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| 1 | Biofunctional magnesium coated Ti6Al4V scaffold enhances osteogenesis and angiogenesis in vitro and in vivo for orthopedic application显示文摘The insufficient osteogenesis and osseointegration of porous titanium based scaffold limit its further application.Early angiogenesis is important for scaffold survival.It is necessary to develop a multifunctional surface on titanium scaffold with both osteogenic and angiogenic properties.In this study,a biofunctional magnesium coating is deposited on porous Ti6Al4V scaffold.For osseointegration and osteogenesis analysis,in vitro studies reveal that magnesium-coated Ti6Al4V co-culture with MC3T3-E1 cells can improve cell proliferation,adhesion,extracellular matrix(ECM)mineralization and ALP activity compared with bare Ti6Al4V cocultivation.Additionally,MC3T3-E1 cells cultured with magnesium-coated Ti6Al4V show significantly higher osteogenesisrelated genes expression.In vivo studies including fluorochrome labeling,micro-computerized tomography and histological examination of magnesium-coated Ti6Al4V scaffold reveal that new bone regeneration is significantly increased in rabbits after implantation.For angiogenesis studies,magnesium-coated Ti6Al4V improve HUVECs proliferation,adhesion,tube formation,wound-healing and Transwell abilities.HUVECs cultured with magnesium-coated Ti6Al4V display significantly higher angiogenesis-related genes(HIF-1αand VEGF)expression.Microangiography analysis reveal that magnesium-coated Ti6Al4V scaffold can significantly enhance the blood vessel formation.This study enlarges the application scope of magnesium and provides an optional choice to the conventional porous Ti6Al4V scaffold with enhanced osteogenesis and angiogenesis for further orthopedic applications. | Peng Gao Bo Fan Xiaoming Yu Wenwen Liu Jie Wu Lei Shi Di Yang Lili Tan Peng Wan Yulin Hao Shujun Li Wentao Hou Ke Yang Xiaokang Li Zheng Guo | 2020 | Bioactive Materials2020，5，3： | 15 |
| 2 | Macrophage-activating lipopeptide-2 downregulates the expression of ATP-binding cassette transporter A1 by activating the TLR2/ NF-KB/ZNF202 pathway in THP-1 macrophages显示文摘 | Liangjie Peng Zizhen Zhang Min Zhang Xiaohua Yu Feng Yao Yulin Tan Dan Liu Duo Gong Huang Chong Xiaoyan Liu Xilong Zheng Guoping Tian Chaoke Tang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，4： | 6 |
| 3 | Magnetic granulometry of recent sediments from the Huguang Maar and its implication for provenience显示文摘To understand the origin and its climatic implications of the Huguang Maar sediments, we conducted laser grain size analysis and rock mangtic measurement for the recent deposits from the Huguang Maar and for the volcanic rocks of the caldera for comparison. The grain size distributions are dominated by clayey silts for both the bulk sediments and magnetic separates. Acquisition of isothermal remanent magnetization (IRM) and thermal demagnetization of IRM suggest (titano) magnetite as the dominating magnetic mineral in the sediments; high coercivity minerals are not detected. Therefore, the ratio of the susceptibility of anhysteretic remanent magnetization (kARM) to the weak field magnetic susceptibility (k), kARM/k can be used to estimate the grain size of magnetite. The sediments and volcanic rocks yield values of 13.7 and 11.8 for the kARM/k, respectively, corresponding to grain size values of ~0.03 μm and ~0.05 μm. The magnetic granulometry of lake sediments is distinctive from one of the Chinese loess, in which published data suggest a value of 6.0 for kARM/k, and grain size of ~0.1 μm, but is akin to the nearby volcanic rocks. Although a Loess Plateau source of the lake sediments cannot be fully ruled out, the catchment is most probably the main source. We explain the slightly finer magnetite grain size in sediments than in the volcanic rocks as being disintegrated of particles during erosion and transportation. We conclude that there is no evidence for aeolian input of the Loess Plateau dusts into the Huguang Maar, and the relationship between magnetic parameters of the lake sediments and winter monsoon intensity is probably more complicated than previously thought. | HAN YuLin TAN XiaoDong CHEN Zhong XIANG Rong ZHANG LanLan | 2010 | Chinese Science Bulletin2010，55，4： | 4 |
