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| 1 | SHRIMP single zircon U-Pb dating of the Kongling high-grade metamorphic terrain: Evidence for >3.2 Ga old continental crust in the Yangtze craton显示文摘Single zircons from two trondhjemitic gneisses and two clastic metasedimentary rocks without Eu anomaly of the Kongling high-grade metamorphic terrain are dated by the in situ SHRIMP U-Pb method. The results show that the trondhjemitic magma emplaced at 2947-2903 Ma. Concordant age of as old as 3.3 Ga is present in the detrital zircons from the clastic metasedimentary rocks. Together with the depleted mantle Nd model age (TDM =3.2-3.3 Ga) of the clastic metasedimentary rocks, this documents the presence of Paleoarchean continental crust in the Yangtze craton. | 高山 凌文黎 QIU Yumin Neal J.McNaughton David I.Groves | 2001 | Science China Earth Sciences2001，44，4： | 47 |
| 2 | 哈达门沟金矿床成岩成矿时代的定点定年研究显示文摘哈达门沟大型钾长石 -石英脉型金矿床位于华北地台北缘西段的乌拉山地区。矿区西部的大桦背花岗岩和矿区内的伟晶岩脉与金矿化均具有较为密切的空间关系 ,这导致不少研究者认为哈达门沟金矿床与大桦背岩体或伟晶岩之间也具有时间和成因联系。通过采用先进的高灵敏的高分辨率的离子探针 (SHRIMP)对大桦背岩体、伟晶岩脉和钾长石化蚀变岩进行的锆石 U- Pb定点定年研究表明 :伟晶岩脉形成于 (1836± 5)× 10 6a,属吕梁旋回 ;大桦背岩体形成于 (353± 7)× 10 6a,应为海西旋回早期产物 ;金矿化年龄小于或等于 (132± 2 )× 10 6a,应为燕山晚期。这些年龄结果说明 ,本区金矿化比大桦背岩体晚至少 2 2 0× 10 6a,这排除了金矿化与大桦背岩体和伟晶岩脉之间有任何成因联系的可能性。蚀变岩的年龄还证明 ,虽然乌拉山和胶东地区金矿床的围岩和年龄不同 ,但两地区的金矿化却几乎同时发生。此外 ,大桦背岩体的形成年龄与华北地块和蒙古古陆块碰撞作用发生的时间基本一致 ,因此大桦背岩体的 SHRIMP年龄为这一碰撞作用提供了可靠的年代学证据。 | 苗来成 Yumin Qiu 关康 Neal M cNaughton 裘有守 罗镇宽 David Groves | 2000 | 矿床地质2000，19，2： | 48 |
| 3 | 内蒙古乌拉山地区大桦背岩体SHRIMP锆石U-Pb年代学研究显示文摘大桦背花岗岩体位于内蒙古乌拉山地区,东距哈达门沟大型钾长石—石英金矿床约5km。前人对该岩体曾做过不少同位素年代学研究,所得结果相差较大,但是多数研究者认为大桦背岩体与区内金矿化具有成因联系。本文采用先进的高灵敏、高分辨率的离子探针(SHRIMP)对大桦背岩体进行了锆石U-Ph定点定年研究。结果表明,大桦背岩体的形成年龄为353±7Ma,应为海西旋回早期产物。此年龄比已得到的乌拉山金矿区成矿年龄大至少70Ma,因而推测大桦背岩体与金矿化之间不存在直接的成因联系。 | 苗来成 Yumin QIU 关康 Neal McNAUGHTON 裘有守 罗镇宽 David GROVES | 2001 | 地质论评2001，47，2： | 34 |
| 4 | 大别山英山和熊店榴辉岩单颗粒锆石SHRIMPU-Pb年代学研究显示文摘报道了对大别山高压 -超高压带河南罗山熊店和湖北英山蜜蜂尖两地榴辉岩单颗粒锆石SHRIMPU -Pb原位 (in situ)定年结果 .英山超高压榴辉岩年龄有 4组 :(773± 2 0 )Ma ,(73 0± 16)Ma ,(4 61± 7)Ma和 (2 62± 6)Ma ,其中以 (4 61± 7)Ma占绝对优势 .熊店高压榴辉岩有 3组年龄 :(4 4 9± 14 )Ma ,(3 0 7± 14 )Ma和 (2 16± 4)Ma .两地榴辉岩中均存在约 45 0Ma的早古生代奥陶纪年龄 ,它们均具有极低的Zr含量 (9× 10 - 6 ~ 19× 10 - 6 ) .结合熊店榴辉岩样品具有类似于MORB的微量元素特征和εNd值 (4 5 0Ma时为 + 6.5 6) ,说明该古生代年龄应代表古生代洋壳和岛弧物质俯冲经高压 -超高压变质作用的产物 .由于奥陶纪高压 -超高压事件的年龄同时出现在英山和熊店榴辉岩中 ,且熊店榴辉岩中清楚地记录了三叠纪高压-超高压事件 ,表明大别高压 -超高压带北界无论是在奥陶纪或三叠纪时均应在熊店榴辉岩以北的桐柏 | 高山 Yumin QIU 凌文黎 Neal J.McNaughton 张本仁 张国伟 张泽明 钟增球 索书田 | 2002 | 地球科学(中国地质大学学报)2002，27，5： | 27 |
