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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Fast and Accurate Determination of K, Ca, and Mg in Human Serum by Sector Field ICP-MS 显示文摘 | Yu L L Davis W C Ordonez Y N | 2013 | Analytical and Bioanalytical Chemistry2013，405，27： | 1 |
| 3 | An adaptive Kalman filter for dynamic harmonic state estimation and harmonic injection tracking显示文摘 | Yu K K C Watson N R Arrillaga J | 2005 | IEEE Transactions on Power Delivery2005，20，2： | 1 |
| 4 | LIGHT, a New Member of the TNF Superfamily, and Lymphotoxin α Are Ligands for Herpesvirus Entry Mediator显示文摘 | Davide N Mauri Reinhard Ebner Rebecca I Montgomery Kristine D Kochel Timothy C Cheung Guo-Liang Yu Steve Ruben Marianne Murphy Roselyn J Eisenberg Gary H Cohen Patricia G Spear Carl F Ware | 1998 | Immunity1998，，： | 1 |
| 5 | Silicon nanowires prepared by laser ablation at high temperature 显示文摘 | Zhang Y F Tang Y H Wang N Yu D P Lee C S Bello I Lee S T | 1998 | Applied Physics Letters1998，72，15： | 1 |
| 6 | A novel density-tunable nanoeomposites of CdTe quantum dots linked to dendrimer-tethered multiwall carbon nanotubes显示文摘 | Zeng Y L Tang C R Wang H W Jiang J H Tian M N Shen G L Yu R Q | 2008 | Spectrochimica Acta Part A:Molecular and Biomolecular Spectroscopy2008，70，5： | 1 |
| 7 | Mesoporous Fe2O3-doped TiO2 nanostructured fibers with higher photocatalytic activity显示文摘 | Zhan S H Yang J Y Liu Y Wang N Dai J J Yu H B Gao X C Li Y | 2011 | Journal of Colloid and Interface Science2011，355，2： | 1 |
| 8 | 显示文摘 | Tho N D Chau N Yu S C | 2006 | J Magn Magn Mater2006，304，2： | 1 |
| 9 | Comparative study of anion polyacrylamide (APAM) adsorption-related fouling o a PVDF UF membrane and a modified PVDF UF membrane 显示文摘 | YiXS Shi W X Yu S L Sun N Jin L M Wang S Zhang B Ma C Sun L P | 2012 | Desalination2012，286，： | 1 |
| 10 | Coning and characterization of SYAP1, a down regulated gene in human hepatocellular carcinoma 显示文摘 | Yc C Yu YL Wang N | 2004 | Acta Biol Exp Sinica2004，34，4： | 1 |
| 11 | Identifying the radioactive coefficient of an evolutional type heat conduction equa-tion by optimization method显示文摘 | Deng Z C Yang L Yu J N | | 0，，： | 1 |
| 12 | An adaptive kalman filter for dynamic harmonic state estimation and harmonic injection tracking 显示文摘 | Yu K K C Watson N R Arrillaga J | 2005 | IEEE Transaction on Power Delivery2005，20，2： | 1 |
| 13 | Studies on the Effectiveness of NaFeEDTA-Forti ]ed Soy Sauce in Controlling Iron Deciency: A Population-Based Intervention Trial 显示文摘 | Chen J Zhao X Zhang X Yin S Piao J Huo J Yu B Qu N Lu Q Wang S Chen C | 2005 | Food and NutritionBulletin2005，26，2： | 1 |
| 14 | Biochemical compos-ition and nutritional value analysis of Chinese mitten crab, Eriocheir sinensis, grown in pond显示文摘 | Chen K Li E C Yu N | 2013 | Global Adv Res J Agricult Sci2013，2，6： | 1 |
| 15 | Neuronal androgen receptor regulates insulin sensitivity via suppression of hypothalamie NF-κB-mediated PTP1B expression 显示文摘 | Yu I C Lin H Y Liu N C | 2013 | Diabetes2013，62，2： | 1 |
| 16 | An LMS style variable taplength algorithm for structure adaptation 显示文摘 | GONG Yu COWAN C F N | 2005 | IEEE Transactions on Signal Processing2005，53，7： | 1 |
| 17 | Effects of CaF2 and CaCI2 addition on the formation of llCaO ~ 7A1203 ~ CaS solid solution in the CaO-A1203 slag显示文摘 | Lyu N N Yu J K Su C | 2013 | Metalurgia International2013，6，： | 1 |
| 18 | Graphene-Based Supercapacitor with an Ultrahigh Energy Density显示文摘 | Liu C J Yu Z N | 2010 | NanoLetters2010，10，12： | 1 |
| 19 | Optical and photocatalytic properties of composite TiO2/ZnO thin films显示文摘 | Giannakopoulou T Todorova N Giannouri M Yu J G Trapalis C | 2014 | Catalysis Today2014，230，： | 1 |
| 20 | Improvements of image sharing with steganography and authentication 显示文摘 | Yang C N Chen T S Yu K H ct al | 2007 | Journal of Systems and Software2007，80，7： | 1 |
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