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| 1 | Preventive effect of a pectic polysaccharide of the common cranberry Vaccinium oxycoccos L. on acetic acid-induced colitis in mice显示文摘AIM: To study isolation and chemical characterization of pectin derived from the common cranberry Vaccinium oxycoccos L. (oxycoccusan OP) and the testing of its preventive effect on experimental colitis.METHODS: Mice were administrated orally with OP two days prior to a rectal injection of 5% acetic acid and examined for colonic damage 24 h later. Colonic inflammation was characterized by macroscopical injury and enhanced levels of myeloperoxidase activity measured spectrophotometrically with o-phenylene diamine as the substrate. The mucus contents of the colon were determined by the Alcian blue dye binding method. Vascular permeability was estimated using 4% Evans blue passage after i.p. injection of 0.05 mol/L acetic acid. RESULTS: In the mice treated with OP, colonic macroscopic scores (1.1 ± 0.4 vs 2.7, P < 0.01) and the total square area of damage (10 ± 2 vs 21 ± 7, P < 0.01) were significantly reduced when compared with the vehicle-treated colitis group. OP was shown to decrease the tissue myeloperoxidase activity in colons (42 ± 11 vs 112 ± 40, P < 0.01) and enhance the amount of mucus of colitis mice (0.9 ± 0.1 vs 0.4 ± 0.1, P < 0.01). The level of colonic malondialdehyde was noted to decrease in OP-pretreated mice (3.6 ± 0.7 vs 5.1 ± 0.8, P < 0.01). OP was found to decrease the inflammatory status of mice as was determined by reduction of vascular permeability (161 ± 34 vs 241 ± 21, P < 0.01). Adhesionof peritoneal neutrophils and macrophages was also shown to decrease after administration of OP (141 ± 50 vs 235 ± 37, P < 0.05).CONCLUSION: Thus, a preventive effect of pectin from the common cranberry, namely oxycoccusan OP, on acetic acid-induced colitis in mice was detected. A reduction of neutrophil infiltration and antioxidant action may be implicated in the protective effect of oxycoccusan. | Sergey V Popov Pavel A Markov Ida R Nikitina Sergey Petrishev Vasily Smirnov Yury S Ovodov | 2006 | World Journal of Gastroenterology2006，12，41： | 9 |
| 2 | Recent advances of laser-spectroscopy based techniques for applications in breath analysis 显示文摘 | Matthew R M Yury B Gerard W | 2007 | J Breath Res2007，1，1： | 1 |
| 3 | Bond market structure in the presence of marked point processes显示文摘 | BjOrk T Yuri K Wolfgang R | 1997 | Mathematical Finance1997，7，2： | 1 |
| 4 | Modeling of transienttwo-phase liquid-liquid flow in pipelines显示文摘 | Nunez-solis R Fairuzov Yuri V | 2001 | A- merican Society of Mechanical Engineers Fluids Engineering Di-vision (Publication) FED Fluids Engineer- ingDivision 20012001，256，： | 1 |
| 5 | N- (2-Carboxyethyl) Chitosan: Regioselective Synthesis, Characterization and Protolytic Equilibria显示文摘 | Skorik Yury A Comes Carlos A R Vasconcelos M Teresa S D | 2003 | Carbohydr Res2003，338，3： | 1 |
| 6 | Prioritizing abandoned coal mine reclamation projects within the contiguous United States using Geographic information system extrapolation显示文摘 | Yuri G~ Andrew V Matthew R and Erica M | 2003 | Environmental Management2003，32，： | 1 |
| 7 | Effect of prenatal and prepubertal genistein exposure on N-methyl-N-nitrosourca-induced mammary tumorigenesis in female Sprague-Dawley rats 显示文摘 | Pei R J Sato M Yuri T | 2003 | In Vivo2003，17，4： | 1 |
| 8 | Effects of different dura- tions of estrogen and progesterone treatment on development of N-methyl-N-nitrosourea-induced mammary carcinomas in female Lewis rats显示文摘 | Yuri T Tsukamoto R Uehara N | 2006 | In Vivo2006，20，6： | 1 |
| 9 | Challenges to effective cancer control in China, India, and Russia显示文摘 | Paul E Goss Kathrin Strasser-Weippl Brittany L Lee-Bychkovsky Lei Fan Junjie Li Yanin Chavarri-Guerra Pedro E R Liedke C S Pramesh Tanja Badovinac-Crnjevic Yuri Sheikine Zhu Chen You-lin Qiao Zhiming Shao Yi-Long Wu Daiming Fan Louis W C Chow Jun Wang Qio | 2014 | Lancet Oncology2014，，5： | 1 |
| 10 | Feasibility of laparoscopic adrenalectomy for large adrenal masses显示文摘 | Yuri W Novitsky MD Donald R | | 0，，02： | 1 |
| 11 | Efficient numerical solution for highly transient flows显示文摘 | Haroun M Adeyemi O Yuri R | 2006 | Chemical engineering science2006，61，： | 1 |
| 12 | Biphasic effects of zeranol on the growth of estrogen receptor-positive human breast carcinoma cells 显示文摘 | Yuri T Tsukamoto R Miki K | 2006 | Oncology Reports2006，16，6： | 1 |
| 13 | Oscillation criteria for certain nonlinear differential equations显示文摘 | Yuri V R | 1992 | Journal of Mathematical Analysis and Applications1992，29，： | 1 |
| 14 | Novel Sensor Technology for Shear and Normal Strain Detection with Generalized Electrostriction显示文摘 | Filanc-Bowen Torrey R Geun Hyung Kim Shkel Yuri M | 2002 | Sensors2002，2，： | 1 |
| 15 | Ion-pairing high-performance liquid chromatographic method for the determination of Saminosalicylic acid and related impurities in bulk chemi- cal显示文摘 | Brian SK Tom C Yury R | 1991 | J Chormatogr1991，588，12： | 1 |
| 16 | Note on ' Oscillation criteria for second order linear differential equations' 显示文摘 | Yuri V R | 1996 | J Math Anal Appl1996，203，： | 1 |
| 17 | Oscillation criteria for second order nonlinear perturbed differential equations显示文摘 | Yuri V R | 1997 | J Math Anal Appl1997，215，： | 1 |
| 18 | Feasibility of laparoscopic adrenalectomy for large adrenal masses显示文摘 | Yuri W Novitsky MD Donald R | 2003 | Surg Laparosc Endosc Percutan Tech2003，13，2： | 1 |
| 19 | Structural characterisation and environmental application of organoclays for the removal of phenolic compounds显示文摘 | Yuri Park Godwin A. Ayoko Erzsébet Horváth Róbert Kurdi Janos Kristof Ray L. Frost | 2012 | Journal of Colloid And Interface Science2012，，： | 1 |
| 20 | On oscillation of a second order nonlinear delay differential equation显示文摘 | Yuri V R | 2000 | Funkcialaj Ekvacioj2000，43，： | 1 |
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