| 5 | The Reference Genome Sequence of Scutellaria baicalensis Provides Insights into the Evolution of Wogonin Biosynthesis显示文摘Scutellaria baicalensis Georgi is important in Chinese traditional medicine where preparations of dried roots,'Huang Qin,' are used for liver and lung complaints and as complementary cancer treatments. We report a high-quality reference genome sequence for S. baicalensis where 93% of the 408.14-Mb genome has been assembled into nine pseudochromosomes with a super-N50 of 33.2 Mb. Comparison of this sequence with those of closely related species in the order Lamiales, sesamum indicum and Salvia splendens,revealed that a specialized metabolic pathway for the synthesis of 4'-deoxyflavone bioactives evolved in the genus Scu-tellaria. We found that the gene encoding a specific cinnamate coenzyme A ligase likely obtained its newfunc- tion following recent mutations, and that four genes encoding enzymes in the 4'-deoxyflavone pathway are present as tandem repeats in the genome of S. baicalensis. Further analyses revealed that gene duplications, segmental duplication, gene amplification, and point mutations coupled to gene neo- and subfunctionaliza-tions were involved in the evolution of 4'-deoxyflavone synthesis in the genus Scutellaria. Our study not only provides significant insight into the evolution of specific flavone biosynthetic pathways in the mint family, Lamiaceae, but also will facilitate the development of tools for enhancing bioactive productivity by metabolic engineering in microbes or by molecular breeding in plants. The reference genome of S. baicalensis is also useful for improving the genome assemblies for other members of the mint family and offers an important foundation for decoding the synthetic pathways of bioactive compounds in medicinal plants. | Qing Zhao Jun Yang Meng-Ying Cui Jie Liu Yumin Fang Mengxiao Yan Wenqing Qiu Huiwen Shang Zhicheng Xu Reheman Yidiresi Jing-Ke Weng Tomas Pluskal Marielle Vigouroux Burkhard Steuernagel Yukun Wei Lei Yang Yonghong Hu Xiao-Ya Chen Cathie Martin | 2019 | Molecular Plant2019，12，7： | 23 |
| 6 | 显示文摘 | Zongyao Rui Richard J. Goldfarb Yumin Qiu Taihe Zhou Renyi Chen Franco Pirajno Grace Yun | 2002 | Mineralium Deposita (-)2002，，3： | 1 |
| 7 | Geology, distribution, and classification of gold deposits in the western Qinling belt, central China显示文摘 | Mao Jingwen Qiu Yumin Richard J | 2002 | Minerallum Delmsita2002，37，： | 1 |
| 8 | PEG-SOD and Myocardiai Protection Studies in theBtood-and Crystalloid-Perfused Rabbit and Rat Hearts显示文摘 | Manuel Galinianes Yumin QiU | 1992 | Circulation1992，86，： | 1 |
| 9 | Geology, geochronology, and tectonic setting of the Jiapigou gold deposits, southern Jilin Province, China显示文摘 | Miao Laicheng Qiu Yumin Fan Weiming | 2005 | Ore Geology Reviews2005，26，： | 1 |
| 10 | 显示文摘 | Jingwen Mao Richard J. Goldfarb Zhengwei Zhang Wenyi Xu Yumin Qiu Jun Deng | 2002 | Mineralium Deposita (-)2002，，3： | 1 |
| 11 | Geology,distribution,and classification of gold deposits in the western Qinling belt,central China显示文摘 | Mao Jinwen Qiu Yumin Goldfarb RJ | 2002 | Mineralium Deposita2002，37，： | 1 |
