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1TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang 2016Cell Research2016,26,9:13
2CFD simulation of smooth and T-abrupt exits in circulating fluidized bed risers显示文摘Gas-solid flow in circulating fluidized bed(CFB) risers depends not only on operating conditions but also on exit configurations.Few studies investigated the effects of exit configurations on flow structure using computational fluid dynamics(CFD).This paper provides a 2D two-fluid model to simulate a cold bench-scale square cross-section riser with smooth and T-abrupt exits.The drag force between the gas and solid phases plays an important role in CFD.Since the drag force model based on homogeneous twophase flow,such as the Wen-Yu correlation,could not capture the heterogeneous structures in gas-solid f;ow,the structure-dependent energy-minimization multi-scale(EMMS) drag force model(Wang,Ge,& Li,2008),applicable for Geldart B particles(sand),was integrated into the two-fluid model.The calculated axial solids hold-up profiles were respectively exponential curve for smooth exit and C-shaped curve for T-abrupt exit,both consistent with experimental data.This study once again proves the key role of drag force in CFD simulation and also shows the validity of CFD simulation(two-fluid model) to describe exit effects on gas-solid flow in CFB risers.Xuezhi Wu Fan Jiang Xiang Xu Yunhan Xiao 2010Particuology2010,8,4:9
3Sensitivity-enhanced surface plasmon resonance sensor utilizing a tungsten disulfide (WS_2) nanosheets overlayer显示文摘Tungsten disulfide(WS_2), as a representative layered transition metal dichalcogenide(TMDC) material, possesses important potential for applications in highly sensitive sensors. Here, a sensitivity-enhanced surface plasmon resonance(SPR) sensor with a metal film modified by an overlayer of WS_2 nanosheets is proposed and demonstrated. The SPR sensitivity is related to the thickness of the WS_2 overlayer, which can be tailored by coating a WS_2 ethanol suspension with different concentrations or by the number of times of repeated post-coating.Benefitting from its large surface area, high refractive index, and unique optoelectronic properties, the WS_2 nanosheet overlayer coated on the gold film significantly improves the sensing sensitivity. The highest sensitivity(up to 2459.3 nm∕RIU) in the experiment is achieved by coating the WS_2 suspension once. Compared to the case without a WS_2 overlayer, this result shows a sensitivity enhancement of 26.6%. The influence of the WS_2 nanosheet overlayer on the sensing performance improvement is analyzed and discussed. Moreover, the proposed WS_2 SPR sensor has a linear correlation coefficient of 99.76% in refractive index range of 1.333 to 1.360. Besides sensitivity enhancement, the WS_2 nanosheet overlayer is able to show additional advantages, such as protection of metal film from oxidation, tunability of the resonance wavelength region, biocompatibility, capability of vapor,and gas sensing.HAO WANG HUI ZHANG JIANGLI DONG SHIQI HU WENGUO ZHU WENTAO QIU HUIHUI LU JIANHUI YU HEYUAN GUAN SHECHENG GAO ZHAOHUI LI WEIPING LIU MIAO HE JUN ZHANG ZHE CHEN YUNHAN LUO 2018Photonics Research2018,6,6:8
4Study on Adjoint-Based Optimization Method For Multi-Stage Turbomachinery显示文摘Adjoint-based optimization method is a hotspot in turbomachinery.First,this paper presents principles of adjoint method from Lagrange multiplier viewpoint.Second,combining a continuous route with thin layer RANS equations,we formulate adjoint equations and anti-physical boundary conditions.Due to the multi-stage environment in turbomachinery,an adjoint interrow mixing method is introduced.Numerical techniques of solving flow equations and adjoint equations are almost the same,and once they are converged respectively,the gradients of an objective function to design variables can be calculated using complex method efficiently.Third,integrating a shape perturbation parameterization and a simple steepest descent method,a frame of adjoint-based aerodynamic shape optimization for multi-stage turbomachinery is constructed.At last,an inverse design of an annular cascade is employed to validate the above approach,and adjoint field of an Aachen 1.5 stage turbine demonstrates the conservation and areflexia of the adjoint interrow mixing method.Then a direct redesign of a 1+1 counter-rotating turbine aiming to increase efficiency and apply constraints to mass flow rate and pressure ratio is taken.Weiwei Li Yong Tian Weilin Yi Lucheng Ji Weiwei Shao Yunhan Xiao 2011Journal of Thermal Science2011,20,5:6