| 4 | Cretaceous synfolding remagnetization components revealing tectonic rotation of the middle Yangtze fold belt显示文摘To reveal the deformation process of the middle Yangtze fold belt, we conducted a paleomagnetic study on Middle Triassic limestones and Middle to Late Jurassic sandstones from Wanzhou, Chongqing. Stepwise thermal and alternating field demagnetization were used to isolate the multi-component re- manent magnetizations. The Jurassic samples were overprinted by recent geomagnetic field, while three magnetization components were isolated from the Middle Triassic samples. A low temperature component (LTC) was isolated at temperatures below 200℃, an intermediate temperature component (ITC) at 200―360℃ and a high temperature component (HTC) at 400―460℃. The LTC is distributed around the present-day Earth magnetic field, probably a viscous component. Stepwise unfolding indi- cates that the maximum precision parameters of ITC and HTC components are achieved at 33±8% and 50±27% (with 95% confidence) unfolding, respectively. The best-clustered ITC mean direction, Dec = 11.2°, Inc = 45.2° (α95 = 4.5°, N = 34), corresponding to a paleopole at 79.3°N, 219.5°E (dp = 3.6°, dm = 5.7°), is consistent with the Cretaceous reference direction of the South China Block (SCB). The best-clustered HTC mean direction (taking 70% unfolding), Dec = 24.2°, Inc =49.0° (α95 = 3.6°, N = 23), corresponding to a paleopole at 69.2°N, 195.5°E (dp =3.1°, dm = 4.8°), suggests a clockwise rotation of 12.8°±3.5°. These synfolding remagnetization components clearly reveal that a clockwise rotation happened at the middle stage of folding, thus supporting that at least part of the variation in fold axis strikes is due to orocline rotation. Combined with published data, our analysis indicates that the Wan- zhou-Xiangxi segment of the middle Yangtze fold belt experienced oroclinal bending. Furthermore, a published post-folding component isolated from the Middle Triassic Puqi Formation suggests a 27.5°±5.8° clockwise rotation, confirming that at least 50% of the observed clockwise rotations in the eastern middle Yangtze fold belt can be attributed to oroclinal bending. The remagnetization data and geological evidence observed in the middle Yangtze fold belt suggest that collision between SCB and North China Block (NCB) probably lasted till the early period of Early Cretaceous. | ZHANG Hui TAN XiaoDong HAN YuLin | 2007 | Chinese Science Bulletin2007，52，20： | 4 |
| 5 | Multi-omic characterization of genome-wide abnormal DNA methylation reveals diagnostic and prognostic markers for esophageal squamous-cell carcinoma显示文摘This study investigates aberrant DNA methylations as potential diagnosis and prognosis markers for esophageal squamous-cell carcinoma(ESCC),which if diagnosed at advanced stages has<30%five-year survival rate.Comparing genome-wide methylation sites of 91 ESCC and matched adjacent normal tissues,we identified 35,577 differentially methylated CpG sites(DMCs)and characterized their distribution patterns. | Yiyi Xi Yuan Lin Wenjia Guo Xinyu Wang Hengqiang Zhao Chuanwang Miao Weiling Liu Yachen Liu Tianyuan Liu Yingying Luo Wenyi Fan Ai Lin Yamei Chen Yanxia Sun Yulin Ma Xiangjie Niu Ce Zhong Wen Tan Meng Zhou Jianzhong Su Chen Wu Dongxin Lin | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 2 |
| 6 | Calcium channel blockers and Alzheimer's disease显示文摘Alzheimer's disease is characterized by two pathological hallmarks: amyloid plaques and neurofi-brillary tangles. In addition, calcium homeostasis is disrupted in the course of human aging. Recent research shows that dense plaques can cause functional alteration of calcium signals in mice with Alzheimer's disease. Calcium channel blockers are effective therapeutics for treating Alzheimer's disease. This review provides an overview of the current research of calcium channel blockers in-volved in Alzheimer's disease therapy. | Yi Tan Yulin Deng Hong Qing | 2012 | Neural Regeneration Research2012，7，2： | 2 |
