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| 1 | Spatial-temporal Characteristics of Land Subsidence Corresponding to Dynamic Groundwater Funnel in Beijing Municipality,China显示文摘Due to long-term over-exploitation of groundwater in Beijing Municipality,regional groundwater funnels have formed and land subsidence has been induced.By combining a groundwater monitoring network,GPS monitor-ing network data,radar satellite SAR data,GIS and other new technologies,a coupled process model based on the dy-namic variation of groundwater and the deformation response of land subsidence has been established.The dynamic variation of groundwater funnels and the land subsidence response process were analyzed systematically in Beijing.Study results indicate that current groundwater funnel areas are distributed mainly in the southwest of Shunyi District,the northeast of Chaoyang District and the northwest of Tongzhou District,with an average decline rate of groundwa-ter level of 2.66 m/yr and a maximum of 3.82 m/yr in the center of the funnels.Seasonal and interannual differences exist in the response model of land subsidence to groundwater funnels with uneven spatial and temporal distribution,where the maximum land subsidence rate was about-41.08 mm/yr and the area with a subsidence rate greater than 30 mm/yr was about 1637.29 km2.Although a consistency was revealed to exist between a groundwater funnel and the spatial distribution characteristics of the corresponding land subsidence funnel,this consistency was not perfect.The results showed that the response model of land subsidence to the dynamic variation of groundwater was more revealing when combining conventional technologies with InSAR,GIS,GPS,providing a new strategy for environmental and hydrogeological research and a scientific basis for regional land subsidence control. | CHEN Beibei GONG Huili LI Xiaojuan LEI Kunchao ZHANG Youquan LI Jiwei GU Zhaoqin DANG Yanan | 2011 | Chinese Geographical Science2011，21，6： | 13 |
| 2 | Character and Causes of Population Distribution in Shenyang City,China显示文摘Character of population distribution is one of the focuses studied by urban geography. Using the fifth national census data as basic data and using areal interpolation method, this paper analyzes character of urban population dis- tribution of Shenyang City, Northeast China, in terms of three aspects of statistical character, spatial auto-correlation and spatial structure. Furthermore, this research analyzes the factors affecting the population distribution of the city. The main conclusions include: 1) There is an obvious structure character of population distribution in the grid with a grain of 300m, which is appropriate scale when researching population distribution in Shenyang City. 2) Urban population dis- tribution has the character of assembling while population density distribution takes on variability in Shenyang City. 3) Population density distribution shows spatial auto-correlation within 7.36km. Spatial heterogeneity of population density is low. 4) Urban center, population distribution barycenter and population density maximum points separate each other. Population density distribution has multi-cores character. 5) Layout of governments, primary schools, middle schools, colleges, hospitals and marketplaces affects population distribution directly. With the increase of distance to these factors, population density decreases as logarithm. | DU Guoming ZHANG Shuwen ZHANG Youquan | 2006 | Chinese Geographical Science2006，16，3： | 12 |
