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| 1 | Clinicopathological features and the outcome of surgical management for adenocarcinoma of the appendix显示文摘AIM:To present a comprehensive analysis of incidence,clinicopathological features,appropriateness of surgical procedures,and survival for adenocarcinoma of the appendix.METHODS:A retrospective case analysis was conducted for the 10-year period 1998-2008.All patients diagnosed with adenocarcinoma of the appendix were analyzed for their demographics details,clinical features,tumor incidence and characteristics,tumor stage,surgical procedures performed,and their survival.RESULTS:Nine thousand three hundred and twentythree patients underwent appendectomies during the study period,and of these,10 (0.1%:8 men and 2 women with a mean age of 53.1 years,age range 21-83 years) were found to have primary adenocarcinoma of the appendix.Appendicular neoplasia was not suspected pre-operatively in any of the patients.Six (60%) patients underwent secondary right hemicolectomy.Four (40%) cases had appendectomy alone,and two of them died,whereas all those who underwent right hemicolectomy are alive and disease free.Five (50%) were reported to have grade 1 disease,three (30%) grade 2,and two (20%) grade 3 with mean survival of 34,48,and 22 mo,respectively.Six (60%) patients presented with advanced disease (Duke's C and D).At the end of follow up (mean period:37.9 mo),eight patients are alive and disease free at the end of follow up.Overall mean survival was 36.3 mo (conf idence interval;16%-56%) with 41.3 and 16 mo for men and women,respectively.Mean survival for those with and without lymph node involvement was 33.6 and 40.2 mo,respectively.Right hemicolectomy gave better results than appendectomy alone,although the difference was not statistically signif icant due to the small number of cases.CONCLUSION:Adenocarcinoma of the appendix is extremely rare neoplasm with varied presentations,and is usually advanced when diagnosed.Right hemicolectomy is the treatment of choice for such tumors. | Salman Yousuf Guraya Hamdi Hameed Almaramhy | 2011 | World Journal of Gastrointestinal Surgery2011，3，1： | 10 |
| 2 | Who benefits from percutaneous closure of patent foramen ovale vs medical therapy for stroke prevention? In-depth and updated metaanalysis of randomized trials显示文摘BACKGROUND A few randomized clinical trials(RCT) and their meta-analyses have found patent foramen ovale closure(PFOC) to be beneficial in prevention of stroke compared to medical therapy. Whether the benefit is extended across all groups of patients remains unclear.AIM To evaluate the efficacy and safety of PFOC vs medical therapy in different groups of patients presenting with stroke, we performed this meta-analysis of RCTs.METHODS Electronic search of PubMed, EMBASE, Cochrane Central, CINAHL and ProQuest Central and manual search were performed from inception through September 2018 for RCTs. Ischemic stroke(IS), transient ischemic attack(TIA), a composite of IS, TIA and systemic embolism(SE), mortality, major bleeding,atrial fibrillation(AF) and procedural complications were the major outcomes.Random-effects model was used to perform analyses.RESULTS Meta-analysis of 6 RCTs including 3560 patients showed that the PFOC,compared to medical therapy reduced the risk of IS [odds ratio: 0.34; 95%confidence interval: 0.15-0.78; P = 0.01] and the composite of IS, TIA and SE [0.55(0.32-0.93); P = 0.02] and increased the AF risk [4.79(2.35-9.77); P < 0.0001]. No statistical difference was observed in the risk of TIA [0.86(0.54-1.38); P = 0.54],mortality [0.74(0.28-1.93); P = 0.53] and major bleeding [0.81(0.42-1.56); P = 0.53]between two strategies. Subgroup analyses showed that compared to medical therapy, PFOC reduced the risk of stroke in persons who were males, ≤ 45 years of age and had large shunt or atrial septal aneurysm.CONCLUSION In certain groups of patients presenting with stroke, PFOC is beneficial in preventing future stroke compared to medical therapy. | Khagendra Dahal Adil Yousuf Hussam Watti Brannen Liang Sharan Sharma Jharendra Rijal Pavan Katikaneni Kalgi Modi Neeraj TANDon Michael Azrin Juyong Lee | 2019 | World Journal of Cardiology2019，11，4： | 4 |