| 7 | Existence and uniqueness of smooth solution for the system of ferro-magnetic chain显示文摘 | Zhou Yulin Guo Boling Tan Shaobin | 1991 | Science in China1991，，： | 2 |
| 8 | The opposite prognostic significance of nuclear and cytoplasmic p21 expression in resectable gastric cancer patients显示文摘 | Yefei Huang Weimin Wang Yansu Chen Yulin Huang Jianbing Zhang Song He Yongfei Tan Fulin Qiang Aiping Li Oluf Dimitri R?e Shouyu Wang Yan Zhou Jianwei Zhou | 2014 | Journal of Gastroenterology2014，，11： | 2 |
| 9 | Dynamic Analyses of a Simply Supported Double-Beam System Subject to a Moving Mass with Fourier Transform Technique显示文摘In order to study the dynamic characteristics of a simply supported double-beam system under a moving mass,the system of fourth-order dynamic partial differential equations of a simply supported double-beam system was transformed into a system of second-order dynamic ordinary differential equations relative to time coordinates by performing the finite sin-Fourier Transform relative to space coordinates.And the analytical solution of the dynamic response of the simply supported double-beam system under a moving mass was obtained by solving the system of dynamic ordinary differential equations.The analytical method and ANSYS numerical method were used to calculate the dynamic responses of several simply supported double-beam systems under a moving mass at different speeds.The influences of inertial effect,mass movement speed,and Winkler-layer spring stiffness and damping on the dynamic responses of simply supported double-beam systems were analyzed.According to the study results,the analytical calculation results in this paper fit well with the ANSYS finite element numerical calculation results,demonstrating the rationality of the analytical method.The inertial effect has a significant influence on the dynamic response characteristics of the simply supported double-beam system.The simply supported double-beam system underwent several resonant speeds under a moving mass,and the Winkler-layer spring stiffness has a relatively significant effect on the vibration of the first beam. | Lizhong Jiang Xilin Chai Zhihua Tan Wangbao Zhou Yulin Feng Zhipeng Lai Lan Zheng | 2019 | Computer Modeling in Engineering & Sciences2019，，10： | 1 |
| 10 | Crystallography,Packing Mode,and Aggregation State of Chlorinated Isomers for Efficient Organic Solar Cells显示文摘Revealing the molecular packing,intermolecular interactions,and aggregation behaviors in the nanocrystalline bulk heterojunction(BHJ)domains undertake the tasks for future materials design for efficient solar cells,especially in understanding the structure–property relationship of isomeric non-fullerene acceptors(NFAs).Theoretical calculations reveal that 2ClIC-βδ,withβ-andδ-chlorine-substituted terminal groups,achieves a relatively higher dipole moment for enhanced intermolecular interactions.More importantly,when comparing the single-crystal X-ray diffraction patterns of three isomeric NFAs,BTIC-BO4Cl-βδ,BTIC-BO4Cl-βγ,and BTIC-BO4Cl,the synergistic effect of chlorine atoms at theβ-andδ-positions endows BTIC-BO4Cl-βδbetter molecular planarity with a dihedral angle of 1.14°.In turn,this creates the shortestπ∙∙∙πdistance(3.28Å)and smallest binding energies(−51.66 kcal mol^(−1))of the three NFAs,resulting in the tightest three-dimensional network packing structure with a framework of L_(x)=14.0Åand L_(y)=13.6Å.Such a structure has multiple intermolecular interactions for better charge transfer.However,the chlorine atomat theγ-position in the other two isomers contributes to non-intermolecular interactions with subordinate packing arrangements.Subsequently,the red-shifted UV-absorption and higher electron mobility observed in neat films of BTIC-BO4Cl-βδagree well with its more ordered crystallinity.This leads to a more suitable fiber-like phase separation in the corresponding active blend,ultimately improving the device performance with superior charge transport.As a result,the highest power conversion efficiency of 17.04%with a current density of 