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| 1 | Differential expression of cell cycle regulators in HCV-infection and related hepatocellular carcinoma显示文摘AIM:To investigate cell cycle proteins in chronic hepatitis C virus infection in order to analyze their role in the process of hepatocyte transformation and to characterize their prognostic properties. METHODS:Subjects of the current study included 50 cases of chronic hepatitis C(CHC) without cirrhosis,30 cases of CHC with liver cirrhosis(LC) ,and 30 cases of hepatitis C-related hepatocellular carcinoma(HCC) admitted to the Department of Hepato-Gastroenterology,Theodor Bilharz Research Institute(TBRI) ,Giza,Egypt.Fifteen wedge liver biopsies,taken during laparoscopic cholecystectomy,were also included as normal controls.Laboratory investigations including urine and stool analysis,liver function tests and prothrombin concentration;serologic markers for viral hepatitis and ultrasonography were done for all cases of the study together with immunohistochemical analysis using primary antibodies against Cyclin D1,Cyclin E,p21,p27 and Rb/p105 proteins. RESULTS:Normal wedge liver biopsies didn't express Cyclin E or Rb/p105 immunostaining but show positive staining for Cyclin D1,p21 and p27.Cyclin D1 expressed nuclear staining that was sequentially increased from CHC to LC(P<0.01) to HCC(P<0.001) cases;meanwhile,Cyclin E revealed nuclear positivity only in the case of HCCs patients that was directly correlated to Rb/p105 immuno-reactivity.The expression of p21 and p27 was significantly increased in CHC and LC cases compared to normal controls and HCCs with no significant difference between well-and poorlydifferentiated tumors.p21 showed only a nuclear pattern of staining,while,p27 presented with either cytoplasmic and/or nuclear reactivity in all studied cases.Correlation analysis revealed a direct relation between Cyclin D1 and p21 in CHC cases(P<0.001) ,between Cyclin D1 and Cyclin E in HCCs(P<0.01);however,an inverserelationship was detected between Cyclin D1 and p21 or p27(P<0.001) and between p21 and Rb/p105(P<0.05) in HCCs. CONCLUSION:Upregulation of Cyclin D1 in CHC plays a vital role in the development and differentiation of HCC;while,Cyclin E may be a useful marker for monitoring tumor behavior.p21 and p27 can be used as predictive markers for HCC.Furthermore,higher expression of Rb/p105 as well as inverse relation with p21 and histologic grades suggests its important role in hepatic carcinogenesis. | Azza E El Bassiouny Mona M Nosseir Mona K Zoheiry Noha A Ameen Ahmed M Abdel-Hadi Ibrahim M Ibrahim Suher Zada Abdel-Hakeem Saad El-Deen Nora E El-Bassiouni | 2010 | World Journal of Hepatology2010，2，1： | 3 |
| 2 | Indications for routine repeat head computed tomography (CT) stratified by severity of traumatic brain injury显示文摘 | Brown C V Zada G Salim A | | 0，，6： | 1 |
| 3 | Cyclic changes in the differentiation of lymphoid cells in reptiles显示文摘 | El Ridi R Zada S Afifi A | 1988 | Cell Different1988，24，： | 1 |
| 4 | Pathogenesis and treatment of intracranial arachnoid cysts in pediatric patients younger than 2 years of age显示文摘 | ZADA G KRIEGER M D MCNATY S A | 2007 | Neurosurg Focus2007，22，2： | 1 |
| 5 | Indications for routine repeat head computed tomography (CT) stratified by severity of traumatic brain injury 显示文摘 | Brown CV Zada G Salim A | 2007 | J Trauma2007，62，6： | 1 |
| 6 | Indications for routine repeat head computed tomography (CT) stratified by severity of traumatic brain injury 显示文摘 | Brown CV Zada G Salim A | 2007 | J Trauma2007，62，6： | 1 |
| 7 | Ternary water in oil microemuisions made of cationic surfactants, water and aromatic solvents 2 droplet sizes and interactions and exchange of material between droplets 显示文摘 | LANG J ZADA R | 1990 | J Phys Chem1990，94，： | 1 |
| 8 | Downregula- tion of c-Jun expression and cell cycle regulatory mole- cules in acute myeloid leukemia cells upon CD44 ligation 显示文摘 | Zada A A Singh S M Reddy V A | 2003 | Oncogene2003，22，15： | 1 |
| 9 | Minimally invasive posterior atlantoa- xial fusion:a cadaveric and clinical feasibility study显示文摘 | Taghva A Attenello FJ Zada G | 2013 | World Neurosurg2013，80，34： | 1 |
| 10 | Indications for routinerepeat head computed tomography(CT)stratified by se-verity of traumatic brain injury显示文摘 | Brown CV Zada G Salim A | 2007 | Trauma2007，62，6： | 1 |
| 11 | Development of sol-gel formulations for slow release of pheromones显示文摘 | ZADA A FALACH L BYERS J A | 2009 | Chemoecology2009，19，： | 1 |
| 12 | Proteomic analysis of acute promyelocytic leukemia:PML-RARα leads to decreased phosphorylation of OP18 at sefine 63显示文摘 | Zada A Geletu M Pulikkan J | 2006 | Proteomics2006，6，21： | 1 |
| 13 | Ternary water in oil rnicroemuisions made of cationic Surfactants,water and aromatic solvents 2 droplet sizes and interactions and exchange of material between droplets显示文摘 | Jada A Lang J Zada R | 1990 | J Phys Chem1990，94，： | 1 |
| 14 | Sex pheromone and analogs of the citrus mealybug,Planococcus citri:Synthesis and biological activity显示文摘 | Dunkelblum E Zada A Gross S | 2002 | IOBC wprs Bulletin2002，25，： | 1 |
| 15 | Indications for routine repeat head computed tomography (CT) stratified by severity of traumatic brain injury显示文摘 | Brown CV Zada G Salim A | 2007 | J Trauma2007，62，6： | 1 |
| 16 | Surgery and radiosurgery for acromegaly: a review of indications, operative techni- ques, outcomes, and complications 显示文摘 | Marquez Y Tuchman A Zada G | 2012 | Intern J Endocrinol2012，2012，38： | 1 |
| 17 | Ternary water in oil microemuisions made of cationic surfactants, water and aromatic solvents 2 droplet sizes and interactions and exchange of material between droplets显示文摘 | JADA A LANG J ZADA R | 1990 | J Phys Chem1990，94，： | 1 |
| 18 | Enzymatic transesterification of racemic lavandulol:preparation of the two enantiomeric alcohols and of the two enantiomers of lavandulyl senecioate显示文摘 | ZADA A HAREL M | | 0，，： | 1 |
| 19 | Sex pheromone and analogs of the citrus mealybug, Planococcus citri: Synthesis and biological activity显示文摘 | Dunkelblum E Zada A Gross S | 2002 | IOBC Wprs Bulletin2002，25，： | 1 |
| 20 | Sex pheromone and analogs of the citrus mealybug, Planococcus citri : Synthesis and biological activity 显示文摘 | Dunkelblum E Zada A Gross S | 2002 | IOBC Wprs Bulletin2002，25，： | 1 |
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