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| 1 | Efficient Protocols for the General Millionaires' Problem显示文摘Secure multiparty computation(SMC) is a research focusing in the international cryptographic community. The protocols used to address the millionaires' problem are the basic building blocks of most SMC protocols and their efficiency dominates that of many other SMC protocols. To the best of our knowledge, almost all protocols used to address the millionaires' problem are based on integers, which means that their applications are limited. In this study, we propose precise and efficient protocols for rational numbers based on additively homomorphic encryptions. One of our protocols is inspired by computational geometry and it reduces the millionaires' problem to computing the area of a triangle formed by three private points. This approach can determine whether the relationship between two private inputs is greater than, equal to or less than, and it has a much lower computational complexity compared with existing methods. We proved that these protocols are secure using simulation paradigm. Our approaches can be used in many SMC protocols that involve rational numbers and integers, and they can also be used directly to solve some secure multiparty computational geometry problem in rational number field. | LI Shundong GUO Yimin ZHOU Sufang DOU Jiawei WANG Daoshun | 2017 | Chinese Journal of Electronics2017，26，4： | 8 |
| 2 | GSDME enhances Cisplatin sensitivity to regress non-small cell lung carcinoma by mediating pyroptosis to trigger antitumor immunocyte infiltration显示文摘Dear Editor,Non-small cell lung cancer(NSCLC)is the most common type of lung cancers.Since the majority of NSCLC patients are diagnosed at the advanced stage with a dramatic impact on the prognosis,chemotherapy is still the mainstay of treatment.Cisplatin(CDDP)remains one of the most widely used first-line drugs in the therapy of NSCLC,based on the clinical data that the poor outcomes of untreated NSCLC patients(5%overall survival at 1 year)have shown improvements in natural history of disease after CDDPbased chemotherapy(15%overall survival at 1 year).1 Nevertheless,Cisplatin has strong toxic side effects and many NSCLC patients treated with CDDP are easy to occur drug insensitivity,near-to-invariably leading to relapse and therapeutic failure.Therefore,finding novel target molecules which can regulate CDDP innate sensitivity is vital to improve clinical efficacy.For decades,a long-held consensus is that caspases-3-induced apoptosis is the major pattern for antitumor role of CDDP.The CDDP can promote cancer cell elimination via rewiring proproliferative signaling to pro-apoptotic pathway.However,apoptosis resistance readily occurs after CDDP treatment and it is of great significance to explore whether other types of programmed cell death can effectively heighten innate CDDP sensitivity. | Zhouyangfan Peng Pengfei Wang Wei Song Qingmei Yao Yinjia Li Linglong Liu Yapei Li Sufang Zhou | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 3 | Clinical Observation on 34 Cases of Chronic Atrophic Gastritis Treated with Shenlian Twelve Flavors显示文摘[Objectives]The research aimed to observe the curative effect of Shenlian Twelve Flavors in treating CAG patients with spleen deficiency and blood stasis toxin.[Methods]66 cases of CAG patients with spleen deficiency and blood stasis toxin were selected,32 cases in the control group and 34 cases in the observation group were generated according to the random number table method.The control group was treated with Moluodan;the observation group was treated with Shenlian Twelve Flavors.After treatment,the effective rate,TCM symptom score,gastroscopic score,pathological score,serum gastrin 17(G-17)level,and adverse reactions were compared between the two groups.[Results]The total effective rates of control group and observation group were 84.37%and 91.18%,respectively,and there was no statistical significance between the two groups(P>0.05).For the improvement of TCM symptom score,both groups were improved significantly compared with that before treatment,and observation group was better than control group(P<0.05).For the improvement of gastroscopic score,both groups were improved compared with that before treatment,and observation group was better than control group(P<0.05).For the improvement of pathological scores,both groups were improved compared with that before treatment,but there was no statistical significance between the two groups(P>0.05).[Conclusions]Shenlian Twelve Flavors has definite clinical efficacy in the treatment of CAG with spleen deficiency and blood stasis toxin.It could improve clinical symptoms,delay pathological progress,and regulate the level of G-17.There is no obvious adverse reaction,and it is worthy of clinical reference. | Jincheng WANG Sufang ZHOU Leiming MAO Jiao XU Chuang LIU | 2022 | Medicinal Plant2022，13，4： | 0 |