| 3 | Computed tomography for pancreatic injuries in pediatric blunt abdominal trauma显示文摘AIM:To evaluate the efficacy of computed tomography scan in diagnosing and grading the pattern of pancreatic injuries in children. METHODS:We conducted a retrospective study to review medical files of children admitted with blunt pancreatic injuries to the Maternity and Children Hospital Al-Madina Al-Munawwarah, Kingdom of Saudi Arabia. The demographic details and mechanisms of injury were recorded. From the database of the Picture Archiving and Communication System of the radiology department, multidetector computed tomography (MDCT) images of the pancreatic injuries, severity, type of injuries and grading of pancreatic injuries were established. RESULTS:Seven patients were recruited in this study over a period of 5 years; 5 males and 2 females with a mean age of 7 years (age range 5-12 years). Fall from height was the most frequent mechanism of injury, reported in 5 (71%), followed by road traffic accident (1 patient, 14%) and cycle handlebar (1 patient, 14%) injuries. According to the American Association for the Surgery of Trauma grading system, 1 (14%) patient sustained Grade Ⅰ, 1 (14%) Grade Ⅱ, 3 (42%) GradeⅢ and 2 (28%) patients were found to have Grade Ⅴ pancreatic injuries. This indicated a higher incidence of severe pancreatic injuries; 5 (71.4%) patients were reported to have Grade Ⅲ and higher on the injury scale. Three (42%) patients had associated abdominal organ injuries. CONCLUSION: Pediatric pancreatic injuries due to blunt abdominal trauma are rare. The majority of the patients sustained extensive pancreatic injuries. MDCT findings are helpful and reliable in diagnosing and grad- ing the pancreatic injuries. | Hamdi Hameed Almaramhy Salman Yousuf Guraya | 2012 | World Journal of Gastrointestinal Surgery2012，4，7： | 3 |
| 4 | The pH of Cement-based Materials:A Review显示文摘Cement-based materials (CBMs),such as paste,mortar and concrete,are highly alkaline with an initial high pH of approximately 12.0 to 13.8.CBMs have a high pH due to the existing oxide mineral portlandite and alkali metal contents in Portland cement.The high pH of concrete provides excellent protection and reinforces the steel bars against corrosion.The pH of concrete does not remain constant due to ageing and other defect-causing factors,such as chloride ingress,alkali leaching,carbonation,corrosion,acid attack,moisture and biodegradation process.Reducing the concrete pH has negative impact on the strength,durability and service life of concrete buildings.However,the high pH of concrete may also cause concrete structure deterioration,such as alkali silica reaction,porosity and moisture related damages in concrete structures.The pH of CBMs can be influenced by high temperatures.For instance,the extremely high volume (85%-100%) of slag-blended cement pastes shows considerable pH reduction from 12.80 to 11.34 at 800 ℃.As many concrete structure deterioration are related to concrete pH,using an accurate and reliable method to measure pH and analyse the durability of reinforced concrete structure based on pH values is extremely important.This study is a comprehensive review of the pH of CBM in terms of measurement,limitations and varying values for different CBM types. | Sumra Yousuf Payam Shafigh Zainah Ibrahim | 2020 | Journal of Wuhan University of Technology(Materials Science)2020，35，5： | 3 |
