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| 1 | Relevance of α-defensins(HNP1-3) and defensin β-1 in diabetes显示文摘AIM: To investigate the genetic background of human defensin expression in type 1 and 2 diabetes.METHODS: Associations between DEFA1/DEFA3 gene copy number polymorphism and diabetes as well as between the promoter polymorphisms of DEFB1 and diabetes were studied. The copy number variation of the DEFA1/DEFA3 genes was determined in 257 diabetic patients(117 patients with type 1 and 140 with type 2 diabetes). The control group consisted of 221 age- and gender-matched healthy blood donors. The cumulative copy numbers of the DEFA1/DEFA3 genes were detected by using quantitative PCR analysis. To evaluate the HNP 1-3(human neutrophil peptide 1-3 or α-defensin) levels in the circulation, plasma HNP 1-3 concentrations were measured by ELISA. The expression of DEFA1/A3 in peripheral leukocytes of the diabetic patients was measured by quantitative RT PCR analysis. Three SNPs of the human DEFB1(human defensin β-1) gene: DEFB1 G-20A(rs11362), DEFB1 C-44G(rs1800972) and DEFB1 G-52A(rs1799946) were genotyped by Custom TaqMan? Real Time PCR assay.RESULTS: Significant differences were observed in HNP1-3 levels between the healthy subjects and both groups of diabetic patients. The mean ± SE was 28.78 ± 4.2 ng/mL in type 1 diabetes, and 29.82 ± 5.36 ng/mL in type 2 diabetes, vs 11.94 ± 2.96 ng/mL in controls; P < 0.01 respectively. There was no significant difference between patients with type 1 and type 2 diabetes in the high plasma concentrations of HNP1-3. The highest concentrations of α-defensin were found in diabetic patients with nephropathy(49.4 ± 4.8 ng/mL), neuropathy(38.7 ± 4.8 ng/mL) or cardiovascular complications(45.6 ± 1.45 ng/L). There was no significant difference in the cumulative copy numbers of DEFA1/DEFA3 genes between controls and patients, or between patients with the two types of diabetes. Comparisons of HNP 1-3 plasma level and DEFA1/A3 copy number of the same patient did not reveal significant relationship between defensin-α levels and the gene copy numbers(r2 = 0.01). Similarly, no positive correlation was observed between the copy numbers and the mRNA expression levels of DEFA1/A3. Regarding the C-44G polymorphism of DEFB1, the GG 'protective' genotype was much less frequent(1%-2%) among both groups of patients than among controls(9%).CONCLUSION: Elevated HNP1-3 levels in diabetes are independent of DEFA1/DEFA3 copy numbers, but GG genotype of C-44G SNP in DEFB1 gene may result in decreased defensin β-1 production. | Balázs Csaba Németh Tamás Várkonyi Ferenc Somogyvári Csaba Lengyel Katalin Fehértemplomi Szabolcs Nyiraty Péter Kempler Yvette Mándi | 2014 | World Journal of Gastroenterology2014，20，27： | 4 |
| 2 | Classification using adaptive wavelets for feature extraction显示文摘 | Yvette M Danny C Jerry K | 1997 | IEEE Transactions on Pattern Analysis and Machine Intelligence1997，19，10： | 2 |
| 3 | Quantitative modeling of arabidopsis development显示文摘 | Lars M Yvette E Brendan L | 2005 | Plant Physiology2005，139，10： | 1 |
| 4 | Clinical results of the re-fixation of a Chevron olecranon osteotomy using an intramedullary cancellous screw and suture tension band显示文摘 | Wagener ML Dezillie M Yvette H | 2015 | Strategies in Trauma and Limb Reconstruction2015，10，1： | 1 |
| 5 | Low molecular weight heparin loaded pH-sensitive microparticles 显示文摘 | YVETTE M NATHALIE U FATIMA E G | 2007 | Int J Pharm2007，335，12： | 1 |