| 4 | Polynomial AND homomorphic cryptosystem and applications显示文摘Homomorphic cryptosystems are fundamental and highly effective cryptographic primitives for addressing security problems arising in information processing,data analysis and data applications,particularly in secure cloud computing and secure multiparty computation.To privately compute functions such as E(x1∧···∧xt),E(x1∨···∨xt)and E[(x11∧···∧xm1)∨···∨(x1 n∧···∧xmn)](m disjunctive normal form(mD NF))on E(x1),...,E(xt)and E(x11),...,E(xmn)without knowing the decryption key,Boolean homomorphic cryptosystems are necessary.Exploring new homomorphic cryptosystems to solve these problems is appealing,and is of high theoretical and practical significance.To solve problems such as these,we propose a polynomial AND homomorphic cryptosystem based on the ideal theory of abstract algebra;the scheme can be obtained from available multiplicatively homomorphic cryptosystems such as the El Gamal.We prove that the cryptosystem is semantically secure.This polynomial AND homomorphic cryptosystem is a highly effective tool for designing various cryptographic protocols.As examples,we demonstrate its applications to privately compute any DNF(i.e.,P(X1,...,Xm)=E[(x11∧···∧xm1)∨···∨(x1 n∧···∧xmn)]on ciphertexts E(xij)of xij without knowing the decryption key)and the intersection and union of certain private sets. | Shundong LI Sufang ZHOU Jiawei DOU Wenli WANG | 2020 | Science China(Information Sciences)2020，63，1： | 0 |
| 5 | Fusion of EGFP and porcine α 1,3GT genes decrease GFP expression显示文摘Objective:To investigate the effect of fusion proteins expressed by the fused gene of porcineα1,3 galactosyltransierase(α1,3 GT) and enhanced green fluorescent protein(EGFP) on the green fluorescence intensity of EGFP.Methods:The fragment containingα1.3GT was firstly recovered after the pcDNA3.1-α1.3GT recombinant vector were digested with BamHl and EcoRI,and then,the resultant fragment was ligated to the pEGFP-N1 vector which was also digested with the same enzymes.The new recombinant eukaryotic expression pEGFP/a 1,3GT vector was obtained and sequenced.The pEGFP/α1,3GT was used to transfect human lung carcinoma cells A549 and HEKC 293FT,and the expression of EGFP was quantitatively analyzed by fluorescent microscope and flow cytometry.Results:The positive percentage of A549 was 80.5%,and that of 293 FT was 86.5%48 hours after the two cell lines both were transfected by pEGFP-N1.The positive percentage of A549 was 75.8%,and that of 293 FT was 81.2%48 hours after the two cell lines were transfected by pEGFP/α1.3GT.The mean fluorescence intensities of A549 transfected with pEGFP-N1 and pEGFP/α1.3GT were 1.21 and 0.956,respectively when compared with that of A549 without transfection.Meanwhile,the those of the 293FT that were transfected with pEGFP-N1 and pEGFP/αl,3GT were 7.66 and 1.00.respectively when compared with that of 293FT cells without transfection.Conclusions:These results suggested that the expression of EGFP gene fused with porcineα1,3GT gene was partly inhibited. | Yongxiang Zhao Jing Tang Qin Yao Yuan Zhou Huange Zhao Xiaoyun Zeng Jiaqi Shi Guorong Luo Xiaoxun Xie Sufang Zhou Zuguo Liu Xiaoling Lu Donghai Lin Jianming Liu | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，12： | 0 |
| 6 | A neutralizing-protective supersite of human monoclonal antibodies for yellow fever virus显示文摘The yellow fever virus(YFV)is a life-threatening human pathogen.Owing to the lack of available therapeutics,non-vaccinated individuals are at risk.Here,we isolated eight human monoclonal antibodies that neutralize YFV infection.Five recognized overlapping epitopes and exhibited potent neutralizing activity.Two(YD6 and YD73)were ultra-potent and conferred complete protection against the lethal challenge of YFV as both prophylactics and therapeutics in a mouse model.Crystal structures revealed that YD6 engaged the YFV envelope protein in both pre-and post-fusion states,suggesting viral inhibition by a“double-lock”mechanism.The recognition determinants for YD6 and YD73 are clustered at the premembrane(prM)-binding site.Notably,antibodies targeting this site were present in minute traces in YFV-infected individuals but contributed significantly to neutralization,suggesting a vulnerable supersite of YFV.We provide two promising candidates for immunotherapy against YFV,and the supersite represents an ideal target for epitope-based vaccine design. | Yan Li Zhihai Chen Lili Wu Lianpan Dai Jianxun Qi Yan Chai Shihua Li Qihui Wang Zhou Tong Sufang Ma Xiaomin Duan Shuning Ren Rui Song Mifang Liang Wenjun Liu Jinghua Yan George F.Gao | 2022 | The Innovation2022，3，6： | 0 |
| 7 | Science Learning Starts in Childhood显示文摘A model car in a kindergarten in Beijing’s Haidian District clearly mystifies and fascinates a class of hawk-eyed children.The rays of sun set the car moving.Boys and girls alike jostle to take a good look at this solar-powered auto.Some lie on the ground and peer beneath it to check they aren’t being fooled.The class as a whole peppers the lecturer with questions.This is a science class at Middle Class 2 at the Chinese Academy of Sciences(CAS)No.3 Kindergarten.The lecturer,Jin Kui,is director of the SC2 research division | LIU SUFANG ZHOU LIN | 2017 | China Today2017，66，6： | 0 |
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