| 3 | Evaluation of hollow fiber T-type zeolite membrane modules for ethanol dehydration显示文摘This work presents the design of hollow fiber T-type zeolite membrane modules with different geometric configurations. The module performances were evaluated by pervaporation dehydration of ethanol/water mixtures. Strong concentration polarization was found for the modules with big membrane bundles. The concentration polarization was enhanced at high temperature due to the higher water permeation flux. The increase of feed flow could improve water permeation flux for the membrane modules with small membrane bundle.Computational fluid dynamics was used to visualize the flow field distribution inside of the modules with different configurations. The membrane module with seven bundles exhibited highest separation efficiency due to the uniform distribution of flow rate. The packing density could be 10 times higher than that of the tubular membrane module. The hollow fiber membrane module exhibited good stability for ethanol dehydration. | Xuerui Wang Ji Jiang Dezhong Liu Youquan Xue Chun Zhang Xuehong Gu | 2017 | Chinese Journal of Chemical Engineering2017，25，5： | 7 |
| 4 | Silencing of PRR11 suppresses cell proliferation and induces autophagy in NSCLC cells显示文摘Our previous studies have demonstrated that proline-rich protein 11(PRR11)is a novel tumor-related gene and implicates in regulating the proliferation in lung cancer.However,its precise role in cell cycle progression remains unclear.Our recent evidences show that PRR11 silencing has an effect on autophagy in non-small-cell lung cancer(NSCLC)cells.Two human NSCLC cell lines,H1299 and A549 were transiently transfected with against PRR11 siRNA.The Cell Counting Kit-8 and plate clone formation assay showed that downregulation of PRR11 inhibited the cell proliferation associated with cell cycle related genes reduced.And our data suggested that PRR11 depletion expression enhanced the autophagosomes formation,followed with downregulation of P62 and upregulation of LC3-II protein.Furthermore,the immunoblotting results indicated that silencing of PRR11 inactivated the Akt/mTOR signaling pathway.Collectively,these results demonstrated PRR11 had an effective role in autophagy in NSCLC cells through Akt/mTOR autophagy signaling pathways.Therefore,it is helpful to clarify the function of PRR11 in tumorigenesis of NSCLC. | Lian Zhang Yunlong Lei Ying Zhang Yi Li Youquan Bu Fangzhou Song Chundong Zhang | 2018 | Genes & Diseases2018，5，2： | 6 |
| 5 | Discovering Overlapping Communities by Clustering Local Link Structures显示文摘Recent advances point out that the existing community detection methods commonly face two challenges:incorrect base-structures and incorrect membership of weak-ties.To overcome both problems,a Local link structure(LLS) clustering based method for overlapping community detection is proposed.We extend the similarity of a pair of links to a group of links named LLS,and thus transform mining LLSs as a pattern mining problem.We prove that LLS with an appropriate threshold can filter weak-ties in the form of bridge and local bridge with its span being larger than 3.A compositive framework is presented for overlapping community detection based on LLS mining and clustering.Comparative experiments on both synthetical and real-world networks demonstrate that our method has advantage over six existing methods on discovering higher quality communities. | TAO Haicheng WANG Youquan WU Zhi'ang BU Zhan CAO Jie | 2017 | Chinese Journal of Electronics2017，26，2： | 3 |
| 6 | Nano CuO/ZSM-5 zeolite as a green and efficient catalyst for dehydration of 1,4-butanediol to tetrahydrofuran显示文摘Nano CuO/ZSM-5 zeolite was prepared and used as a catalyst for dehydration of 1,4-butanediol(BDO) to tetrahydrofuran(THF) in liquid-phase. It was found that the 4.6 wt% CuO/ZSM-5 displayed good catalytic performance, and nearly 100%of BDO conversion and more than 99% of THF selectivity could be achieved by a rotary evaporator reactor at 170 °C under the atmospheric pressure. With such mild reaction conditions, 2400 g BDO could be converted to THF over 1 g catalyst under semi-continuous operation. Characterizations with X-ray diffraction(XRD), temperature-programmed reduction(TPR),NH3-temperature programmed desorption(TPD), X-ray photoelectron spectroscopy(XPS), transmission electron microscope(TEM) and Brunauer-Emmett-Teller(BET) over fresh and used 4.6 wt% CuO/ZSM-5 were conducted. Based on the results of the characterization and catalytic performance of 4.6 wt% CuO/ZSM-5, it can be conjectured that the formed 1–3 nm CuO nanoparticles, suitable acidity of the catalyst due to the synergic interaction of CuO and ZSM-5 support promoted the dehydration of BDO to THF. | Yan Long Shimin Liu Yuqing Fei Qinghe Li Youquan Deng | 2017 | Science China Chemistry2017，60，7： | 3 |
