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| 1 | Effect of switching from treatment with nucleos(t)ide analogs to pegylated interferon α-2a on virological and serological responses in chronic hepatitis B patients显示文摘AIM To investigate the efficacy of switching to pegylated interferon-α-2a(Peg IFNα-2a) treatment in nucleos(t)ide analog(NA)-treated chronic hepatitis B(CHB) responder patients. METHODS A 48-wk prospective and retrospective treatment trial of NA-treated CHB patients who had received entecavir(ETV) for at least 48 wk and had serum hepatitis B virus(HBV)-DNA < 500 IU/m L, serum hepatitis B envelope antigen(HBe Ag) < 100 S/CO, serum alanine aminotransferase, and aspartate aminotransferase levels < 2 × the upper limit of normal of 40 IU/L was performed. The effects on virological and serological responses and adverse reactions to 0.5 mg daily ETV for 48 wk vs switching to Peg IFNα-2a were compared. Forty-four patients were randomized to be switched from NA treatment to the Peg IFNα-2a group, and 44 patients were simultaneously randomized to the ETV group. RESULTS After 48 wk of therapy, the decrease in hepatitis B surface antigen(HBs Ag) levels was greater in the Peg IFNα-2a group than in the ETV group(3.1340 log10 IU/m L vs 3.6950 log10 IU/m L, P = 0.00). Seven patients who were anti-HBs-positive at baseline achieved HBs Ag loss when switched to Peg IFNα-2a(15.91% vs 0%,P = 0.018). The HBe Ag serological conversion rate was higher in the Peg IFNα-2a group than in the ETV group; however, the difference was not significant because of the small sample sizes(34.38% vs 21.88%, P = 0.232). In the Peg IFNα-2a group, patients with HBs Ag levels < 1500 IU/m L at baseline had higher HBe Ag seroconversion and HBs Ag loss rates at week 48 than those with HBs Ag levels ≥ 1500 IU/m L(HBe Ag seroconversion: 17.86% vs 62.5%, P = 0.007; HBs Ag loss: 41.67% vs 6.25%, P = 0.016). Moreover, patients with HBs Ag levels < 1500 IU/m L at week 24 had higher HBs Ag loss rates after therapy than those with HBs Ag levels ≥ 1500 IU/m L(36.84% vs 0%, P = 0.004). However, there were no statistically significant differences in HBe Ag seroconversion rates(47.06% vs 25.93%, P = 0.266). CONCLUSION NA-treated CHB patients switched to sequential Peg IFNα-2a achieved highly potent treatment termination safely. | Li-Ting He Xiao-Guang Ye Xiao-Yuan Zho | 2016 | World Journal of Gastroenterology2016，22，46： | 15 |
| 2 | Analysis of a Dynamic Model of Host-parasite Interaction with Delay and Treatment显示文摘In this paper, the dynamic behaviors of a host-parasite model with intracellular delay and drug treatment is investigated. we obtain the basic reproductive ratio R0 , which determined the behaviors of the system. If R0<1, the infection-free equilibrium is globally asymptotic stability. If 1 3, by choosing the delay τ as a bifurcation parameter, the infection equilibrium bifurcate a family of periodic solution as τ crosses a critical value. Furthermore, we give some examples to verify our theoretical results and discuss the sensitivity of the drug efficacy and effect of the delay. In the finally, we give a brief discussion. | ZHO Yu | 2013 | Chinese Quarterly Journal of Mathematics2013，28，1： | 3 |
| 3 | Quenchability and magnetic properties of Nd4Fe82B14显示文摘 | Tiemin Zho | 1998 | J Mater Sci Technol1998，14，： | 2 |
| 4 | Cypovirus capsid protein VP5 has nucleoside triphosphatase activity显示文摘As a major protein of cypovirus capsid shell, VP5 per-forms as the clamp protein to stabilize the capsid shellstructure (Yu et al., 2008). And as a part of viral RNA(vRNA) replication machinery, VP5 has been found topossess an ATP-independent RNA chaperoning activity(Yang et al., 2014). Here, we report that VP5 also has thenucleoside triphosphatase (NTPase) activity, which canhydrolyze all kinds of NTPs and dNTPs. Thus, ourfinding reveals that VP5 is a multifunctional protein thatmay be involved in diverse processes during cypovirallife cycle. | Jie Yang Qi Qian Teng—Feng Li Xueli Yang Sok Jin W on Xi Zho | 2017 | Virologica Sinica2017，32，4： | 2 |
