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| 1 | Aqueous Self-Assembly of Block Copolymers to Form Manganese Oxide-Based Polymeric Vesicles for Tumor Microenvironment-Activated Drug Delivery显示文摘Molecular self-assembly is crucially fundamental to nature.However,the aqueous self-assembly of polymers is still a challenge.To achieve self-assembly of block copolymers [(polyacrylic acid-block-polyethylene glycol-block-polyacrylic acid(PAA68-b-PEG86-b-PAA68)] in an aqueous phase,manganese oxide(MnO2) is first generated to drive phase separation of the PAA block to form the PAA68-b-PEG68-b-PAA68/MnO2 polymeric assembly that exhibits a stable structure in a physiological medium.The polymeric assembly exhibits vesicular morphology with a diameter of approximately 30 nm and high doxorubicin(DOX) loading capacity of approximately 94%.The transformation from MnO2 to Mn2+caused by endogenous glutathione(GSH)facilitates the disassembly of PAA68-b-PEG68-b-PAA68/MnO2 to enable its drug delivery at the tumor sites.The toxicity of DOXloaded PAA68-b-PEG68-b-PAA69/MnO2 to tumor cells has been verified in vitro and in vivo.Notably,drug-loaded polymeric vesicles have been demonstrated,especially in in vivo studies,to overcome the cardiotoxicity of DOX.We expect this work to encourage the potential application of polymer self-assembly. | Yalei Miao Yudian Qiu Mengna Zhang Ke Yan Panke Zhang Siyu Lu Zhongyi Liu Xiaojing Shi Xubo Zhao | 2020 | Nano-Micro Letters2020，12，9： | 2 |
| 2 | Studies on the corrosion behavior of yttrium-implanted zircaloy-4显示文摘 | Jian Xu Xinde Bai Yudian Fan Wenliang Liu Hongbin Bei | 2000 | Journal of Materials Science2000，，24： | 1 |
| 3 | Effect of yttrium ion implantation on aqueous corrosion resistance of zircaloy-4显示文摘 | Jian Xu Xinde Bai An Jin Yudian Fan | 2000 | Journal of Materials Science Letters2000，，18： | 1 |
| 4 | The Air Oxidation of Yttrium Ion Implanted Zircaloy-4 at 500℃ 显示文摘 | Bai Xinde Xu Jian He Fei Fan Yudian | 2000 | Nuclear Instruments and Methods in Physics Research B2000，160，： | 1 |
| 5 | INTERFACIAL REACTIONS OF METAL FILMS WITH AlN SUBSTRATE显示文摘INTERFACIALREACTIONSOFMETALFILMSWITHAlNSUBSTRATEHeXiangjun;TaoKun;FanYudian(DepartmentofMaterialsScienceandEngineering,Tsingh... | He Xiangjun Tao Kun Fan Yudian (Department of Materials Science and Engineering, Tsinghua University, Beijing 100084) | 1996 | 中国有色金属学会会刊:英文版1996，6，2： | 1 |
| 6 | The Influence of Yttrium Ion Implantation on the Oxidation Behavior of Zircaloy-4 at 600 °C显示文摘 | Fei He Xinde Bai Jian Xu Sheguan Wang Jin An Zhiying Sun Yudian Fan | 1999 | Journal of Materials Science Letters1999，，9： | 1 |
| 7 | lnfluence of the carbon source on biological activity and morphology of Bacillus thuringiensis parasporal crystals 显示文摘 | Yudian T F Salamakha O V Olekhnovich EV | 1992 | Microbiology(Moscow)1992，61，： | 1 |
| 8 | Studies on the corrosion behavior of yttrium-implanted zircaloy-4显示文摘 | Jian Xu Xinde Bai Yudian Fan Wenliang Liu Hongbin Bei | 2000 | Journal of Materials Science2000，，24： | 1 |
| 9 | Effect of yttrium ion implantation on aqueous corrosion resistance of zircaloy-4显示文摘 | Jian Xu Xinde Bai An Jin Yudian Fan | 2000 | Journal of Materials Science Letters2000，，18： | 1 |
| 10 | 3-Hydroxybutyrate ameliorates insulin resistance by inhibiting PPARγSer273 phosphorylation in type 2 diabetic mice显示文摘3-Hydroxybutyrate(3HB)is a small ketone body molecule produced endogenously by the body in the liver.Previous studies have shown that 3HB can reduce blood glucose level in type 2 diabetic(T2D)patients.However,there is no systematic study and clear mechanism to evaluate and explain the hypoglycemic effect of 3HB.Here we demonstrate that 3HB reduces fasting blood glucose level,improves glucose tolerance,and ameliorates insulin resistance in type 2 diabetic mice through hydroxycarboxylic acid receptor 2(HCAR2).Mechanistically,3HB increases intracellular calcium ion(Ca^(2+))levels by activating HCAR2,thereby stimulating adenylate cyclase(AC)to increase cyclic adenosine monophosphate(cAMP)concentration,and then activating protein kinase A(PKA).Activated PKA inhibits Raf1 proto-oncogene serine/threonine-protein kinase(Raf1)activity,resulting in a decrease in extracellular signal-regulated kinases 1/2(ERK1/2)activity and ultimately inhibiting peroxisome proliferator-activated receptorγ(PPARγ)Ser273 phosphorylation in adipocytes.Inhibition of PPARγSer273 phosphorylation by 3HB altered the expression of PPARγregulated genes and reduced insulin resistance.Collectively,3HB ameliorates insulin resistance in type 2 diabetic mice through a pathway of HCAR2/Ca^(2+)/cAMP/PKA/Raf1/ERK1/2/PPARγ. | Yudian Zhang Zihua Li Xinyi Liu Xinyu Chen Shujie Zhang Yuemeng Chen Jiangnan Chen Jin Chen Fuqing Wu Guo-Qiang Chen | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 0 |
| 11 | Gender Recognition by MULBP显示文摘Gender recognition has gained more attention. However, most of the studies have focused on face images acquired under controlled conditions. In this paper, we investigate gender recognition on real-life faces. We proposed a gender recognition scheme, which is composed of four parts: face detection, median filter, feature extraction, and gender classifier. MULBP features are adopted and combined with a SVM classifier for gender recognition. The MULBP feature is robust to noise and illumination variations. In the experiment, we obtain 98.32% using LFW database and 97.30% on Samsung Gender dataset, which shows the superior performance in gender recognition compared with the conventional operators. | Yudian JI Chuang GAN | 2013 | 软件2013，34，1： | 0 |
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