| 5 | Giant mesenteric fibromatosis:Report of a case and review of the literature显示文摘Mesenteric fibromatosis poses a diagnostic and therapeutic challenge.This paper presents a 35-year-old female complaining of vague abdominal pain of 2 mo duration.Her computed tomography scan and magnetic resonance imaging revealed a pelvi-abdominal heterogenous mass with significant displacement of the small bowel and urinary bladder.She underwent surgical excision of the mass with resection and anastomosis of the involved loop of the small intestine.Histological examination confirmed mesenteric fibromatosis without infiltration of the bowel.The patient remained well during the 6 mo follow-up. | Mohammed Khalid Mirza Gari Salman Yousuf Guraya Amir Mounir Hussein Moustafa Mahmoud Nafady Hego | 2012 | World Journal of Gastrointestinal Surgery2012，4，3： | 3 |
| 6 | Evaluation of biomarkers, genetic mutations, and epigenetic modifications in early diagnosis of pancreatic cancer显示文摘BACKGROUND Pancreatic cancer(PC)is one of the deadliest malignancies with an alarming mortality rate.Despite significant advancement in diagnostics and therapeutics,early diagnosis remains elusive causing poor prognosis,marred by mutations and epigenetic modifications in key genes which contribute to disease progression.AIM To evaluate the various biological tumor markers collectively for early diagnosis which could act as prognostic biomarkers and helps in future therapeutics of PC in Kashmir valley.METHODS A total of 50 confirmed PC cases were included in the study to evaluate the levels of carbohydrate antigen 19-9(CA 19-9),tissue polypeptide specific antigen(TPS),carcinoembryonic antigen(CEA),vascular endothelial growth factor-A(VEGF-A),and epidermal growth factor receptor(EGFR).Mutational analysis was performed to evaluate the mutations in Kirsten rat sarcoma(KRAS),Breast cancer type 2(BRCA-2),and deleted in pancreatic cancer-4(DPC-4)genes.However,epigenetic modifications(methylation of CpG islands)were performed in the promoter regions of cyclin-dependent kinase inhibitor 2A(p16;CDKN2A),MutL homolog 1(hMLH1),and Ras association domain-containing protein 1(RASSF1A)genes.RESULTS We found significantly elevated levels of biological markers CA 19-9(P≤0.05),TPS(P≤0.05),CEA(P≤0.001),and VEGF(P≤0.001).Molecular genetic analysis revealed that KRAS gene mutation is predominant in codon 12(16 subjects,P≤0.05),and 13(12 subjects,P≤0.05).However,we did not find a mutation in DPC-4(1203G>T)and BRCA-2(617delT)genes.Furthermore,epigenetic modification revealed that CpG methylation in 21(P≤0.05)and 4 subjects in the promoter regions of the p16 and hMLH1 gene,respectively.CONCLUSION In conclusion,CA 19-9,TPS,CEA,and VEGF levels were significantly elevated and collectively have potential as diagnostic and prognostic markers in PC.Global data of mutation in the KRAS gene commonly in codon 12 and rare in codon 13 could augment the predisposition towards PC.Additionally,methylation of the p16 gene could also modulate transcription of genes thereby increasing the predisposition and susceptibility towards PC. | Bilal Rah Manzoor Ahmad Banday Gh Rasool Bhat Omar J Shah Humira Jeelani Fizalah Kawoosa Tahira Yousuf Dil Afroze | 2021 | World Journal of Gastroenterology2021，27，36： | 2 |
| 7 | Epidemiological aspects of Budd-Chiari in Egyptian patients:A single-center study显示文摘AIM:To describe the socio-demographic features,etiology,and risk factors for Budd-Chiari syndrome(BCS) in Egyptian patients.METHODS:Ninety-four Egyptian patients with confirmed primary Budd-Chiari syndrome were presented to the Budd-Chiari Study Group(BCSG) and admitted tothe Tropical Medicine Department of Ain Shams University Hospital(Cairo,Egypt) . Complete clinical evaluation and laboratory investigations,including a throm bophiliaworkup and full radiological assessment,were performed to determine underlying