5Ribosome Biogenesis Factor Bmsl-like Is Essential for Liver Development in Zebrafish显示文摘Ribosome biogenesis in the nucleolus requires numerous nucleolar proteins and small non-coding RNAs.Among them is ribosome biogenesis factor Bmsl,which is highly conserved from yeast to human.In yeast,Bmsl initiates ribosome biogenesis through recruiting Rcll to pre-ribosomes.However,little is known about the biological function of Bmsl in vertebrates.Here we report that Bmsl plays an essential role in zebrafish liver development.We identified a zebrafish bms1l^(sq163) mutant which carries a T to A mutation in the gene bmsl-like(bms1l).This mutation results in L^(152) to Q^(152) substitution in a GTPase motif in Bmsll.Surprisingly,bmsll^(sq163) mutation confers hypoplasia specifically in the liver,exocrine pancreas and intestine after 3 days post-fertilization(dpf).Consistent with the bmsll^(sq163) mutant phenotypes,whole-mount in situ hybridization(WISH) on wild type embryos showed that bmsll transcripts are abundant in the entire digestive tract and its accessory organs.Immunostaining for phospho-Histone 3(P-H3) and TUNEL assay revealed that impairment of hepatoblast proliferation rather than cell apoptosis is one of the consequences of bms1l^(sq163) giving rise to an under-developed liver.Therefore,our findings demonstrate that Bmsll is necessary for zebrafish liver development.Yong Wanga,Yue Luoa,Yunhan Hong(b,),Jinrong Peng(a,),Lijan Lo(a,b,) a College of Animal Sciences,Zhejiang University,Hangzhou 310058,China b Department of Biological Sciences,National University of Singapore,Science Drive 4,Singapore 117543,Singapore 2012Journal of Genetics and Genomics2012,39,9:4
6The Influence of Fuel-Air Swirl Intensity on Flame Structures of Syngas Swirl-Stabilized Diffusion Flame显示文摘Flame structures of a syngas swirl-stabilized diffusion flame in a model combustor were measured using the OH-PLIF method under different fuel and air swirl intensity.The flame operated under atmospheric pressure with air and a typical low heating-value syngas with a composition of 28.5% CO,22.5% H2 and 49% N2 at a thermal power of 34 kW.Results indicate that increasing the air swirl intensity with the same fuel,swirl intensity flame structures showed little difference except a small reduction of flame length;but also,with the same air swirl intensity,fuel swirl intensity showed great influence on flame shape,length and reaction zone distribution.Therefore,compared with air swirl intensity,fuel swirl intensity appeared a key effect on the flame structure for the model combustor.Instantaneous OH-PLIF images showed that three distinct typical structures with an obvious difference of reaction zone distribution were found at low swirl intensity,while a much compacter flame structure with a single,stable and uniform reaction zone distribution was found at large fuel-air swirl intensity.It means that larger swirl intensity leads to efficient,stable combustion of the syngas diffusion flame.Weiwei Shao Yan Xiong Kejin Mu Zhedian Zhang Yue Wang Yunhan Xiao 2010Journal of Thermal Science2010,19,3:4
7Loss of gonadal soma derived factor damaging the pituitary-gonadal axis in medaka显示文摘Medaka sex is determined by dmy/dmrt1b Y,the doublesex and mab-3 domain gene on the Y chromosome[1,2].Most recent studies have revealed a germ cell-intrinsic cue for the sperm-egg fate decision present in medaka,leading to spermatogenesis occurrence in a female gonadal environment without the presence of dmy[3].Targeted disruption of dmy,or sex related genes,suchKaiqing Sun Lidong Fan Chuanyun Wang Xiaoyu Yang Shuangguang Zhu Xi Zhang Xiaowu Chen Yunhan Hong Guijun Guan 2017Science Bulletin2017,62,3:4
8Photonic cavity enhanced high-performance surface plasmon resonance biosensor显示文摘Herein we propose a novel strategy to enhance surface plasmon resonance(SPR)by introducing a photonic cavity into a total-internal-reflection architecture.The photonic cavity,which is comprised of a highly reflective photonic crystal(PC),defect layers,and a gold(Au)film,enables Fabry–Perot(FP)resonances in the defect layers and therefore narrows the SPR resonance width in the metallic surface as well as increases the electric field intensity and penetration depth in the evanescent region.The fabricated sensor exhibits a 5.7-fold increase in the figure of merit and a higher linear coefficient as compared with the conventional Au-SPR sensor.The demonstrated PC/FP cavity/metal structure presents a new design philosophy for SPR performance enhancement.GUI-SHI LIU XIN XIONG SHIQI HU WEICHENG SHI YAOFEI CHEN WENGUO ZHU HUADAN ZHENG JIANHUI YU NUR HIDAYAH AZEMAN YUNHAN LUO ZHE CHEN 2020Photonics Research2020,8,4:4
