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| 1 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 2 | Copper uptake and regulation in a copper-tolerant decapod Cambarusbartoni(Fabricius)(Decapoda,Crustacea)显示文摘 | Zia S Alikhan M A | 1989 | Bulletin of Environmental Contamination and Toxicology1989，42，1： | 1 |
| 3 | Acute respiratory and systemic toxicity of pulmo nary exposure to rutile Fe-doped TiO2 nanorods显示文摘 | Nemmar A Melghit K AI-Salam S Zia S Dhanasekaran S At toub S et aI | 2011 | Toxicolo gy2011，279，13： | 1 |
| 4 | Control theoretic approach to tracking radar: first step towards cognition显示文摘 | Haykin S Zia A Xue Y | 2011 | Digital Signal Processing2011，21，6： | 1 |
| 5 | Nicotine enhances expression of the alpha 3, alpha 4, alpha 5, and alpha 7 nicotinic receptors modulating calcium metabolism and regulating adhesion and motility of respiratory epithelial cells显示文摘 | Ndoye A Nguyen VT | 1997 | Res Commun Mol Pathol Pharmacol1997，97，： | 1 |
| 6 | Rabies molecular virology,diagno- sis,prevention and treatment显示文摘 | Yousaf MZ Qasim M Zia S | 2012 | Virol J2012，9，1： | 1 |
| 7 | Incorporating the endoscope into middle ear surgery显示文摘 | Ghaffar S Ikram M Zia S | 2006 | Ear Nose Throat J2006，85，9： | 1 |
| 8 | Incorporating theendoscope into middle ear surgery 显示文摘 | Ghaffar S Ikram M Zia S | 2006 | Ear Nose Throat J2006，85，9： | 1 |
| 9 | Effect of light,salinity,and temperature on seed germination of Limonium stocksii显示文摘 | ZIA S KHAN M A | 2004 | Can J Bot2004，82，： | 1 |
| 10 | Monoclonal antibody alpha IR-3 inhibits non-small cell lung cancer growth in vitro and in vivo 显示文摘 | Zia F Jacobs S Kull F Jr | 1996 | J Cell Biochem Suppl1996，24，： | 1 |
| 11 | Receptor-mediated inhibition of keratinocyte migration by nicotinic acid modulation of calcium flux and intracellular concentration显示文摘 | Ndoye A Lee TX | 2000 | J Pharmacol Sci2000，293，： | 1 |
| 12 | Pediatric tracheostomy:complicationsand role of home care in a developing country显示文摘 | Zia S Arshad M Nazir Z | 2010 | Pediatr Surg Int2010，26，3： | 1 |
| 13 | Amniotic fluid derived stem cells with a renal progenitor phenotype inhibit interstitial fibrosis in renal isehemia and reperfusion injury in rats 显示文摘 | MONTEIRO CARVALHO MORI DA CUNHA MG ZIA S OLIVEIRA ARCOLINO F | 2015 | PLoS One2015，10，8： | 1 |
| 14 | Development of a blenmycin hamster model of subchrenic lung fibrosis pathology显示文摘 | Zia S Hyde DM Girl SN | 1992 | Pathology1992，24，： | 1 |
| 15 | Chemo-radiotherapy:an al- ternative to surgery for squamous cell carcinoma of the rec- tum-report of six patients and literature review显示文摘 | Rasheed S Yap T Zia A | 2009 | Colorectal Dis2009，11，2： | 1 |
| 16 | Role of 2 organizational vision and adaptability in knowledge management 显示文摘 | Shahzad K Zia S A Aslam M M H | 2013 | Problems and Perspectives in Management2013，11，2： | 1 |
| 17 | Synthesis of chitin-bentonite clay based polyurethane bio-nanocomposites 显示文摘 | Zuber M Zia K M Mahboob S | 2010 | International Journal of Biological Macromolecules2010，47，2： | 1 |
| 18 | Cognitive tracking radar 显示文摘 | Haykin S Amin Zia Arasaratnam I | 2010 | IEEE Xplore2010，，： | 1 |
| 19 | Negative phase-sequence voltages on E&W transmission system显示文摘 | ZIA E DAVID S | 2006 | IEEE Transactions on Power Delivery2006，21，3： | 1 |
| 20 | Bio-active cardenolides from the leaves of Nerium oleander显示文摘 | Sabira Begum Bina S Siddiqui Razia Sultana Atiya Zia Amin Suria | 1998 | Phytochemistry1998，，3： | 1 |
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