disease etiologies.RESULTS:BCS was chronic in 79.8% of patients,acute or subacute in 19.1%,and fulminant in 1.1%.Factor V Leiden mutation(FVLM) was the most common etiological cause of disease(53.1%) ,followed by mutation of the gene encoding methylene tetra-hydrofolate reductase(MTHFR) (51.6%) . Current orrecent hormonal treatment was documented in 15.5%of females,and BCS associated with pregnancy was present in 17.2% of females. Etiology could not be determined in 8.5% of patients. Males had significantly higher rates of MTHFR gene mutation and Beh et's disease,and females had significantly higher ratesof secondary antiphos pholipid antibody syndrome.A highly significant positive relation ship was evident between the presence of Beh et's disease and inferiorven a caval occlusion,either alone or combined with occlusion of the hepatic veins(P < 0.0001) .CONCLUSION:FVLM is the most common disease etiology and MTHFR the second most common in Egyptian BCS patients. BCS etiology tends to vary with geographic region. | Mohammad Sakr Eman Barakat Sara Abdelhakam Hany Dabbous Said Yousuf Mohamed Shaker Ahmed Eldorry | 2011 | World Journal of Gastroenterology2011，17，42： | 2 |
| 8 | Intelligent unit commitment with vehicle-to-grid —A cost-emission optimization显示文摘 | Ahmed Yousuf Saber Ganesh Kumar Venayagamoorthy | 2009 | Journal of Power Sources2009，，3： | 2 |
| 9 | 多浪羊与小尾寒羊皮下脂肪组织转录组分析显示文摘旨在探索多浪羊(D组)与小尾寒羊(X组)皮下脂肪组织中的特异性表达基因,并研究其潜在的作用,为理解绵羊脂肪组织发育规律以及对脂代谢相关疾病的预防和治疗研究提供依据。本研究选取脂肪沉积能力存在差异、健康无病、体况良好、种内个体体重相近(约50 kg)的雌性成年多浪羊和小尾寒羊为试验材料,分为D组(试验组)和X组(对照组),每组3个重复,采集位于背最长肌的皮下脂肪组织,应用RNA-Seq技术和生物信息学方法进行转录组测序并对结果进行分析。以|Fold change|≥2,P adjust≤0.05为标准筛选差异表达基因,通过对差异表达基因进行GO功能注释和KEGG通路富集分析,得到与脂肪沉积和脂代谢有关的差异基因。为了验证测序数据的可靠性,本研究随机选取了6个差异表达基因进行qRT-PCR验证。结果显示,在6个样本中共检测到38672个已知的mRNAs,新的mRNAs为1606个,在两组中共有839个差异表达基因,其中有320个差异基因在多浪羊组中上调表达,有519个差异基因在多浪羊组中下调表达。通过GO功能注释分析发现,差异表达基因主要参与脂质分解代谢过程、脂质生物合成过程、脂质分解代谢负调控过程、MAPK级联反应调控、对甘油三酯的反应等生物学过程。KEGG通路富集结果显示,差异表达基因显著富集到了PI3K-Akt、MAPK、胰岛素以及PPAR等信号通路中。qRT-PCR结果与测序结果一致,表明测序结果可靠。通过对多浪羊和小尾寒羊皮下脂肪组织进行转录组测序以及生物信息学分析,筛选到与脂肪沉积和脂代谢相关的差异表达基因,这些基因主要参与脂质生物合成、脂质代谢等过程,其中COL 1A1、AKT 2、SCD、LPL、PCK 1与PPP 2R5A可能在多浪羊与小尾寒羊的皮下脂肪组织的沉积与代谢中发挥重要作用。 | 刘天义 冯卉 Salsabeel Yousuf 解领丽 苗向阳 | 2021 | 畜牧兽医学报2021，52，12： | 2 |
| 10 | lncRNA在动物脂肪沉积中的研究进展显示文摘长链非编码RNA(long non-coding RNA,lncRNA),是一种长度大于200个核苷酸的调控性非编码RNA,能在转录水平、转录后水平及表观遗传水平等多个层面影响基因的表达。脂肪生成是一个复杂而有序的过程。大量研究表明,lncRNA在脂肪生成过程中扮演着重要角色,它可以影响脂质代谢及成脂分化等多种生物过程,从而间接影响肉品质。这对于提高畜禽肉品质、避免养殖业饲料过多转化成脂肪所导致的浪费以及对预防和治疗与脂肪代谢相关的疾病都具有重要意义。对lncRNA的基本特征、在动物脂肪沉积中的作用进展进行了综述,以期为培育优质畜禽,预防和治疗与脂肪代谢相关的疾病提供理论依据。 | 刘天义 冯卉 SALSABEEL Yousuf 解领丽 苗向阳 | 2021 | 中国生物工程杂志2021，41，11： | 2 |
| 11 | Dramatic response of hepatitis C patients chronically infected with hepatitis C virus genotype 3 to sofosbuvirbased therapies in Punjab, Pakistan: A prospective study显示文摘AIM To prospectively evaluate the efficacy of sofobuvir(SOF) in hepatitis C patients infected with hepatitis C virus(HCV) genotype 3 in Pakistan.METHODS The present study was performed with the coordination of gastroenterology and pathology departments of Shalamar Hospital Lahore from August 2014 to May 2016. The total number of patients included in this study was 1375 and all of them were infected with HCV genotype 3. On the basis of drug combinations, all the patients were separated into two groups. The first group of patients was treated for 24 wk with SOF(Sovaldi? by Gilead Sciences) plus ribavirin(RBV) [Ribazol? by Getz Pharma Pakistan(PVT) Ltd], while the patients of the second group were treated with SOF + RBV + pegylatedinterferon(peg IFN) alfa-2 a(Ropegra by Roach) for 12 wk. HCV genotyping and viral load measurement were performed on fully automated Abbott Real-Time PCR system(Abbott m24 sp automated nucleic acid extraction system and Abbott m2000 rt amplification system; abbott Molecular, Des Plaines, IL, United States). For