9Investigation of Coal Fueled Chemical Looping Combustion Using Fe_3O_4 as Oxygen Carrier:Influence of Variables显示文摘Chemical-looping combustion (CLC) is a novel combustion technique with inherent CO2 separation.Magnetite (Fe3O4) was selected as the oxygen carrier.Shenhua coal (Inner Mongolia,China),straw coke and natural coke were used as fuels for this study.Influences of operation temperatures,coal to Fe3O4 mass ratios,and different kinds of fuels on the reduction characteristics of the oxygen carrier were investigated using an atmosphere thermogravimetric analyzer (TGA).Scanning electron microscopy (SEM) was used to analyse the characteristic of the solid residues.Experimental results shown that the reaction between the coal and the oxygen carrier become strong at a temperature of higher than 800℃.As the operation temperature rises,the reduction conversion rate increases.At the temperatures of 850oС,900℃,and 950℃,the reduction conversion rates were 37.1%,46.5%,and 54.1% respectively.However,SEM images show that at the temperature of higher than 950℃,the iron oxides become melted and sintered.The possible operation temperature should be kept around 900℃.When the mass ratios of coal to Fe3O4 were 5/95,10/90,15/85,and 20/80,the reduction conversion rates were 29.5%,40.8%,46.5%,and 46.6% respectively.With the increase of coal,the conversion rate goes up.But there exist an optimal ratio around 15/85.Comparisons based on different kinds of fuels show that the solid fuel with a higher volatile and a more developed pore structure is conducive to the reduction reactivity of the oxygen carrier.Xiaoyan Sun Wenguo Xiang Sha Wang Wendong Tian Xiang Xu Yanji Xu Yunhan Xiao 2010Journal of Thermal Science2010,19,3:3
10Numerical simulation and experimental validation of gas–solid flow in the riser of a dense fluidized bed reactor显示文摘Gas–solid flow in the riser of a dense fluidized bed using Geldart B particles(sand),at high gas velocity (7.6–15.5 m/s)and with comparatively high solid flux(140–333.8 kg/m2 s),was investigated experimentally and simulated by computational fluid dynamics(CFD),both two-and three-dimensional and using the Gidaspow,O’Brien-Syamlal,Koch-Hill-Ladd and EMMS drag models.The results predicted by EMMS drag model showed the best agreement with experimental results.Calculated axial solids hold-up pro- files,in particular,are well consistent with experimental data.The flow structure in the riser was well represented by the CFD results,which also indicated the cause of cluster formation.Complex hydrody- namical behaviors of particle cluster were observed.The relative motion between gas and solid phases and axial heterogeneity in the three subzones of the riser were also investigated,and were found to be consistent with predicted flow structure.The model could well depict the difference between the two exit configurations used,viz.,semi-bend smooth exit and T-shaped abrupt exit.The numerical results indicate that the proposed EMMS method gives better agreement with the experimental results as compared with the Gidaspow,O’Brien-Syamlal,Koch-Hill-Ladd models.As a result,the proposed drag force model can be used as an efficient approach for the dense gas–solid two-phase flow.Xueyao Wang Fan Jiang xiang xu Shengdian Wang Xuezhi Wu Baoguo Fan Liangliang Liao Jiachang Wang Yunhan Xiao 2009Particuology2009,7,4:3
11Energy and Exergy Analysis of a Novel Efficient Combined Process by Hydrothermal Degradation and Superheated Steam Drying of Degradable Organic Wastes显示文摘This paper considers the combination of hydrothermal degradation(HTD)and superheated steam(SHS)drying indisposal and processing of degradable organic wastes in municipal solid wastes(MSW).In SHS drying, a fractionof dryer thermal energy input can be recovered and used to satisfy the heat requirement in maintaining the HTDoperating temperature.Both energy and exergy analysis are applied to the combined process.The analysis coversranges of dryer inlet temperatures of 202.38-234.19℃ and feed water content of 32.5-65%.Thermal energyanalysis shows that the combination of HTD and SHS drying can achieve thermal energy self-sufficiency(TES)by manipulating process variables.The exergy analysis indicates the location,type,and magnitude of the exergylosses during the whole process by applying the second law of thermodynamics.Shuqing GUO Yunhan XIAO Wendong TIAN Zhedian ZHANG 2006Journal of Thermal Science2006,15,3:2
