| 1 | Image matching algorithm based on SIFT using color and exposure information显示文摘Image matching based on scale invariant feature transform(SIFT) is one of the most popular image matching algorithms, which exhibits high robustness and accuracy. Grayscale images rather than color images are generally used to get SIFT descriptors in order to reduce the complexity. The regions which have a similar grayscale level but different hues tend to produce wrong matching results in this case. Therefore, the loss of color information may result in decreasing of matching ratio. An image matching algorithm based on SIFT is proposed, which adds a color offset and an exposure offset when converting color images to grayscale images in order to enhance the matching ratio. Experimental results show that the proposed algorithm can effectively differentiate the regions with different colors but the similar grayscale level, and increase the matching ratio of image matching based on SIFT. Furthermore, it does not introduce much complexity than the traditional SIFT. | Yan Zhao Yuwei Zhai Eric Dubois Shigang Wang | 2016 | Journal of Systems Engineering and Electronics2016，27，3： | 5 |
| 2 | Effects of preventive acupuncture or moxibustion at the Guanyuan acupoint on expression of interleukin-2 and its receptors in hypothalamus, serum, and uterus of menopausal rats显示文摘BACKGROUND: Previous studies have indicated preventive acupuncture and moxibustion at the Guanyuan point have positive effects on the immune system of menopausal rats. OBJECTIVE: To observe the effects of preventive acupuncture or moxibustion at the Guanyuan point on interleukin-2 (IL-2) and its receptor (IL-2R mRNA) levels in hypothalamus, serum, and uterus of menopausal rats. DESIGN: Randomized control animal experiment. SETTING: School of Acupuncture and Moxibustion, Beijing University of Chinese Medicine. MATERIALS: This study was performed at the Laboratory of Beijing University of Chinese Medicine from November 2004 to July 2005. The vaginal smear method was used to determine the estrus cycle of 9.5-month-old Sprague Dawley (SD) female rats. Three continuous estrus cycles were measured, and 160 rats with estrus cycle disorder, weighing (300 ± 20) g, were included in this study. The rats were randomly divided into four groups: preventive acupuncture group (n =48), preventive moxibustion group (n =48), model groups (n =48), and 10-month-old group (n =16). Sixteen 3.5-month-old healthy SD female rats, weighing (240 ± 20) g, were also assigned to the young group. All rats were clean grade and were purchased from the Laboratory Animal Center, Beijing University of Chinese Medicine. The experiment was in accordance with animal ethics standards. METHODS: Acupuncture was applied to the preventive acupuncture group at 10 months of age. The needle was inserted upward and perpendicularly two fen to a point that was two fen below the Guanyuan point. The rats freely moved around during needle retention (20 minutes). Acupuncture was administered twice a week and continued for eight weeks. A moxa cone (small) moxibustion was applied to the preventive moxibustion group at 10 months of age. The rats were caught gently and kept at the same position as the preventive acupuncture group. The moxa cone was ignited and held to the Guanyuan point directly. Only one moxa cone was used each time. After moxibustion, the local skin turned slightly red. Moxibustion was used twice a week and continued for eight weeks. Nothing except gently catching and lying was administered to the model group and the young group. MAIN OUTCOME MEASURES: Radioimmunoassay, in situ hybridization, and similar methods were employed to detect IL-2 in serum and the uterus, as well as IL-2R mRNA expression in the hypothalamus and uterus arcuate nuclei, of the preventive acupuncture group, preventive moxibustion group, model groups (at 12, 14, and 16 months), 10 month old group (at 10 months), and the young group (at 4 months). RESULTS: All 176 rats were included in the final analysis. ① IL-2R mRNA: IL-2R mRNA expression decreased significantly in the uterus of 12-, 14-, and 16-month-old model groups and in the hypothalamus of 14- and 16-month-old model groups (P < 0.05-0.01). Compared to the same month-aged model groups, the expression of IL-2R mRNA increased significantly in the hypothalamus and uterus of 16-month-old preventive acupuncture or moxibustion groups (P < 0.05-0.01).② IL-2: IL-2 in serum of 12- and 14-month-old model groups and in the uterus of 12-, 14-, and 16-month-old model groups decreased significantly compared to the young group (P < 0.05-0.01). IL-2 serum levels increased significantly in the 16-month-old group with preventive moxibustion; in addition, IL-2 expression levels increased significantly in the uterus of the 12-month-old group with preventive moxibustion, as well as the 12- and 16-month-old groups with preventive acupuncture (P < 0.05-0.01). CONCLUSION: As a rat ages and becomes menopausal, IL-2R mRNA expression in the hypothalamus anduterus, as well as IL-2 levels in the serum and uterus, decrease. However, preventive acupuncture and preventive moxibustion can repress the decrease to some extent. This effect is even greater in the late stages of menopause (16-month-old rats). | Xiaohong Li Yuwei He Jieping Xie Lufen Zhang Dengfang Zhou Jinghui Zhai Rui Zhan Jun Zhou Limin Qu Yangchun Tian | 2008 | Neural Regeneration Research2008，3，1： | 5 |
| 4 | He-Wei Granule enhances anti-tumor activity of cyclophosphamide by changing tumor microenvironment显示文摘Objective:He-Wei Granule(HWKL)is a modern product derived from the modified formulation of traditional Chinese medicine Banxia Xiexin Decoction(BXD),which remarkedly enhanced the anti-proliferation activity of cyclophosphamide(CTX)on HepG2 and SGC-7901 cell lines in vitro in our previous research.The aim of the study was to investigate the synergistic effects of HWKL and CTX using a transplanted H22 hepatocellular carcinoma mouse model.Methods:The CTX-toxic-reducing efficacy of HWKL was evaluated by hematology indexes,organ indexes and marrow DNA detection.To investigate the underlying mechanisms,histopathology test,immunohistochemistry test and TUNEL staining were conducted.The efficacy of HWKL on the micro-vessel density(MVD)in tumor tissue was also evaluated by measuring CD34 level.Results:High dose HWKL(6.75 g/kg)markedly attenuated CTX-induced hepatotoxicity and myelosuppression while significantly enhanced CTX anticancer efficacy in vivo.Further mechanism investigation suggested that high dose HWKL significantly increased cleaved Caspase 3 level and promoted apoptosis in tumor tissue by up-regulating Bax expression and down-regulating Bcl-2 and FasL expressions.Compared with CTX alone group,the decrease in LC-3B and Beclin 1 levels suggested that the autophagy in H22 carcinoma was significantly inhibited with addition of high dose HWKL.ELISA assay results indicated that the autophagy inhibition was achieved by decreasing p53 expression,blocking PI3K/AKT/mTOR pathway and recovering Th1/Th2 cytokine balance.In addition,CD34 and EGFR immunohistochemistry assay suggest that high dose HWKL could significantly decrease micro-vessel density(MVD)and inhibit angiogenesis in H22 carcinoma.Conclusion:It can be concluded that high-dose HWKL enhanced CTX efficacy by promoting apoptosis,inhibiting autophagy and angiogenesis in tumor tissue while significantly alleviated CTX-induced toxicity,and could be applied along with CTX in clinical treatment as a supplement agent. | Jianxiu Zhai Zehai Song Hang Chang Yuwei Wang Na Han Zhihui Liu Jun Yin | 2022 | Chinese Herbal Medicines2022，14，1： | 0 |
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