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| 1 | Contribution of functional KIR3DL1 to ankylosing spondylitis显示文摘Increasing evidence points to a role for killer immunoglobulin-like receptors(KIRs)in the development of autoimmune diseases.In particular,a positive association of KIR3DS1(activating receptor)and a negative association of KIR3DL1(inhibitory receptor)alleles with ankylosing spondylitis(AS)have been reported by several groups.However,none of the studies analyzed these associations in the context of functionality of polymorphic KIR3DL1.To better understand how the KIR3DL1/3DS1 genes determine susceptibility to AS,we analyzed the frequencies of alleles and genotypes encoding functional(KIR3DL1*F)and non-functional(KIR3DL1*004)receptors.We genotyped 83 AS patients and 107 human leukocyte antigen(HLA)-B27-positive healthy controls from the Russian Caucasian population using a two-stage sequence-specific primer PCR,which distinguishes KIR3DS1,KIR3DL1*F and KIR3DL1*004 alleles.For the patients carrying two functional KIR3DL1 alleles,those alleles were additionally genotyped to identify KIR3DL1*005 and KIR3DL1*007 alleles,which are functional but are expressed at low levels.KIR3DL1 was negatively associated with AS at the expense of KIR3DL1*F but not of KIR3DL1*004.This finding indicates that the inhibitory KIR3DL1 receptor protects against the development of AS and is not simply a passive counterpart of the segregating KIR3DS1 allele encoding the activating receptor.However,analysis of genotype frequencies indicates that the presence of KIR3DS1 is a more important factor for AS susceptibility than the absence of KIR3DL1*F.The activation of either natural killer(NK)or T cells via the KIR3DS1 receptor can be one of the critical events in AS development,while the presence of the functional KIR3DL1 receptor has a protective effect.Nevertheless,even individuals with a genotype that carried two inhibitory KIR3DL1 alleles expressed at high levels could develop AS. | Ivan V Zvyagin Ilgar Z Mamedov Olga V Britanova Dmitriy B Staroverov Evgeni L Nasonov Anna G Bochkova Anna V Chkalina Alexei A Kotlobay Dmitriy O Korostin Denis V Rebrikov Sergey Lukyanov Yuri B Lebedev Dmitriy M Chudakov | 2010 | Cellular & Molecular Immunology2010，7，6： | 5 |
| 2 | Molecular pathways of liver regeneration:A comprehensive review显示文摘The liver is a unique parenchymal organ with a regenerative capacity allowing it to restore up to 70%of its volume.Although knowledge of this phenomenon dates back to Greek mythology(the story of Prometheus),many aspects of liver regeneration are still not understood.A variety of different factors,including inflammatory cytokines,growth factors,and bile acids,promote liver regeneration and control the final size of the organ during typical regeneration,which is performed by mature hepatocytes,and during alternative regeneration,which is performed by recently identified resident stem cells called“hepatic progenitor cells”.Hepatic progenitor cells drive liver regeneration when hepatocytes are unable to restore the liver mass,such as in cases of chronic injury or excessive acute injury.In liver maintenance,the body mass ratio is essential for homeostasis because the liver has numerous functions;therefore,a greater understanding of this process will lead to better control of liver injuries,improved transplantation of small grafts and the discovery of new methods for the treatment of liver diseases.The current review sheds light on the key molecular pathways and cells involved in typical and progenitor-dependent liver mass regeneration after various acute or chronic injuries.Subsequent studies and a better understanding of liver regeneration will lead to the development of new therapeutic methods for liver diseases. | Yana V Kiseleva Sevak Z Antonyan Tatyana S Zharikova Kirill A Tupikin Dmitry V Kalinin Yuri O Zharikov | 2021 | World Journal of Hepatology2021，13，3： | 2 |
