecosystems is useful in fostering biodiversity awareness and the need for decision-making at different scales.Conclusion:Thus,these findings indicate that land-use management strategies for the middle and southeast parts of the watershed are particularly important for future management of biodiversity and the integrated ecosystem services of the entire watershed landscape. | Youjia Liang Lijun Liu | 2017 | Ecosystem Health and Sustainability2017，3，5： | 2 |
| 8 | Synthesis of cationic styrene-acrylic acid ester copolymer emulsion for paper sizing显示文摘Surface sizing is an effective way to increase paper’s water-resistance and printability.The purpose of this study was to study synthesis process to develop an efficient cationic styrene-acrylic acid ester emulsion(SAE)for the surface sizing of paper.Dimethylaminoethyl methacrylate methyl chloride(DMC)was used as the cationic monomer,and cationic starch or native starch was used as the emulsion stabilizer to copolymerize with styrene and butyl acrylate.The results indicated that the SAE synthesized with cationic starch and DMC had a high cationic charge density and a high DMC conversion rate.Paper sized with the cationic SAE had higher surface strength and lower Cobb value than the paper sized with other surface sizing agents such as,anionic SAE,and cationic or oxidized starch.Scanning electron micrographs revealed that the paper sized with a combination of oxidized starch and cationic SAE had smoother surface morphology when compared to the paper sized with oxidized starch alone,or with oxidized starch and anionic SAE. | Xinlei Wu Youjia Cui Yi Jing Joseph Mosseler | 2016 | Journal of Bioresources and Bioproducts2016，1，1： | 1 |
| 9 | Cooperative Caching for Scalable Video Coding Using Value-Decomposed Dimensional Networks显示文摘Scalable video coding(SVC)has been widely used in video-on-demand(VOD)service,to efficiently satisfy users’different video quality requirements and dynamically adjust video stream to timevariant wireless channels.Under the 5G network structure,we consider a cooperative caching scheme inside each cluster with SVC to economically utilize the limited caching storage.A novel multi-agent deep reinforcement learning(MADRL)framework is proposed to jointly optimize the video access delay and users’satisfaction,where an aggregation node is introduced helping individual agents to achieve global observations and overall system rewards.Moreover,to cope with the large action space caused by the large number of videos and users,a dimension decomposition method is embedded into the neural network in each agent,which greatly reduce the computational complexity and memory cost of the reinforcement learning.Experimental results show that:1)the proposed value-decomposed dimensional network(VDDN)algorithm achieves an obvious performance gain versus the traditional MADRL;2)the proposed VDDN algorithm can handle an extremely large action space and quickly converge with a low computational complexity. | Youjia Chen Yuekai Cai Haifeng Zheng Jinsong Hu Jun Li | 2022 | China Communications2022，19，9： | 1 |
| 10 | Cloning,sequencing and expression of a dextransucrase gene (dexYG) from Leuconostoc mesenteroides显示文摘 | ZHANG Hongbin HU Youjia ZHU Chunbao | | 0，，： | 1 |
| 11 | Cloning, sequencing and expression of a dextransucrase gene (dexYG) from Leuconostoc mesenteroides显示文摘 | ZHANG Hongbin HU Youjia ZHU Chunbao | 2008 | Biotechnology Letters2008，30，： | 1 |
| 12 | The histopathological features of the explanted lungs from an end-stage COVID-19 patient显示文摘Although the pathological findings of coronavirus disease 2019(COVID-19)associated with acute respiratory distress syndrome(ARDS)have been reported in previous studies,the data of histopatho-logical features of end-stage COVID-19 lungs are still lacking.We have previously reported the clini-cal features and managements of three COVID-19 patients with irreversible deterioration of pulmonary function who received lung transplantation(LT)after being supported by extracorporeal membrane oxygenation(ECMO)[1]. | Kai Li Youjia Yu Ding Li Changxing Luan Li Hu Jie Wang Jingjing Ding Yanfang Yu Hang Yang Jingyu Chen Feng Chen Chuan Su | 2020 | Forensic Sciences Research2020，5，4： | 1 |
| 13 | Improvement of Cephalosporin C Production by Recombinant DNA Integration in Acremonium chrysogenum显示文摘 | Yan Liu Guihua Gong Liping Xie Ning Yuan Chunbao Zhu Baoquan Zhu Youjia Hu | 2010 | Molecular Biotechnology2010，，2： | 1 |
