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| 1 | Relevance of α-defensins(HNP1-3) and defensin β-1 in diabetes显示文摘AIM: To investigate the genetic background of human defensin expression in type 1 and 2 diabetes.METHODS: Associations between DEFA1/DEFA3 gene copy number polymorphism and diabetes as well as between the promoter polymorphisms of DEFB1 and diabetes were studied. The copy number variation of the DEFA1/DEFA3 genes was determined in 257 diabetic patients(117 patients with type 1 and 140 with type 2 diabetes). The control group consisted of 221 age- and gender-matched healthy blood donors. The cumulative copy numbers of the DEFA1/DEFA3 genes were detected by using quantitative PCR analysis. To evaluate the HNP 1-3(human neutrophil peptide 1-3 or α-defensin) levels in the circulation, plasma HNP 1-3 concentrations were measured by ELISA. The expression of DEFA1/A3 in peripheral leukocytes of the diabetic patients was measured by quantitative RT PCR analysis. Three SNPs of the human DEFB1(human defensin β-1) gene: DEFB1 G-20A(rs11362), DEFB1 C-44G(rs1800972) and DEFB1 G-52A(rs1799946) were genotyped by Custom TaqMan? Real Time PCR assay.RESULTS: Significant differences were observed in HNP1-3 levels between the healthy subjects and both groups of diabetic patients. The mean ± SE was 28.78 ± 4.2 ng/mL in type 1 diabetes, and 29.82 ± 5.36 ng/mL in type 2 diabetes, vs 11.94 ± 2.96 ng/mL in controls; P < 0.01 respectively. There was no significant difference between patients with type 1 and type 2 diabetes in the high plasma concentrations of HNP1-3. The highest concentrations of α-defensin were found in diabetic patients with nephropathy(49.4 ± 4.8 ng/mL), neuropathy(38.7 ± 4.8 ng/mL) or cardiovascular complications(45.6 ± 1.45 ng/L). There was no significant difference in the cumulative copy numbers of DEFA1/DEFA3 genes between controls and patients, or between patients with the two types of diabetes. Comparisons of HNP 1-3 plasma level and DEFA1/A3 copy number of the same patient did not reveal significant relationship between defensin-α levels and the gene copy numbers(r2 = 0.01). Similarly, no positive correlation was observed between the copy numbers and the mRNA expression levels of DEFA1/A3. Regarding the C-44G polymorphism of DEFB1, the GG 'protective' genotype was much less frequent(1%-2%) among both groups of patients than among controls(9%).CONCLUSION: Elevated HNP1-3 levels in diabetes are independent of DEFA1/DEFA3 copy numbers, but GG genotype of C-44G SNP in DEFB1 gene may result in decreased defensin β-1 production. | Balázs Csaba Németh Tamás Várkonyi Ferenc Somogyvári Csaba Lengyel Katalin Fehértemplomi Szabolcs Nyiraty Péter Kempler Yvette Mándi | 2014 | World Journal of Gastroenterology2014，20，27： | 4 |
| 2 | Glucagon-like peptide 2:A nutrientresponsive gut growth factor显示文摘 | Douglas G B Yvette P Barbara S | 2001 | The Journal of Nutrition Bethesda2001，131，3： | 1 |
| 3 | Imaging Changes in the Pancreas in Cystic Fibrosis: A Retrospective Evaluation of 55 Cases Seen Over a Period of 9 Years显示文摘 | Jean Feigelson Yvette Pécau Myriam Poquet Patricia Terdjman Jacqueline Carrère Jean-Pierre Chazalette Claude Ferec | 2000 | Journal of Pediatric Gastroenterology and Nutrition2000，，2： | 1 |
| 4 | Glucagon - Like Peptide 2: ANutrient - Responsive Gut Growth Faetor显示文摘 | Douglas GB Yvette P Barbara S | 2001 | Recent Advances in Nutritional Science2001，131，： | 1 |
| 5 | Plasma levels of IL-6 correlate with hemodynamic abnormalities in acute pancreatitis in rabbits显示文摘 | Zoltán Jambrik Mariann Gy?ngy?si Péter Hegyi László Czakó Tamás Takács András Farkas Yvette Mándy Csaba Góg Dietmar Glogar Miklós Csanády | 2002 | Intensive Care Medicine2002，，12： | 1 |
| 6 | New medium for the simultaneous detection of total coliforms and escherichia coli in water显示文摘 | KR ISTEN P B CLIFFORD C R YVETTE R R | 1993 | Applied and Environmental Microbiology1993，59，11： | 1 |
| 7 | NF-κB activation is detrimental in arginine-induced acute pancreatitis显示文摘 | Zoltán Rakonczay Katalin Jármay József Kaszaki Yvette Mándi Ern? Duda Péter Hegyi Imre Boros János Lonovics Tamás Takács | 2003 | Free Radical Biology and Medicine2003，，6： | 1 |
| 8 | Identification of Empirical Models for the Prediction of the Plasticity Index:Case of the KhôDepression in South Benin显示文摘The plasticity index is an essential design parameter used as a standard input in fine-grained soil investigation programs.It is used to estimate the plasticity and physical properties of soils,and indirectly their strength properties.This index is determined from the Atterberg limit tests,starting from the limits of liquidity and plasticity.However,the realization of the test considered as basic and simple,is not so much.The effects of the operator,the calibration of the apparatus and the environmental aspects during the tests affect the reliability and accuracy of the results.In this paper,the objective is to overcome these difficulties by evaluating the plasticity index of clay and loam soils by considering only the values of the liquid limit.Soil samples were collected from 0 to 5 m depth in the localities of the Khôdepression in Benin.On these samples,Atterberg limit tests were performed in the laboratory.Using MATLAB’s Curve Fitting Toolbox,linear,exponential and power prediction models were analyzed.The results showed that there is indeed a good correlation between the plasticity index and the liquid limit of the soils.For the linear model,it was observed R2 equal to 0.9891.For the exponential model,R2 is 0.98871 and for the power model 0.9802.A study of the residual plot validated the models found,as well as comparisons with well-known literature sources.Through the equations obtained,it is now possible to study the plasticity of soils in the Khôdepression only from the liquid limit,without determining the plasticity limit. | Koffi Judicaël AGBELELE Yvette Sèdjro TANKPINOU KIKI Abalo P’KLA Gbênihon Céleste-Amour KENOUKON | 2022 | 材料科学与工程(中英文A版)2022，12，2： | 0 |
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