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| 1 | Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: experts' consensus statement显示文摘Since the outbreak of 2019 novel coronavirus infection (2019-nCoV) in Wuhan City,China,by January 30,2020,a total of 9692 confirmed cases and 15,238 suspected cases have been reported around 31 provinces or cities in China.Among the confirmed cases,1527 were severe cases,171 had recovered and been discharged at home,and 213 died.And among these cases,a total of 28 children aged from 1 month to 17 years have been reported in China.For standardizing prevention and management of 2019-nCoV infections in children,we called up an experts' committee to formulate this experts' consensus statement.This statement is based on the Novel Coronavirus Infection Pneumonia Diagnosis and Treatment Standards (the fourth edition) (National Health Committee) and other previous diagnosis and treatment strategies for pediatric virus infections.The present consensus statement summarizes current strategies on diagnosis,treatment,and prevention of 2019-nCoV infection in children. | Kunling Shen Yonghong Yang Tianyou Wang Dongchi Zhao Yi Jiang Runming Jin Yuejie Zheng Baoping Xu Zhengde Xie Likai Lin Yunxiao Shang Xiaoxia Lu Sainan Shu Yan Bai Jikui Deng Min Lu Leping Ye Xuefeng Wang Yongyan Wang Liwei Gao | 2020 | World Journal of Pediatrics2020，16，3： | 56 |
| 2 | Geochronology of Baogutu porphyry copper deposit in Western Junggar area, Xinjiang of China显示文摘Baogutu copper deposit in Western Junggar area is a mesoscopic porphyry deposit found in recent years. Study on its geochronology will help further understand ore genesis and regional ore-forming pattern. A series of small quartz-diorite and granodiorite stocks outcrop at Baogutu area, numbered I―X according to their size. A detailed exploration on Number V stock confirmed it as a mesoscopic scale copper deposit, and various exploration work has been carried out on other stocks with ore-forming evidence. This paper studies geochronology of Number V stock using zircon SHRIMP U-Pb and single mineral K-Ar method. Twenty-five SHRIMP ages yield two 206Pb/238U weighed mean ages of 335.6 ± 7.8 Ma and 311.4 ± 3.3 Ma respectively. The older date is considered to be inherited zircon from either surrounding rock tuff or deep granitoid batholith, whereas the younger date is the formation age of ore-bearing intrusion. K-Ar ages of ore-forming biotites, 296.0 ± 3.7 Ma and 297.3 ± 3.8 Ma, in combination with Re-Os age of molybdenite, 310 Ma, confirm the ore-forming age of 310-296 Ma. Granophyre and dioritic porphyrite dikes cut Number V stock and their K-Ar ages range from 278 to 240 Ma, which confine the lower boundary of the mineralization. The framework of Baogutu ore-forming geochrono-logy can be established based on these data. | LIU YuLin GUO LiShuang LIU YuDe SONG HuiXia SONG Biao ZHANG Rui XU FaJun ZHANG YunXiao | 2009 | Science China Earth Sciences2009，52，10： | 33 |
| 3 | Aquaporin JcPIP2 is Involved in Drought Responses in Jatropha curcas显示文摘水隧道蛋白质, aquaporins,在在植物的 transmembranewater 运动的戏基础角色。编码 aquaporin 的新全身的 cDNA 从 Jatropha curcas 的幼苗被孤立。质膜的基因从 J 的内在的蛋白质(果仁) 。curcas (JcPIP2 ) 包含了 843 bp 编码 280 氨基酸的蛋白质的开的读框架。氨基酸顺序与 Ricinus communis 果仁显示出 94% 身份。JcPIP2 互补 RNA intoXenopus 卵母细胞的注射增加了 10 褶层卵母细胞的渗透的水渗透。有 anti-JcPIP2 抗体的 Immunodetection ofJcPIP2 显示这蛋白质无所不在地位于植物的所有测试纸巾。调查在 aquaporins 和干旱抵抗 inJ 之间的关系。curcas,许多 JcPIP2 在二 J 的幼苗被检验。curcas 人口, GaoYouCSC63 和 YanBian S1,在有 PEG6000 的水赤字下面。在地条件下面,那些二张人口, GaoYou CSC63 是抵抗的浇赤字,而是 YanBian S1 是敏感的浇剥夺。与干旱应力的增加的度, JcPIP2 水平在幼苗 ofGaoYou CSC63 增加了,而在 YanBian S1 的幼苗没有重要变化。比较 withYanBian S1, GaoYou CSC63 也显示出更高的根在在水赤字下面的幼苗的水力的电导率和更低的减少趋势。这些结果显示 JcPIP2 可能在 J 在干旱抵抗起了一个作用。curcas。 | Ying ZHANG Yunxiao WANG Luding JIANG Ying XU Yingchun WANG Daihua LU Fang CHEN | 2007 | Acta Biochimica et Biophysica Sinica2007，39，10： | 13 |
