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| 1 | Value of a newly sequenced bacterial genome显示文摘Next-generation sequencing(NGS) technologies have made high-throughput sequencing available to medium- and small-size laboratories, culminating in a tidal wave of genomic information. The quantity of sequenced bacterial genomes has not only brought excitement to the field of genomics but also heightened expectations that NGS would boost antibacterial discovery and vaccine development. Although many possible drug and vaccine targets have been discovered, the success rate of genome-based analysis has remained below expectations. Furthermore, NGS has had consequences for genome quality, resulting in an exponential increase in draft(partial data) genome deposits in public databases. If no further interests are expressed for a particular bacterial genome, it is more likely that the sequencing of its genome will be limited to a draft stage, and the painstaking tasks of completing the sequencing of its genome and annotation will not be undertaken. It is important to know what is lost when we settle for a draft genome and to determine the 'scientific value' of a newly sequenced genome. This review addresses the expected impact of newly sequenced genomes on antibacterial discovery and vaccinology. Also, it discusses the factors that could be leading to the increase in the number of draft deposits and the consequent loss of relevant biological information. | Eudes GV Barbosa Flavia F Aburjaile Rommel TJ Ramos Adriana R Carneiro Yves Le Loir Jan Baumbach Anderson Miyoshi Artur Silva Vasco Azevedo | 2014 | World Journal of Biological Chemistry2014，5，2： | 7 |
| 2 | Splenic and portal venous obstruction in chronic pancreatitis显示文摘 | Pr. Pierre Bernades André Baetz Philippe Lévy Jacques Belghiti Yves Menu Fran?ois Fékété | 1992 | Digestive Diseases and Sciences1992，，3： | 2 |
| 3 | A new cold-induced alfalfa gene is associated with enhanced hardening at subzero temperature显示文摘 | MONROY A F YVES C SERGE L | 1993 | Plant Physid1993，102，： | 1 |
| 4 | Optimization of anthocyanin,flavonol and phenolic acid extractions from Delonix regia tree flowers using ultrasound-assisted water extraction显示文摘 | Adje Felix Lozano Yves F Lo zano Paul | | 0，，03： | 1 |
| 5 | Scanning probe microscopy显示文摘 | Colton Richard J Baselt David R Dufrêne Yves F Green John-Bruce D Lee Gil U | 1997 | Chemical Biology1997，1，3： | 1 |
| 6 | The impli-cations of spatial variability in surface seal hydraulic resistance for infiltration in a mound and depression microtopography显示文摘 | Dennis M F Yves Le Bissonnais Philippe Quetin | 1998 | Catena1998，32，： | 1 |
| 7 | Immunomodulatory peptides obtained by the enzymatic hydrolysis of whey protein显示文摘 | SYLVIC F G YVES P DIANC S | 2006 | International Dairy Journal2006，16，11： | 1 |
| 8 | Design and function of novel superplasticizers for more durable high performance concrete显示文摘 | Yves F Houst Paul Bowen Francois Perche | 2008 | Cement and Concrete Research2008，38，： | 1 |
| 9 | The inverse {0,1 t-knapsack prob- lem : theory, algorithms and computational experiments 显示文摘 | Julien R Jose R F Yves D S | 2013 | Discrete Optimization2013，0，2： | 1 |
| 10 | Scanning probe microscopy显示文摘 | Richard J Colton^* David R Baselt Yves F Dufrkne John -Bruce D Greenand Gil U Lee | 1997 | Chemical Biology1997，1，： | 1 |
| 11 | Status, source and health risk assessment of polycyclic aromatic hydrocarbons in street dust of an industrial city, NW China 显示文摘 | Jiang Y F Hu X F Yves U J | 2014 | Ecotoxicology and Environmental Safety2014，106，： | 1 |
| 12 | A Simplified View on Chemical Effects Perturbing the Action of Superplasticizers显示文摘 | Robert J Flatt Yves F Houst | 2001 | Cement and Concrete Research2001，31，： | 1 |
| 13 | Successful management of a large pulmonary cement embolus after percutaneous vertebroplasty:a case report显示文摘 | Katrien F Yves T Bart P | 2003 | Spine2003，28，20： | 1 |
| 14 | Studies on wind and plant interactions on French Atlantic coastal dunes 显示文摘 | Bressolier C Thomas Yves - F | 1979 | Journal of sedimentary petrology1979，47，1： | 1 |
| 15 | Splenic and portal venous obstruction in chronic pancreatitis显示文摘 | Pr. Pierre Bernades André Baetz Philippe Lévy Jacques Belghiti Yves Menu Fran?ois Fékété | 1992 | Digestive Diseases and Sciences1992，，3： | 1 |
| 16 | Design and function of novel superplasticizers for more durable high performance concrete (superplast project) 显示文摘 | Houst Yves F Paul Bowe Francois Perche | 2008 | Cement and Concrete Research2008，38，： | 1 |
| 17 | Mechanical properties of high density polyurethane foams: Ⅱ Effect of the filler size 显示文摘 | Saint- Michel F Chazeau L Jean - Yves C | 2006 | Composites Science and Technology2006，66，15： | 1 |
| 18 | Wood machining properties of white spruce from plantation forests显示文摘 | Hernandez E R Cecilia B Yves F | 2011 | Forest Products Journal2011，51，6： | 1 |
| 19 | Immunomodulatory peptides obtained by the enzymatic hydrolysis of whey proteins 显示文摘 | Sylvie F G Yves P Diane S | 2006 | International Dairy Journal2006，16，11： | 1 |
| 20 | Orientation dependent modulation of apparent speed: psychophysical evidence显示文摘 | Sbastien G Peggy S Yves F | 2002 | Vision Research2002，42，25： | 1 |
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