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| 1 | Human enamel thickness and ENAM polymorphism显示文摘The tooth enamel development gene, enamelin(ENAM), showed evidence of positive selection during a genome-wide scan of human and primate DNA for signs of adaptive evolution. The current study examined the hypothesis that a single-nucleotide polymorphism(SNP) C14625T(rs7671281) in the ENAM gene identified in the genome-wide scan is associated with a change in enamel phenotype. African Americans were selected as the target population, as they have been reported to have a target SNP frequency of approximately 50%, whereas non-Africans are predicted to have a 96% SNP frequency. Digital radiographs and DNA samples from 244 teeth in 133 subjects were analysed, and enamel thickness was assessed in relation to SNP status,controlling for age, sex, tooth number and crown length. Crown length was found to increase with molar number, and females were found to have thicker enamel. Teeth with larger crowns also had thicker enamel, and older subjects had thinner enamel.Linear regression and generalized estimating equations were used to investigate the relationship between enamel thickness of the mandibular molars and ENAM SNP status; enamel in subjects with the derived allele was significantly thinner(P = 0.040)when the results were controlled for sex, age, tooth number and crown length. The derived allele demonstrated a recessive effect on the phenotype. The data indicate that thinner dental enamel is associated with the derived ENAM genotype. This is the first direct evidence of a dental gene implicated in human adaptive evolution as having a phenotypic effect on an oral structure. | Diane M Daubert Joanna L Kelley Yuriy G Udod Carolina Habor Chris G Kleist Ilona K Furman Igor N Tikonov Willie J Swanson Frank A Roberts | 2016 | International Journal of Oral Science2016，8，2： | 2 |
| 2 | Plasmon-Enhanced Photoluminescence of SiC Quantum Dots for Cell Imaging Applications显示文摘 | Yuriy Zakharko Tetiana Serdiuk Tetyana Nychyporuk Alain Gélo?n Mustapha Lemiti Vladimir Lysenko | 2012 | Plasmonics2012，，4： | 1 |
| 3 | An investigation of co-fired varistor-ferrite materials 显示文摘 | Aran R Yurii G K Ramesh R | 2004 | Journal of the European Ceramic Society2004，24，： | 1 |
| 4 | Financial constraints and innovation:why poor countries don't catch up显示文摘 | YURIY G MONIKA S | 2013 | Journal of the European Economic Association2013，11，5： | 1 |
| 5 | Analytical light-scattering solution for Chebyshev particles显示文摘 | DMITRIY P YURIY S VIDEEN G | 2007 | Opt Soc Am A2007，24，4： | 1 |
| 6 | Laser diodes emitting up to 25 W at 808 nm显示文摘 | V V Bezotosnyi Vadim Yu Bondarev Oleg N Krokhin G T Mikaelyan V A Oleshchenko Valerii F Pevtsov Yurii M Popov E A Cheshev | 2009 | Quantum Electronics2009，，3： | 1 |
| 7 | Multifunctioual magnetic-fluorescent nanocomposites for biomedical applications显示文摘 | Serena A C Yury P R Yurii K G | 2008 | Nanoscale Res Lett2008，3，： | 1 |
| 8 | Recent advances in research on carbon nanotube-polymer composites显示文摘 | Michele T B Yurii K G | 2010 | Advance Materials2010，22，15： | 1 |
| 9 | Reaction kinetics of gas generation in selected source rocks of the West Siberian Basin: implications for the mass balance of early-thermogenic methane显示文摘 | Rainer G Schaefer Yurii I Galushkin Antje Kolloff Ralf Littke | 1999 | Chemical Geology1999，，1： | 1 |
| 10 | Expression profiling identifies microRNA signature in pancreatic cancer显示文摘 | Eun JL Yuriy G Jinmai J | 2007 | Intl J Cancer2007，120，5： | 1 |
| 11 | Highly efficient and stable catalyst for peroxynitrite decomposition显示文摘 | Yurii V G Alan J B Jennifer J C | 2001 | Can J Chem2001，79，56： | 1 |
| 12 | An investigation of cofired varistor-ferrite materials显示文摘 | ARAN R YURII G K RAMESH R | 2004 | Journal of the European Ceramic Society2004，24，7： | 1 |
| 13 | Expression profiling identifies microRNA signature in pancreatic cancer显示文摘 | Eun J L Yuriy G Jinmai J | 2007 | Int J Cancer2007，120，5： | 1 |
| 14 | Atomic force microscopy studies of living cells: visualization of motility,division, aggregation, transformation and apoptosis 显示文摘 | Yurii G K Alexander J M Alexander M | 1997 | J Struc Biol1997，120，： | 1 |
| 15 | Structure and properties ofB4C-SiCcomposites显示文摘 | Yurii G T Viktor F B Emmanuil V P | 2005 | Powder Metallurgyand Metal Ceramics2005，44，34： | 1 |
| 16 | Association of microRNA expression in hepatocellular carcinomas with hepatitis in- fection, cirrhosis, and patient survival 显示文摘 | Jinmai J Yuriy G IIeana A | 2008 | Clin Cancer Res2008，14，3： | 1 |
| 17 | An investigation of cofired varistor-ferrite materials 显示文摘 | Aran R Yurii G K Ramesh R | 2004 | J Eur Ceram Soc2004，24，： | 1 |
| 18 | Hepatobiliary system and intestinal injury in new coronavirus infection(COVID-19):A retrospective study显示文摘BACKGROUND An important area of effective control of the coronavirus disease 19(COVID-19)pandemic is the study of the pathogenic features of severe acute respiratory syndrome coronavirus 2 infection,including those based on assessing the state of the intestinal microbiota and permeability.AIM To study the clinical features of the new COVID-19 in patients with mild and moderate severity at the stage of hospitalization,to determine the role of hepatobiliary injury,intestinal permeability disorders,and changes in the qualitative and quantitative composition of the microbiota in the development of systemic inflammation in patients with COVID-19.METHODS The study was performed in 80 patients with COVID-19,with an average age of 45 years,19 of whom had mild disease,and 61 had moderate disease severity.The scope of the examination included traditional clinical,laboratory,biochemical,instrumental,and radiation studies,as well as original methods for studying microbiota and intestinal permeability.RESULTS The clinical course of COVID-19 was studied,and the clinical and biochemical features,manifestations of systemic inflammation,and intestinal microbiome changes in patients with mild and moderate severity were identified.Intestinal permeability characteristics against the background of COVID-19 were evaluated by measuring levels of proinflammatory cytokines,insulin,faecal calprotectin,and zonulin.CONCLUSION This study highlights the role of intestinal permeability and microbiota as the main drivers of gastroenterological manifestations and increased COVID-19 severity. | Konstantin V Kozlov Konstantin V Zhdanov Anna K Ratnikova Vyacheslav A Ratnikov Artem V Tishkov Vladimir Grinevich Yuriy A Kravchuk Panteley I Miklush Polina O Nikiforova Vera V Gordienko Alexander F Popov Boris G Andryukov | 2023 | World Journal of Clinical Cases2023，11，10： | 0 |
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