| 4 | A Multicenter Study of Viral Aetiology of Community-Acquired Pneumonia in Hospitalized Children in Chinese Mainland显示文摘Community-acquired pneumonia(CAP) is one of the leading causes of morbidity and mortality in children worldwide.In this study,we aimed to describe the aetiology of viral infection of pediatric CAP in Chinese mainland.During November2014 to June 2016,the prospective study was conducted in 13 hospitals.The hospitalized children under 18 years old who met the criteria for CAP were enrolled.The throat swabs or nasopharyngeal aspirates(NPAs) were collected which were then screened 18 respiratory viruses using multiplex PCR assay.Viral pathogens were present in 56.6%(1539/2721) of the enrolled cases,with the detection rate of single virus in 39.8% of the cases and multiple viruses in 16.8% of the cases.The most frequently detected virus was respiratory syncytial virus(RSV)(15.2%,414/2721).The highest detection rate of virus was in <6-month-age group(70.7%,292/413).RSV,human metapneumovirus(HMPV),human parainfluenza viruses(HPIVs) and influenza B virus(Flu B) showed the similar prevalence patterns both in north and south China,but HPIVs,Flu A,human bocavirus(HBoV),human adenovirus(HAdV) and human coronaviruses(HCoVs) showed the distinct circulating patterns in north and south China.Human enterovirus/human rhinovirus(HEV/HRV)(27.6%,27/98),HBoV(18.4%,18/98),RSV(16.3%,16/98) and HMPV(14.3%,14/98) were the most commonly detected viruses in severe pneumonia cases with single virus infection.In conclusion,viral pathogens are frequently detected in pediatric CAP cases and may therefore play a vital role in the aetiology of CAP.RSV was the most important virus in hospitalized children with CAP in Chinese mainland. | Yun Zhu Baoping Xu Changchong Li Zhimin Chen Ling Cao Zhou Fu Yunxiao Shang Aihuan Chen Li Deng Yixiao Bao Yun Sun Limin Ning Shuilian Yu Fang Gu Chunyan Liu Ju Yin Adong Shen Zhengde Xie Kunling Shen | 2021 | Virologica Sinica2021，36，6： | 7 |
| 5 | RNF13: a novel RING-type ubiquitin ligase over-expressed in pancreatic cancer显示文摘由 E3 ubiquitin ligases 的蛋白质 ubiquitination 在癌症开发起一个重要作用。在这研究,我们提供 RING-finger-containing 蛋白质 RNF13 是 ER/Golgi 联系膜的 E3 ubiquitin ligase,它的戒指手指领域为 ubiquitin ligase 活动被要求的试验性的证据。胰腺的 ductal 腺癌(PDAC ) 和从 72 个病人的 paracancerous 正常纸巾的 Immunohistochemical 分析在 30 件肿瘤样品记录了 RNF13 在表示上(41.7% , 30/72 ) ,并且它的表示显著地与组织学的分级被联系(P = 0.024 ) 。另外, RNF13 在癌症前期的损害被检测:在长期的胰腺炎(CP ) 和胰腺的 intraepithelial 瘤形成(PanIN ) 的管状的建筑群(79.3% , 23/29 并且 62.8% , 22/35,分别地) 。而且,染色的 RNF13 显著地与 Tenascin-C 表示被相关(P = 0.004 ) 在 PDAC 样品,进一步在癌症支持 RNF13 的角色前进。在胰腺的 MiaPaca-2 癌症房间的野类型然而并非戒指域异种 RNF13 的在表示上由矩阵 metalloproteinase-9 增加了侵略潜力和 gelatinolytic 活动。一起拿,这些调查结果表明 RNF13 是涉及胰腺的 carcinogenesis 的新奇 E3 ubiquitin ligase;由 RNF13 的蛋白质的调停 ubiquitin 的修正可以参予胰腺的癌症开发。 | Qiang Zhang Yunxiao Meng Lei Zhang Jie Chen Dahai Zhu | 2009 | Cell Research2009，19，3： | 6 |
| 6 | Regulation of flowering time in chrysanthemum by the R2R3 MYB transcription factor CmMYB2 is associated with changes in gibberellin metabolism显示文摘The switch from vegetative growth to reproductive growth is a key event in the development of a plant.Here,the product of the chrysanthemum gene CmMYB2,an R2R3 MYB transcription factor that is localized in the nucleus,was shown to be a component of the switching mechanism.Plants engineered to overexpress CmMYB2 flowered earlier than did wild-type plants,while those in which CmMYB2 was suppressed flowered later.In both the overexpression and RNAi knockdown plants,a number of genes encoding proteins involved in gibberellin synthesis or signaling,as well as in the response to photoperiod,were transcribed at a level that differed from that in the wild type.Both yeast two-hybrid and bimolecular fluorescence complementation assays revealed that CmMYB2 interacts with CmBBX24,a zinc-finger transcription factor known to regulate flowering by its influence on gibberellin synthesis. | Lu Zhu Yunxiao Guan Yanan Liu Zhaohe Zhang Muhammad Abuzar Jaffar Aiping Song Sumei Chen Jiafu Jiang Fadi Chen | 2020 | Horticulture Research2020，7，1： | 5 |
