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| 1 | Evolutionary trace analysis of eukaryotic DNA topoisomerase I superfamily: Identification of novel antitumor drug binding site显示文摘The studies of novel inhibitors of DNA topoisomerase I (Topo I) have already be-come very promising in cancer chemotherapy. Identifying the new drug-binding residues is playing an important role in the design and optimization of Topo I inhibitors. The designed com-pounds may have novel scaffolds, thus will be helpful to overcome the toxicities of current camptothecin (CPT) drugs and may provide a solution to cross resistance with these drugs. Mul-tiple sequence alignments were performed on eukaryotic DNA topoisomerase I superfamily and thus the evolutionary tree was constructed. The Evolutionary Trace method was applied to iden-tify functionally important residues of human Topo I. It has been demonstrated that class-specific hydrophobic residues Ala351, Met428, Pro431 are located around the 7,9-position of CPT, indi-cating suitable substitution of hydrophobic group on CPT will increase antitumor activity. The conservative residue Lys436 in the superfamily is of particular interest and new CPT derivatives designed based on this residue may greatly increase water solubility of such drugs. It has also been demonstrated that the residues Asn352 and Arg364 were conservative in the superfamily, whose mutation will render CPT resistance. As our molecular docking studies demonstrated they did not make any direct interaction with CPT, they are important drug-binding site residues for future design of novel non-camptothecin lead compounds. This work provided a strong basis for the design and synthesis of novel highly potent CPT derivatives and virtual screening for novel lead compounds. | SONG Yunlong QI Yunpeng ZHANG Wannian SHENG Chunquan ZHANG Min YAO Jianzhong YU Jianxin MIAO Zhenyuan ZHOU Youjun ZHU Ju L(U) Jiaguo | 2005 | Science China(Life Sciences)2005，48，4： | 5 |
| 2 | Colonization of endophyte Acremonium sp. D212 in Panax notoginseng and rice mediated by auxin and jasmonic acid显示文摘Endophytic fungi can be beneficial to plant growth. However, the molecular mechanisms under-lying colonization of Acremonium spp. remain unclear. In this study, a novel endophytic Acremonium strain was isolated from the buds of Panax notoginseng and named Acremonium sp. D212. The Acremonium sp. D212 could colonize the roots of P. notoginseng, enhance the resistance of P. notoginseng to root rot disease, and promote root growth and saponin bio-synthesis in P. notoginseng. Acremonium sp. D212 could secrete indole-3-acetic acid (IAA) and jasmonic acid (JA), and inoculation with the fungus increased the endogenous levels of IAA and JA in P. noto-ginseng. Colonization of the Acremonium sp. D212 in the roots of the rice line Nipponbare was dependent on the concentration of methyl jasmonate (MeJA) (2–15μmol/L) and 1-naphthalenacetic acid (NAA) (10–20μmol/L). Moreover, the roots of the JA signaling-defective coi1-18 mutant were colonized by Acremonium sp. D212 to a lesser degree than those of the wild-type Nipponbare and miR393b-overexpressing lines, and the colonization was res-cued by MeJA but not by NAA. It suggests that the cross-talk between JA signaling and the auxin biosynthetic pathway plays a crucial role in the colonization of Acremonium sp. D212 in host plants. | Li Han Xuan Zhou Yiting Zhao Shusheng Zhu Lixia Wu Yunlu He Xiangrui Ping Xinqi Lu Wuying Huang Jie Qian Lina Zhang Xi Jiang Dan Zhu Chongyu Luo Saijie Li Qian Dong Qijing Fu Kaiyuan Deng Xin Wang Lei Wang Sheng Peng Jinsong Wu Weimin Li JiǐíFriml Youyong Zhu Xiahong He Yunlong Du | 2020 | Journal of Integrative Plant Biology2020，62，9： | 2 |
| 3 | Optical wavelet matched filter 显示文摘 | Danny Roberge Yunlong Sheng | 1994 | Applied Optics1994，33，23： | 1 |
| 4 | Phased-only sampled fiber Bragg gratings for high-channel-count chromatic dispersion compensation 显示文摘 | Li Hongpu Sheng Yunlong Li Yao Rothenberg J E | 2003 | J Lightwave Technol2003，21，20： | 1 |
| 5 | Registration and Fusion of Retinal Images--An Evaluation Study 显示文摘 | France Laliberte Langis Gagnon Yunlong Sheng | 2003 | IEEE Transactions on Medical Imaging2003，22，5： | 1 |