| 7 | A COMPARATIVE STUDY ON SHILLING DETECTION METHODS FOR TRUSTWORTHY RECOMMENDATIONS显示文摘 | Youquan Wang Liqiang Qian Fanzhang Li Lu Zhang | 2018 | Journal of Systems Science and Systems Engineering2018，27，4： | 3 |
| 8 | Mechanically activated starch magnetic microspheres for Cd(Ⅱ)adsorption from aqueous solution显示文摘Magnetic starch microspheres(AAM-MSM)were synthesized via an inverse emulsion graft copolymerization by using mechanically activated cassava starch(MS)as a crude material,acrylic acid(AA)and acrylamide(AM)as graft copolymer monomers,and methyl methacrylate(MMA)as the dispersing agent and used as an adsorbent for the removal of Cd(Ⅱ)ions from aqueous solution.Fourier-transform infrared spectroscopy(FT-IR),X-ray photoelectron spectroscopy(XPS),scanning electron microscopy(SEM),and vibrating sample magnetometry(VSM)were used to characterize the AAM-MSM adsorbent.The results indicated that AA,AM,and MMA were grafted to the MS,and the Fe_(3)O_(4) nanoparticles were encapsulated in the AAM-MSM adsorbent microspheres.The adsorbent exhibited a smooth surface,uniform size,and good sphericity because of the addition of the MMA and provided more adsorption sites for the Cd(Ⅱ)ions.The maximum adsorption capacity of Cd(Ⅱ)on the AAM-MSM was 39.98 mg·g^(-1).The adsorbents were superparamagnetic,and the saturation magnetization was 16.7 A·m^(2)·kg^(-1).Additionally,the adsorption isotherms and kinetics of the adsorption process were further investigated.The process of Cd(Ⅱ)ions adsorbed onto the AAM-MSM could be described more favorably by the pseudo-second-order kinetic and Langmuir isothermal adsorption models,which suggested that the chemical reaction process dominated the adsorption process for the Cd(Ⅱ)and chemisorption was the rate-controlling step during the Cd(Ⅱ)removal process. | Xinling Xie Xiaona Zhao Xuan Luo Tongming Su Youquan Zhang Zuzeng Qin Hongbing Ji | 2021 | Chinese Journal of Chemical Engineering2021，34，5： | 3 |
| 9 | A Method of Cracks Image Segmentation Based on the Means of Multiple Thresholds显示文摘 | Youquan He Hanxing Qiu | 2012 | 通讯和计算机(中英文版)2012，9，10： | 3 |
| 10 | Metabolomics analysis for skin ulceration syndrome of Apostichopus japonicus based on UPLC/Q-TOF MS显示文摘Skin ulceration syndrome(SUS)is the main diseases aff ected the development of sea cucumber(Apostichopus japonicus)culture industries.To better observe the changes in the sea cucumber A.japonicus with SUS and understand the pathogenesis of the disease,activities of superoxide dismutase(SOD),catalase(CAT),and level of malondialdehyde(MDA)in coelomic fluid were detected using the Assay Kit and metabolites in the body wall were assessed using ultra-performance liquid chromatography and quadrupole-time of flight mass spectrometry.The results indicated that level of MDA was increased during SUS compared with healthy individuals(P<0.01),but activities of SOD and CAT were reduced(P<0.05).In metabolomics analysis,metabolites,such as adenosine,choline,betaine aldehyde,palmitic acid,and taurine,were found to be upregulated and 2-oxoadipic acid,anthranilic acid(vitamin L1),thioetheramide-PC,cholesterol-3-sulfate,and pentadecanoic acid were downregulated(VIP>1 and P<0.1).Pathway enrichment analysis indicated most enrichment of KEGG pathways were mainly related to energy metabolism,immunity,and osmoregulation such as ABC transporters,glycine,serine and threonine metabolism,tryptophan metabolism and neuroactive ligand-receptor interaction.Our study reflected the difference in enzyme activity and metabolites between A.japonicus with SUS and those without,which will provide reference data for investigating SUS. | Yang ZHANG Youquan WANG Xiaoyu LIU Beichen DING Yi SUN Yaqing CHANG Jun DING | 2021 | Journal of Oceanology and Limnology2021，39，4： | 2 |