| 7 | Evolution of urban black and odorous water:The characteristics of microbial community and driving-factors显示文摘Urban black blooms that are primarily caused by organic carbon are deleterious environmental problems.However,detailed studies on the microbial characteristics that form urban black blooms are lacking.In this study,we observed the composition,diversity,and function of bacterial community in the overlying water and sediments during the occurrence and remediation of urban black blooms using high-throughput 16S rRNA gene amplicon sequencing analysis.First,we found that pivotal consortia in the overlying water increased significantly during the formation of black blooms,including the genera Acidovorax,Brevundimonas,Pusillimonas,and Burkholderiales involved in the degradation of refractory organics,as well as the genera Desulfovibrio,Dechloromonas,and Rhizobium related to the production of black and odorous substances.An RDA analysis revealed that chemical oxygen demand,dissolved oxygen,and oxidation reduction potential were related to the changes in microbial community composition.Furthermore,aeration was found to accelerate the removal of ammonia nitrogen and enhance the function of microbial community by stimulating the growth of order Planktomycetes during the remediation of black blooms,but aeration substantially damaged the microbial diversity and richness.Therefore,the health of the aquatic ecosystem should be comprehensively considered when aeration is applied to restore polluted waterbodies.Notably,we observed a large number of pathogenic bacteria in urban black blooms,which emphasizes the importance of treating domestic sewage so that it is harmless.Together,these findings provide new insights and a basis to prevent and manage urban black blooms. | Dan Zhang Huilan Yang Shuhuan Lan Chen Wang Xudong Li Yunxiao Xing Hua Yue Qiulin Li Ling Wang Yifei Xie | 2022 | Journal of Environmental Sciences2022，34，2： | 4 |
| 8 | Single capillary oximetry and tissue ultrastructural sensing by dual-band dual-scan inverse spectroscopic optical coherence tomography显示文摘Measuring capillary oxygenation and the surrounding ultrastructure can allow one to monitor a microvascular niche and better understand crucial biological mechanisms.However,capillary oximetry and pericapillary ultrastructure are challenging to measure in vivo.Here we demonstrate a novel optical imaging system,dual-band dual-scan inverse spectroscopic optical coherence tomography(D2-ISOCT),that,for the first time,can simultaneously obtain the following metrics in vivo using endogenous contrast:(1)capillary-level oxygen saturation and arteriolar-level blood flow rates,oxygen delivery rates,and oxygen metabolic rates;(2)spatial characteristics of tissue structures at length scales down to 30 nm;and(3)morphological images up to 2mm in depth.To illustrate the capabilities of D2-ISOCT,we monitored alterations to capillaries and the surrounding pericapillary tissue(tissue between the capillaries)in the healing response of a mouse ear wound model.The obtained microvascular and ultrastructural metrics corroborated well with each other,showing the promise of D2-ISOCT for becoming a powerful new non-invasive imaging tool. | Rongrong Liu James A.Winkelmann Graham Spicer Yunxiao Zhu Aya Eid Guillermo A.Ameer Vadim Backman Ji Yi | 2018 | Light(Science & Applications)2018，7，1： | 4 |
| 9 | Experimental Investigation on Heat Transfer Coefficient during Upward Flow Condensation of R410A in Vertical Smooth Tubes显示文摘This paper presents an experimental investigation on condensation of R410 A upward flow in vertical tubes with the same inner diameter of 8.02 mm and different lengths of 300 mm, 400 mm, 500 mm and 600 mm. Condensation experiments were performed at mass fluxes of 103-490 kg m-2s-1. The saturation temperatures of experimental condition were 31℃, 38℃and 48℃, alternatively. The average vapor quality in the test section is between 0.91 and 0.98. The effects of tube length, mass flux and condensation temperature on condensation were discussed. Four correlations used for the upward flow condensation were compared with the experimental data obtained from various experimental conditions. A modified correlation was proposed within a ±15% deviation range. | YANG Yunxiao JIA Li | 2015 | Journal of Thermal Science2015，24，2： | 4 |
