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| 1 | Intensity modulated radiation therapy and chemotherapy for Ioca advanced pancreatic cancer:Results of feasibility study显示文摘AIM: To explore whether intensity modulated radiation therapy (IMRT) in combination with chemotherapy could increase radiation dose to gross tumor volume without severe acute radiation related toxicity by decreasing the dose to the surrounding normal tissue in patients with locally advanced pancreatic cancer.METHODS: Twenty-one patients with locally advanced pancreatic cancer were evaluated in this clinical trial,Patients would receive the dose of IMRT from 21Gy to 30Gy in 7 to 10 fractions within two weeks after conventional radiotherapy of 30Gy in 15 fractions over 3 weeks. The total escalation tumor dose would be 51, 54,57, 60Gy, respectively. 5-fluororacil (5-FU) or gemcitabine was given concurrently with radiotherapy during the treatment course.RESULTS: Sixteen patients who had completed the radiotherapy plan with doses of 51Gy (3 cases), 54Gy (3 cases), 57Gy (3 cases) and 60Gy (7 cases) were included for evaluation. The median levels of CA19-9 prior to and after radiotherapy were 716 U/ml and 255 U/ml respectively (P<0.001) in 13 patients who demonstrated high levels of CA19-9 before radiotherapy. Fourteen patients who suffered from pain could reduce at least 1/3-1/2 amount of analgesic intake and 5 among these patients got complete relief of pain. Ten patients improved in Kamofsky performance status (KPS). The median follow-up period was 8 months and one-year survival rate was 35 %. No patient suffered more than grade Ⅲ acute toxicities induced by radiotherapy.CONCLUSION: Sixty Gy in 25 fractions over 5 weeks with late course IMRT technique combined with concurrent 5-FU chemotherapy can provide a definitely palliative benefit with tolerable acute radiation related toxicity for patients with advanced pancreatic cancer. | Yong-RuiBai Guo-HuaWu Wei-JianGuo Xu-GongWu YuanYao YinChen Ren-HuaZhou Dong-QinLu | 2003 | World Journal of Gastroenterology2003，9，11： | 5 |
| 2 | Study of the performance of steel fiber reinforced concrete to water and saltfreezing condition显示文摘 | Ditao Niu Lei Jiang Min Bai Yuanyao Miao | 2013 | Materials and Design2013，44，： | 1 |
| 3 | Palladium-catalyzed cross-coupling of trifluoroisopropenylzinc reagent with halides显示文摘 | Biao Jiang Yuanyao Xu | 1992 | Tetrahedron Letts1992，33，4： | 1 |
| 4 | E-beam pat- reined gold nanodot arrays on optical fiber tips for localizedsurface plasmon resonance biochemical sensing显示文摘 | Lin Yongbin Zou Yang Mo Yuanyao | 2010 | Sensors2010，10，10： | 1 |
| 5 | An efficient protein preparation for proteomic analysis of developing cotton fibers by 2‐DE显示文摘 | YuanYao Yi‐WeiYang Jin‐YuanLiu | 2006 | ELECTROPHORESIS2006，，22： | 1 |
| 6 | Polymer-assisted synthesis of hydroxyapatite nanoparticle显示文摘 | Tseng Y H Kuo C S LI Yuanyao | 2009 | Materials Science and Engineering2009，29，3： | 1 |
| 7 | Properties of potassium titanate whisker reinforced polytetrafluoroethylene‐based friction materials of ultrasonic motors显示文摘 | YuFan Qing‐JunDing Zhi‐YuanYao | 2012 | J Appl Polym Sci2012，，5： | 1 |
| 8 | Synthesis, electrical measurement, and field emission properties ofa-Fe2O3 nanowires 显示文摘 | Hsu Lichieh Li Yuanyao Hsiao Chunyen | 2008 | Nanoscale Research Letters2008，3，9： | 1 |
| 9 | Activation studies of vapor-grown carbon fibers with supercritical fluids显示文摘 | Li Yuanyao Kazuhiro Mochidzuki Akiyoshi Sakoda | 2001 | Carbon2001，39，14： | 1 |
| 10 | Optimization of HPLC conditions for 15 naturally occurring protobererine type quaternary alkaloids 显示文摘 | Zhou Yuanyao Chen Yanxiang Zhu Bin | 1988 | Acia Pharm Sin1988，23，12： | 1 |
| 11 | QIAO Yong'an(乔永安),Several problem of calculative on tailings flow[J]显示文摘 | XU Yuanyao(许远瑶) | | 人民黄河0，，： | 1 |
| 12 | The importance of heat evolution during the overcharge process and the protection mechanism of electrolyte additives for prismatic lithiumion batteries显示文摘 | CHEN Y S HU Chichang LI Yuanyao | | 0，，01： | 1 |