| 6 | Real-world Multisensor Image Alignment Using Edge Focusing and Hausdorff Distances显示文摘 | Sheng Yunlong Yang Xiangjie McReynolds Daniel | 1995 | SPIE Proc Sensor Fusion:Architerctures Algorithms and Applications Ⅲ1995，3719，： | 1 |
| 7 | Circular-Fourier-radial-Mellin transform descriptors for pattern recognition显示文摘 | Yunlong Sheng Jacques Duvernoy | 1986 | Journal of the Optical Society of America A1986，3，6： | 1 |
| 8 | Reservoir Characteristics of Fine-grained Sedimentary Rocks in Saline Lakes in the Cenozoic Upper Ganchaigou Formation,Southwestern Qaidam Basin,NW China显示文摘Cenozoic fine-grained sedimentary rocks in the southwestern Qaidam Basin,as typical salinized lacustrine sediments,are significantly different from those in other freshwater lakes under the impact of the high salinity in the lake.Many fine-grained sedimentary rock samples were selected from the lower member of Neogene(N_(1))in the Gaskule Oilfield,Qaidam Basin,northwest China,with the aim to analyze and test their petrology,pore structure,and organic geochemical characteristics and determine its genesis and geological significance.Based on previous results,a new genesis of mixed sedimentary rocks is proposed.The Cenozoic lacustrine fine-grained sedimentary rocks in SW Qaidam Basin belong to mixed sedimentary rocks,which can be divided into three types,including carbonate and terrigenous clastic-bearing mudstone,carbonate-bearing to terrigenous clastic mixed sedimentary rocks,and carbonate-terrigenous clastic mixed sedimentary rocks.The geneses of mixing are quite different from that of mixed marine rocks.According to the sedimentary characteristics of the salinized lakes,three new geneses of mixed deposits are proposed:syn-sedimentary mixing,varve interbedded mixing,and biogenic mixing.The reservoir spaces of the Cenozoic lacustrine fine-grained sedimentary rocks in SW Qaidam Basin include residual intergranular pores,intercrystalline pores,microfractures,and minor dissolved pores.The reservoirs have super-low porosity and ultra-low permeability,with a porosity of 1.82%-21.04%,averaging 7.71%,and permeability of(0.0028-254.86)×10^(−3)μm^(2),averaging 2.82×10^(−3)μm^(2).The test results of total organic carbon(TOC)content show that the highest content of organic carbon reached 1.41%,and those of vitrinite reflectance show that Ro ranges from 0.525%-0.824%,with an average of 0.806%.The organic geochemical characteristics show that the fine-grained mixed sedimentary rocks of SW Qaidam Basin have the potential for self-generation and self-storage.As an unconventional reservoir,it has potential industrial value.This is the first study of fine-grained sedimentary rocks in the Qaidam Basin,which offers certain theoretical and practical values. | SHENG Jun LIU Jincheng LI Yunlong ZOU Haiyan LONG Anlin WANG Lin LI Jiyong QI Qingshan YANG Xiaojing LI Yanan | 2022 | Acta Geologica Sinica(English Edition)2022，96，3： | 1 |
| 9 | Orthogonal Fourier-Mellin moments for invariant pattern recognition显示文摘 | Sheng Yunlong Shen Lixin | 1994 | Journal of the Optical Society of America1994，11，6： | 1 |
| 10 | Optical wavelet transform显示文摘 | Yunlong Sheng DannyRoberge Harold H Szu | 1992 | Optical Engineering1992，31，9： | 1 |
| 11 | Orthogonal Fourier-Mellin moments for invariant pattern recognition显示文摘 | Sheng Yunlong Shen Lixin | 1994 | J Opt Soc Am A1994，11，6： | 1 |
| 12 | Constructing virtual combinatorial fragment libraries based upon MDL Drug Data Report database显示文摘Structural analysis of known drugs or drug-like compounds provides important information for drug design. The 142553 drug molecules in the MDL Drug Data Report database were analyzed, and then the common structural features were extracted. According to the common structural features, drug molecules were segmented into 32017 fragments, including 13642 ring fragments, 10076 linker fragments, and 8299 side chain fragments. These fragments were further used to establish three types of virtual combinatorial fragment libraries: a basic framework library containing 13574 rings; a linker library of 8051 linkers and a pharmacophore library of 34244 fragments combined by rings and side chains. After energy minimization, all fragments in the above three libraries maintain reasonable geometrical features and spatial conformations, and would be useful for building a virtual combinatorial database and de novo drug design. | ZHANG Min SHENG ChunQuan XU Hui SONG YunLong ZHANG WanNian | 2007 | Science China Chemistry2007，50，3： | 1 |