| 14 | Integrated assessment of the supply-demand relationship of ecosystem services in the Loess Plateau during 1992-2015显示文摘Landscape alterations and ecosystem services(ES)are crucial elements that affect the socioecological development of ecologically fragile regions.To provide scientific support for the land-use planning and regional ecological restoration to achieve sustainable development goals(SDGs)in the Loess Plateau from 1992 to 2015,this study proposes an integrated assessment framework for assessing the supply-demand match and equilibrium of ES combining potential relationships between landscape alterations,ES,and sustainable development at the county and regional scales.Results show that more than 85%of local counties have a supply-demand mismatch in terms of ecosystem services.Supply-demand distributions for provisioning and supporting services were relatively balanced compared to cultural services,which were imbalanced.Although the overall supply-demand relationship is relatively balanced because of the significant influence of ecological restoration,it shows an increasing trend toward imbalance as human-land conflict is prominent in some regions.SDGs emphasize on specific ES information such as ecosystem conservation,sustainable agriculture,and urban construction.Furtherly,positive impacts from landscape dynamics can improve the supply capacity of the ES and contribute to regional sustainability. | Dan Wang Youjia Liang Shouzhang Peng Zhangcai Yin Jiejun Huang | 2022 | Ecosystem Health and Sustainability2022，8，1： | 1 |
| 15 | An integrated analysis approach to LUCC at regional scale:A case study in the Ganzhou District of Zhangye City,China显示文摘Land use/cover change(LUCC) models are helpful tools for analyzing driving forces and processes of land use changes,assessing ecological impacts of land use change and decision-making for land use planning.However,no single model is able to capture all the essential key processes to explore land use change at different spatial-temporal scales and make a full assessment of driving factors and macro-ecological impacts.Taken Ganzhou District as a case study,this paper describes an integrated analysis(IA) approach by combining with system dynamics(SD) model,the Conversion of Land Use and its Effects at Small regional extent(CLUE-S) model and landscape indices method to analyze land use dynamics at different spatial-temporal scales.The SD model was used to calculate and predict demands for different land use types at the macro-scale as a whole during 2000-2035.The LUCC process was simulated at a high spatial resolution with the spatial consideration of land use spatial policies and restrictions to satisfy the balance between land use demand and supply by using the CLUE-S model,and Kappa values of the map simulation are 0.86 and 0.81 in 2000 and 2005,respectively.Finally,we evaluated the macro-ecological effect of LUCC and optimized scenario managements of land use by using landscape indices method.The IA approach could be used for better understanding the complexity of land use change and provide scientific support for land use planning and management,and the simulation results also could be used as a source data for scenario analysis of different hydrological and ecological processes based on different underlying surface of LUCC. | YouJia Liang ZhongMin Xu | 2012 | Research in Cold and Arid Regions2012，4，4： | 1 |
| 16 | Iron adjustable element undernormal and high iron environment impact on the distribution ofintracellular calcium ions 显示文摘 | Li Guangfei lin Hua Xu Youjia | 2011 | China Experimental SurgicalMagazine2011，28，9： | 1 |
| 17 | Self‐training maximum classifier discrepancy for EEG emotion recognition显示文摘Even with an unprecedented breakthrough of deep learning in electroencephalography(EEG),collecting adequate labelled samples is a critical problem due to laborious and time‐consuming labelling.Recent study proposed to solve the limited label problem via domain adaptation methods.However,they mainly focus on reducing domain discrepancy without considering task‐specific decision boundaries,which may lead to feature distribution overmatching and therefore make it hard to match within a large domain gap completely.A novel self‐training maximum classifier discrepancy method for EEG classification is proposed in this study.The proposed approach detects samples from a new subject beyond the support of the existing source subjects by maximising the discrepancies between two classifiers'outputs.Besides,a self‐training method that uses unlabelled test data to fully use knowledge from the new subject and further reduce the domain gap is proposed.Finally,a 3D Cube that incorporates the spatial and frequency information of the EEG data to create input features of a Convolutional Neural Network(CNN)is constructed.Extensive experiments on SEED and SEED‐IV are conducted.The experimental evaluations exhibit that the proposed method can effectively deal with domain transfer problems and achieve better performance. | Xu Zhang Dengbing Huang Hanyu Li Youjia Zhang Ying Xia Jinzhuo Liu | 2023 | CAAI Transactions on Intelligence Technology2023，8，4： | 1 |
| 18 | High-speed environment on theinfluence of the zebra fish bone formation 显示文摘 | Chen Bin Liu Chen Xu Youjia | 2013 | Chinese DiseaseOsteoporosis and Bone Mineral Salt Magazine2013，6，3： | 1 |
| 19 | Robust fadal features localization on rotation arbitrary multi-view face in complex background显示文摘 | Fu Youjia He Yam Li Jianwei | | 0，，2： | 1 |
| 20 | MicroRNAs reprogram normal fibroblasts into cancer-associated fibroblasts in ovarian cancer显示文摘 | Mitra AK Marion Z Youjia H | 2012 | Cancer Discov2012，2，12： | 1 |
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