| 10 | Synthesis, characterization and tribological evaluation of novel1,4-diazabicyclo[2.2.2]octane based dicationic ionic liquids as efficient antiwear lubricant additives显示文摘Ionic liquids have developed and been applied in lubricant field since 2001. Nevertheless, it is little known about novel dicationic ionic liquids for tribology applications in the past several years. In this paper, a sequence of novel dicationic ionic liquids based on 1,4-diazabicyclo[2.2.2]octane cations(DABCO) and different anions have been designed and identified. The structures of ILs were confirmed by Fourier transform infrared(FTIR) spectra, multinuclear(~1H,^(13)C,^(11)B,^(31)P and ^(19)F) magnetic resonance and mass spectrometry. The effects of anion type on thermal properties, wettability, kinematic viscosity and tribological properties were studied. It is found that all of these dicationic ionic liquids as additives exhibit excellent anti-wear and friction-reducing properties in PEG synthetic base oil under boundary lubrication conditions for steel-to-steel contact, which offers great potential for the highly efficient lubricant additives. Simultaneously, novel 1,4-diazabicyclo[2.2.2]octane cation offers an exceptional chance for the research and development of dicationic ionic liquids in various applications. | ZHAO LiNa CAI Tao ZHANG YunXiao YE MengTing SHANG WangJi LIU Dan TONG DingYi LIU ShengGao | 2019 | Science China(Technological Sciences)2019，62，2： | 3 |
| 11 | One-pot In-situ Synthesis of Sn/Carbon-fibers Nanocomposite by Chemical Vapor Deposition and Its Li-storage Properties显示文摘Sn/carbon-fibers(CFs) nanocomposite has been prepared by chemical vapor deposition with in-situ catalytic growth of CFs.The nanocomposite has been characterized by X-ray diffraction(XRD),field emission scanning electron microscopy(FE-SEM),transmission electron microscopy(TEM) and Raman spectrum.The electrochemical performance of the nanocomposite has been investigated by galvanostatic cycling and cyclic voltammetry(CV).It has been found that a three-dimensional conductive network forms by the interconnected CFs,which offers conductive channels for the Sn nanoparticles.The nanocomposite gives a first charge capacity of 385 mAh.g-1 and exhibits an improved cycling stability than bare Sn. | J.Xie Yunxiao Zheng Shuangyu Liu Gaoshao Cao Xinbing Zhao | 2012 | Journal of Materials Science & Technology2012，28，3： | 3 |
| 12 | The association of cerebrospinal fluid pressure with optic nerve head and macular vessel density显示文摘The present study aims to investigate the effect of temporary cerebrospinal fluid pressure(CSFP) reduction on optic nerve head(ONH) and macular vessel density(VD) using optical coherence tomography angiography.Forty-four eyes of 44 adults with diagnostic lumbar puncture and CSFP reduction were recruited.Thirty-two eyes of 32 healthy volunteers were controls.ONH and macular VD images were evaluated differences between baseline and after CSFP reduction.The results showed that the mean CSFP decreased from(11.6±2.1) mm Hg to(8.2±3.4) mm Hg(P<0.001).VD in the macular regions decreased significantly after CSFP reduction in the study group(all P<0.05).The control group showed no significant changes in macular VD(all P>0.05).In the study group,decreased VD in the macular parainferior region was associated with CSFP reduction(R^(2)=0.192,P=0.003),the reduction of macular VD in parafoveal(R^(2)=0.098,P=0.018),parainferior(R^(2)=0.104,P=0.021),parasuperior(R^(2)=0.059,P=0.058),paranasal(R^(2)=0.057,P=0.042),paratemporal(R^(2)=0.079,P=0.026) was associated with mean ocular perfusion pressure decrease following CSFP reduction.ONH vessel density did not differ after CSFP reduction(all P>0.05).In conclusion,macular vessel density decreased in association with CSFP reduction.Retinal vessel density in the macular region is more sensitive than that in peripapillary region after CSFP reduction. | Xiangxiang Liu Mohamed M.Khodeiry Danting Lin Yunxiao Sun Qing Zhang Jiawei Wang Richard K.Lee Ningli Wang | 2022 | Science China(Life Sciences)2022，65，6： | 3 |