| 13 | Orthogonal Fourier-Mellin moments for invariant pattern recognition显示文摘 | SHENG Yunlong SHEN Lixin | 1994 | Journal Optical Society American1994，11，6： | 1 |
| 14 | Polynomial phase masks for extending the depth of field of a microscope 显示文摘 | Caron Nicolas Sheng Yunlong | 2008 | Appl Opt2008，47，22： | 1 |
| 15 | Phased-Only sampled fiber Bragg gratings for high -channel-count chromatic dispersion compensation显示文摘 | YUNLONG SHENG YAO LI JOSHUA E ROTHENBERG | 2003 | Journal of Lightwave Technology2003，21，9： | 1 |
| 16 | Osteocyte Egln1/Phd2 links oxygen sensing and biomineralization via FGF23显示文摘Osteocytes act within a hypoxic environment to control key steps in bone formation.FGF23,a critical phosphate-regulating hormone,is stimulated by low oxygen/iron in acute and chronic diseases,however the molecular mechanisms directing this process remain unclear.Our goal was to identify the osteocyte factors responsible for FGF23 production driven by changes in oxygen/iron utilization.Hypoxia-inducible factor-prolyl hydroxylase inhibitors(HIF-PHI)which stabilize HIF transcription factors,increased Fgf23 in normal mice,as well as in osteocyte-like cells;in mice with conditional osteocyte Fgf23 deletion,circulating i FGF23 was suppressed.An inducible MSC cell line(‘MPC2’)underwent FG-4592 treatment and ATACseq/RNAseq,and demonstrated that differentiated osteocytes significantly increased HIF genomic accessibility versus progenitor cells.Integrative genomics also revealed increased prolyl hydroxylase Egln1(Phd2)chromatin accessibility and expression,which was positively associated with osteocyte differentiation.In mice with chronic kidney disease(CKD),Phd1-3 enzymes were suppressed,consistent with FGF23 upregulation in this model.Conditional loss of Phd2 from osteocytes in vivo resulted in upregulated Fgf23,in line with our findings that the MPC2 cell line lacking Phd2(CRISPR Phd2-KO cells)constitutively activated Fgf23 that was abolished by HIF1αblockade.In vitro,Phd2-KO cells lost iron-mediated suppression of Fgf23 and this activity was not compensated for by Phd1 or-3.In sum,osteocytes become adapted to oxygen/iron sensing during differentiation and are directly sensitive to bioavailable iron.Further,Phd2 is a critical mediator of osteocyte FGF23 production,thus our collective studies may provide new therapeutic targets for skeletal diseases involving disturbed oxygen/iron sensing. | Megan L.Noonan Pu Ni Emmanuel Solis Yamil G.Marambio Rafiou Agoro Xiaona Chu Yue Wang Hongyu Gao Xiaoling Xuei Erica L.Clinkenbeard Guanglong Jiang Sheng Liu Steve Stegen Geert Carmeliet William R.Thompson Yunlong Liu Jun Wan Kenneth E.White | 2023 | Bone Research2023，11，1： | 1 |
| 17 | Orthogonal Fourier-Mellin Moments for Invariant Pattern Recognition显示文摘 | Sheng Yunlong Shen Lixin | 1994 | Opt Soc Am A1994，11，： | 1 |
| 18 | Orthogonal fourier-mellin moments for invariant pattern recognition 显示文摘 | SHENG Yunlong SHEN Lixin | 1994 | Journal of Optical Society of America1994，11，： | 1 |
| 19 | Effects of BMP2 and VEGF165 on the osteogenic differentiation of ratbone marrow?derived mesenchymal stem cells显示文摘 | Zhaowei Lin Jiang?Sheng Wang Lijun Lin Jingwen Zhang Yunlong Liu Ming Shuai Qi Li | 2014 | Experimental and Therapeutic Medicine2014，，3： | 1 |
| 20 | Key problems and solutions in arch dam heightening显示文摘The dam heightening,which is an effective way to increase reservoir volume,has been paid close attention by engineers.Three problems should be dealt with when an arch dam needs to be heightened:stress state getting worse at dam heel,cracking on new added concrete dam surface,and weak bonding between new added concrete and old dam.Taking Geba arch dam as an example,these problems are examined in details through simulation analysis by the finite element method.The tensile stresses on dam’s surface and joint face that have certain relations to the dam heightening can be controlled by some measures. | Zuoguang FU Yunlong HE Sheng SU | 2011 | Frontiers of Structural and Civil Engineering2011，5，1： | 0 |
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