| 13 | Ethylene thiourea exposure induces neurobehavioral toxicity in zebrafish by disrupting axon growth and neuromuscular junctions显示文摘Ethylene thiourea(ETU)converted from ethylene bisdithiocarbamate(EBDC)fungicides has aroused great concern because of its prevalence and harmful effects.Although ETU-induced neurotoxicity has been reported,the potential mechanisms remain unclear.This study provided insights into its neurotoxic effects at environmentally relevant concentrations in zebrafish.Our findings showed that embryonic exposure to ETU decreased the hatch rate and delayed somite development.Furthermore,ETU treatment significantly reduced the dark velocity in the locomotion assay.The upregulated tendency of the mitogen-activated protein kinases(MAPK)pathway(mknk1,atf4,mapkapk3)screened by transcriptome analysis implied motor neuron degeneration,which was validated by subsequent morphological observation,as axon length and branches were truncated in the 62.5μg/L ETU group.However,although the rescue experiment with a p38 MAPK inhibitor(SB203580)successfully ameliorated axon degeneration,it failed to reverse the locomotion behaviors.Further exploration of transcriptome data revealed the varied expression of presynaptic scaffold protein-related genes(pcloa,pclob,bsna),whose downregulation might impair the neuromuscular junction(NMJ).Therefore,we reasonably suspected that ETU-induced neurobehavioral deficits might result from the combined effects of the MAPK pathway and presynaptic proteins.Considering this,we highlighted the necessity to take precautions and early interventions for susceptible ETU-exposed populations. | Jingming Wang Zhiquan Yu Yongfeng Wang Yuanyao Chen Lin Xiao Yanjun Zong Qiyuan Feng Lianqi Peng Huiping Zhang Chunyan Liu | 2024 | Journal of Environmental Sciences2024，，3： | 0 |
| 14 | Liguzinediol protects against apoptosis induced by doxorubicin in H9C2 cells显示文摘OBJECTIVE Liguzinediol is a derivative of the natural active ingredient ligustrazine,and we found that liguzinediol has significant positive inotropic effects,which are stronger than that of TMP.Besides,it does not lead to arrhythmia,hypotension and other side effects.This study aims to investigate the anti-apoptotic effects of liguzinediolon H9C2 cells.METHODS Apoptotic H9C2 cells induced by DOX were observed by electron microscope and FCM analysis.The protein expressions of Bax,Bcl-2,caspases 3 and NF-κB were detected by Western blotting.RESULTS Apoptotic H9C2 cells induced by DOX were observed,but without apoptotic bodies in liguzinediol group.Declined peak of H9C2 cell apoptosis was seen in liguzinediol group by FCM analysis.And downregulation of Bax,caspases 3,NF-κB and upregulation of Bcl-2 were found by Western blotting.CONCLUSION Liguzinediol protected cardiomyocytes against apoptosis through downregulation of Bax and caspases 3 and upregulation of Bcl-2.Liguzinediol can inhibited cardiomyocyte apoptosis through the NF-κB signal pathway. | YuLI ChaoLIN Ya-yunZHANG YuanYAO XiangWU WeiLI Hui-minBIAN | 2015 | 中国药理学与毒理学杂志2015，29，S1： | 0 |
| 15 | Analysis of China Natural Gas Industry Prosperity Index for the 2nd Quarter of 2023显示文摘The statistics of the China Natural Gas Industry Prosperity Index showed that the China Natural Gas Industry Prosperity Index was 266.31 in the 2nd quarter of 2023,up 3.5%from the 1st quarter of 2023,a stably prosperous state in the short term and a very prosperous state in the medium to long term;the prosperity index of natural gas production companies was 371.69 in the 2nd quarter of 2023,up 5.1%from the 1st quarter of 2023,an increasingly prosperous state in the short term and a very prosperous state in the medium to long term. | Shen Xilin Zhou Cuilan Liang Wenhao Gao Yuanyao | 2023 | China Oil & Gas2023，30，3： | 0 |
| 16 | Impact of Economic Transformation on Energy Demand in Southwest China and Forecast显示文摘'Economic transformation'has become the main path to promote China's social and economic development,and many regions have increased the importance and attention to'economic transformation',and the Southwest region is no exception.Many cities in Southwest China are developing new energy sources to promote economic development and economic transformation.Economic transformation and economic development in Southwest China are mutually influencing and interacting,while energy development in Southwest China and its local economic development are mutually promoting and influencing,so economic transformation also affects energy demand and development in Southwest China.The importance of economic transformation should be taken into consideration. | Yuanyao Gao | 2022 | 经济管理学刊(中英文版)2022，11，2： | 0 |
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