123D full-loop simulation and experimental verification of gas-solid flow hydrodynamics in a dense circulating fluidized bed显示文摘Because of their advantages of high efficiency and low cost,numerical research methods for large-scale circulating fluidized bed(CFB) apparatus are gaining ever more importance.This article presents a numerical study of gas-solid flow dynamics using the Eulerian granular multiphase model with a drag coefficient correction based on the energy-minimization multi-scale(EMMS) model.A three-dimensional,full-loop,time-dependent simulation of the hydrodynamics of a dense CFB apparatus is performed.The process parameters(e.g.,operating and initial conditions) are provided in accordance with the real experiment to enhance the accuracy of the simulation.The axial profiles of the averaged solid volume fractions and the solids flux at the outlet of the cyclone are in reasonable agreement with experimental data,thereby verifying the applicability of the mathematical and physical models.As a result,the streamline in the riser and standpipe as well as the solids distribution contours at the cross sections is analyzed.Computational fluid dynamics(CFD) serves as a basis for CFB modeling to help resolve certain issues long in dispute but difficult to address experimentally.The results of this study provide the basis of a general approach to describing dynamic simulations of gas-solid flows.Xueyao Wang Xuezhi Wu Fulin Lei Jing Lei Yunhan Xiao 2014Particuology2014,12,5:2
13An aerodynamic design and numerical investigation of transonic centrifugal compressor stage显示文摘In the present paper,the design of a transonic centrifugal compressor stage with the inlet relative Mach number about 1.3 and detailed flow field investigation by three-dimensional CFD are described.Firstly the CFD program was validated by an experimental case.Then the preliminary aerodynamic design of stage completed through in-house one-dimensional code.Three types of impellers and two sets of stages were computed and analyzed.It can be found that the swept shape of leading edge has prominent influence on the performance and can enlarge the flow range.Similarly,the performance of the stage with swept impeller is better than others.The total pressure ratio and adiabatic efficiency of final geometry achieve 7:1 and 80% respectively.The vane diffuser with same airfoils along span increases attack angle at higher span,and the local flow structure and performance is deteriorated.Weilin Yi Lucheng Ji Yong Tian Weiwei Shao Weiwei Li Yunhan Xiao 2011Journal of Thermal Science2011,20,3:2
14Simultaneous recovery of rare earth elements and phosphorus from phosphate rock by phosphoric acid leaching and selective precipitation:Towards green process显示文摘Phosphate rock has been considered as one of the potential promising resources for rare earth elements(REEs). But the cost issues and the technical challenges caused by the low content of REEs in ores did hinder the further development of REEs recovery technologies. In order to explore a green process for the recovery of REEs from phosphate rock, this study investigates the effects of phosphoric acid concentration, liquid-to-solid ratio(L/S ratio), leaching time and temperature on the leaching efficiencies of the major components from phosphate rock. A REEs recovery of 94.3% and a phosphorus recovery of 95.3%are achieved under the optimal conditions of attacking phosphate rock using 30%P_2 O_5 acid with an L/S ratio of 10:1 and a stirring speed of 250 r/min at 25 ℃ for 4 h. Then,the selective precipitation of REEs with 81.3% REEs recovery is realized by heating up the leaching solution from 25 to 90 ℃ and keeping for4 h. Thereafter, more than 95% phosphoric acid is recovered by H_2 SO_4 and high purity gypsum, more than95% CaSO_4(tested by XRF), is also produced at the same time. Ultimately, a green process that leaches phosphate rock with H_3 PO_4, selectively precipitates REEs from leaching solution by heating up, recovers H_3 PO_4 with H2 SO4 is proposed. Compared with REE recovery in traditional processes, this process owns the merits of simple operation, energy saving and minimum wastes.Shengxi Wu Longsheng Zhao Liangshi Wang Xiaowei Huang Yunhan Zhang Zongyu Feng Dali Cui 2019Journal of Rare Earths2019,37,6:2
15Diffractive multifocal intraocular lens implantation in patients with monofocal intraocular lens in the contralateral eye显示文摘AIM:To evaluate clinical outcomes of unilateral implantation of a diffractive multifocal intraocular lens(IOL)in patients with contralateral monofocal IOL.METHODS:Twenty-two patients who already had implantation of a monofocal IOL in unilateral eye underwent implantation of a diffractive multifocal IOL in contralateral eye were enrolled.After 1,6,and 12 mo,uncorrected and distant corrected distant visual acuity(UCDVA and DCDVA),uncorrected and distant corrected intermediate-visual acuity(UCIVA and DCIVA),uncorrected and distant corrected near visual acuity(UCNVA and DCNVA),and contrast sensitivity were obtained.Halo/glare symptoms,spectacle dependence,and patient satisfaction were also evaluated.RESULTS:The