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| 1 | Nat Med:靶向两分子或有助于彻底治愈白血病显示文摘科学家在癌细胞内发现两个信号蛋白能够让癌细胞抵抗化疗。研究表明阻断这两种蛋白能够增强化疗对人类白血病小鼠模型的治疗效果。相关研究结果发表在国际学术期刊NatureMedicine上。研究人员发现在治疗中阻断c-Fos和Dusp1这两个蛋白能够治愈一些受激酶驱动且抵抗治疗的白血病和实体瘤。 | Meenu Kesarwani, Zachary Kincaid, Ahmed Gomaa, Erika Huber, Sara Rohrabaugh, Zain Siddiqui, Muhammad F Bouso, Kakajan Komurov, James C Mulloy, Jose A Cancelas, H Leighton Grimes Mohammad Azam Tahir Latif Ming Xu H Leighton Grimes Mohammad Azam | 2017 | 现代生物医学进展2017，17，17： | 4 |
| 2 | Oncogenic fingerprint of epidermal growth factor receptor pathway and emerging epidermal growth factor receptor blockade resistance in colorectal cancer显示文摘Epidermal growth factor receptor(EGFR) has been an attractive target for treatment of epithelial cancers, including colorectal cancer(CRC). Evidence from clinical trials indicates that cetuximab and panitumumab(antiEGFR monoclonal antibodies) have clinical activity in patients with metastatic CRC. The discovery of intrinsic EGFR blockade resistance in Kirsten RAS(KRAS)-mutant patients led to the restriction of anti-EGFR antibodies to KRAS wild-type patients by Food and Drug Administration and European Medicine Agency. Studies have since focused on the evaluation of biomarkers to identify appropriate patient populations that may benefit from EGFR blockade. Accumulating evidence suggests that patients with mutations in EGFR downstream signaling pathways including KRAS, BRAF, PIK3CA and PTEN could be intrinsically resistant to EGFR blockade. Recent whole genome studies also suggest that dynamic alterations in signaling pathways downstream of EGFR leads to distinct oncogenic signatures and subclones which might have some impact on emerging resistance in KRAS wild-type patients. While anti-EGFR monoclonal antibodies have a clear potential in the management of a subset of patients with metastatic CRC, further studies are warranted to uncover exact mechanisms related to acquired resistance to EGFR blockade. | Zain A Sobani Ashwin Sawant Mikram Jafri Amit Keith Correa Ibrahim Halil Sahin | 2016 | World Journal of Clinical Oncology2016，7，5： | 3 |
| 3 | Infectious diseases in the aftermath of monsoon flooding in Pakistan显示文摘Pakistan is ranked 9th in terms of flood-affected countries worldwide.In the summer of 2010,the northern province of Khyber-Pakhtunkhwa received more than 312 mm of rain in a 56 hour period.This resulted in over 1 600 deaths across the region.In addition,over 14 million people were directly affected by this record-breaking deluge.Flood affected regions serve as ideal breeding grounds for pathogens,leading to the spread of diseases.The poor standards of hygiene in camps set up for individuals displaced by the floods also contribute to this.It is essential that those involved in relief efforts are aware of the epidemiology of diseases that have historically seen a sudden upsurge after natural disasters.Keeping this in mind,we conducted a simple review of literature.An extensive literature search was conducted using the PubMed data base and online search engines.Articles published in the last 20 years were considered along with some historical articles where a background was required.Seven major diseases were identified to increase substantially in the aftermath of natural disasters.They were then classified into acute and sub-acute settings.Diarrhea,skin&eye infections and leptospirosis were identified in the acute setting while malaria,leishmaniasis,respiratory infections and hepatitis were identified in the sub-acute setting. | Maryam Baqir Zain A Sobani Amyn Bhamani Nida Shahab Bham Sidra Abid Javeria Farook M Asim Beg | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，1： | 2 |