| 11 | SKA2/FAM33A:A novel gene implicated in cell cycle,tumorigenesis,and psychiatric disorders显示文摘SKA2(spindle and KT associated 2),also referred to as FAM33A(family with sequence similarity 33,member A),is a recently identified gene involved in cell cycle regulation,and growing evidence is implicating its roles in tumorigenesis and psychiatric disorders.It has been demonstrated that SKA2,along with its coworkers SKA1 and SKA3,constitutes the SKA complex which plays a critical role in the maintenance of the metaphase plate and/or spindle checkpoint silencing during mitosis.SKA2 is over-expressed both in cancer cell lines and clinical samples including small cell lung cancer and breast cancer,whereas downregulation of SKA2 is associated with depression and suicidal ideation.The expression of SKA2 is regulated by transcription factors including NF-kB and CREB,miRNAs as well as DNA methylation.In this review,we provide an overview of studies that reveal SKA2 gene and protein characteristics as well as physiological function,with a special focus on its transcription regulatory mechanisms,and also provide a summary regarding the translational opportunity of the SKA2 gene as a clinical biomarker for cancers and psychiatric disorders. | Mengyu Xie Youquan Bu | 2019 | Genes & Diseases2019，6，1： | 2 |
| 12 | 肺癌细胞中沉默PRR11诱发自噬并抑制细胞增殖显示文摘PRR11是近期研究发现的一个肿瘤相关新基因,在肺癌、胃癌及胆管癌等多种恶性肿瘤患者中呈现高表达,并与病人预后呈现负相关,提示PRR11基因高表达对于细胞增殖、侵袭迁移及体外成瘤等恶性表型具有重要作用。 | 张辉洁 Lian Zhang Yunlong Lei Ying Zhang Yi Li Youquan Bu Fangzhou Song Chundong Zhang | 2018 | 重庆医科大学学报2018，43，9： | 2 |
| 13 | Comparison of 16 slice multi-detector computed tomography and breath hold 3D magnetic resonance angiography in the detection of coronary stenosis显示文摘Objective To compare 16-slice multi-detector spiral computed tomography (MDCT) and breathhold 3D magnetic resonance (MR) coronary angiography in the visualization of coronary arteries and the accuracy of detecting significant (> 50%) coronary stenoses in patients with suspected coronary artery disease. Methods Forty patients were examined by 16-slice CT (GE, Lightspeedl6)and MR (GE,Twinspeed) within 3 days; 31 of them underwent conventional coronary angiography (CAG) within 2 weeks after CT and MR scan. CT was performed with 16× 1.25 mm detector collimation, 0.5 s rotation time and images were reconstructed at 60%-75% of the cardiac cycle. MR was performed with breath hold 3D FIESTA (TR4.0 ms, TE1.7 ms, flip angle 65, slice thickness 3 mm, FOV 280 mm, matrix 256× 192). Mean heart rate was 63 ± 5.8 bpm and β-blocker was used in 24 patients. MR and CT image quality was evaluated in 9 coronary segments (RCA1, RCA2, RCA3, LM, LAD1, LAD2, LAD3, LCX1, LCX2) using a four-point grading scale.Sensitivity, specificity, positive predictive value, negative predictive value and accuracy were calculated for detection of significant stenosis using CAG as the gold standard. Results 16-slice CT showed higher image quality in most coronary segments except RCA2.Forty-three segments were diagnosed as significant stenosis by CAG, 36 and 27 of these were correctly detected by CT and MR respectively. Sensitivity, specificity, positive predictive value, and negative predictive value of 16-slice CT and MR for detecting significant stenosis were 83 %, 84 %, 49 %, 97 % and 63 %, 90 %, 55 %, 93 %, respectively. Conclusion Sixteen-slice CT showed higher image quality in most coronary segments excepted for middle RCA. 16-slice CT had higher sensitivity than MR for detection of coronary significant stenosis, whereas MR had higher specificity than CT. Both CT and MR showed high negative predictive value,which is useful for excluding coronary stenosis in symptomatic patients. | Xin LIU Zulong CAI Youquan CAI Shaohong ZHAO Ningyu AN Yuangui GAO | 2006 | Journal of Geriatric Cardiology2006，3，1： | 2 |