26.07 mA cm^(−2)was obtained with the BTIC-BO4Cl-βδ-based device.The carrier dynamics test and grazing incidence wide-angle X-ray scattering measurement indicate that the packing arrangement of molecules in the nanocrystalline BHJ domains is consistent with their crystallinity.This work investigates the structure–property differences in three acceptors and emphasizes the effect of isomeric chlorine substitution,which suggests that changes in the crystal packing arrangement,especially the size of the framework,have a considerable influence on charge carrier transport and ultimately are reflected on the device efficiency elevation. | Hanjian Lai Xue Lai Zi-Yi Chen Yulin Zhu Hengtao Wang Hui Chen Pu Tan Yiwu Zhu Yuanzhu Zhang Feng He | 2023 | CCS Chemistry2023，5，5： | 1 |
| 11 | Stretchable graded multichannel self-powered respiratory sensor inspired by shark gill显示文摘Respiratory sensing provides a simple,non-invasive,and efficient way for medical diagnosis and health monitoring,but it relies on sensors that are conformal,accurate,durable,and sustainable working.Here,a stretchgll structure can convert transverse elastic deformation into longitudinal elastic deformation during stretching.able,multichannel respiratory sensor inspired by the structure of shark gill cleftis reported.The bionic shark Combining the optimized bionic shark gll structure with the piezoelectric and the triboelectric effect,the bionic shark gill respiratory sensor(BSG-RS)can produce a graded electrical response to different tensile strains.Based on this feature,BSG-RS can simultaneously monitor the breathing rate and breathing depth of the human body accurately,and realize the effective recognition of the different human body's breathing state under the supporting software,With good stretchability,wearabilit,acuracy,and long-term stability(50,0oo cycles),BSG-RS is expected to be applied as self-powered smart wearables for mobile medical diagnostic analysis in the future. | Yang Zou Yansong Gai Puchuan Tan Dongjie Jiang Xuecheng Qu Jiangtao Xue Han Ouyang Bojing Shi Linlin Li Dan Luo Yulin Deng Zhou Li Zhong Lin Wang | 2022 | Fundamental Research2022，2，4： | 1 |
| 12 | Emergy Analysis of the Agricultural Eco-economic System in Dongting Lake Area of Hunan Province显示文摘[Objective]The research aimed to discuss eco-efficiency of the agro-ecosystem in Dongting Lake area of Hunan.[Method]By referring to emergy research method,emergy structure,function and efficiency of the system were analyzed according to emergy input-output data of the system in 2009.[Result]The system had developed economy,and mechanization and modernization degrees were higher.Emergy output of the system was unbalanced,and market pricing of the agricultural product was significantly lower,especially farming product.Seen from sustainable development index and environmental loading ratio of the system,the system was full of vitality and development potential.The pressure of natural resources and environment was not very great,but the system accommodated too many populations.[Conclusion]Basic direction of the agricultural policy in the zone was further shortening industrial and agricultural price scissors,continuing to implement price protection of the farming product,adjusting agricultural and product structures and transferring surplus labor. | Yulin Zhu Chang Tan Mingjie Li Yuzi Long Maoxi Wang Maozhang Hou Xiaomin Li | 2013 | Meteorological and Environmental Research2013，4，11： | 0 |
| 13 | Togni-ⅡReagent Mediated Selective Hydrotrifluoromethylation and Hydrothiolation of Alkenes显示文摘Based on the redox reactions of Togni-Ⅱreagent and thiols,a thiol-tuned selective functionalization of unactivated olefins was disclosed.In combination with aryl thiols,stoichiometric amount of Togni-Ⅱreagent prompted a hydrotrifluoromethylation of alkenes,in which,aryl thiols played as reductant and hydrogen source;while by utilization of alkyl thiols,catalytic amount of Togni-Ⅱreagent initiated thiol-ene and thiol-yne reactions.The reported applications are characterized by their operational simplicity and wide functional group tolerance. | Shuang Teng Lingkui Meng Bingbing Xu Guangsheng Tu Peng Wu Zhiwen Liao Yulin Tan Jian Guo Jing Zeng Qian Wan | 2021 | Chinese Journal of Chemistry2021，39，12： | 0 |
