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| 1 | 肿瘤浸润髓系细胞上表达的共抑制分子B7S1抑制抗肿瘤CD8 T细胞的功能显示文摘文章简介近年来,肿瘤免疫治疗蓬勃发展,为人类战胜癌症带来了一线曙光。阻断PD-1/PD-L1通路的抗体药物可以提高CD8 T细胞的抗肿瘤活性,疗效显著优于传统治疗手段。然而,只有小部分实体瘤病人可以对PD-1/PD-L1免疫治疗产生应答. | 黎静 Younghee Lee Yanjian Li Yu Jiang Huiping Lu Wenjuan Zang Xiaohong Zhao Liguo Liu Yang Chen Haidong Tan 杨志英 Michael Q Zhang Tak W.Mak Ling Ni 董晨 | 2019 | 科学新闻2019，0，2： | 6 |
| 2 | Identification of common microRNA-mRNA regulatory biomodules in human epithelial cancer显示文摘The complex regulatory network between microRNAs and gene expression remains an unclear domain of active research.We proposed to address in part this complex regulation with a novel approach for the genome-wide identification of biomodules derived from paired microRNA and mRNA profiles,which could reveal correlations associated with a complex network of dys-regulation in human cancer.Two published expression datasets for 68 samples with 11 distinct types of epithelial cancers and 21 samples of normal tissues were used,containing microRNA expression and gene expression profiles,respectively.As results,the microRNA expression used jointly with mRNA expression can provide better classifiers of epithelial cancers against normal epithelial tissue than either dataset alone(P=1×10-10,F-test).We identified a combination of 6 microRNA-mRNA biomodules that optimally classified epithelial cancers from normal epithelial tissue(total accuracy = 93.3%;95% confidence intervals:86%-97%),using penalized logistic regression(PLR) algorithm and three-fold cross-validation.Three of these biomodules are individually sufficient to cluster epithelial cancers from normal tissue using mutual information distance.The biomodules contain 10 distinct microRNAs and 98 distinct genes,including well known tumor markers such as miR-15a,miR-30e,IRAK1,TGFBR2,DUSP16,CDC25B and PDCD2.In addition,there is a significant enrichment(Fisher's exact test P=3×10-10) between putative microRNA-target gene pairs reported in 5 microRNA target databases and the inversely correlated microRNA-mRNA pairs in the biomodules.Further,microRNAs and genes in the biomodules were found in abstracts mentioning epithelial cancers(Fisher's Exact test,unadjusted P<0.05).Taken together,these results strongly suggest that the discovered microRNA-mRNA biomodules correspond to regulatory mechanisms common to human epithelial cancer samples.In conclusion,we developed and evaluated a novel comprehensive method to systematically identify,on a genome scale,microRNA-mRNA expression biomodules common to distinct cancers of the same tissue.These biomodules also comprise novel microRNA and genes as well as an imputed regulatory network,which may accelerate the work of cancer biologists as large regulatory maps of cancers can be drawn efficiently for hypothesis generation. | YANG XiNan LEE Younghee FAN Hong SUN Xiao LUSSIER Yves A | 2010 | Chinese Science Bulletin2010，55，31： | 3 |
| 3 | Application of TRIZ creativity intensification approach to chemical process safety显示文摘 | Junghwan Kim Jinkyung Kim Younghee Lee | 2009 | Journal of Loss Prevention in the Process Industries2009，22，： | 1 |
| 4 | Development of a risk assessment program for chemical terrorism显示文摘 | Lee Younghee Kim Jinkyung Kim Junghwan | 2010 | Korean Journal of Chemical Engineering2010，27，2： | 1 |
| 5 | A Unified Scheme of Shot Boundary Detection and Anchor Shot Detection in News Video Story Parsing 显示文摘 | HANSUNG LEE JAEHAK YU YOUNGHEE IM | 2011 | Multimedia Tools and Applications2011，51，3： | 1 |
| 6 | Application of TRIZ creativity intensification approach to chemical process safety显示文摘 | KIM Junghwan KIM Jinkyung LEE Younghee | 2009 | Journal of Loss Prevention in the Process Industries2009，22，6： | 1 |
| 7 | The tourism area life cycle in kim yujeong literary village显示文摘 | Younghee Lee Weaver D | 2014 | Asia Pacific Journal of Tourism Research2014，19，2： | 1 |
| 8 | Development of an Integrated Biospecimen Bank and Multidisciplinary Clinical Database For Pancreatic Cancer显示文摘 | Rosa F. Hwang MD Huamin Wang MD PhD Axbal Lara MBA Henry Gomez MD Tracy Chang BS Nicole Sieffert BA Younghee Moon BS Sabina Ram MS Stuart Zimmerman PhD Jeffrey H. Lee MD Peter W. T. Pisters MD Eric P. Tamm MD Jason B. Fleming MD James L. Abbruzzese MD Do | 2008 | Annals of Surgical Oncology2008，，5： | 1 |
| 9 | Involvement of NF-κB in the regulation of S100A6 gene expression in human hepatoblastoma cell line HepG2显示文摘 | Joung Hyuck Joo Jae Wha Kim Younghee Lee | 2003 | Biochem Biophys Res Commun2003，307，： | 1 |