| 13 | Corrosion engineering boosting bulk Fe_(50)Mn_(30)Co_(10)Cr_(10)high-entropy alloy as high-efficient alkaline oxygen evolution reaction electrocatalyst显示文摘Oxygen evolution reaction(OER)is a critical process in electrocatalytic water splitting.However,the development of low-cost,highly efficient OER electrocatalysts by a simple method that can be used for industrial application on a large scale is still a huge challenge.Recently,high entropy alloy(HEA)has acquired extensive attention,which may provide answers to the current dilemma.Here,we report bulk Fe_(50)Mn_(30)Co_(10)Cr_(10),which is prepared by 3D printing on a large scale,as electrocatalyst for OER with high catalytic performance.Especially,an easy approach,corrosion engineering,is adopted for the first time to build an active layer of honeycomb nanostructures on its surface,leading to ultrahigh OER performance with an overpotential of 247 mV to achieve a current density of 10 mA cm^(-2),a low Tafel slope of 63 mV dec^(-1),and excellent stability up to 60 h at 100 mA cm^(-2)in 1 M KOH.The excellent catalytic activity mainly originates from:(1)the binder-free self-supported honeycomb nanostructures and multi-component hydroxides,which improve intrinsic catalytic activity,provide rich active sites,and reduce interfacial resistance;and(2)the diverse valence states for multiple active sites to enhance the OER kinetics.Our findings show that corrosion engineering is a novel strategy to improve the bulk HEA catalytic performance.We expect that this work would open up a new avenue to fabricate large-scale HEA electrocatalysts by 3D printing and corrosion engineering for industrial applications. | Pengfei Zhou Dong Liu Yuyun Chen Mingpeng Chen Yunxiao Liu Shi Chen Chi Tat Kwok Yuxin Tang Shuangpeng Wang Hui Pan | 2022 | Journal of Materials Science & Technology2022，，14： | 3 |
| 14 | Effects of biochar and litter on carbon and nitrogen mineralization and soil microbial community structure in a China fir plantation显示文摘To investigate the effects of biochar addition(1 or 3%)to the soil of a China fir plantation with or without litter,we conducted a 90-day incubation experiment.We also studied the C and N dynamics and the microbial community structure of the soil.In soil without litter,the application of biochar at a rate of 3%significantly decreased CO2 emissions,while addition of 1%biochar had no effect.Biochar application did not affect the net N mineralization rate but significantly reduced the NH4?concentration after 90 days.In litter-enriched soil,biochar application had no significant effect on total CO2 emissions;however,application of 3%biochar significantly reduced the net N mineralization rate.Biochar application to soil with or without litter immediately reduced the dissolved organic carbon(DOC)concentration independent of the application rate,which was primarily due to sorption of DOC by the biochar.Phospholipid fatty acid analysis demonstrated that both concentrations of added biochar to soil(with or without litter)altered the soil microbial community structure at the end of incubation,although the effect of biochar was not as strong as the effect of time or litter application.The effect of biochar addition alone on microbial community structure was inconsistent over time.Litter added to soil significantly increased fungi and reduced Gram-positive bacteria.In the presence of litter,biochar applied at both 1%and 3%significantly increased(p<0.05)the proportion of actinomycete only at day 90.Our results indicate biochar as a potentially effective measure for C sequestration in the test soil of a China fir plantation,even in the presence of litter. | Ying Li Chuifan Zhou Yunxiao Qiu Mulualem Tigabu Xiangqing Ma | 2019 | Journal of Forestry Research2019，30，5： | 3 |