| 4 | Stem cells for spinal cord regeneration:Current status显示文摘 | Zain A Sobani Syed A | | 0，，： | 1 |
| 5 | Ultra high quality factor one dimensional photonic crystaL/photonic wire micro-cavities in silicon- on-insulator(SOI) 显示文摘 | ZAIN A R M JOHNSON N P SOREL M | 2008 | Optics Express2008，16，11： | 1 |
| 6 | Multi-objective hybrid evolutionary algorithms for radial basis function neural network design 显示文摘 | QASEM S N SHAMSUDD1N S M ZAIN A M | 2012 | Knowledge-Based Systems2012，27，1： | 1 |
| 7 | Overview of NSGA-Ⅱfor optimizing machining process parameters显示文摘 | Yusoff Y Ngadiman M S Zain A M | 2011 | Procedia Engineering2011，15，： | 1 |
| 8 | Prediction of surface rough- ness in the end milling machining using artificial neural net- work 显示文摘 | Zain A M Haron H Sharif S | 2010 | Expert System with Applications2010，37，2： | 1 |
| 9 | Application of Input Shaping Control Strategy for Reducing Chatter Noise in the Automotive Wiper System 显示文摘 | Ahmad A Md Zain M Z Abu-Bakar A R | 2008 | Information Technology2008，4，1： | 1 |
| 10 | Overview of PSO for op timization process parameters of machining 显示文摘 | Yusup N Zain A M Hashim S Z M | 2012 | Procedia En gineering2012，29，1： | 1 |
| 11 | Research and development on aspects of daylighting fundamentals Review Article显示文摘 | Alrubaih M S Zain M F M Alghoul M A | 2013 | Renewable and Sustainable Energy Reviews2013，21，： | 1 |
| 12 | Trends in urbanization and patterns of land use in the Asian mega cities Jakarta, Bangkok and Metro Manila 显示文摘 | Murakami A Medrial Zain A Takeuchi K | 2005 | Landscape and Urban Planning2005，70，3： | 1 |
| 13 | Comparison of clomiphene citrate, metformin, or the combination of both for first-line ovulation induction, achievement of pregnancy, and live birth in Asian women with polycystic ovary syndrome: a randomized controlled trial显示文摘 | Zain MM Jamaluddin R Ibrahim A | 2009 | Fertil Steril2009，91，2： | 1 |
| 14 | Integrated ANN- GA for estima- ting the minimum value for machining performance显示文摘 | ZAIN A M HARON H SHARIF S | 2012 | Internation- al Journal of Production Research2012，50，1： | 1 |
| 15 | Trends in urbanization andpatterns of land use in the Asian mega cities Jakarta,Bangkok,and MetroManila显示文摘 | Murakamia A Zain A M Takeuchi K | 2005 | Landscape and Urban Planning2005，70，3： | 1 |
| 16 | Prediction of surface roughness in the end milling machining using artificial neural network显示文摘 | ZAIN A M HARON H SHARIF S | 2010 | Expert Systems with Applications2010，37，2： | 1 |
| 17 | Biological activity of fungal secondary metabolites显示文摘 | ZAIN M E AWAAD A S AL-OTHMAN M R | 2013 | Int J Chem Appl Bioi Sd2013，1，1： | 1 |
| 18 | Evolutionary techniques in optimizing machining parameters: Review and recent applications (2007-2011)显示文摘 | YUSUP N ZAIN A HASHIM S | 2012 | Expert Systems with Applications2012，39，10： | 1 |
| 19 | Application of input shaping control strategy for reducing chatter noise in the automotive wiper system显示文摘 | A Ahmad M Z Md Zain | 2008 | IEEE2008，97，81424： | 1 |
| 20 | Optimization of process parameters in the ahrasi,ce wateret machining using integrated SA-GA显示文摘 | ZAIN A M HARON H SHARIF S | 2011 | Applied Soft Computing2011，11，8： | 1 |
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