| 10 | Validity of pressure ulcer risk assessment scales: Cubbin and Jackson, Braden, and Douglas scale显示文摘 | Jun Seongsook Jeong Ihnsook Lee Younghee | 2004 | International J of Nurs Studies2004，4，： | 1 |
| 11 | Validity of pressure ulcer scale;Cubbin and Jackson, Bra- den and Douglas scale显示文摘 | Jun Seongsook RN Jeong Ihnsook RN Lee Younghee RN | 2004 | Int J Nurs Stud2004，41，2： | 1 |
| 12 | Validity of pressure ulcer risk assessment scales; Cubbin and Jackson, Braden, and Douglas scale显示文摘 | Jun Seongsook RN Jeong lhnsook RN Lee Younghee RN | 2004 | IntJ Nurs Stud2004，41，2： | 1 |
| 13 | Novel transcriptional regulation of the schlafen-2 gene in macrophages in response to TLR-triggered stimulation显示文摘 | Wern-Joo Sohn Dongbum Kim Keun-Wook Lee Min-Soo Kim Sanghoon Kwon Younghee Lee Doo-Sik Kim Hyung-Joo Kwon | 2007 | Molecular Immunology2007，，13： | 1 |
| 14 | Sub-stitution effect of hydroxyl groups on the 1 H and 13 Cchemical shifts in hydroxyflavonols显示文摘 | Lee Sunhee Park Younghee Lim Yoongho? | 2008 | Bulletin KoreanChem Societ2008，29，8： | 1 |
| 15 | Formation of ZSM-5 on Silicon Carbide Fibers for Catalytic Support显示文摘 | Yoon-joo Lee Dong-geun Shin Younghee Kim Woo-teck Kwon Soo-ryong Kim Doh-hyung Riu | 2016 | 材料科学与工程(中英文B版)2016，6，5： | 0 |
| 16 | Boosting in-plane anisotropy by periodic phase engineering in two-dimensional VO_(2) single crystals显示文摘In-plane anisotropy(IPA)due to asymmetry in lattice structures provides an additional parameter for the precise tuning of characteristic polarization-dependent properties in two-dimensional(2D)materials,but the narrow range within which such method can modulate properties hinders significant development of related devices.Herein we present a novel periodic phase engineering strategy that can remarkably enhance the intrinsic IPA obtainable from minor variations in asymmetric structures.By introducing alternant monoclinic and rutile phases in 2D VO_(2)single crystals through the regulation of interfacial thermal strain,the IPA in electrical conductivity can be reversibly modulated in a range spanning two orders of magnitude,reaching an unprecedented IPA of 113.Such an intriguing local phase engineering in 2D materials can be well depicted and predicted by a theoretical model consisting of phase transformation,thermal expansion,and friction force at the interface,creating a frame-work applicable to other 2D materials.Ultimately,the considerable adjustability and reversibility of the presented strategy provide opportunities for future polarization-dependent photoelectric and optoelectronic devices. | Meng Ran Chao Zhao Xiang Xu Xiao Kong Younghee Lee Wenjun Cui Zhi-Yi Hu Alexander Roxas Zhengtang Luo Huiqiao Li Feng Ding Lin Gan Tianyou Zhai | 2022 | Fundamental Research2022，2，3： | 0 |
| 17 | Residents' Perceptions of Multi-linguistic Landscape in Tourism Destination显示文摘 | Rachel, Minqi Ruan Maria, Younghee Lee | 2017 | Chinese Business Review2017，16，2： | 0 |
| 18 | Automatic Verification of Biochemical Network Using Model Checking Method显示文摘这研究集中于用模型检查的在生物过程的所有可能的路径的为活动范围能力,转变逻辑和层次结构的方法的自动寻找并且验证。为在在生物过程的复杂、大的网络以内的其他的路径的自动搜索和确认能提供解决方案的可观的数量,它是困难的手工地处理。模型检查是为如果,验证的一个自动方法一个电路或一个条件,表示了为一个并发的转变系统,满足在时间的逻辑表示的一套性质,例如计算的树逻辑(CTL ) 。这篇文章表示模型检查在生物化学的网络确认是可行的,它为在生化法特殊行为的性质查询并且寻找在模拟上显示出某些优点。 | Jinkyung Kim Younghee Lee Il Moon | 2008 | Chinese Journal of Chemical Engineering2008，16，1： | 0 |
| 19 | Effect of preparation method of noble metal supported catalyts on formaldehyde oxidation at room temperature: Gas or liquid phase reduction显示文摘Formaldehyde(HCHO) is toxic to the human body and is one of the main threats to the indoor air quality(IAQ). As such, the removal of HCHO is imperative to improving the IAQ,whereby the most useful method to effectively remove HCHO at room temperature is catalytic oxidation. This review discusses catalysts for HCHO room-temperature oxidation,which are categorized according to their preparation methods, i.e., gas-phase reduction and liquid-phase reduction methods. The HCHO oxidation performances, structural features,and reaction mechanisms of the different catalysts are discussed, and directions for future research on catalytic oxidation are reviewed. | Younghee Jang Ye Hwan Lee Hanki Eom Sang Moon Lee Sung Su Kim | 2022 | Journal of Environmental Sciences2022，34，12： | 0 |
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