| 3 | Improvement of wrinkles by an all trans-retinoic acid derivative, D-δ-toeopheryl retinoate显示文摘 | YURI O | 2006 | Journal of Der matological Science2006，，2： | 1 |
| 4 | Fermented Red Ginseng Extract Inhibits Cancer Cell Proliferation and Viability显示文摘 | Jisun O h Seong Bin Jeon Yuri Lee | 2015 | J Med Food2015，18，4： | 1 |
| 5 | AFM study of membrane proteins,cytochrome P450 2B4,and NADPH -cytochrome P450 reductase and their complex formation显示文摘 | OLGA I K IGOR V Y YURI O I | 1999 | Archives of Biochem and Biophysic1999，371，1： | 1 |
| 6 | Expression of adiponectin receptors and its possible implication in the human endometrium 显示文摘 | Yuri T Yutaka O Toshimasa Y | 2005 | Endocrinology2005，47，： | 1 |
| 7 | The resonant retina: exploiting vibration noise to optimally detect edges in an image显示文摘 | M O Hongler Yuri L de Meneses | 2003 | IEEE Transactions on pattern analysis and machine intelligence2003，25，9： | 1 |
| 8 | Cooperative luminescence and absorption in ytterbium-doped silica fiber and the fiber nonlinear transmission coefficient at λ=980 nm with a regard to the Ytterbium ions-pairs'effect显示文摘 | Alexander V K Yuri O B Itzel L M | 2006 | Optics Express2006，14，9： | 1 |
| 9 | Efficient numerical solution for highly transient flows显示文摘 | Haroun M Adeyemi O Yuri R | 2006 | Chemical engineering science2006，61，： | 1 |
| 10 | PEG-modified gold nanorods with a stealth character for in vivo applications显示文摘 | Takuro N Masato Y Yuri O | 2006 | Journal of Controlled Release2006，114，3： | 1 |
| 11 | Effects of UV irradiation on the sebaceous glandand sebum secretion in hamsters 显示文摘 | Yasuchiyo A Hirohiko A Yuri O | 2003 | J Dermatol Sci2003，31，2： | 1 |
| 12 | Pharmacological Characterization of SAR407899, a Novel Rho-Kinase Inhibitor显示文摘 | Matthias L?hn Oliver Plettenburg Yuri Ivashchenko Aimo Kannt Armin Hofmeister Dieter Kadereit Matthias Schaefer Wolfgang Linz Markus Kohlmann Jean-Marc Herbert Philip Janiak Stephen E. O’Connor Hartmut Ruetten | 2009 | Hypertension2009，，3： | 1 |
| 13 | Poly(ethylene terephthalate) thermo-mechanical and thermo-oxidative degradation mechanisms显示文摘 | Wanderson Rom(a)o Marcos F Franco Yuri E Corilo | | 0，，： | 1 |
| 14 | One-pot synthesis of linear-hy- perbranched amphiphilic block copolymers based on polyglycerol de- rivatives and their micelles显示文摘 | Yurie O Sueun L Kim D H | 2013 | Biomaeromolecules2013，14，7： | 1 |
| 15 | Productions of ultra-fine fowders and their use in high energetic composi- tions显示文摘 | Yuri F I Mirswan N O Valentin S S | 2003 | Propell Explos Pyrotechn2003，28，6： | 1 |
| 16 | Generation of active oxygen species from advanced glycation end-products (AGE)under ultraviolet lightA (UVA)irriadiation显示文摘 | Hitoshi M Yuri O Hiromu S | 1997 | Biochem Biophys Res Com1997，235，： | 1 |
| 17 | Natural colour reproduction d human skin for telemedicine 显示文摘 | Yuri O Obi T Yamagaohi M | 1998 | Proc of Medical Imaging1998，3335，： | 1 |
| 18 | Norepinephrine enhance fibrosis mediated by TGF-β in cardiac fibroblasts 显示文摘 | Yuri A Naoto A kira O | 2002 | Hypertension2002，40，2： | 1 |
| 19 | Bright Spatial Solitons in Defocusing Kerr Media Supported by Cascaded Nonlinearities显示文摘 | BANG O YURI KIVSHAR s | 1997 | Opt Lett1997，22，22： | 1 |
| 20 | Robust stabilization of infinite-dimensional systems using sliding-mode output feedback control 显示文摘 | Yury O Yiming L | 2004 | International Journal of Control2004，77，12： | 1 |
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