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| 1 | Sparse SAR imaging based on L_(1/2) regularization显示文摘In this paper,a novel method for synthetic aperture radar(SAR)imaging is proposed.The approach is based on L1/2 regularization to reconstruct the scattering field,which optimizes a quadratic error term of the SAR observation process subject to the interested scene sparsity.Compared to the conventional SAR imaging technique,the new method implements SAR imaging effectively at much lower sampling rate than the Nyquist rate,and produces high-quality images with reduced sidelobes and increased resolution.Also,over the prevalent greedy pursuit and L1 regularization based SAR imaging methods,there are remarkable performance improvements of the new method.On one hand,the new method significantly reduces the number of measurements needed for reconstruction,as supported by a phase transition diagram study.On the other hand,the new method is more robust to the observation noise.These fundamental properties of the new method are supported and demonstrated both by simulations and real SAR data experiments. | ZENG JinShan FANG Jian XU ZongBen | 2012 | Science China(Information Sciences)2012，55，8： | 18 |
| 2 | Efficient DPCA SAR imaging with fast iterative spectrum reconstruction method显示文摘The displaced phase center antenna(DPCA)technique is an effective strategy to achieve wide-swath synthetic aperture radar(SAR)imaging with high azimuth resolution.However,traditionally,it requires strict limitation of the pulse repetition frequency(PRF)to avoid non-uniform sampling.Otherwise,any deviation could bring serious ambiguity if the data are directly processed using a matched filter.To break this limitation,a recently proposed spectrum reconstruction method is capable of recovering the true spectrum from the nonuniform samples.However,the performance is sensitive to the selection of the PRF.Sparse regularization based imaging may provide a way to overcome this sensitivity.The existing time-domain method,however,requires a large-scale observation matrix to be built,which brings a high computational cost.In this paper,we propose a frequency domain method,called the iterative spectrum reconstruction method,through integration of the sparse regularization technique with spectrum analysis of the DPCA signal.By approximately expressing the observation in the frequency domain,which is realized via a series of decoupled linear operations,the method performs SAR imaging which is then not directly based on the observation matrix,which reduces the computational cost from O(N2)to O(N log N)(where N is the number of range cells),and is therefore more efficient than the time domain method.The sparse regularization scheme,realized via a fast thresholding iteration,has been adopted in this method,which brings the robustness of the imaging process to the PRF selection.We provide a series of simulations and ground based experiments to demonstrate the high efficiency and robustness of the method.The simulations show that the new method is almost as fast as the traditional mono-channel algorithm,and works well almost independently of the PRF selection.Consequently,the suggested method can be accepted as a practical and efficient wide-swath SAR imaging technique. | FANG Jian ZENG JinShan XU ZongBen ZHAO Yao | 2012 | Science China(Information Sciences)2012，55，8： | 2 |
| 3 | A new kind of magnetic targeting induction heating drug carrier and its physical and biological properties显示文摘Nano-carbon and iron composite―carbon-coated iron nanoparticles (CCINs) produced by carbon arc method can be used as a new kind of magnetic targeting induction heating drug carrier for cancer therapy. The structure and morphology of CCINs are studied by X-ray diffraction (XRD) and transmission electron microscope (TEM). Mossbauer spectra of these nanoparticles show that they contain only iron and carbon, without ferric carbide and ferric oxide. CCINs can be used as the magnetic drug carrier, with the effect of targeting magnetic induction heating in its inner core and higher drug adsorption in its nano-carbon shell outside because of its high specific surface area. CCINs can