| 15 | Overexpression of the CmJAZ1-like gene delays flowering in Chrysanthemum morifolium显示文摘Chrysanthemum(Chrysanthemum morifolium)is one of the four major cut-flower plants worldwide and possesses both high ornamental value and cultural connotation.As most chrysanthemum varieties flower in autumn,it is costly to achieve annual production.JAZ genes in the TIFY family are core components of the jasmonic acid(JA)signaling pathway;in addition to playing a pivotal role in plant responses to defense,they are also widely implicated in regulating plant development processes.Here,we characterized the TIFY family gene CmJAZ1-like from the chrysanthemum cultivar‘Jinba’.CmJAZ1-like localizes in the nucleus and has no transcriptional activity in yeast.Tissue expression pattern analysis indicated that CmJAZ1-like was most active in the root and shoot apex.Overexpressing CmJAZ1-like with Jas domain deletion in chrysanthemum resulted in late flowering.RNA-Seq analysis of the overexpression lines revealed some differentially expressed genes(DEGs)involved in flowering,such as the homologs of the flowering integrators FT and SOC1,an FUL homolog involved in flower meristem identity,AP2 domain-containing transcription factors,MADS box genes,and autonomous pathway-related genes.Based on KEGG pathway enrichment analysis,the differentially transcribed genes were enriched in carbohydrate metabolic and fatty acid-related pathways,which are notable for their role in flowering in plants.This study preliminarily verified the function of CmJAZ1-like in chrysanthemum flowering,and the results can be used in molecular breeding programs aimed at flowering time regulation of chrysanthemum. | Yunxiao Guan Lian Ding Jiafu Jiang Yuanyue Shentu Wenqian Zhao Kunkun Zhao Xue Zhang Aiping Song Sumei Chen Fadi Chen | 2021 | Horticulture Research2021，8，1： | 3 |
| 16 | Electrical resistivity-temperature characteristics enhancement of insulating cross-linked polyethylene composites by incorporating positive temperature coefficient particles with different Curie temperatures显示文摘Incorporating positive temperature coefficient(PTC)ceramic particles into polymers provides a prospective alternative solution for suppressing severe electric field distortions caused by negative temperature coefficient(NTC)of electrical resistivity within polymer insulation in high voltage direct current cable.The effect of the Curie temperature of PTC particles on the inhibition of the NTC effect of cross-linked polyethylene(XLPE)is investigated in this study.Positive temperature coefficient particles with varied Curie temperatures are surface-modified and melt blending with XLPE.The modified particles are dispersed on averagely in the matrix.The electrical resistivity,space charge behaviour,and direct current(DC)electrical breakdown strength of the samples are investigated at different temperatures,exploring the effect of the Curie temperature of PTC particles on suppressing the NTC effect of XLPE.It is demonstrated that the reduction in Curie temperature can further suppress the NTC effect of XLPE,enhance the DC strength at elevated temperatures,and inhibit the internal space charge accumulation.The reduction in the Curie temperatures means that the initiation of the PTC effect advances,exhibiting a higher potential barrier and inhibiting the NTC effect more effectively.This work may give a reference for improving the temperature stability of DC properties for XLPE cable insulation. | Guimin Jiang Yuanxiang Zhou Chenyuan Teng Yunxiao Zhang Xin Huang Lei Xue Luming Zhou | 2023 | High Voltage2023，8，1： | 2 |