the assessment of sustained virological response(SVR), all HCV RNA negative patients were followed for 12weeks after the treatment completion. Any patient with less than 12 IU/m L viral load after 12 wk of treatment completion was considered as a sustained virological responder(SVR-12).RESULTS A total of 1375 patients chronically infected with HCV genotype 3 were treated with two drug combinations SOF + RBV and SOF + RBV + peg IFN alfa-2 a. On the basis of these drug combinations, patients were divided into two groups(first and second). Overall SVR-12 was excellent in both groups(99.17% and 97.91%). Older patients(> 40 years) of second group showed lower SVR-12(93.46%) compared to first group older patients(98.79%), while in the younger patients of both groups, the SVR-12 rate was almost the same(99.54% in first group and 99.05% in second group). No such difference regarding SVR-12 rate was seen in males and females of first group patients(99.68% and 98.88%, respectively), while in second group the males were found to be better responders compared to females(98.96% and 95%). The SVR-12 rate in previously treated patients of first group was better(99.34%) than second group(93.70%), while na?ve patients of second group were marginally better responders(99.25%) than first group(97.80%). Rapid viral response at week-4 was found to be a very effective predictor for assessing the SVR rate at this stage of therapy in both groups. Headache, anemia and fatigue were common side effects in both groups either treated with SOF + RBV or SOF + RBV + peg IFN alfa-2 a, while the overall percentage of the side effects was higher in second group.CONCLUSION The remarkable SVR response rate of HCV genotype 3 infected patients to SOF provided a new way to look forward to eliminate hepatitis C from our region. | Sajjad Iqbal Muhammad Haroon Yousuf Muhammad Iftikhar Yousaf | 2017 | World Journal of Gastroenterology2017，23，44： | 2 |
| 12 | Hemolytic disease of the fetus and newbom caused by anti-D and anti-S alloantibodies: a case report显示文摘 | Yousuf R Sufia Abdul Aziz Yusof N | 2012 | J reed Case Reports2012，6，1： | 1 |
| 13 | Towards respiration management in radiation treatment of lung tumors:transferring regions of interest from planning CT to kilovoltage X-ray images显示文摘 | Ataer-Cansizoglu E Bas E Yousuf M | | 0，，： | 1 |
| 14 | Incidental diagnosis of intradural lumbar disc herniation during discography:a case report显示文摘 | Benyamin R Vallejo R Yousuf N | 2007 | Pain Pract2007，7，4： | 1 |
| 15 | Retrospective compari- son of an endoscopic assisted versus a purely endoscopic approach to sellar tumour resection 显示文摘 | Miner WW Sommer DD Yousuf K | 2008 | J Otolaryngol Head Neck Surg2008，37，6： | 1 |
| 16 | Chemica and physical effects of sodium lignosulfonate superplasticizer on the hydration of Portland cement and solidification/stabilization consequences显示文摘 | Yousuf A M Padmavathy Paltta Hess Thomas R | 1995 | Cemnt and Concrete Research1995，25，3： | 1 |
| 17 | Submental versus platysma flap for the reconstruction of complex facial defects following resection of head and neck tumors显示文摘 | Jawad Safdar Fa-Yu Liu Yousuf Moosa | 2014 | Oral Maxillofac Surg Clin North Am2014，26，3： | 1 |
| 18 | Intelligent unit commitment with vehicle-to-grid-A cost-emission optimization显示文摘 | Ahmed Yousuf Saber Ganesh Kumar Venayagamoorthy | 2010 | Journal of Power Sources2010，195，3： | 1 |
| 19 | Synthesis of polystyrene-clay nanocomposites via emulsion polymeri- zation using a reactive surfactant 显示文摘 | Syed Qutubuddin Xiao-an Fu Yousuf Tajuddin | 2002 | Polymer Bulletin2002，48，2： | 1 |
| 20 | High-sensitivity C reactive protein and cardiovascular disease:a resolute belief or an elusive link显示文摘 | Yousuf O Mohanty BD Martin SS | 2013 | J Am Coll Cardiol2013，62，5： | 1 |
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