mean age was 67.86±7.25 y and the average interval between two IOL implantations was 645.82±878.44 d.At 1 mo,binocular UCDVA was lower than 0.20 logMAR in 76%of patients(mean 0.12±0.13 logMAR),which increased to 90%by 6 and 12 mo.The binocular UCDVA was significantly better than the monocular results(P<0.05)at 1,6,and 12 mo.Additionally,UCNVA was lower than 0.40 logMAR in 82%of patients,increasing to 90%by 6 and 12 mo.Mean UCNVA in the multifocal IOL implanted eye was statistically significantly better than that in the monofocal IOL implanted eye(P<0.05)at 1,6,and 12 mo.About 5%of patients at 1 and 6 mo,reported'severe glare or halo'.Patient satisfaction rates were 95%and 91%at 6 and 12 mo,respectively.CONCLUSION:Unilateral implantation of multifocal IOL in patients with a contralateral,monofocal IOL implantation results in high patient satisfaction rate,with low severe glare or halo rate during follow-up.It can represent a good option for patients who have previously had a monofocal IOL implantation regardless of two year interval duration between two IOL implantations.Jae Yong Kim Yunhan Lee Hun Jae Won Hyerin Jeong Jin Hyoung Park Myoung Joon Kim Hungwon Tchah 2020International Journal of Ophthalmology(English edition)2020,13,5:2
16Research of the Gas-solid Flow Character Based on the DEM Method显示文摘Numerical simulation of gas-solid flow behaviors in a rectangular fluidized bed is carried out three dimensionally by the discrete element method (DEM).Euler method and Lagrange method are employed to deal with the gas phase and solid phase respectively.The collided force among particles,striking force between particle and wall,drag force,gravity,Magnus lift force and Saffman lift force are considered when establishing the mathematic models.Soft-sphere model is used to describe the collision of particles.In addition,the Euler method is also used for modeling the solid phase to compare with the results of DEM.The flow patterns,particle mean velocities,particles' diffusion and pressure drop of the bed under typical operating conditions are obtained.The results show that the DEM method can describe the detailed information among particles,while the Euler-Euler method cannot capture the micro-scale character.No matter which method is used,the diffusion of particles increases with the increase of gas velocity.But the gathering and crushing of particles cannot be simulated,so the energy loss of particles' collision cannot be calculated and the diffusion by using the Euler-Euler method is larger.In addition,it is shown by DEM method,with strengthening of the carrying capacity,more and more particles can be schlepped upward and the dense suspension upflow pattern can be formed.However,the results given by the Euler-Euler method are not consistent with the real situation.Xueyao Wang and Yunhan Xiao Research Center for Clean Energy and Power,Chinese Academy of Sciences Key Laboratory of Advanced Energy and Power,Chinese Academy of Sciences (Institute of Engineering Thermophysics),Beijing,100190,China 2011Journal of Thermal Science2011,20,6:2
17Fabrication and Microstructure of W/Cu Functionally Graded Material显示文摘W/Cu functionally gradient material (FGM) has excellent mechanical properties since it can effectively relax interlayer thermal stresses caused by the mismatch between their thermal expansion coefficients. W/Cu FGM combines the advantages of tungsten such as high melting point and service strength, with heat conductivity and plasticity of copper at room temperature. Thus it demonstrates satisfactory heat corrosion and thermal shock resistance and will be a promising candidate as divertor component in thermonuclear de-vice. Owing to the dramatic difference of melting point between tungsten and copper, conventional processes meet great difficulties in fabricating this kind of FGMs. A new approach termed graded sintering under ultra-high pressure (GSUHP) is proposed, with which a near 96% relative density of WICu FGM that contains a full distribution spectrum (0-100%W) has been successfully fabricated. Suitable amount of transition metals (such as nickel, zirconium, vanadium) is employed as additives to activate tungsten’s sintering, enhance phase wettability and bonding strength between W and Cu. Densification effects of different layer of FGM were investigated. Microstructure morphology and interface elements distribution were observed and analyzed. The thermal shock performance of W/Cu FGM was also preliminarily tested.Yunhan Ling, Jiangtao Li, Zhangjian Zhou, Changchun Ge Laboratory of Special Ceramics & Powder Metallurgy, University of Science and Technology Beijing, Beijing 100083, China 2001Journal of University of Science and Technology Beijing2001,8,3:2