| 14 | Acoustoelastic effects on mode waves in a fluid-filled pressurized borehole in triaxially stressed formations显示文摘基于 acoustoelasticity 的非线性的理论,认为 triaxial 是陆上的应力,在地上凿穿的液体静电干扰压力和液体非线性的效果联合,单极 Stoneley 波浪和偶极子的分散曲线曲折波浪在同类的各向同性的形成沿着地上凿穿轴宣传被使用不安方法调查。到频率的敏感系数和速度压力系数的关系也被分析。阶段速度分散的变化弄弯的结果表演被与第三顺序的有弹性的常数有关的三个敏感系数主要影响。曲折波浪的一个裂口和分散的交叉曲折波浪弄弯的地上凿穿压力集中原因在与单轴的水平压力方向平行、正常的方向极化了。导致压力的形成 anisotropy 仅仅依赖于水平吝啬的陆上的压力,附加压力和液体静电干扰的陆上的应力和独立人士迫使的水平 deviatoric。从 0 ~ 1 的水平陆上的压力比率减少导致压力的形成 anisotropy。这做曲折波浪分散曲线的交叉不可区分。模式波浪的分散曲线上的液体非线性的效果是小的并且能被忽略。 | Ping'en Li Youquan Yin Xianyue Su | 2006 | Acta Mechanica Sinica2006，22，6： | 2 |
| 15 | ^(68)Gallium-labelled PSMA-PET/CT as a diagnostic and clinical decision-making tool in Asian prostate cancer patients following prostatectomy显示文摘Objective: Prostate cancers(PCa) in Asian individuals are molecularly distinct from those found in their Caucasian counterparts.There is no risk stratification tool for Asian men with rapid biochemical recurrence(BCR) following radical prostatectomy(Rad P). This study aims to assess the detection rate of ^(68)Ga-prostate-specific membrane antigen-positron emission tomography/computed tomography(PSMA-PET/CT) for diagnosis of clinical recurrence and as a treatment decision making tool in Asian patients with BCR post-Rad P.Methods: ^(68)Ga PSMA-PET and CT body with/without bone scan [conventional workup(CWU)] were performed in 55 Asian patients with BCR within 36 months post-Rad P. Two blinded reviewers assessed the images. Detection rates of ^(68)Ga PSMAPET/CT were evaluated, and impact on management was reviewed by comparison with CWU.Results: Median time to BCR post-Rad P was 8.1 months. Detection rate for ^(68)Ga PSMA-PET/CT was 80%(44/55). A positive scan was significantly associated with increasing prostate-specific antigen(PSA) level [odds ratio(OR) = 1.13(95% CI 1.05–1.30), P =0.017], but not with higher Gleason grade or shorter PSA doubling time. Compared to CWU, ^(68)Ga PSMA-PET/CT detected an additional 106 lesions in 33/44 patients with a positive scan, resulting in a change in management in 25/44(56.8%) patients: 10 to hormonal therapy(HT) and whole pelvis radiotherapy(RT) in addition to bed RT, and 15 to palliative HT alone.Conclusions: In the present report, we demonstrated the diagnostic and treatment decision utility of ^(68)Ga PSMA-PET/CT in Asian men with rapid BCR. Detection of small volume nodal and systemic recurrences at low PSA levels(< 1.0 ng/mL) highlights the role of the tool in assigning patients to treatment intensification with HT-RT or palliative HT in polymetastatic disease. | Janice S.H.Tan Charles X.Y.Goh Yen Sin Koh Youquan Li Jeffrey K.L.Tuan Eu Tiong Chua Terence W.K.Tan Michael L.C.Wang Lui Shiong Lee Kae Jack Tay Ravindran Kanesvaran Chee Keong Toh Aaron K.T.Tong Winnie W.C.Lam Melvin L.K.Chua | 2019 | Cancer Biology & Medicine2019，16，1： | 2 |
| 16 | Important Green Chemistry and Catalysis: Non-phosgene Syntheses of Isocyanates - Thermal Cracking Way显示文摘 | Peixue Wang Shimin Liu Youquan Deng | 2017 | Chinese Journal of Chemistry2017，35，6： | 2 |
| 17 | Esterification of aliphatic acids with olefin promoed by Bronsted acidic ionic liquids显示文摘 | GU Yanlong SHI Feng DENG Youquan | 2004 | Journal of Molecular Catalysis A:Chemical2004，212，： | 1 |
| 18 | Alkylations of Benzene in Room Temperature Ionic Liquids Modified with HCl显示文摘 | Kun Q Youquan D | 2001 | Molecular Catalysis A : Chemical2001，171，： | 1 |
| 19 | Catalytic Beckmann Rearrangement of Ketoximes in Ionic Liquids显示文摘 | Jiajian Peng Youquan Deng | 2001 | Tetrahedron Letters2001，42，40： | 1 |
| 20 | 显示文摘 | Yanlong Gu Feng Shi Youquan Deng | 2003 | Catalysis Communications2003，4，： | 1 |
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