absorb Epirubicin (EPI) of 160 μg/mg measured by an optical spectrometer. In acute toxicity experiment with mice, the median lethal dose (LD50) of EPI is 16.9 mg/kg, while that of EPI-CCINs mixture is 20.7 mg/kg and none of the mice died after pure CCINs medication. The results show that pure CCINs belong to non-toxic grade and EPI delivery in mixture with CCINs can reduce its acute toxicity in mice. The magnetic properties of CCINs and their magnetic induction heating are investigated. The iron nanoparticle in its inner core has better magnetism with a good effect on targeting magnetic induction heating. When the CCINs are mixed with physiological salt water and are injected uniformly in pig's liver, the temperature goes up to 48℃. While in the case that CCINs are filled in a certain section of pig's liver, the temperature goes up to 52℃. In both cases the temperature is high enough to kill the cancer cell. CCINs have potential applications in cancer therapy. | ZHANG HaiYan CHEN YiMing ZHENG Yun LAO XiangMing ZENG GuoXun PANG JinShan WU QiGuang LI JinQing | 2009 | Science China(Technological Sciences)2009，52，10： | 2 |
| 4 | EXTRAPUSH FOR CONVEX SMOOTH DECENTRALIZED OPTIMIZATION OVER DIRECTED NETWORKS显示文摘在这笔记。 | Jinshan Zeng WotaoYin | 2017 | Journal of Computational Mathematics2017，35，4： | 2 |
| 5 | Platinum-crosslinking polymeric nanoparticle for synergetic chemoradiotherapy of nasopharyngeal carcinoma显示文摘Despite extensive use of radiotherapy in nasopharyngeal carcinoma(NPC)treatment because of its high radiosensitivity,there have been huge challenges in further improving therapeutic effect,meanwhile obviously reducing radiation damage.To this end,synergistic chemoradiotherapy has emerged as a potential strategy for highly effective NPC therapy.Here,we developed RGD-targeted platinum-based nanoparticles(RGD-PtNPs,denoted as RPNs)to achieve targeted chemoradiotherapy for NPC.Such nanoparticles consist of an RGD-conjugated shell and a cis-platinum(CDDP)crosslinking core.Taking advantage of RGD,the RPNs may effectively accumulate in tumor,penetrate into tumor tissues and be taken by cancer cells,giving rise to a high delivery efficiency of CDDP.When they are fully enriched in tumor sites,the CDDP loaded RPNs can act as radiotherapy sensitizer and chemotherapy agents.By means of X-ray-promoted tumor cell uptake of nanoparticle and CDDP-induced cell cycle arrest in radiation-sensitive G2/M phases,RPNs may offer remarkable therapeutic outcome in the synergistic chemoradiotherapy for NPC. | Yuxun Ding Xiaohui Xiao Lingli Zeng Qiuping Shang Wei Jiang Sha Xiong Xiaohui Duan Jun Shen Ruibing Wang Jinshan Guo Yue Pan | 2021 | Bioactive Materials2021，6，12： | 1 |
| 6 | The natural course of bacillus Calmette-Guerin induced bladder lesions:A long-term follow-up study and systematic review显示文摘Objective:Bacillus Calmette-Gue´rin(BCG)instillation is the standard adjuvant treatment for intermediate-and high-risk non-muscle-invasive bladder cancer after transurethral resection.Nevertheless,its toxicity often causes bladder complications.On follow-up cystoscopy,post-BCG bladder lesions can be pathologically benign,urothelial carcinoma recurrence,or other types of bladder malignancy.Only a small number of case reports have been published on post-BCG bladder lesions.Their clinical features,natural course,and management remain unknown.Methods:We retrospectively studied cystoscopic videos and medical records of BCG-treated bladder cancer patients at our center.During a long-term follow-up,we took biopsies on tumor-like lesions and described their changes.In addition,we summarized previous studies on post-BCG bladder lesions by systematic literature searching and review.Results:We described a series of three cases with post-BCG bladder lesions mimicking tumor recurrence from a total of 38 cases with follow-up data for more than 5 years.Those lesions could last,grow,or disappear spontaneously,and remain pathological benign for years.In systematic review,we identified and analyzed a total of 15 cases with post-BCG bladder lesions with detailed clinical information.Eleven of the 15 were benign and have a good prognosis with nephrogenic adenoma being the most common pathological type.Conclusion:Based on previous studies and our experience,benign lesions after BCG instillation cannot distinguish with cancer recurrence by cystoscopy alone,even under narrow band imaging mode.Nonetheless,given most of them have a good prognosis,random biopsy or transurethral resection might be spared in the patients with long-term negative biopsy and urine cytology. | Chong Ma Shuxiong Zeng Lihe Dai Huan Han Ruixiang Song Jinshan Xu Xing Ai Chuanliang Xu | 2023 | Asian Journal of Urology2023，10，3： | 0 |