| 5 | EVOLUTION OF STATISTICAL DISTRIBUTION OF PIT GEOMETRIC PARAMETERS UNDER FATIGUE LOADING显示文摘The pits and pit-associated fatigue crack initiation of the offshore structure steel A537cLlhave been investigated under salt water spray condition.The tests were interrupted on sched-ule to make plastic replica of corroded specimen surface on which many randomly distributedpits can be found.The development of the geometric parameters of pits was obtained and thestatistical distributions of these parameters were determined.Instead of depth,the ratio ofdepth to width is the most dominant parameter in relation to crack initiation.Also,the pittingwas enhanced when low frequency or high stress range was applied and although stress rangehas no effect on the nucleation of pits,it can accelerate the initiation of cracks from pits. | ZHO U Xiangyang KE Wei Institute of Corrosion and Protection of Metals,Academia Sinica,Shenyang,ChinaZANG Qishan Institute of Metal Research,Academia Sinica,Shenyang,China ZHOU Xiangyang,Institute of Corrosion and Protection of Metals,Academia Sinica,Shenyang 110015,China | 1990 | Acta Metallurgica Sinica(English Letters)1990，3，11： | 2 |
| 6 | Positive Solutions for Fourth-order Delay Differential Equation of Boundary Value Problem with p-Laplacian显示文摘In this work, we investigate the following fourth-order delay differential equation of boundary value problem with p-Laplacian(Φp(u))(t) + a(t)f(t, u(t- τ), u(t)) = 0, 0 < t < 1;u(0) = u(0) = 0, u(1) = αu(η);u(t) = 0,- τ≤ t ≤ 0.By using Schauder fixed-point theorem, some sufficient conditions are obtained which guarantee the fourth-order delay differential equation of boundary value problem with p-Laplacian has at least one positive solution. Some corresponding examples are presented to illustrate the application of our main results. | ZHANG Yu-chuan ZHO U Zong-fu | 2014 | Chinese Quarterly Journal of Mathematics2014，29，2： | 2 |
| 7 | Percolation of ITZs in con crete and effects of attributing Factors 显示文摘 | ZHENG J J ZHO'U X Z | 2007 | Journal of Materials in Civil Engineering2007，19，9： | 1 |
| 8 | Sphere decoding algorithms with im- proved radius searc显示文摘 | ZHO W GIANNAKIS G | 2005 | IEEE Trans Commun2005，53，： | 1 |
| 9 | Exploring Chinese users' acceptance of instant messaging using the theory of planned behavior, the technology acceptance model, and the flow theory显示文摘 | Yaobin Lu Tao Zho Bin Wangc | 2009 | Computers in Human Behavior2009，，25： | 1 |
| 10 | Discovery of novel and dif- ferentially expressed mieroRNAs between fetal and adult backfat in cattle显示文摘 | Sun J Zho T Y Cai H | 2014 | PLoS One2014，9，90： | 1 |
| 11 | Homoharringtonine combined with cytarabine to treat chronic myelogenous leukemia in myeloid blast crisis and its impact on bone marrow CD34 + CD7 + cells显示文摘 | Li Y Deng Z Zho J | 2014 | Acta Haematol2014，132，2： | 1 |
| 12 | ZnO nanorod lightemitting diodes fabricated by electrochemical approaches 显示文摘 | GUO H ZHO J LIN Z | 2008 | Electrochem Commun2008，10，1： | 1 |
| 13 | Simian virus 40 late gene expression is regulated by members of the steroid/thyroid hormone receptor surperfamily显示文摘 | Zho F Mertz R J | 1995 | Proc Natl Acad Sci USA1995，92，19： | 1 |
| 14 | Mitogen - activated protein kinase signaling, oxygen sensoring and hypoxic induction of neurogenesis 显示文摘 | Zho L | 2005 | Neurodegener Dis2005，3，12： | 1 |
| 15 | Sunlight-assisted degradation of dye pollutant in Ag3PO4suspension显示文摘 | Gem M Zhum N Zho Y | 2012 | Industrial and Engineering Chemistry Research2012，51，： | 1 |
| 16 | New method for high-performance liquid chromatographic separation and fluorescence detection of ginsenosides 显示文摘 | Shangguan D H Han H W Zho R | 2001 | Journal of Chromatography A2001，910，2： | 1 |
| 17 | Comparison of several independent population means when their samples contain log-normal and possibly zero observations 显示文摘 | Zho XH Tu W | 1999 | Biometrics1999，55，2： | 1 |
| 18 | Prediction and experiment of coreshell particle morphology of vinyl acetate and butyl acrylate 显示文摘 | Sum P Q Zho K Liu D H | 2002 | J Appl Polym Sci2002，83，13： | 1 |
| 19 | A new theory consistency index based on deduction theories in several logic systems显示文摘 | Zho u H J Wang G J | 2006 | Fuzzy Sets and Sy stems2006，157，3： | 1 |
| 20 | 显示文摘 | Hao HN Zho J Lotoczky G | 2001 | J Neurochem2001，77，4： | 1 |
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