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| 1 | Palaeoclihlatic Indicators of China's Quaternary Saline Lake Sediments and Hydrochemistry显示文摘In this paper the authors classify saline lake sediments into the cold, warm and eurythermal phases, reveal the consistency between the zoning of hydrochemical types of modern saline lake water and climatic zoning and give climatic parameters under the conditions of typical cold phase (mirabilite and natron), warm phase (thenar-dite) and slightly warm phase (bloedite) saline lake deposition. | ZHENG Mianping, ZHAO Yuanyi and LIU JunyingResearch & Development Center of Saline Lake and Epithermal Deposits,Chinese Academy of Geological Sciences, Beijing 100037 | 2000 | Acta Geologica Sinica(English Edition)2000，74，2： | 17 |
| 2 | Excavating bioactivities of nanozyme to remodel microenvironment for protecting chondrocytes and delaying osteoarthritis显示文摘Osteoarthritis(OA)is the main cause of disability in the elderly.Effective intervention in the early and middle stage of osteoarthritis can greatly prevent or slow down the development of the disease,and reduce the probability of joint replacement.However,there is to date no effective intervention for early and middle-stage OA.OA microenvironment mainly destroys the balance of oxidative stress,extracellular matrix synthesis and degradation of chondrocytes under the joint action of biological and mechanical factors.Herein,hollow Prussian blue nanozymes(HPBzymes)were designed via a modified hydrothermal template-free method.The aim of this study was to investigate the effects of HPBzymes on chondrocytes and the progression of OA.The intrinsic bioactivities of HPBzymes were excavated in vitro and in vivo,remodeling microenvironment for significantly protecting chondrocytes and delaying the progression of traumatic OA by inhibiting reactive oxygen species(ROS)and Rac1/nuclear factor kappa-B(NF-κB)signaling in a rat model.HPBzyme significantly diminished interleukin(IL)-1β-stimulated inflammation,extracellular matrix degradation,and apoptosis of human chondrocytes.HPBzyme attenuated the expression of Rac1 and the ROS levels and prevented the release and nuclear translocation of NF-κB.Deeply digging the intrinsic bioactivities of nanozyme with single component to remodel microenvironment is an effective strategy for ROS-associated chronic diseases.This study reveals that excavating the bioactivities of nanomedicine deserves attention for diagnosis and treatment of severe diseases. | Weiduo Hou Chenyi Ye Mo Chen Wei Gao Xue Xie Jianrong Wu Kai Zhang Wei Zhang Yuanyi Zheng Xiaojun Cai | 2021 | Bioactive Materials2021，6，8： | 5 |
| 3 | Clusterin as a serum biomarker candidate contributes to the lung fibroblasts activation in chronic obstructive pulmonary disease显示文摘Background:Fibrosis in the peripheral airways contributes to airflow limitation in patients with chronic obstructive pulmonary disease(COPD).However,the key proteins involved in its development are still poorly understood.Thus,we aimed to identify the differentially expressed proteins(DEPs)between smoker patients with and without COPD and elucidate the molecular mechanisms involved by investigating the effects of the identified biomarker candidate on lung fibroblasts.Methods:The potential DEPs were identified by isobaric tags for relative and absolute quantitation(iTRAQ)-based proteomic analysis.The messenger RNA and protein levels of clusterin(CLU)in COPD patients and 12%cigarette smoke extract(CSE)-treated human bronchial epithelial cells were determined at the indicated time points.Furthermore,anin vitro COPD model was established via the administration of 8%CSE to normal human lung fibroblasts(NHLFs)at indicated time points.The effects of CSE treatment andCLU silencing on proliferation and activation of lung fibroblasts were analyzed.Results:A total of 144 DEPs were identified between COPD patients and normal smokers.The iTRAQ-based proteomics and bioinformatics analyses identified CLU as a serum biomarker candidate.We also discovered that CLU levels were significantly increased(P<0.0001)in Global Initiative for Obstructive Lung Disease II,III,and IV patients and correlated(P<0.0001)with forced expiratory volume in 1 s(R=-0.7705),residual volume(RV)(R=0.6281),RV/total lung capacity(R=0.5454),and computerized tomography emphysema(R=0.7878).Similarly,CLU levels were significantly increased in CSE-treated cells at indicated time points(P<0.0001).The CSE treatment significantly inhibited the proliferation,promoted the inflammatory response,differentiation of NHLFs,and collagen matrix deposition,and induced the apoptosis of NHLFs;however,these effects were partially reversed byCLU silencing.Conclusion:Our findings suggest that CLU may play significant roles during airway fibrosis in COPD by regulating lung fibroblast activation. | Qiang Zhang Yuanyi Yue Rui Zheng | 2022 | Chinese Medical Journal2022，，9： | 1 |
| 4 | 2D antimonene-integrated composite nanomedicine for augmented low-temperature photonic tumor hyperthermia by reversing cell thermoresistance显示文摘The overexpression of heat shock proteins(HSPs)in tumor cells can activate inherent defense mechanisms during hyperthermia-based treatments,inducing thermoresistance and thus diminishing the treatment efficacy.Here,we report a distinct“non-inhibitor involvement”strategy to address this issue through engineering a calcium-based nanocatalyst(G/A@CaCO_(3)-PEG).The constructed nanocatalyst consists of calcium carbonate(CaCO_(3))-supported glucose oxidase(GOD)and 2D antimonene quantum dots(AQDs),with further surface modification by lipid bilayers and polyethylene glycol(PEG).The engineered G/A@CaCO_(3)-PEG nanocatalyst features prolonged blood circulation,which is stable at neutral pH but rapidly degrades under mildly acidic tumor microenvironment,resulting in rapid release of drug cargo in the tumor microenvironment.The integrated GOD effectively catalyzes the depletion of glucose for reducing the supplies of adenosine triphosphate(ATP)and subsequent down-regulation of HSP expression.This effect then augments the therapeutic efficacy of photothermal hyperthermia induced by 2D AQDs upon irradiation with near-infrared light as assisted by reversing the cancer cells’thermoresistance.Consequently,synergistic antineoplastic effects can be achieved via low-temperature photothermal therapy.Systematic in vitro and in vivo evaluations have demonstrated that G/A@CaCO_(3)-PEG nanocatalysts feature potent antitumor activity with a high tumor-inhibition rate(83.92%).This work thus paves an effective way for augmenting the hyperthermia-based tumor treatments via restriction of the ATP supply. | Jianrong Wu Xiaojun Cai Gareth R.Williams Zheying Meng Weijuan Zou Li Yao Bing Hu Yu Chen Yuanyi Zheng | 2022 | Bioactive Materials2022，7，4： | 0 |
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