| 7 | Improving Soil Fertility with Different Planting Patterns in Rocky Desertification Areas显示文摘[Objectives]This study was conducted to investigate the effect of different planting patterns on soil improvement in rocky desertification areas.[Methods]The one-way ANOVA analysis method was used to statistically analyze the soil physical and chemical properties,enzyme activity,microbial quantity,CEC,ECEC,and aggregate content distribution with different planting patterns.[Results]The walnut+sesame+mung bean planting pattern showed the highest soil available phosphorus,available potassium,porosity,non-capillary porosity,and contents of free living nitrogen-fixing bacteria,organophosphate-dissolving bacteria,bacteria,fungi and actinomycetes,at 63.2 mg/kg,178.8 mg/kg,22.85%,6.89%,10.0×10^6 bacteria/g,18.0×10^6 bacteria/g,21.0×10^5 CFU/g,5.7×10^3 CFU/g and 7.9×10^5 CFU/g,respectively,and it reduced soil bulk density(the same as treatment F and treatment E)compared with other planting patterns.The walnut+American chicory+sweet potato planting pattern had the highest alkali-hydrolyzale nitrogen,organic matter,CEC,ECEC,water-air ratio and moisture content,which were 227.9 mg/kg,46.30 g/kg,36.38 cmol/kg,24.00 cmol/kg,8.13,and 32.89%,respectively,and it reduced soil bulk density,increased capillary porosity,acid phosphatase,and contents of bacteria and actinomycetes compared with single cropping of walnut.[Conclusions]Interplanting crops under walnut forests is an effective measure to improve the ecological environment of rocky desertification farmland. | Fang QIN Lirong SU Chengcheng ZENG Qin LI Tieguang HE Yuefeng YU Nan WEI Yuanqing MENG Aina WEI Jinshan WEI Daizu XIE | 2020 | Agricultural Biotechnology2020，9，6： | 0 |
| 8 | A new generation M^(pro)inhibitor with potent activity against SARS-CoV-2 Omicron variants显示文摘Emerging SARS-CoV-2 variants, particularly the Omicron variant and its sublineages, continually threaten the global public health.Small molecule antivirals are an effective treatment strategy to fight against the virus. However, the first-generation antivirals eithershow limited clinical efficacy and/or have some defects in pharmacokinetic (PK) properties. Moreover, with increased use of thesedrugs across the globe, they face great pressure of drug resistance. We herein present the discovery and characterization of a newgeneration antiviral drug candidate (SY110), which is a potent and selective inhibitor of SARS-CoV-2 main protease (Mpro). Thiscompound displayed potent in vitro antiviral activity against not only the predominant SARS-CoV-2 Omicron sublineage BA.5, butalso other highly pathogenic human coronaviruses including SARS-CoV-1 and MERS-CoV. In the Omicron-infected K18-hACE2mouse model, oral treatment with SY110 significantly lowered the viral burdens in lung and alleviated the virus-induced pathology.Importantly, SY110 possesses favorable PK properties with high oral drug exposure and oral bioavailability, and also an outstandingsafety profile. Furthermore, SY110 exhibited sensitivity to several drug-resistance Mpro mutations. Collectively, this investigationprovides a promising new drug candidate against Omicron and other variants of SARS-CoV-2. | Chong Huang Huiping Shuai Jingxin Qiao Yuxin Hou Rui Zeng Anjie Xia Lingwan Xie Zhen Fang Yueyue Li Chaemin Yoon Qiao Huang Bingjie Hu Jing You Baoxue Quan Xiu Zhao Nihong Guo Shiyu Zhang Ronggang Ma Jiahao Zhang Yifei Wang Ruicheng Yang Shanshan Zhang Jinshan Nan Haixing Xu Falu Wang Jian Lei Hin Chu Shengyong Yang | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 0 |
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