| 14 | Puerarin mediated miR-30b-5p targeting fibroblast activation protein against oral submucous fibrosis显示文摘Background:Puerarin(Pue)has been reported to be a natural active ingredient with multiple antifibrotic properties.This work aimed at exploring the function of Pue in oral submucousfibrosis(OSF)treatment.Methods:Human oral mucosafibroblasts(hOMF)were induced with transforming growth factor beta1(TGF-β1)and intervened with Pue.Expressions offibrosis-related markers were analyzed by Western blot and IF staining.Cell viability was characterized by the CCK-8 assay.Expressions of miR-30 family members were quantified by qRT-PCR.The correlation betweenfibroblast activation protein(FAP)and miR-30 family expression was evaluated by the Pearson correlation coefficient.Bioinformatics prediction and dual-luciferase reporter assay were employed to verify the regulation between FAP and miR-30b-5p.The specific mechanism of Pue on OSF was explored through the promotion or inhibition of miR-30b-5p.Results:After induction by TGF-β1,hOMF showed upregulated Collagen I,Collagen III,and FAP expressions,while miR-30 family expression was downregulated with miR-30b-5p being the most significant.Pue intervention inhibited the excessive proliferation of TGF-β1-induced hOMF,downregulated FAP,collagen type 3(COL3A1),collagen type 1(COL1A1),matrix metalloproteinase 1(MMP1),and matrix metalloproteinase 3(MMP3)expressions,and restored miR-30 family expression.Bioinformatics prediction and dual-luciferase reporter assay revealed that miR-30b-5p selectively inhibited FAP expression.Mechanistically,miR-30b-5p mimic suppressed the excessive proliferation of TGF-β1-induced hOMF and declinedfibrosis levels.Pue intervention significantly reversed the promotion of TGF-β1-induced OSF by miR-30b-5p inhibition.Conclusion:Pue mediated miR-30b-5p targeting FAP against OSF,which provided a theoretical basis for the pathogenesis research and Pue application in OSF. | SAIFEI XIE HUI XIE JINCAI GUO JIN TAN YULIN YU MINYI ZHANG SHANG WEN | 2024 | BIOCELL2024，48，4： | 0 |
| 15 | DIRECT REVASCULARIZATION OF THE ISCHEMIC MYOCARDIUM USING Nd:YAG LASER显示文摘For the establishment of direct revascularication of the ischemic myocardium,aNd: YAG laser with a wavelength of 1060 nm and an opitic fiber diameter of 500 umwas used to create 20 to 25 transmural channels in the central ischemic region of theleft ventricle after the coronary was ligatured.The channels were created from theepicard1al surface to the endocardium and each channel received about 64 joules of | Gang Wang Weiyong Liu Zhon ghua Wang Yulin Liao Youchi Guo Hongmei Tan Nan Yi Department of Thoracic and Cardiovascular Surgery,Xijing Hospital,Xi’an 710032,Shanxi,China | 1993 | Chinese Journal of Biomedical Engineering(English Edition)1993，2，4： | 0 |
| 16 | Hyparillums A and B: polycyclic polyprenylated acylphloroglucinols from Hypericum patulum显示文摘Hyparillums A(1)and B(2),two previously unidentified polycyclic polyprenylated acylphloroglucinols(PPAPs)with intricate architectures,were isolated from Hypericum patulum Thunb.Hyparillum A was the first PPAP with eight-carbon rings based on an unprecedented 6/6/5/6/6/5/6/4 octocyclic system featuring a rare heptacyclo[10.8.1.11,10.03,8.08,21.012,19.014,17]docosane core.In contrast,hyparillum B featured a novel heptacyclic architecture(6/6/5/6/6/5/5)based on a hexacyclo[9.6.1.11,9.03,7.07,18.011,16]nonadecane motif.Furthermore,hyparillums A and B demonstrated promising inhibitory effects on the proliferation of murine splenocytes stimulated by anti-CD3/anti-CD28 monoclonal antibodies and lipopolysaccharide,exhibiting half-maximal inhibitory concentration(IC50)values ranging from 6.13±0.86 to 12.69±1.31μmol·L−1. | DUAN Yulin SHI Zhengyi SONG Fei HOU Zhangrong TAN Xiaosheng ZHANG Yeting HAO Xincai CHEN Gang QI Changxing ZHANG Yonghui | 2024 | Chinese Journal of Natural Medicines2024，22，3： | 0 |
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