| 17 | 16S rRNA gene sequencing analysis of gut microbiome in a mini-pig diabetes model显示文摘Background:Currently,increasing attention is being paid to the important role of intestinal microbiome in diabetes.However,few studies have evaluated the characteristics of gut microbiome in diabetic miniature pigs,despite it being a good model animal for assessing diabetes.Methods:In this study,a mini-pig diabetes model(DM)was established by 9-month high-fat diet(HFD)combined with lowdose streptozotocin,while the animals fed standard chow diet constituted the control group.16S ribosomal RNA(rRNA)gene sequencing was performed to assess the characteristics of the intestinal microbiome in diabetic mini-pigs.Results:The results showed that microbial structure in diabetic mini-pigs was altered,reflected by increases in levels of Coprococcus_3 and Clostridium_sensu_stricto_1,which were positively correlated with diabetes,and decreases in levels of the bac-teria Rikenellaceae,Clostridiales_vadinBB60_group,and Bacteroidales_RF16_group,which were inversely correlated with blood glucose and insulin resistance.Moreover,PICRUSt-predicted pathways related to the glycolysis and Entner-Doudoroff superpathway,enterobactin biosynthesis,and the L-tryptophan biosynthesis were significantly elevated in the DM group.Conclusion:These results reveal the composition and predictive functions of the intestinal microbiome in the mini-pig diabetes model,further verifying the relationship between HFD,gut microbiome,and diabetes,and providing novel insights into the application of the mini-pig diabetes model in gut microbiome research. | Miaomiao Niu Yuqiong Zhao Lei Xiang Yunxiao Jia Jifang Yuan Xin Dai Hua Chen | 2022 | Animal Models and Experimental Medicine2022，5，1： | 2 |
| 18 | Long-term case study of a Wuzhishan miniature pig with diabetes显示文摘Background:Miniature pigs are attractive animal models for exploring diabetes because they are similar to humans in terms of physiological structure and metabolism.However,little is known about the complications of diabetes in pigs.Methods:In this study,a 28-month observation of a Wuzhishan miniature pig with streptozotocin(STZ)-induced(120 mg/kg)diabetes was conducted,to investigate diabetes-related complications and the possibility of self-recovery in miniature pigs.Blood glucose,serum and urinary biochemistry was measured,and histopathologic examinations of eyes,kidney and pancreas were made.Results:During the observation,diabetic complications of eyes and kidney were observed.The eye complications included bilateral cataracts in the 15th month and degeneration of inner retina and microaneurysm in the 28th month.Kidney complications included glomerular mesangial expansion,focal segmental glomerular sclerosis,and renal tubular epithelial degeneration,but no proteinuria was observed.By 28 months after the application of STZ,with no treatment given,blood glucose had recovered and the number of pancreatic islet beta-cells had increased significantly.Conclusions:We showed that the STZ-induced diabetes model in miniature pigs could accurately mimic the pathological changes of human diabetes,and that pancreatic islet beta-cell regeneration did occur in an adult miniature pig,providing a new means for exploring diabetic complications and pancreatic islet beta-cell regeneration. | Miaomiao Niu Yaqian Liu Lei Xiang Yuqiong Zhao Jifang Yuan Yunxiao Jia Xin Dai Hua Chen | 2020 | Animal Models and Experimental Medicine2020，3，1： | 2 |
| 19 | Coaxial laser cladding of A1203-13 TiO2 powders on Ti-6AI-4V alloy显示文摘 | CHEN YUNXIAO WU DONGJIANG MA GUAN- GYI | 2012 | Surface Coatings Technology2012，，228： | 1 |
| 20 | Direct Asymmetric Aldol Reaction Co-catalyzed by Amphiphilic Prolinamide Phenol and Lewis Acidic Metal on Water显示文摘一条途径为直接不对称的丁间醇醛反应基于各种各样的水兼容机路易斯酸和脂性的组包含 amphiphilic prolinamide 合作催化剂的联合被评估了。从从碱金属氯化物盐屏蔽到转变的女人,金属, LiCl, ZnCl2 和 SnCl2 导致最高的 stereoselectivities。优化催化条件(有在水上的房间温度的 10 mol% MCl2 或 20 mol% LiCl 的 10 mol% prolinamide ) 与改进 enantioselectivities (多达 99% ee ) 给了反产品与相比中等 stereoselective 过程基于 prolinamide 激活仅仅。 | Tao Zhang Yunxiao Zhang Zaichun Li Zhongtai Song Hao Liu Jingchao Tao | 2013 | Chinese Journal of Chemistry2013，31，2： | 1 |
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