| 12 | 显示文摘 | Jingwen Mao Yumin Qiu Richard J. Goldfarb Zhaochong Zhang Steve Garwin Ren Fengshou | 2002 | Mineralium Deposita (-)2002，，3： | 1 |
| 13 | 显示文摘 | Jingwen Mao Yumin Qiu Richard J. Goldfarb Zhaochong Zhang Steve Garwin Ren Fengshou | 2002 | Mineralium Deposita (-)2002，，3： | 1 |
| 14 | Application of ethyl chlomformate derivafization for gas chromatography-mass spectrometry based metabonomic profiling 显示文摘 | Qiu Yunping Su Mingming Liu Yumin | 2007 | Anal Chim Acta2007，583，2： | 1 |
| 15 | A new green technology for direct production of low molecular weight chitosan 显示文摘 | WANG WEIPING DUA YUMIN QIU YANLIN | 2008 | Carbohydrate Polymers2008，74，1： | 1 |
| 16 | 显示文摘 | Yumin Qiu David I. Groves Neal J. McNaughton Liang-gen Wang Taihe Zhou | 2002 | Mineralium Deposita (-)2002，，3： | 1 |
| 17 | 显示文摘 | Jingwen Mao Yumin Qiu Richard J. Goldfarb Zhaochong Zhang Steve Garwin Ren Fengshou | 2002 | Mineralium Deposita (-)2002，，3： | 1 |
| 18 | SOX2-dependent expression of dihydroorotate dehydrogenase regulates oral squamous cell carcinoma cell proliferation显示文摘Oral squamous cell carcinoma(OSCC)become a heavy burden of public health,with approximately 300000 newly diagnosed cases and 145000 deaths worldwide per year.Nucleotide metabolism fuel DNA replication and RNA synthesis,which is indispensable for cell proliferation.But how tumor cells orchestrate nucleotide metabolic enzymes to support their rapid growth is largely unknown.Here we show that expression of pyrimidine metabolic enzyme dihydroorotate dehydrogenase(DHODH)is upregulated in OSCC tissues,compared to non-cancerous adjacent tissues.Enhanced expression of DHODH is correlated with a shortened patient survival time.Inhibition of DHODH by either shRNA or selective inhibitors impairs proliferation of OSCC cells and growth of tumor xenograft.Further,loss of functional DHODH imped de novo pyrimidine synthesis,and disrupt mitochondrial respiration probably through destabilizing the MICOS complex.Mechanistic study shows that transcriptional factor SOX2 plays an important role in the upregulation of DHODH in OSCC.Our findings add to the knowledge of how cancer cells co-opt nucleotide metabolism to support their rapid growth,and thereby highlight DHODH as a potential prognostic and therapeutic target for OSCC treatment. | Xuemei Qiu Sheng Jiang Yanxuan Xiao Yumin He Tao Ren Lu Jiang Rui Liu Qianming Chen | 2021 | International Journal of Oral Science2021，13，1： | 1 |
| 19 | 显示文摘 | Yumin Qiu David I. Groves Neal J. McNaughton Liang-gen Wang Taihe Zhou | 2002 | Mineralium Deposita (-)2002，，3： | 1 |
| 20 | 显示文摘 | Craig J. Hart Richard J. Goldfarb Yumin Qiu Lawrence Snee Lance D. Miller Marti L. Miller | 2002 | Mineralium Deposita (-)2002，，3： | 1 |
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