18Unsteady Numerical Simulation of Hot Streak/Blades Interaction and Film Cooling显示文摘Deeply research on management and application of hot streak is an important way to breakthrough technique obstacle of aero engine hot components.Numerical method is a useful instrument to investigate the correlative problems.Firstly the paper developed independently three dimensional unsteady parallel computational code-MpiTurbo based on Fortran 90 and MPI at Linux operating system.Then unsteady numerical simulation was carried out to investigate impacts of the factors,which included circumferential locations of hot streak and clocking positions of blade rows,on the thermal environment of a 1+1 counter-rotating turbine.The results clearly indicated that clocking positions of hot streak/blade row and blade row/blade row had great influence on the time-averaged temperature distribution of the third blade row.Therefore,it can be effective for improving thermal environment of turbine to optimize blade parameters and clocking positions.Lastly film cooling layout was designed by the repetitious steady simulation based on source term method.And the flow structure detail was given by the unsteady simulation.Weilin Yi,Lucheng Ji and Yunhan Xiao Research Center for Energy and Power,Chinese Academy of Sciences,Beijing,China Key Laboratory of Advanced Energy and Power,Chinese Academy of Sciences,(Institute of Engineering Thermophysics),Beijing,China P.O.Box 2706,Beijing 100190,China 2010Journal of Thermal Science2010,19,5:2
19Dynamic games for secure and resilient control system design显示文摘Modern control systems are featured by their hierarchical structure composed of cyber,physical and human layers.The intricate dependencies among multiple layers and units of modern control systems require an integrated framework to address cross-layer design issues related to security and resilience challenges.To this end,game theory provides a bottom-up modeling paradigm to capture the strategic interactions among multiple components of the complex system and enables a holistic view to understand and design cyber-physical-human control systems.In this review,we first provide a multi-layer perspective toward increasingly complex and integrated control systems and then introduce several variants of dynamic games for modeling different layers of control systems.We present game-theoretic methods for understanding the fundamental tradeoffs of robustness,security and resilience and developing a cross-layer approach to enhance the system performance in various adversarial environments.This review also includes three quintessential research problems that represent three research directions where dynamic game approaches can bridge between multiple research areas and make significant contributions to the design of modern control systems.The paper is concluded with a discussion on emerging areas of research that crosscut dynamic games and control systems.Yunhan Huang Juntao Chen Linan Huang Quanyan Zhu 2020National Science Review2020,7,7:2
20Off-design performance of a chemical looping combustion (CLC) combined cycle:effects of ambient temperature显示文摘The present work investigates the influence of ambient temperature on the steady-state off-design thermodynamic performance of a chemical looping combustion(CLC) combined cycle.A sensitivity analysis of the CLC reactor system was conducted,which shows that the parameters that influence the temperatures of the CLC reactors most are the flow rate and temperature of air entering the air reactor.For the ambient temperature variation,three off-design control strategies have been assumed and compared:1) without any Inlet Guide Vane(IGV) control,2) IGV control to maintain air reactor temperature and 3) IGV control to maintain constant fuel reactor temperature,aside from fuel flow rate adjusting.Results indicate that,compared with the conventional combined cycle,due to the requirement of pressure balance at outlet of the two CLC reactors,CLC combined cycle shows completely different off-design thermodynamic characteristics regardless of the control strategy adopted.For the first control strategy,temperatures of the two CLC reactors both rise obviously as ambient temperature increases.IGV control adopted by the second and the third strategy has the effect to maintain one of the two reactors' temperatures at design condition when ambient temperature is above design point.Compare with the second strategy,the third would induce more severe decrease of efficiency and output power of the CLC combined cycle.Jinling Chi Bo Wang Shijie Zhang Yunhan Xiao 2010Journal of Thermal Science2010,19,1:2
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