| 6 | Spinal extradural metastasis:review of current treatment options显示文摘 | RONALD H YVETTE M WINETTE T | 2008 | CA Cancer J Clin2008，58，4： | 1 |
| 7 | Surgical management and complex treatment of infected pancreatic necrosis: 18-year experience at a single center显示文摘 | Gyula Farkas M.D. Ph.D. D.Sc János Márton M.D. Ph.D. Yvette Mándi M.D. Ph.D. D.Sc Lászlá Leindler M.D | 2006 | Journal of Gastrointestinal Surgery2006，，2： | 1 |
| 8 | Single versus multiple fraction radiotherapy in patients with painful bone metastases:cost-utility analysis based on a randomized trial 显示文摘 | Wibert B Van den Hout Yvette M Van der Linden | 2003 | Journal of the National Cancer Institute2003，95，3： | 1 |
| 9 | Isolation of Alicyclobacillus and the influence of different growth parameters显示文摘 | CORLI W R YVETTE S M | 2011 | International Journal of Food Microbiology2011，146，1： | 1 |
| 10 | Oxygen free radical scavenger capacity in aqueous models of different procyanidins from grape seeds显示文摘 | Jorge M Ricardo Da Silva Nicole Darmon Yvette Fernandez | 1991 | J Agric Food Chem1991，39，9： | 1 |
| 11 | Laparoscopic resection is safe and feasible for large(≥6 cm)pheochromocytomas without suspicion of malignancy显示文摘 | Yvette M Haggi Mazeh Rebecca S | 2012 | Endocr Pract2012，18，5： | 1 |
| 12 | Food depriva-tion induces chronic stress and affects thyroid hormone metabolism in Senegalese sole (Solea senegalensis) post-larvae显示文摘 | Yvette S W Gonzalo M R Manuel Y | 2012 | Comparative Biochemistry and Physi-ology A-Molecular and Integrative Physiology2012，162，4： | 1 |
| 13 | Plasma levels of IL-6 correlate with hemodynamic abnormalities in acute pancreatitis in rabbits显示文摘 | Zoltán Jambrik Mariann Gy?ngy?si Péter Hegyi László Czakó Tamás Takács András Farkas Yvette Mándy Csaba Góg Dietmar Glogar Miklós Csanády | 2002 | Intensive Care Medicine2002，，12： | 1 |
| 14 | A Role for hypertrophic astrocytes and astrocyte precursors in a case of rapidly progressive multiple sclerosis显示文摘 | Yvette M Sang ML Michael CL | 2003 | Muhiple Sclerosis2003，9，4： | 1 |
| 15 | Food deprivation induces chronic stress and affects thyroid hormone metabolism in Senegalese sole (Solea senegalensis) post-larvae显示文摘 | Yvette S W Gonzalo M R Manuel Y | | 0，，： | 1 |
| 16 | Fibroblast and prostate tumor cell cross - talk : Fibro-blast differentiation,TGF - ,and extracellular matrix down-regulation显示文摘 | Vivien J Coulson - Thomas Tarsis F Gesteira Yvette M Coulson -Thomas | 2010 | Exp Cell Res2010，316，19： | 1 |
| 17 | Bridging the gap : a col- laborative to reduce peripherally inserted central catheter infec- tions in the home care environment显示文摘 | Katherine B Yvette H Michael M etal | 2013 | The Ochsner Journal2013，13，： | 1 |
| 18 | Elevated n-terminal pro-b- type natriuretie peptide levels : the effect of chronic obstructive pulmonary disease显示文摘 | Yvette R B van Gestel M Don D S | 2009 | JACC2009，53，5： | 1 |
| 19 | NF-κB activation is detrimental in arginine-induced acute pancreatitis显示文摘 | Zoltán Rakonczay Katalin Jármay József Kaszaki Yvette Mándi Ern? Duda Péter Hegyi Imre Boros János Lonovics Tamás Takács | 2003 | Free Radical Biology and Medicine2003，，6： | 1 |
| 20 | Laparoscopic resection is safe and feasible for large (≥ 6cm) pheochromocytomas without suspicion of malignancy显示文摘 | Yvette M Carter MD Haggi M | | 0，，5： | 1 |
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