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	题名	作者	年代	出处	被引量
1	Irsogladine maleate and rabeprazole in non-erosive reflux disease: A double-blind, placebo-controlled study显示文摘AIM:To evaluate the efficacy of adding irsogladine maleate(IM) to proton-pump inhibitor(PPI) therapy in non-erosive reflux disease(NERD) treatment.METHODS:One hundred patients with NERD were recruited and randomized to receive rabeprazole plus IM(group I) or rabeprazole plus placebo(group P).The efficacy of the treatment was assessed using the Frequency Scale for the Symptoms of Gastroesophageal Reflux Disease(FSSG) and the short form(SF)-36 quality of life questionnaires after four weeks of treatment.We also assessed whether patients with NERD with minimal changes(grade M) had different responses to the therapies compared with patients who did not have minimal changes(grade N).RESULTS:Group I and group P showed significant improvements in their FSSG scores after the treatment(from 17.9 ± 7.9 to 9.0 ± 7.6, and from 17.7 ± 7.3 to 11.2 ± 7.9, respectively, P = 0.0001), but there was no statistically significant difference between the FSSG scores in group I and those in group P.Subgroup analysis showed that significant improvements in the FSSG scores occurred in the patients in group I who had NERD grade N(modified Los Angeles classification)(7.8 ± 7.4 vs 12.5 ± 9.8, P = 0.041).The SF-36 scores for patients with NERD grade N who had received IM and rabeprazole were significantly improved in relation to their vitality and mental health scores.CONCLUSION:The addition of IM to rabeprazole significantly improves gastroesophageal reflux diseasesymptoms and the quality of the lives of patients with NERD grade N.	Takayoshi Suzuki Masashi Matsushima Aya Masui Shingo Tsuda Jin Imai Jun Nakamura Yoko Tsukune Tetsufumi Uchida Hiroki Yuhara Muneki Igarashi Jun Koike Tetsuya Mine	2015	World Journal of Gastroenterology2015，21，16：	8
2	Meta‐analysis: the risk of venous thromboembolism in patients with inflammatory bowel disease显示文摘	H. Yuhara C. Steinmaus D. Corley J. Koike M. Igarashi T. Suzuki T. Mine	2013	Aliment Pharmacol Ther2013，，10：	5
3	Pharmacologic prophylaxis of post-endoscopic retrograde cholangiopancreatography pancreatitis: protease inhibitors and NSAIDs in a meta-analysis显示文摘	Hiroki Yuhara Masami Ogawa Yoshiaki Kawaguchi Muneki Igarashi Tooru Shimosegawa Tetsuya Mine	2014	Journal of Gastroenterology2014，，3：	2
4	Dynamic modeling and simulation of a flexible robotic manipulator 显示文摘	Gamarra-Rosado V O Yuhara E A O	1999	Robotics1999，17，5：	1
5	A case of bladder tumor producing granulocyte colony-stimulating factor显示文摘	Ishida K Yuhara K Kanimoto Y	2004	Hinyoki- ka Kiyo2004，50，4：	1
6	PACAP and NGF cooperatively enhance choline acetyltransferase activity in postnatal basal forebrain neurons by complementary induction of its different mRNA species 显示文摘	Yuhara A Ishii K Nishio C	2003	Biochem Biophys Res Commun2003，301，2：	1
7	PACAP has a neurotrophie effect on cultured basal forebrain cholinergic neurons from adult rats显示文摘	Yuhara A Nishio C Abiru Y	2001	Brain Res Dev Brain Res2001，131，12：	1
8	JNdi-l: A neodymium isotopic reference in consistency with Lalolla neodymium 显示文摘	Tanaka T Togashi S Kamioka H Amakawa H Kagami H Hamamoto T Yuhara M Orihashi Y J Yoneda S Shimizu H Kunimaru T Takahashi K Yanagi T Nakano T Fujimaki H Shinjo R Asahara Y Tanimizu M Dragusanu C	2000	Chemical Geology2000，168，：	1
9	Optimizing parameters for fiat-panel detector digital tomosynthesis 显示文摘	Machida H Yuhara T Mori T	2010	Radiographics2010，30，2：	1
10	Dynamic modeling andsimulation of a flexible robotic manipulator显示文摘	Gamarra2Rosado VO Yuhara EAO	1999	Robotics1999，17，5：	1
11	Dynamic modeling and simulation of a flexible robotic manipulator 显示文摘	Yuhara E A O	1999	Robotics1999，17，5：	1
12	Commercial Applications of Mass-Produced Fiber Optic Gyros显示文摘	Kajioka H Kumagai T Yuhara T		0，，：	1
13	A Review of Four Wheel Steering Studies from the Viewpoint of Vehicle Dynamics and Control显示文摘	Furukawa Y Yuhara N Sano S	1989	Vehicle System Dynamics1989，18，1：	1
14	Postoperative follow-up of olecranon fracture by digital tomosynthesis radiography显示文摘	Machida H Yuhara T Sabol JM	2011	Jpn J Radiol2011，29，8：	1
15	Advanced Steering SystemAdaptable to Lateral Control Task and Driver,s Inten-tion 显示文摘	YUHARA N TAJIMA J	2001	Vehicle System Dynamics2001，36，23：	1
16	Optimizing parameters for flat-panel detector digital tomosynthesis显示文摘	Machida H Yuhara T Mori T	2010	Radingraphics2010，30，2：	1
17	Pharmacologic prophylaxis of post-endoscopic retrograde cholangiopancreatography pancreatitis: protease inhibitors and NSAIDs in a meta-analysis 显示文摘	Yuhara H Ogawa M Kawaguchi Y	2014	J Gastroenterol2014，49，3：	1
18	An Analytical Approach to the Prediction of Handling Qualities of Vehicles with Advanced Steering Control System Using Multi-input Driver Model 显示文摘	SHINICHIRO Horiuchi NAOHIRO Yuhara	2000	Journal of Dynamic Systems Measurement and Control2000，122，：	1
19	Dynamic modeling and simulation of a flexible robotic manipulator 显示文摘	Gamarra-Rosado V O Yuhara E A O	1999	Robotica1999，17，5：	1
20	Methods of extracting potential undercut and determining optimum withdrawal direction for mold designing 显示文摘	MACHIZUKI T YUHARA N	1992	Int J Jpn Soe Pree Eng1992，26，：	1

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